Gene ksr-1 (Nematode worm)

ksr-1

Species: Nematode worm
Alias: CE25854, ksr-1, F13B9.4, F13B9.5, sur-3, aSWK423, sar-2
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 8278903-8287043, WormBase Genetic Map location: X:-0.254161,

Classification

Group: TKL
Family: RAF
Subfamily: KSR

Sequence

Name Sequence Type Origin Length Description Download
ksr-1.AA Protein Genbank 771 None Fasta, JSON
ksr-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ksr-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1 ksr-1.AA C1 216-269 21 7.8e-11 43.24 SMART 1-61 (61) Show / Hide 
Range on Protein: 216-269
Range on HMM: 1-61/61
Sequence Identity: 21% (14 aa)

HKWHRSTKFRFSGDAVCHFCQRPLGFGFLNA----WEKCRSCKWKVHTQCKGRVGD-------SC
|.||. ..    ... |. |. .....| ..    . .|. ||.|.| .|. .| .       .|
HHWHWWRF----KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase ksr-1.AA KSR 477-745 52 2.2e-197 662.0 In-house 1-272 (272) Show / Hide 
Range on Protein: 477-745
Range on HMM: 1-272/272
Sequence Identity: 52% (143 aa)

DKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGSQSLYTLLHVVREKLDLAT
.|....||.||||||.||...|.||.|.|.|.||.|.....|.||.||..||||||.||.||.|..|.......||||.||||.||...||.|||||...
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

TRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKSGYLTSKF-WTNYIAPELAMAMRTEYDEYECDDFPFSENSDVY
|..|||||||...|||.|.|.||||.||||..|.|.||||||||..|..||.|..|....|.... |..|.||||..|||..||||.|...|||..||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AFGCVWFEMLTGALPYAGELPHQILFAKTQG--IRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKL
|||..|.||..|..|........|.....||  .|.||.||.|..|.||.|..||...||.|||..||...|
AFGTIWYEMICGEWPFKYQCAESIIWQMCQGEGMRQVLRNVQCGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase ksr-1.AA RAF 478-745 41 2.1e-160 539.15 In-house 1-275 (275) Show / Hide 
Range on Protein: 478-745
Range on HMM: 1-275/275
Sequence Identity: 41% (116 aa)

KQAP-IIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSD--GQYGMVMSLSKGSQSLYTLLHVVRE-KLD
.|.. .||.||||.|.||...||||||...|...... .....|| ||..||.|||.||.||.||.|..  ..|..|....||| .||. .||... |.|
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPE-HQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGS-TLYHHIHVQKTEKFD

LATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHP-KQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDFPFSENS
...|..|||||||...|||.|.|.|.||.||||.|.....|||||||....||.... ..|........|....|||....||...|||.||..|||..|
MNWTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQS

DVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLP----NVKCTQELKELLVSCWNTAPQDRPTLTDINLKL
||||||.||.|...|..||... .|...............    .|.|..|.||||..||...|..||....|. ..
DVYAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase ksr-1.AA RAF 478-747 32 4.1e-75 242.95 In-house 2-282 (282) Show / Hide 
Range on Protein: 478-747
Range on HMM: 2-282/282
Sequence Identity: 32% (92 aa)

KQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKA-EEFKLEVSAYKNTRHDNIALFLGYFMSDG--QYGMVMSLSKGSQSLYTLLHVVRE--KL
.  . || |.|| | ||  .||||||.  ... . .  .|   || ||..||.|||.||.||.||   .    |  |     .| |||  .||     |.
MVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHS-SLYHHIHVQETREKF

DLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKSGYLTSKFWTNYIAPELAM--AMRTEYDEYECDDFPFSE
|. ..  |..|.||. .||| |.|.| ||.|.||.|.  ..|.|.|||   .|..  |. .   .    |  ..||| .    .    |    |. |.| 
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

NSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNV-----KCTQELKELLVSCWNTAPQDRPTLTDINLKLTA
 ||||.|| | .|..|. .|| ..  .. ....  |   ..|       .| . ...|.  ||   ...||    |  ..| 
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase ksr-1.AA TKL 483-745 23 5.4e-72 245.49 In-house 1-364 (364) Show / Hide 
Range on Protein: 483-745
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

IGRGRFGKVLRGFHYG-----------DVAVKVYTMEH-----------------------ISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFM-----
||.|.||.| .| . |           |||||.. ...                         .||.  .... |.   ...||.|| .|.|| .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SDGQYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIAQQICQAVSYLHT--------KKILHKDLRSKNILLESKNK--------------
        ..||...|| . .|   |..|.        .  . ..|..|.....|||.        ..|.| || |||||. ....              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VVITDFGILSMKRLAHPKQKSG---------------YLTSKFWTNYIAPELAMAM--RTEY---DEYECDDFPFSENSDVYAFGCVWFEMLTGALPYA-
. |.|||.  ..     .....                 |   .... |||. . .   ||.   || .|  |..|| .|||.|| |..|.||. .||. 
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYD

-GELPHQ------ILFAKTQ--GIRPVLP-----------NVKCTQELKELLVSCWNTAPQDRPTLTDINLKL
 .. |..      . |..    | || .|           .  | ...|.|.  ||.. |..||. ..|  .|
YPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Pkinase_Tyr ksr-1.AA Pkinase_Tyr 474-745 25 3.8e-57 194.15 Pfam 1-270 (270) Show / Hide 
Range on Protein: 474-745
Range on HMM: 1-270/270
Sequence Identity: 25% (76 aa)

IEFDKQAPIIGRGRFGKVLRGFHY-------GDVAVKVYTMEHISDASKKA---EEFKLEVSAYKNT-RHDNIALFLGYFM-SDGQ--YGMVMSLSKGSQ
|.|.|.   .|.| ||.| .|  .        .||||.   |   .|....   |.|  |..  |.  .|.||  ..|  .  ...  . .|| . ..  
ITFGKK---LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG-

SLYTLLHVV---REKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMK----RLAHPKQKSGYLTSKFWTNYIAPELAM
.|.. |.     ...|.. .  ....||... .||. |.. | ||. .|.|....|.| |.|||            . |...|     .|.   |||  .
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWM---APECIN

AMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLT-GALP-YAGELPHQILFAK-TQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKL
 ..            |.. |||..|| ...|..| |. | |.|  ..... .   .| |   .  .|..|. .|. .||.  |.|||| ..|  .|
YGK------------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ksr-1.AA TKL-Unique 479-745 27 4.4e-38 131.92 In-house 1-290 (290) Show / Hide 
Range on Protein: 479-745
Range on HMM: 1-290/290
Sequence Identity: 27% (84 aa)

QAPIIGRGRFGKVLRGFH-YGDVAVKVYTMEHI-SDAS-KKAEEFKLEVSAYKNTR-HDNIALFLGYFM----SDGQYGMVMSLSKGSQSLYTLLH----
    ||.| .|.| .| .   .||.|.   .|. .| | .. .||. ||.  |. . |.|| .. || |    . ... .||.   |. ||| .||    
FWNKIGEGGYGQVYKGKWRGYPVAIKQ---FHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGG-SLYDVLHQNNN

-----VVREKLDLATTRKIAQQICQAVSYLHTKK--ILHKDLRSKNILLESK-----NKVVITDFGILSMKR--LAHPKQ-KSGYLTSKFW--TNYIAPE
         ||...   |.|..| |.  |||...  |.| ||.|.|.|. ..     ... | |||.   .   .. ..  ..|   . .   ....|||
NNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

LAMAMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLTGAL------PYAGELPHQILFAKTQ---GIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTD
. .             . .|| ||||.|| |  |..|. .      || |  . |.. ....   . || .||  | .|...|.  ||.  |..||....
VLRMNF----------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPN-HCPKEYRDLIQQCWHHDPSQRPSFDE

INLKL
|  .|
IIHRL
Kinase ksr-1.AA Pkinase 482-745 21 1.3e-35 126.99 Pfam 6-293 (293) Show / Hide 
Range on Protein: 482-745
Range on HMM: 6-293/293
Sequence Identity: 21% (66 aa)

IIGRGRFGKVLRGFHYGD---VAVKVYTMEHISDASKKAEEFKL--EVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGS---QSLYTLLH-VVREKL
.||.| ||.| .. | |.   ||||.   .|..  |.| ..  .  |..  |. .|.||  ....|.... . ||| .  |    ..|.....   . ..
KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEK--SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCF

--DLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKV----VITDFGILSMKRLAHPKQKSGYLTSKFWT-NYIAPELAMAMRTEYDEYECDD
  .  . .... ||.... |.| ..|.| || . |||. ... .     |.|||.   ..      ... .|.   | .|.|||. .           ..
YFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIR-----------GG

FPFSENSDVYAFGCVWFEMLTGALPYAGE------LPHQILFAKTQGIRPVLPNVKCT-------------------QELKELLVSCWNTAPQDRPTLTD
 . .  .|....||. .|||.| .|. |.       . |... . ... .     .|.                   .|.|... .|..  |..||| ..
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

INLK--L
|     .
ILQHPWF
Kinase ksr-1.AA STE 478-737 17 2.1e-31 108.23 In-house 1-347 (359) Show / Hide 
Range on Protein: 478-737
Range on HMM: 1-347/359
Sequence Identity: 17% (63 aa)

