Gene K11D12.10 (Nematode worm)

K11D12.10

Species: Nematode worm
Alias: CE30383, Y58A7A.f, K11D12.10a, K11D12.10, aSWK419
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 5064590-5056209, WormBase Genetic Map location: V:-6.07,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
K11D12.10.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 301 Kinase domain by global Sugen HMM Fasta, JSON
K11D12.10.AA Protein Genbank 883 None Fasta, JSON

Protein domain

Protein domains of K11D12.10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 K11D12.10.AA SH3 72-129 41 2.3e-18 68.24 SMART 1-58 (58) Show / Hide 
Range on Protein: 72-129
Range on HMM: 1-58/58
Sequence Identity: 41% (25 aa)

KAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELN--GKVGLFPSNYAREVT
. ..| | |.|| .||| .  | |||..  .  .|||..|..|  |..|.||||| .|..
PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 K11D12.10.AA SH3_1 75-122 40 2.9e-14 51.13 Pfam 1-49 (49) Show / Hide 
Range on Protein: 75-122
Range on HMM: 1-49/49
Sequence Identity: 40% (20 aa)

VASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRGELN--GKVGLFPS
|| | |.|| .||| .  |.||...  . . ..|..|..|  |..|.|||
VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNTGQEGWFPS
SH3_2 K11D12.10.AA SH3_2 67-128 21 4.6e-08 31.12 Pfam 1-68 (68) Show / Hide 
Range on Protein: 67-128
Range on HMM: 1-68/68
Sequence Identity: 21% (15 aa)

PIRASKAFVA-SYEYEAQKDDELNLPLGAIITLV---TVETNEDGWYRG-EL--NGKV--GLFPSNYAREV
..|. . .|. .|..|   . .|..  | .|..    . . .  .|... |   .|..  |.|||.. .|.
YYRVHCDYVPATYCNENH-EPQLHFKKGDVIKVIDNGDKDWD--NWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase K11D12.10.AA MLK 169-450 49 3.1e-187 624.2 In-house 1-280 (280) Show / Hide 
Range on Protein: 169-450
Range on HMM: 1-280/280
Sequence Identity: 49% (141 aa)

IKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAA
.|||....||..|.....|.|........|......|...||||.||...||.|...|.|.||..|.|.|||||...|..|.|.|.||..||...    .
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK----R

IPLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGTYAWLAP
||..||..||.|.|.||.||....   ..|||||..|.|..|..||||||||||||||||||.......||||||||..|...... |.|.||||||.||
IPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTT-RMSAAGTYAWMAP

EAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISF
|..||.|||..||||||||.||||||.|.||.|..|...|...|.....|.|...||..|.||||||||..|..|||||......
EVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase K11D12.10.AA MLK 169-450 31 5e-118 398.42 In-house 1-291 (291) Show / Hide 
Range on Protein: 169-450
Range on HMM: 1-291/291
Sequence Identity: 31% (99 aa)

IKIKKELQNGRMGEAVGDQMKAAL-----KRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNN----IVRLLGICLEDPY-FGLLLELCEGSSLRN
|.... ...| .|.    .... .       ..|...... |...|... .....|..... |||.|    |....|.||..|. |....| |||.|| |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VCRNLN-----------SDAAIPLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVT
|... .           .|. ........||.|.|.||.|| ..    ..|||||  |.|. | .|                 . ......|||.|||. 
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-IC-----------------H-DMHHGTLKICDFGTS

RKMTAD-ANRFSTAGTYAWLAPEAF---KEGTWSEASDVWSYGVVLWELLTREEPYQ-GHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNF
|...   .|..|.|||||| |||..   .....||..||||.||||||.||||.||. .. |..||...|..|... |. .||..|||||..||| .|. 
RDWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHK

RPKFSTLAISF
||.|.     .
RPSFRQIVQHL
Kinase K11D12.10.AA TKL 175-450 22 1.6e-70 240.62 In-house 1-364 (364) Show / Hide 
Range on Protein: 175-450
Range on HMM: 1-364/364
Sequence Identity: 22% (86 aa)

LQNGRMGEAVGDQMK-------------AALKRFNRHASNFRADVV-----------------STDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPY-
.  |. ||    . .              | |.|..| .... .                    .    .....|... . |.| |||...|.|.. |. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQG--------YVHRDLKADNVLVKEEVCLCMDEEMFQYAYC
            ...  |.|.| ||...           . ....|| ..| ||.||  ..         .||||| .|.||.|    .. ..|  |   
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM--Y---

LKCGKRPFDKLQLKITDFGVTRKMTADAN--------------------RFSTAGTYAWLAPEAFK----------------EGTWSEASDVWSYGVVLW
     .| .   .||.|||  | |. . |                    . .  ||..|.|||...                ... ||..||.|.|.|||
-----NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

