Gene kin-21 (Nematode worm)

kin-21

Species: Nematode worm
Alias: W08D2.8, CE06563, kin-21, aSWK342, Cehd-3
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 9832915-9834802, WormBase Genetic Map location: n/a,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
kin-21.AA Protein Genbank 534 None Fasta, JSON
kin-21.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of kin-21.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 kin-21.AA SH2 61-151 17 1e-12 49.5 SMART 1-87 (87) Show / Hide 
Range on Protein: 61-151
Range on HMM: 1-87/87
Sequence Identity: 17% (17 aa)

RNWYHGMMFGKAAEKLLKWE----SSYIVRRSMGPTHKFLCITARVEDKYFHFQFNWNS-EGWSCPILYEKFPRIPVKRYEHIYQLLDAWSLVVNQ
 .||||.. .. ||.|||..     ...|| |   . ...... |...|. |.. . |   ....  .       . .... . .|.. ..     
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES-NPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDET-------WRRKFPSL-ELVNHYQHNPLG
Kinase kin-21.AA Fer 167-423 36 2.1e-136 459.43 In-house 1-283 (283) Show / Hide 
Range on Protein: 167-423
Range on HMM: 1-283/283
Sequence Identity: 36% (104 aa)

IALENQLGRGAFGEVIKAK-----YVPMGAT-VPTEVAVKRLIGD-AKRPQLVDFCNEANIMTL-LEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYL
. |...||.|||||| |..     . ..... ....|.||..... |.. |. .|..||.||   . |.|.|..||.....||||.|.||..||.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

QRTPN--VPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITK-ELNVK--ISDFGLSVN----ESETKMK-SLKKAPIRWLSPETFSKGLFNEKTD
. ..|  |. ...|......|.||..| |||.||||.||||||..| ....|  |||||.|..    ..  |||  ..|.|||||.|||...|....|||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGVLLTELMTRCAHDPLW------PKNL-KQVQKWIKESEHPHKIEDGDPSELKEIVD-ACCAKIPSVRINFREVKNRLA
|||.||...| .|..|.....      ..|. || .||| ............|.|...|..  |..| |. |... |....| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase kin-21.AA TyrKc 167-422 34 4.3e-100 339.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 167-422
Range on HMM: 1-280/280
Sequence Identity: 34% (101 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLL--EHKNIVALYGFASLQ-------QPIMLVIEFVPGGDLRKY
| |. .||.|||||| |...        ..|||| |  ||    . ||..||.||. |  .|.|||.||| .. |       .|.|.| |..|.|||..|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LQRTPN-VPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLSVNESET-------KMKS-----LKK--APIRWLSPETFSKGL
|... . .. |. ..|.  ||.|| .|.|||.|||||||||||..... ||||||||| .  .        ....      .|   ||||..||.. .| 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FNEKTDVWSYGVLLTELMTRCAHDPLWP----KNLKQVQKWIKESEHPHKIEDG-------DPSELKEIVDACCAKIPSVRINFREVKNRL
|..|.||||.||.. |..|...  .  .    .. ..| ...|. . . . ...        |.|. .|   |..  |. | .|.|.. ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase kin-21.AA Pkinase_Tyr 167-422 36 2.4e-94 320.16 Pfam 1-270 (270) Show / Hide 
Range on Protein: 167-422
Range on HMM: 1-270/270
Sequence Identity: 36% (100 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQ--LVDFCNEANIMTLL-EHKNIVALYGFAS-LQQP--IMLVIEFVPGGDLRKYLQR
| .  .||.|||||| |... . .    ..|||| |  .|  .|  . || .||.||. |  |.||| |||  .  ..|  |..| |..|.|||..||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TPNVPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLSV---NESET-KMKSLKKAPIRWLSPETFSKGLFNEKTDVWSY
     .... |........||.|| .|.||| |||||||||||.|... |||.||||.    |...  ....  | ||.|..|| .. | |..|.||||.
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLTELMTRCAHDP-LWPKNLKQVQKWIKESEHPHKIEDGDPSELKEIVDACCAKIPSVRINFREVKNRL
|||. |..|...  |  .     .| ..|.|. .  .. .. | |. ..   | .. |. |  |.|. ..|
GVLMWEIFTYGE-QPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase kin-21.AA TK 167-422 19 3.9e-89 298.9 In-house 1-486 (486) Show / Hide 
Range on Protein: 167-422
Range on HMM: 1-486/486
Sequence Identity: 19% (95 aa)