KQA-PIIGRGRFGKVLRGFHY----GD--------------VAVKVYTMEHIS-------------DASKKAEEFKLEVSAYKNTR--HDNIALFLGYFM
 .   .||.| ||.| .. .     ..              .|.|.  .|. .             . ... .... |..  |. .  |.||  ..|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------QYGMVMSLSKG--SQSLYTLLHVVREKLD----------LATTRKIAQQICQA-VSYLHTKKILHKDLRSKNILLESKNKVVITDFGILS
 .|       .  ..| .  |    ...   . . . |.              ..|..||...  .||| ..| | |. . ||||     | ..|||. .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MKRLAHP--------------KQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGI--
     ..              .||.  ..      . |||  . ...        | . .. .|.. .||.  ||.||  |.. . |.. .|......  
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQG-R-----DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-------------RPVLPNV------------------KCTQELKELLVSCWNTAPQDRPT
              | ||.                   |...|.|. .  | .  |..|||
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase ksr-1.AA S_TKc 477-748 22 1.5e-27 98.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 477-748
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

DKQAPIIGRGRFGKVLRGFHYG---DVAVKVYTMEHISDASKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSLSKGS-QSLYTLLHVVREK-
 .   .||.| |||| .. | .    ||.|.             | .. |..  |. .|.||  ....| . . . ||| .  |.  .|.....  . . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPKQKSGYLTSKFWTNYIAPELAMAMRTEYDEYECDDFP
    ..  ..|....|||.|. |.| ..|.| ||   |||| .   . |.|||.                |     .|.|||.                .
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------------G

FSE-NSDVYAFGCVWFEMLTGALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINL------KLTAL
..   .|....||. .|||.|  |.     .| .| |             ..|.|...  |..  |..|||  ..        .   .
YGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ksr-1.AA CAMK 482-620 18 7.8e-27 82.9 In-house 1-241 (425) Show / Hide 
Range on Protein: 482-620
Range on HMM: 1-241/425
Sequence Identity: 18% (45 aa)

IIGRGRFGKVLRGFHY-GD--------------VAVKVYTMEHISD------------------------ASKKAEEFKLEVSAYKN-------TRHDNI
..|||.|||| ...|                  ||.|..  . ..|                          |. .... |..  |.        .| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ALFLGYFMSDGQ-------------------YGMVM---SLSKGSQSLYTLLHVVREK-----------------LDLATTRKIAQQICQAVSYLHTKKI
  .. .. .. .                   . |||    .  |   .  |.  ..|.                 .. . .|.. .|||.|| |.| ..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHKDLRSKNILLESK-----------------NKVVITDFG
 | ||   |||| ..                 |.. |.|||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFG
Kinase ksr-1.AA TK 668-745 22 4.7e-20 63.23 In-house 371-486 (486) Show / Hide 
Range on Protein: 668-745
Range on HMM: 371-486/486
Sequence Identity: 22% (26 aa)

FSENSDVYAFGCVWFEMLTGA-LPYAGELPH---------QILFAKTQ-------------GIRPVLPN-VKCT--------------QELKELLVSCWN
|.. |||..||.. .|..| .  ||.|....         | .. . .             | |  .|  . |.              .|. .|. .||.
FTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWH

TAPQDRPTLTDINLKL
  |.|||| ...  .|
YDPEDRPTFSQLHEQL
Kinase ksr-1.AA TK 477-620 14 1.9e-19 61.17 In-house 1-296 (486) Show / Hide 
Range on Protein: 477-620
Range on HMM: 1-296/486
Sequence Identity: 14% (43 aa)

DKQAPIIGRGRFG---KVLRGFHYG----------------------------DVAVKVYTMEH-ISDASKKAEEFK------------LEVSAYKN--T
 .    .|.| ||   .| .|  .|                            .||||. . ..  |.. ...||..            .| .  ..   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHDNIALFLGYFMSD------------GQYGMVMSLSKGSQ---SLYTLLHVVREK--------------------------------------------
.|.||  ..|. . .            . . .|| . ..     || . |.  |.|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDLATTRKIAQQICQAVSYLHTK------KILHKDLRSKNILLESKNK-----------VVITDFG
                               |....   ...||... .||| |      .. | ||   |.|. ..|.           . |.|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
TyrKc ksr-1.AA TyrKc 474-745 24 1.6e-17 60.51 SMART 1-280 (280) Show / Hide 
Range on Protein: 474-745
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

IEFDKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEVSAYKNT--RHDNIALFLGYFMSD-------GQYGMVMSLSKGSQSLYTL
|...|.   .|.| ||.| .|  . .||||.   ..        |.|  | .  ..   .|.||  ..|. ...       ... .|| . ..  .|   
ITLGKK---LGEGAFGEVYKGTWKIQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDY

LHVVREKLDLATTRKIAQQICQAVSYLHTKKILHKDLRSKNILLESKNKVVITDFGILSMKRLAHPK----QKSGYLT------SK--FWTNYIAPELAM
|.  |.|| ...  ... ||..  .||| |.. | ||   |.|. ... | |.|||   . |  . .      . | .      .|  .     |||   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG---LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

AMRTEYDEYECDDFPFSENSDVYAFGCVWFEMLT-GALPYAG-----ELPHQILFAKTQGIRPVLPNV-------KCTQELKELLVSCWNTAPQDRPTLT
           ..  |.. |||..|| . .|..| |. || |       . ...    || |.  |          |..|. ..  .||.  | |||| .
-----------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

DINLKL
.|  ..
EIHECF
Kinase ksr-1.AA TK-Unique 663-745 32 1e-16 54.25 In-house 210-294 (294) Show / Hide 
Range on Protein: 663-745
Range on HMM: 210-294/294
Sequence Identity: 32% (28 aa)

CDDFPF-SENSDVYAFGCVWFEMLT-GALPYAGELPHQILFAKTQGIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLKL
|.. .. .. |||..||.. .|..| || || |  . .|. . ..| |. .|.  |..|. .|. |||.  |..||....|  .|
CYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ksr-1.AA LRRK 668-747 24 1.1e-15 51.98 In-house 259-351 (351) Show / Hide 
Range on Protein: 668-747
Range on HMM: 259-351/351
Sequence Identity: 24% (23 aa)

FSENSDVYAFGCVWFEMLTGA-LPYAGELP-H-----QILFAK--TQGIRPVLP-NVKCTQ-----ELKELLVSCWNTAPQDRPTLTDINLKLTA
..|..|.|.|| . .| ||.  .|. .|..       .... .  . |.||..| .. |..     ....|...||.. |..||. ..|  .|  
YTEKVDCYSFGMILWELLTRQHHPF-DEHDFFDHMQWMEQIEDKIIEGLRPTIPQHY-CPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase ksr-1.AA LRRK 474-621 23 1.1e-13 44.76 In-house 1-224 (351) Show / Hide 
Range on Protein: 474-621
Range on HMM: 1-224/351
Sequence Identity: 23% (54 aa)

IEFDKQAPIIGRGRFG-KVLRGFHYG-----------------------------DVAVKVYTME------------------------------HISDA
... .|   |||| || .| |.   |                             .||.|.....                               ..|.
LKIEEQ---IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDC

SKKAEEFKLEVSAYKNTRHDNIALFLGYFMSDGQYGMVMSL-SKGSQSLYTLLHVVRE--------KLDLATTRKIAQQICQAVSYLHTKK--ILHKDLR
...  ||  ||.   . .|.||   .|. ..   . ||| . . |.  ||..||  ..        ...  .. ||| ||  .. ||| ..  |.| ||.
CRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGD--LYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLK

SKNILL-ESK---------NKVV--ITDFGI
| |||| .|.         . |.  | ||||
SPNILLWSSPQNHSPNYPNAHVCAKIADFGI
Kinase ksr-1.AA TK-Unique 580-621 40 3.4e-12 38.48 In-house 136-179 (294) Show / Hide 
Range on Protein: 580-621
Range on HMM: 136-179/294
Sequence Identity: 40% (18 aa)

IAQQICQAVSYLHT--KKILHKDLRSKNILLESKNKVVITDFGI
.| ||... .||.   ||| |.|| ..|.|| ..... |.|||.
FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGM
Kinase ksr-1.AA CAMK 672-741 17 0.000203 9.36 In-house 315-419 (425) Show / Hide 
Range on Protein: 672-741
Range on HMM: 315-419/425
Sequence Identity: 17% (18 aa)

SDVYAFGCVWFEMLTGALPYAGE-----------------LPHQILFAKTQGIRPVLPNVK------------------CTQELKELLVSCWNTAPQDRP
.|. . |.. . ||.| .|. |.                 | ..|. .| . . | ....                   ..|| | |. .. .. |..|.
CDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRM

TLTDI
|....
TIEQC
Kinase ksr-1.AA TK-Unique 474-494 42 0.326783 0.08 In-house 1-18 (294) Show / Hide 
Range on Protein: 474-494
Range on HMM: 1-18/294
Sequence Identity: 42% (9 aa)

IEFDKQAPIIGRGRFGKVLRG
.|...   .||.|.|| | ||
LEVGD---VIGEGAFGQVWRG