ELLTREEPYQGHIPATIA---------FQIANKGQNLSIG------------DSCPDRWKKLMQDCWNLEPNFRPKFSTLAISF
|.|||..||... . ..           ....||. . |             ..||...||||||||. .|. || |...   .
EILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase K11D12.10.AA Pkinase_Tyr 208-450 29 3.9e-64 217.83 Pfam 40-270 (270) Show / Hide 
Range on Protein: 208-450
Range on HMM: 40-270/270
Sequence Identity: 29% (75 aa)

STDEQ--LEQLKREANLVNGL-SHNNIVRLLGICL--EDP-YFGLLLELCEGSSLRNVCRNL-NSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKA
...||  .| . |||..   | .| |||||.|.|.  ..| .  . .|.... .|..  |.  ... ....  |.....|.|.|||||  ....|||| |
AMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAA

DNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTAGT-----YAWLAPEAFKEGTWSEASDVWSYGVVLWELLTRE-E
 |.||.|                         ... ||.||| .| .. | .  .....       |.|||....|  ...|||||.||..||..|.  .
RNCLVTE-------------------------NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQ

P-YQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISF
| |.|  .. .  .|. .|. . . . |||   .||..||. .|. || || .   .
PTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase K11D12.10.AA TyrKc 169-450 23 1.3e-62 215.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 169-450
Range on HMM: 1-280/280
Sequence Identity: 23% (77 aa)

IKIKKELQNG-----RMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGL--SHNNIVRLLGICLED-------PYFGLLLELCEGS
|. .|.| .|     . |..    .. | |  . .|             .| . |||..   |  .| |||||.|.|...       .   ...|.... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

SLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTAD----
.|..  |.   .  ...  |.....|.|.||||| .....|||| | |.||.|.                          . ||.||| .|. . |    
DLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------------TVKISDFGLSRDIYDDDQQG

----ANRF----STA--GTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGH-----IPATIAFQIANKGQNLSIGDS--------CPDRWKK
      |     ..     . |.|||....|. ...|||||.||..||..|. ..         .... ...   .|  . . ..        |||   .
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

LMQDCWNLEPNFRPKFSTLAISF
.|..||. .|. || ||..   |
IMKQCWHEDPEDRPTFSEIHECF
S_TKc K11D12.10.AA S_TKc 150-454 18 2e-40 141.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 150-454
Range on HMM: 1-231/231
Sequence Identity: 18% (59 aa)

TLSDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLE
     .||.|| ..|.|   |               .. . |.|. .                 |...|| ..     | |||.|.... .  .. . .|
YEILRKIGKGAFGKVYKCRHKK--------------TGRIVAIKIIK-----------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVME

LCEG--SSLRNVCRNLNS---DAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVT
.|.|   .|. . .. ..   .  .|  .   .. |.....||. ..| .||||| .|.|. |                           ..||.|||. 
YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------------HIKICDFGLA

RKMTADANRFSTAGTYAWLAPEAFKEGTWSE-ASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWNLEPNFRPKF
|..       .  ||  ..||| .    ..  ..|.|| |..|.|.|... |..   ....  .|             ..  | ... |.. .|. ||  
RQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA

STLAISF-----KQYA
  .  .       .. 
-EALQDEWDIKCHPWF
Kinase K11D12.10.AA TK-Unique 208-450 27 6.8e-39 131.77 In-house 42-294 (294) Show / Hide 
Range on Protein: 208-450
Range on HMM: 42-294/294
Sequence Identity: 27% (76 aa)

STDEQLEQLKREANLVNGLS-HNNIVRLLGICLEDP-YFGLLLELCEGSSLRNVCR-------------NLN----------SDAAIPLGVLIDWATQVA
.||..  ....|... . |  | |||..||.| ..   . ...| |....|..  |             ||.          ....| .. |. .| |.|
ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIA

EGMEYLTK--QGYVHRDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRK-MTADANRFST---AGTYAWLAPEAFK--EGTW-
 ||||| .  .. ||||| | |||. |                         ....||.||| .|. .|  ..  ..      ..|.|||..|  .|.  
CGMEYLASQRKKIVHRDLCARNVLLTE-------------------------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYH

SEASDVWSYGVVLWELLTR-EEPYQGHIPATIAFQIANKGQNLSIGDSC-PDRWKKLMQDCWNLEPNFRPKFSTLAISF
.. |||||.||..||..|  . || |  .. |  .|  .| ..   ..| ...  .||. ||..||  || |....  .
TTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIR-DGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase K11D12.10.AA Pkinase 210-441 19 3.7e-35 125.38 Pfam 39-282 (293) Show / Hide 
Range on Protein: 210-441
Range on HMM: 39-282/293
Sequence Identity: 19% (53 aa)