IALENQLGRGAFG---EVIKAKYVPM---------------------GATVPTEVAVKRLI---GDAKRPQLV----------DFCNEANIMTLLE----
| |...||.|.||   || |... ..                     .  ..|.|||| |    ..... ..           ||..||..| ..     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNIVALYG-------------FASLQQPIMLVIEFVPGGD----LRKYLQRTPN--------------------------------------------
 |.||| |||             . ..|.|.|.| |..|.||    ||.||.. ..                                            
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VPSKQIIKFAMEIASGMKHLSSK------NVIHRDLAARNCLITKELN-----------VKISDFGLS
                                .. .| . ... ||.|| .|.||      |..||||||||||......           .||.|||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

VN-----------------------------------ESETKMKSLKKAPIRWLSPETFS---------KGLFNEKTDVWSYGVLLTELMTRCAHDPLWP
 .                                   .......|  | ||||..||..          .| | .|.||||.|||. |..|...  . . 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

KNL---------KQVQKWIKE------------------S-----------EHPHKIEDGDPSELKEIVDACCAKIPSVRINFREVKNRL
 .          ..| . ...                              .. | .. ..| |. ..   |... |. | .|......|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase kin-21.AA UTK 167-422 30 1.6e-64 219.65 In-house 1-296 (296) Show / Hide 
Range on Protein: 167-422
Range on HMM: 1-296/296
Sequence Identity: 30% (90 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPT-EVAVKRLIGDAKRPQLVD----FCNEAN---IMTLLE-HKNIVALYGFASLQQPIMLVIEFVPGGDLRKY
..| .|||.|||||| ||....    ...  |||| .  .|. .|  .    | .||.   .|  .. | |.. |.|  . ..|.|.|.|. ..||||.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQRTPN--------VPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKE-------LNVKISDFG---LS--VN---------ESETKMKS-LKK
|.| .         . . | ...|. ||.|| .|.|....||||||||||...        . .||.|||   .|  ||         ||.  |..  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

APIRWLSPETFSKG-LFNEKTDVWSYGVLLTELMTRCAHDPLWPKNLKQVQKWIKESE-HPHKIEDGDPSELKEIVDACCAKIPSVRINFREVKNRL
.|||| .|| . ..  | .|.||||.||.. |..|. .  |    .  || . . .   . ..  .. | .. ... .|... |. | .|...  ..
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase kin-21.AA TK-Unique 167-361 31 7.1e-64 218.53 In-house 1-234 (294) Show / Hide 
Range on Protein: 167-361
Range on HMM: 1-234/294
Sequence Identity: 31% (74 aa)

IALENQLGRGAFGEVIKAKYVP--MGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLLE-HKNIVALYGFASLQQ-PIMLVIEFVPGGDLRKYLQ-RT
. .....|.||||.|.......  ..   .. |||| |  .|   .  || .|...|  |  |.||| ..|     . | |...|..|.|.|..||. . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PN-------------------------VPSKQIIKFAMEIASGMKHLSS--KNVIHRDLAARNCLITKELNVKISDFGLSV---NESETKMK-SLKKAPI
|.                         . .|. . || .||.||..|.|  |...||||.|||.|.|  ...||.|||..    .. .. |. | .. ||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWLSPETFS--KGLF-NEKTDVWSYGVLLTELMT
||..|| ..  .| . ..|.||||.|||. |..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase kin-21.AA Src 167-362 38 7.2e-61 205.51 In-house 1-196 (255) Show / Hide 
Range on Protein: 167-362
Range on HMM: 1-196/255
Sequence Identity: 38% (78 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQ---RTPN
| |. .||.| |||| ....        |.|||| |  .    .  .|  ||.||. | |...|.||   |   ||  | |.   | | .||.   .. .
IKLCRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

VPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLS--VN--ESETKMKSLKKAPIRWLSPETFSKGLFNEKTDVWSYGVLLTEL
.. .| | .|  .|.||. |.|.|.||||||||| |. ... .|. ||||   .   . |  ...  | ||.|  || .. | |. |.||||.|.||||.
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MTR
.|.
VTY
Kinase kin-21.AA TKL 173-422 21 8.9e-59 201.59 In-house 1-364 (364) Show / Hide 
Range on Protein: 173-422
Range on HMM: 1-364/364
Sequence Identity: 21% (80 aa)

LGRGAFGEVIKAKYVPMGATVP-----TEVAVKRLIGD------------------------AKRPQLVDFCNEANIMTLLE--HKNIVALYGFASLQQP
.|.|.|||| |.|.   |  .      ..||||..  .                        .. ..   |. |  || ..   | ||| ..|..   ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------IMLVIEFVPGGDLRKYLQRTPNVPSKQIIKFAMEIASGMKHLSS--------KNVIHRDLAARNCLITKELN--------------V
             ...| |..|||.|. ||.        |....|..||.|| .| |        ...|||||  .|.|. . ..              .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KISDFGLSVNESETK--------------------MKSLKKAPIRWLSPETFS----------------KGLFNEKTDVWSYGVLLTELMTRC---AHDP
||.||||| . |...                    ... .   .||..|| .                 .. ..||.||.|.|..| |..|||   ...|
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

LWPKNLK----QVQKWIKESEHPHKIE------------DGDPSELKEIVDACCAKIPSVRINFREVKNRL
  |  .     . .... .  ..  |             .  | ..|..   |..  |. | .| |.. ||
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase kin-21.AA EGFR 167-361 35 3.5e-47 154.61 In-house 1-198 (258) Show / Hide 
Range on Protein: 167-361
Range on HMM: 1-198/258
Sequence Identity: 35% (70 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYL-QRTPNVP
. .   || |||| | |  ..| | .|   ||.| |     . .  .. .|| .|  ..|...| | |.   .| ..||  . | | |  |. |   |. 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIG

SKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLS--VNESETKMKSLK-KAPIRWLSPETFSKGLFNEKTDVWSYGVLLTELMT
|.. . ... ||.||. |  . ..|||||||| |. .   ||| ||||.   .  |....    | ||.|.  | .... .  . ||||||| . ||||
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMT
Kinase kin-21.AA Src-Unclassified 167-361 33 3.2e-46 156.45 In-house 1-222 (284) Show / Hide 
Range on Protein: 167-361
Range on HMM: 1-222/284
Sequence Identity: 33% (76 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGD-----AKRPQL----VDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKY
. |   |||| |||| ..|.         .|||| .  .     .    |    ..|| ||.||. ..| |.|.||.  |   |.  . |.   | |  .
VHLLRKLGRGQFGEVWYGKWRGK-----VDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQW

LQRTP--NVPSKQI------------IKFAMEIASGMKHLSSKNVIHRDLAARNCLITKEL-----NVKISDFGLS----VNESETKMKSLKKAPIRWLS
|.       . .              .  |  .||||  |.||  .|||||||| ||          ||. ||||     . . .  |.   . |. |  
LREGGGQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMA

PETFSKGLFNEKTDVWSYGVLLTELMT
|| |  | |. |.||||||.|| |.||
PECFIYGNFSIKSDVWSYGILLWEIMT
Kinase kin-21.AA TKL-Unique 169-422 27 7.2e-45 155.39 In-house 1-290 (290) Show / Hide 
Range on Protein: 169-422
Range on HMM: 1-290/290
Sequence Identity: 27% (81 aa)

LENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLI-GDAKRPQLVD-FCNEANIMTLLE-HKNIVALYGFAS----LQQPIMLVIEFVPGGDLRKYLQ--
  | .|.|..|.|.|.|.        ..||.|..     ....... | || |.|  |. |.||| ..|.       .    .| |..||| |...|.  
FWNKIGEGGYGQVYKGKW------RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQN

--------RTPNVPSKQIIKFAMEIASGMKHLSSKN--VIHRDLAARNCLITKE-----LNVKISDFGLSVNES-ETKMKSLKK---------APIRWLS
        .  . . .|..|.|  ||.|| .|....  .|||||  .| |.. .     .|.||.||||| . | ..||..  .         . .||..
NNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PETFSK--GLFNEKTDVWSYGVLLTELMTRCA----HDPLWPKNLKQVQKWIKE--SEHPHKIEDGDPSELKEIVDACCAKIPSVRINFREVKNRL
|| ..    ...|| ||.|.|. | |. ||.       |    . .|. . ...   . . .| .  | |.... ..|..  || | .| |. .||
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase kin-21.AA Src-Echino1 167-361 39 1.4e-44 152.46 In-house 1-192 (252) Show / Hide 
Range on Protein: 167-361
Range on HMM: 1-192/252
Sequence Identity: 39% (79 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGGDLRKYLQRTP--NV
  .....|.| .||| |  .        |.|||| |   .      ||  |||.|  . |..|| .|   | ..|| .| | .  |.|..||.|    .|
LRMDKKIGKGHCGEVWKGVWNGN-----TPVAVKTLKEKT--MSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHV

PSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLS--VNESETKMKSLKKAPIRWLSPETFSKGLFNEKTDVWSYGVLLTELMT
   ..|    .||||| .| ||||.|||||||| |. |   .|| ||||   ... .   |   | ||.| .||    | |  | ||||.|.|.||..|
KMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVT
Kinase kin-21.AA S_TKc 167-424 22 1.7e-44 155.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 167-424
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRPQLVDFCNEANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPG--GDLRKYLQRTPN-
  . ...|.||||.| |.. .        .||.|..          ....| .|.    |.||| ||..    . . .| |...|  |||..|... .  
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----VPSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNVKISDFGLSVNESETKMKSLKKAPIRWLSPETFSKGLFNE-KTDVWSYGVLLT
      |  .. ... .|....... |...|||||   | |...  ..||.||||.         .       ...|| .    ..  | |.|| |..| 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELMTRCAHDPLWPKNLKQVQKWIKESEHPHKIEDGDPSELKEIVDACCAKIPSVRINFREVKN-------RLAM
|.....   |..| ..... | |.            ..|.|.... |. | |. |.   |. .          .
EMLCGY---PPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase kin-21.AA Pkinase 167-422 22 1.6e-37 133.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 167-422
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

IALENQLGRGAFGEVIKAKYVPMGATVPTEVAVKRLIGDAKRP-QLVDFCN--EANIMTLLEHKNIVALYGFASLQQPIMLVIEFVPGG----DLRKYLQ
. .. ..|.|.||.| |.. .  |     .||||..  . ... ...   .  |. ||  | |.||| ||..    . | .| |...||    ||  |..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--RTPNV--PSKQIIKFAMEIASGMKHLSSKNVIHRDLAARNCLITKELNV----KISDFGLSV---NESETKMKSLKKAPIRWLSPETFS-KGLFNEKT
  |  ..  . ....... .|..|.... |...|||||   |.|| .. ..    ||.||||.    . . . |...    .....||          | 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIRGGQYYGPKV

DVWSYGVLLTELMTRCAHDPLWP-K------NLKQVQKWIKESEHPHKIEDGDP-------------------SELKEIVDACCAKIPSVRINFREVKNR
|.||.|..| |....    |..| .      . .|. . |.. . .  ..  ..                   .|.|.... |..| |. |........ 
DMWSCGCILYEMLCGR---PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase kin-21.AA TK-Unique 409-422 50 0.324638 0.09 In-house 281-294 (294) Show / Hide 
Range on Protein: 409-422
Range on HMM: 281-294/294
Sequence Identity: 50% (7 aa)

PSVRINFREVKNRL
|. | .||..|.||
PEERPSFRQIKHRL