Gene kin-23 (Nematode worm)

kin-23

Species: Nematode worm
Alias: W04G5.6, kin-23, W04G5.6N, Cehd-7, CE28099, aSWK381
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 11650256-11648737, WormBase Genetic Map location: I:9.85, Secondary Group: TK

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
kin-23.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 283 Kinase domain by global Sugen HMM Fasta, JSON
kin-23.AA Protein Genbank 396 None Fasta, JSON
kin-23.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of kin-23.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase kin-23.AA KIN16 76-358 48 3e-219 650.1 In-house 1-332 (332) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-332/332
Sequence Identity: 48% (160 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGMKKHPNILSLVG-VVIERN------VMLIMEYVEGGD
...|...|||.||||....|..|.......|.....||||...|.|||.|.|..|.|||||| ..||||.|.||| |.....      .| ..||||.||
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LLKFLKRKS--YVRYQLEPDGD---------------------------------ALCMADLLSFAFQIAHGMQYLERVPC-VHRDLALRNVLIKRNGVI
|.|||...   . ..|...|..                                 .||..||||||.|||.||..|..||| ||||||.|||.|||| .|
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIADFGLARRHENKDYYRTRS-VGTAIPLNWLAPECFEGSIN---KFDSKSDVWSFGVCLFELFSLGEPPYKELESNN--IAYDLLLADFLRKGNQLSQP
|||||||||.||||||||..| ..|..|..|.|||||| ...   ||..||||||.||||.|.|||||.||.....||  ..|. .....|||||.|.||
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQP

EHCTLEIYTFMKACWNLIPEARPSFSACTRFF
|||. |||.||| |||..||.||.|| |..||
EHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase kin-23.AA TyrKc 76-358 33 1.1e-120 408.18 SMART 1-280 (280) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-280/280
Sequence Identity: 33% (105 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGM-KKHPNILSLVGVVIE--------RNVMLIMEYVEG
|. .. .|.|.||.||.....              .||||   ...    ..  ..|...||   ..||||. |.||...          .|..|||...
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GDLLKFLKRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLARRHENK-------DYYRTRS--VGTA
|||...|...             |||.|||||..||| ||.||.. .|.||||| ||.|...|....|.||||.| ....       ||||...   | .
GDLKDYLRKHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-IPLNWLAPECFEGSINKFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEH--------CTLEIYTFMKACWNLIPEAR
 .|. |.||||.    .|| .||||||||||..|.|..|..|| . . .    .  .  ....|. . ||..        |. |.|. || ||.  || |
MLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

PSFSACTRFF
|.||.. ..|
PTFSEIHECF
Kinase kin-23.AA Pkinase_Tyr 76-358 36 4.1e-117 397.27 Pfam 1-270 (270) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-270/270
Sequence Identity: 36% (108 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQ--KKLVYEELKVMCGMKKHPNILSLVGVVI--ERN--VMLIMEYVEGGDL
|.  . .|.| ||.||.....       .  .   .||||   .... .|  ..   .|.|.|. . .||||..|.||..  ..   ....|||...|||
ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

LKFLKRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLARRHENKDYY-RTRSVGTAIPLNWLAPECF
|..|....       .|...|.| |||....||| ||.|||. .|.||||| ||.|...|.|..|.|||||| ..|.||| |.|. |  .|  |.||||.
LDYLRKHR-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECI

EGSINKFDSKSDVWSFGVCLFELFSLGEPP-YKELESNNIAYDLLLADFL-RKGNQLSQPEHCTLEIYTFMKACWNLIPEARPSFSACTRFF
  ..  | .|||||||||...|.|..|| | |...  .       . ... ..|... .||.|. |||. || ||.  || ||.||.. ...
NYGK--FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE------VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase kin-23.AA TK 76-358 23 5.1e-102 342.84 In-house 1-486 (486) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-486/486
Sequence Identity: 23% (116 aa)

ISNEQSIGSGFFG---VVYRAKLRRK--------PTQEVSSHSIYF---------DVAVKESS--NNHDISQKKL--------------VYEELKVMCG-
|  .. .|.| ||   .||....|..        | ... .   ..         .||||     ....  ....                ||.|.||  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMT-V-TLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHS

MKKHPNILSLVGVVIERN-------------VMLIMEYVEGGD----LLKFLK--RKSYVRYQLEPD---------------------------------
. .||||..|.||. .               .|..|||...||    |...|.  |.    .| .||                                 
LGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQ

----------GDALCMADLLS-------------------FAFQIAHGMQYLERVPC------VHRDLALRNVLIKRNGV-----------IRIADFG--
          ...|...|||.                   ...||| ||.||.. .|      |||||| ||.|. .|.|           ..|||||  
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LARRHEN-KDYYRTRSVGT----------------------AIPLNWLAPECFEGSI-------NKFDSKSDVWSFGVCLFELFSLG-EPPYKE
      |||.... .||||..| ||                       .|. |.||||... .       .|| .|||||||||...|.|..| ||.| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

LESNN----IAYDLLLADFLRKG--------------NQLSQPEHCT--------------LEIYTFMKACWNLIPEARPSFSACTRFF
. ...      ..  . ..||.|              ... ||.||.               |.| .|. ||.. || ||.||.. ...
MSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase kin-23.AA TK-Unique 76-358 32 2.2e-76 260.1 In-house 1-294 (294) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-294/294
Sequence Identity: 32% (99 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGMKKHPNILSLVGVVIER--NVMLIMEYVEGGDLLKFL
. ....||.| || |.|.......     ...    ||||    |..  .|.    |...|   ..||||....|. ..   ..|.||||...|.|...|
LEVGDVIGEGAFGQVWRGEVWGIW----KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

KRKSYVRYQL------------EPDGD---ALCMADLLSFAFQIAHGMQYLER--VPCVHRDLALRNVLIKRNGVIRIADFGLARRHENKDYYRTRSVGT
... ... |             .||..   .. . ||..||.||| ||.||..    .|||||. ||||. ...|. |.|||.||. ..   | .     
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

AIPLNWLAPECFEGSINKF-DSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEHC-TLEIYTFMKACWNLIPEARPSFSAC
 ||. |.||| .    . .  .||||||||| ..|.|.||..|| .. . .      . . .|.|  . ||||| . |.| .|| ||.. || ||||...
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD------IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

TRFF
.  .
KHRL
Kinase kin-23.AA Met 77-352 31 1.2e-65 214.13 In-house 1-271 (271) Show / Hide 
Range on Protein: 77-352
Range on HMM: 1-271/271
Sequence Identity: 31% (92 aa)

SNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESS--NNHDISQKKLVYEELKVMCGMKKHPNILSLVGVVIERNV---MLIMEYVEGGDLLK
  .. || |.||.||..... .  .|         .|.|  .     || .    ..|  .| .. .|||.|||.|. ..      . . .| ..|||..
HFDDVIGQGHFGCVYHGMYHDNDGNEH-------HCACKSLHGERITDIQHISQFLREGIMMKHF-DHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKT

FLKRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLARRH-ENKDYYRTRSVGTA---IPLNWLAPEC
| .  .           ..|. ||..|..|.| ||.|.     |||||| || ..    .. .|||||.|     | ||  ..  |.    |. |.||||
FIRNPQ----------NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHH-THPARLPVKWMAPEC

FE------GSINK-FDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKG--NQLSQPEHCTLEIY-TFMKACWNLIPEARPSFS
 .         .. | .||||||||| . ||.  | ||| .  .       ..  .|  |  . |.|||.|   .|   | .||   ||.||.||
LQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNW-----FDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase kin-23.AA UTK 76-358 30 3.4e-65 221.99 In-house 1-296 (296) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-296/296
Sequence Identity: 30% (94 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKL----VYEELK---VMCGMKKHPNILSLVGVVI-ERNVMLIMEYVEGG
.   . .|.| ||.|..|.... . ..  .     |||||. .. .|  |..     . || .   .|   . |||.| ||||.  |   |...|| |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEM-----DVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENG

DLLKFLKRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNG-------VIRIADFG---LARRHEN--------KDYY
||...| |    | ........| . ..|..| .||.|||||..  .|||||| ||.|. ...       |..|||||   ..||  .         .||
DLRSYLRR---HRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

RTRSVGTAIPLNWLAPECFEGSINKFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKG-NQLSQPEHCTLEIYTFMKACWNLIPEAR
 .... ...|. | |||..     .| .||||||||| ..|... |  ||...     . . ... ....|  .. .|..| ...|. |..||.  |. |
YMAQHQDRWPIRWMAPEALTHHT-RFTTKSDVWSFGVVCWEIWTWGRLPYPGM-----SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQER

PSFSACTRFF
|.|   . ..
PDFEDLVQQM
Kinase kin-23.AA TKL 82-358 21 5.3e-62 212.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 82-358
Range on HMM: 1-364/364
Sequence Identity: 21% (85 aa)

IGSGFFGVVYRAKLRR-----KPTQEVSSHSIYFDVAVKESSNNH-------------------------DISQKKLVYEELKVMCGMKKHPNILSLVGV
||||.||.||..|.|      .      |     |||||  . ..                         ..|. .   ||  .|. . .||||....|.
IGSGGFGEVYKGKWRGWGGKCP------S-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGY

VIERN--------------VMLIMEYVEGGDLLKFLKRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLER--------VPCVHRDLALRNVLIKRN
... .               ...|||..||.|| .|                  .  ....| .|| ||.||           | .||||  .|.|...|
CCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDEN

GV--------------IRIADFGLARRHENKD----------------YYRTRSVGTAIPLNWLAPECFEGSIN--------------KFDSKSDVWSFG
.               . |.||||.|.....                  .|...      ..|.|||...|..|              ... |.||.|||
WTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG

VCLFELFSLGEPPYKELESNNIAYDLLLADFLRK----GNQLSQP------------EHCTLEIYTFMKACWNLIPEARPSFSACTRFF
..|.|...  .| |.. ..  |. |. . ... .    |...  |            ..|  ..   |. ||.  ||.||||. ..  .
IVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase kin-23.AA EGFR 76-359 32 2.8e-57 188.67 In-house 1-258 (258) Show / Hide 
Range on Protein: 76-359
Range on HMM: 1-258/258
Sequence Identity: 32% (93 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGMKKHPNILSLVGVVIERNVMLIMEYVEGGDLLKFLKR
.   .  ||| || ||.      |  |    ..   ||.|.  .. . .... . .| .|| .. .||... |.|| .. ...|.  |   | || ... 
LKKVKVLGSGAFGTVYKGIWI--PEGE----NVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVCMHSQMQLVTQYMPYGCLLDYVRQ

KSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLAR--RHENKDYYRTRSVGTAIPLNWLAPECFEGSIN
            |..   .|| ...||| ||||||    |||||| ||||.|    ..|.|||||.   |..|.|   .  |  .|  |.| ||.  .  
HK----------DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEY---HAQGGKMPIKWMALECI--HHR

KFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEHCTLEIYTFMKACWNLIPEARPSFSACTRFFQ
.. ..|||||.|| . ||   |. ||. .. ..|       |.| ||..|.||. ||. .|  |  || . .. || |   .  |.
CYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREI------PDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase kin-23.AA Src 76-358 31 8.6e-57 191.45 In-house 1-255 (255) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-255/255
Sequence Identity: 31% (89 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGMKKHPNILSLVGVVIER-NVMLIMEYVEGGDLLKFLK
|  .. .|.| || |. .. . .            .||||  .  .  |.. .  .| ..|  . .|.....|  |. .   .  . || . | ||..||
IKLCRKLGQGQFGEVWMGYWNGN-----------TKVAVKTLKPGT-MSPEAFL-QEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLK

RKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLARRHE-NKDYYRTRSVGTAIPLNWLAPECFEGSIN
.        ...| .| . .|...| |.| ||.|||.   .||||| ||||.  | |  .|||||||  . ..| |  |. |  .|  | |||..  . .
K--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH-GAKFPIKWTAPEAI--NYG

KFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEHCTLEIYT-FMKACWNLIPEARPSFSACTRFF
.|  ||||||||. | |... |  ||.  .           . . .|  . .|..|  |.|   |. ||.  || || |     |.
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEV------LQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase kin-23.AA KIN6 142-358 35 2.9e-55 181.02 In-house 77-305 (305) Show / Hide 
Range on Protein: 142-358
Range on HMM: 77-305/305
Sequence Identity: 35% (84 aa)

HPNILSLVGVVIERN-VMLIMEYVEGGDLLKFLK-RKSYVR----------YQLEPD--GD--ALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVL
|| . .. | | ..  . |. || . .||||.|. |. |.            ..| .   |   .   ||..||.||. || ||    |.||||| ||||
HPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVL

IKRNG---VIRIADFGLAR-RHENKDYYRTRSVGTAIPLNWLAPECFEGSINKFDSKSDVWSFGVCLFELFSLGEPPYKELESNNI-AYDLLLADFLRKG
.          | ||||.|     .  | ... |   |. |.||||...   .|  ||||||||| .||.||||. || |.    .   ...   ..|.|
VTEGCRMKTCKISDFGLCRYPYMDQFQYTSKG-GRYLPIKWMAPECLKHY--EFSYKSDVWSFGVLMFEMFSLGDVPYPEM----QRPTEMI--EHHRSG

NQLSQPEHCTLEIYTFMKACWNLIPEARPSFSACTRFF
  ...|. |. |||  |. ||.  |. || |.     |
RRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase kin-23.AA Ack 142-358 36 8.4e-52 173.02 In-house 61-266 (266) Show / Hide 
Range on Protein: 142-358
Range on HMM: 61-266/266
Sequence Identity: 36% (81 aa)

HPNILSLVGVVIERNV-MLIMEYVEGGDLLKFLKRKSYVRYQLEPDGDALC-MADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRN-GVIRIADFG
||... | |||      |...|  ..| ||  |.         .. ..|    . |. |. ||| ||.|||   |.||||| ||.|  .    . |.|||
HPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLR---------KHCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFG

LARR-HENKDYYRTRSVG-TAIPLNWLAPECFEGSINKFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEHCTLEIYTF
| |.  .|.||||.       .|. | ||||      .| ..||||.|||.| | || || |.. .    |     |    ..|  | .|..|  .||. 
LMRALGQNEDYYRMEFHRNLKVPFAWCAPECLR--HRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQI-----LQKIDKEGERLPRPDCCPEDIYQM

MKACWNLIPEARPSFSACTRFF
|. ||   |. ||.|||   ..
MMQCWQHHPADRPTFSAIRDQL
Kinase kin-23.AA S_TKc 76-358 21 1.2e-42 148.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-231/231
Sequence Identity: 21% (63 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKKLVYEELKVMCGMKKHPNILSLVGVVIERNVMLIMEYVEG--GDLLKFL
    . ||.| ||.||... ..              ||.|. .        . .. |....    .||||  | .|  . .. ..|||..|  |||....
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYI

KRKSYVRYQLEPDGDALCMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVIRIADFGLARRHENKDYYRTRSVGTAIPLNWLAPECFEGSIN
|.. . ...       .   .  ... ||. ...|. .   .||||   |.|. .  .| |.||||||.                 ....||| .     
KKRGRHGLR-----FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----

KFDS-KSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKGNQLSQPEHCTLEIYTFMKACWNLIPEARPSFSACTR---------FF
...  |.|.||.|..|.|... |.||.      .  .....                . |   |.. |..  || ||.   . .         .|
GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase kin-23.AA Pkinase 76-358 24 3.4e-36 129.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 76-358
Range on HMM: 1-293/293
Sequence Identity: 24% (80 aa)

ISNEQSIGSGFFGVVYRAKLRRKPTQEVSSHSIYFDVAVKESSNNHDISQKK-----LVYEELKVMCGMKKHPNILSLVGVVI-ERNVMLIMEYVEGG--
.  .. |||| ||.||... .  .            ||||. .  |. |.|.     |   |...|  . .||||. | ...  .... ..|||.|||  
YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY

--DLLKFLKRKSYVRYQLEPDGDAL--CMADLLSFAFQIAHGMQYLERVPCVHRDLALRNVLIKRNGVI----RIADFGLARRH-ENKDYYRTRSVGTAI
  ||  ....          .. ..   . .. ... ||. |..|. .  ..|||| . |.||..||.|    .|.|||||. . . ..   |  .||  
VMDLFDYIST---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT--

PLNWLAPECFEGSIN---KFDSKSDVWSFGVCLFELFSLGEPPYKELESNNIAYDLLLADFLRKG--NQLSQPEHCT-------------------LEIY
 ....|||     |.   . ..|.|.||.|. |.|... |.||...   . . .| .   ....|  .  . |. |.                    |  
-PWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC-WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

TFMKACWNLIPEARPSFSACTRF--F
 |.| |... |. ||..  .     |
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase kin-23.AA Ack 76-93 44 0.039995 2.97 In-house 1-18 (266) Show / Hide 
Range on Protein: 76-93
Range on HMM: 1-18/266
Sequence Identity: 44% (8 aa)

ISNEQSIGSGFFGVVYRA
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ITLCEKLGDGCFGVVWRG