DEQLEQLKR--EANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGS----SLRNVCRNLN--SDAAI--PLGVLIDWATQVAEGMEYLTKQGYVHRDLK
....... |  |. . . |.| |||||.... ....  . .|.|||     .|    . .   .. ..  .  .......|...|.||. ..| .|||||
SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF---DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLK

ADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRK--MTADANRFSTAGTYAWLAPEAFK-EGTWSEASDVWSYGVVLWELLTREEPY
 .|.|....  ..                       .||.|||. ..     .    . .||. ..|||  .    .. ..|.||.|..|.|.|... |.
PENILIDNNGHIDA---------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF

QGH----IPATIAFQIANKGQ---NLSIGDSCP-------------------DRWKKLMQDCWNLEPNFRP
.||      ..  . |.....     ..  .|.                   .  |... .|... |. ||
PGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase K11D12.10.AA TK 332-450 20 8.3e-33 106.73 In-house 286-486 (486) Show / Hide 
Range on Protein: 332-450
Range on HMM: 286-486/486
Sequence Identity: 20% (41 aa)

DKLQLKITDFG--------VTRKMTADANRFSTAGTYA---------------------------WLAPEAFK---------EGTWSEASDVWSYGVVLW
.... ||.|||         .|..  | .  .. . ..                           |.|||...         .|. ...|||||.||..|
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

ELLTRE-EPYQGHIPA---------TIAFQIANKGQNLSIG---------------DSCP--------------DRWKKLMQDCWNLEPNFRPKFSTLAI
|..|.  ||| | ..          .  ..   .|. |  .               . ||              . .  |||.||...|. || ||.|  
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRL-CRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHE

SF
 .
QL
Kinase K11D12.10.AA ZAK 336-449 40 8e-31 107.04 In-house 143-257 (257) Show / Hide 
Range on Protein: 336-449
Range on HMM: 143-257/257
Sequence Identity: 40% (47 aa)

LKITDFGVTRKMTADANRFSTAGTYAWLAPEAF-KEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWN
.|| |||  | ..      |  || .|.|||        .|. |||||||||||.|||| || .     |.  |  |.  | |  |||   |.|| .|| 
CKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWK

LEPNFRPKFSTLAIS
 .|  || .      
MDPKDRPNMRQIQSI
Kinase K11D12.10.AA LZK 336-450 36 1e-27 90.44 In-house 126-241 (241) Show / Hide 
Range on Protein: 336-450
Range on HMM: 126-241/241
Sequence Identity: 36% (42 aa)

LKITDFGVTRKMTAD-ANRFSTAGTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLMQDCWN
.|| |||  . .      . | .|| ||.|||  .    ||  |.||.||||||.||.| ||.      | . . .    | . ..||.  | ||. ||.
VKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWS

LEPNFRPKFSTLAISF
  |  || |.      
QKPRNRPSFRQILMHW
Kinase K11D12.10.AA UTK 337-450 29 6.4e-27 89.13 In-house 165-296 (296) Show / Hide 
Range on Protein: 337-450
Range on HMM: 165-296/296
Sequence Identity: 29% (39 aa)

KITDFG---VTRKMTA--------DANRFSTAG----TYAWLAPEAFKEG-TWSEASDVWSYGVVLWELLTR-EEPYQGHIPATIAFQIANKG-QNLSIG
|| |||    .| . .        ... .  ..    . .| ||||. .. . ...|||||.|||.||..|.   || |.  . .. |. |.| . .   
KIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCP

DSCPDRWKKLMQDCWNLEPNFRPKFSTLAISF
..||..  .||..||. .| .|| | .|   .
WDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase K11D12.10.AA TKL-Unique 333-450 27 2e-25 86.75 In-house 153-290 (290) Show / Hide 
Range on Protein: 333-450
Range on HMM: 153-290/290
Sequence Identity: 27% (38 aa)

KLQLKITDFGVTRKMTADANRFST----------AGTYAWLAPEAFKE--GTWSEASDVWSYGVVLWELLTREE------PYQGHIPATIAFQIAN--KG
... || |||  .  . . . ...           |.. |.||| ..    . || |||.|.|.||||..||.       ||||  .  ..  ..   ..
EWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEEN

QNLSIGDSCPDRWKKLMQDCWNLEPNFRPKFSTLAISF
. . |...|| . ..|.|.||. .|  || |..   . 
YRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase K11D12.10.AA TK 208-312 14 1.6e-24 78.5 In-house 67-293 (486) Show / Hide 
Range on Protein: 208-312
Range on HMM: 67-293/486
Sequence Identity: 14% (33 aa)

STDEQLE-------------QLKREANLVNG--LSHNNIVRLLGICLED------------PYFGLLLELCEGSS----LRNVCRNLNSDAA--------
| .|...             .. .|. . .   . | |||||.|.|...            . . ...|.... .    ||.  |.   ..         
SQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDN

-----------------------------------------------------------------IPLGVLIDWATQVAEGMEYLTKQ------GYVHRD
                                                                 ...  |. .. |.|.||||| ..      ..||||
QHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRD

LKADNVLVKEE-------------VCLC
| | |.|| |.             . ..
LAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase K11D12.10.AA Ack 337-450 33 3.8e-23 74.95 In-house 146-266 (266) Show / Hide 
Range on Protein: 337-450
Range on HMM: 146-266/266
Sequence Identity: 33% (41 aa)

KITDFGVTRKMTADANRFSTAGTY------AWLAPEAFKEGTWSEASDVWSYGVVLWELLTR-EEPYQGHIPATIAFQIANKGQNLSIGDSCPDRWKKLM
|| |||  |      ..  ....       || |||. . .. | |||||..|| |||  .  |||. |  .. |  .|  .|. |   | || .  ..|
KICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMM

QDCWNLEPNFRPKFSTLAISF
  ||  .|  ||.|| .   .
MQCWQHHPADRPTFSAIRDQL
Kinase K11D12.10.AA UTK 169-310 21 4.2e-23 75.88 In-house 1-164 (296) Show / Hide 
Range on Protein: 169-310
Range on HMM: 1-164/296
Sequence Identity: 21% (38 aa)

IKIKKELQNG-----RMGEAV-----GDQMKAALKRFNRHASNFRADVVSTDEQLE----QLKREAN---LVNGLS-HNNIVRLLGICLEDPYFGLLLEL
... ..|  |     ......     . .|. |.|  .         . ....| .    .. .||.   .   .. | |..||.|.|. .  . ...|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEY

CEGSSLRNVCR----NLN-SDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEE--------VC
.|...||.. |    ...  ...  |  ....| ..|.||.||  .|.||||| | |.|| .         ||
MENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVC
Kinase K11D12.10.AA Ack 203-305 32 5.1e-21 67.65 In-house 36-138 (266) Show / Hide 
Range on Protein: 203-305
Range on HMM: 36-138/266
Sequence Identity: 32% (33 aa)

RADVVSTDEQLEQLKREANLVNGLSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADN
| |... .. .. . ||..    | | ..||| |. |  |   .  ||... ||    |   ..|  ....| |.. |.|.|| ||  .. .|||| | |
RSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARN

VLV
.|.
ILL
Kinase K11D12.10.AA LZK 226-308 33 1.8e-18 58.82 In-house 44-123 (241) Show / Hide 
Range on Protein: 226-308
Range on HMM: 44-123/241
Sequence Identity: 33% (28 aa)

LSHNNIVRLLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQGYVHRDLKADNVLVKEE
| |.||. ..|.|   | .  ..| |    | .|   | .   |.   ..|| .|.|.||.||     .|||||  |.|. ..
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEV---LRERRTITPQLMVDWSKQIAQGMHYLHQHKIIHRDLKSPNILISHN
Kinase K11D12.10.AA TKL-Unique 171-308 23 2e-15 51.02 In-house 1-148 (290) Show / Hide 
Range on Protein: 171-308
Range on HMM: 1-148/290
Sequence Identity: 23% (37 aa)

IKKELQNGRMGE---AVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLKREANLVNGLS-HNNIVRLLGICL----EDPYFGLLLELCEGSSLRNVCR-
. . .. | .|.   ... . . |.|.|.   . .. ..      .. ...| |. . |  | |||.. |.|       |.. . .| |.|.||..|   
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEM------MQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQ

------NLNSDAAIPLGVLIDWATQVAEGMEYLTKQG--YVHRDLKADNVLVKEE
      | |.   ... . .. | ..| ||.||   .    |||||  |.|| ..
NNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNN
Kinase K11D12.10.AA ZAK 216-310 32 4.3e-09 28.7 In-house 38-143 (257) Show / Hide 
Range on Protein: 216-310
Range on HMM: 38-143/257
Sequence Identity: 32% (34 aa)

LKREANLVNGLSHNNIVRLLGICLEDPY-FGLLLELCEGSSLRNVCRNLNSDAAI------PLGVLIDWATQVAEGMEYLTKQGYV---HRDLKADN-VL
. .||     ..| ||.   |||.| |  ..   |  |  ||        |.          . . . ||||.| || ||     .   |||||  | |.
IEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGNSMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI

VKEEVC
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DKNGVC