Gene M176.9 (Nematode worm)

M176.9

Species: Nematode worm
Alias: M176.9, aSWK346, CE18899
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 9411486-9409248, WormBase Genetic Map location: No interpolated position.,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
M176.9.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
M176.9.AA Protein Genbank 478 None Fasta, JSON

Protein domain

Protein domains of M176.9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 M176.9.AA SH2 56-150 23 3.6e-23 84.21 SMART 1-87 (87) Show / Hide 
Range on Protein: 56-150
Range on HMM: 1-87/87
Sequence Identity: 23% (24 aa)

FKFYHGFLPREDLQATLHNP----GDYLIRVSEVVEGESKVVREIILSLMTGHMEGKQKEKRIHNVVIKRVS-NKFFCEA--ARPFATVADLINYYTKHT
  .|||...||. .. | ||    ||.|.| ||         ....||....        ..... .|.|   .|....    |.| .. .|.|.|... 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES------NPGDYVLSVRWK--------GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNP

GH
. 
LG
SH2 M176.9.AA SH2 58-144 22 1.2e-10 33.06 Pfam 1-81 (81) Show / Hide 
Range on Protein: 58-144
Range on HMM: 1-81/81
Sequence Identity: 22% (21 aa)

FYHGFLPREDLQATLHN----PGDYLIRVSEVVEGESKVVREIILSLMTGHMEGKQKEKRIHNVVIKRVSNK-FFCEAARPFATVADLINYY
.|||...|.. .  | |    .|..|.| ||  .|.      . ||....       . |..  .|.|  |. ...   . |.....|...|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD------YTLSVRDDGP-----GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase M176.9.AA Fer 174-428 42 1.5e-140 473.22 In-house 1-283 (283) Show / Hide 
Range on Protein: 174-428
Range on HMM: 1-283/283
Sequence Identity: 42% (119 aa)

VTVGDVLGEGAFGKVCAG--ELRLKDGSSAEV---AIKMTKA-SAFLSKMKIKEMMNEARFIRN-FNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYM
|| |..|||||||.|. |  .|..|.| ...|   |.|..|  .....|..|||.|.|||..|| ..|.|||..|||..||||..|..|...||||..|.
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KQTKS--VPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHENEVK----ITDFGLSRA----GPSYTTK-TSCKIPIKWLAPETLATLSFSYATD
| .|.  |.....|..|..||.|..|||..|||||||||||||.|...||    |.|||.||.    |..|. | ..||.||.||||||. |  .|..||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VYSWGVTCYEVFVDGAEPFEG----VSNATI-----KADIMANNFYPMPSMTPDEVKEYMSSCIFVEE-SRRATIPLAVAEFE
|.|.||.|.|.| .||||..|    . ....     |..| .... |||. .|.|....| ....... . |.|   .. ...
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase M176.9.AA TyrKc 174-427 33 1.1e-103 351.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 174-427
Range on HMM: 1-280/280
Sequence Identity: 33% (98 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNF--NHKNVVRLYGVAHDE-------QPLYILLELVKGGSLQD
.| |..|||||||.|. |...       .||.|| |..|      ....|.|||  ...  .|.|.||||||. ..       .||.|..|....|.|.|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YMKQTKS-VPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHENE-VKITDFGLSRAGPSY--------TTKT----SCK--IPIKWLAPETLATL
| . ..  ....| ..||. .|.| .|||..||||||.||||||..||  |||.||||||.. ..        . ..    ..|  .||.|.|||.. . 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

SFSYATDVYSWGVTCYEVFVDGAEPFEG-----VSNATIKADIMANNFYPMPSM--------TPDEVKEYMSSCIFVEESRRATIPLAVAEF
 |. ..||.|.||...|.| .|..| .|     .||. . ..... .  | |           |||. . |..|   . . | |    . .|
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase M176.9.AA Pkinase_Tyr 174-409 37 5e-90 305.53 Pfam 1-252 (270) Show / Hide 
Range on Protein: 174-409
Range on HMM: 1-252/270
Sequence Identity: 37% (94 aa)

VTVGDVLGEGAFGKVCAGELR-LKDGSSAEVAIKMTKASAFLSKMK--IKEMMNEARFIRNF-NHKNVVRLYGVAH-DEQP--LYILLELVKGGSLQDYM
.| | .|||||||.|. |... ..|.   .||.|| |     ..    ....|.||.  ... .|.|.||||||   ...|  .|| .|....|.| || 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KQ----TKSVPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLH-ENEVKITDFGLSRAG---PSY-TTKTSCKIPIKWLAPETLATLSFSYATDVY
..     ..... | ...|.  |||..||...||||||.||||||.. .| |||.||||.|.      | ......|.||||.||| ...  |. ..||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SWGVTCYEVFVDGAEP-FEGVSNATIKADI-MANNFYPMPSMTPDEVKEYMSSC
| ||...|.|  |..| ..|.||. ... |   ..  |.|  .|||. . | .|
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQC
Kinase M176.9.AA TK 174-427 19 1.2e-88 297.26 In-house 1-486 (486) Show / Hide 
Range on Protein: 174-427
Range on HMM: 1-486/486
Sequence Identity: 19% (94 aa)

VTVGDVLGEGAFG---KVCAGELRLKDGSSA----------------------EVAIKMTKA-SAFLSKMKIKEMMN----------EARFIRNFN----
.|.|..||||.||   .|. ||.| .... .                      .||.|| |. .|  ..... |.|.          ||. .  ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNVVRLYGVAHDE------------QPLYILLELVKGGS----LQDYMKQTKS---------------------------------------------
 |.|.|||||| ...            .|..|..|....|.    |.|| .. .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPLADRINFCLGAAKGLAYLHQN------NCIHRDIAARNCLLHENE------------VKITDFG---
                               ....... .|. .|.|..|||..      |..|||.||||||..||             .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRAGP---SYTTKT------------------------SCKIPIKWLAPETLA---------TLSFSYATDVYSWGVTCYEVFVDGAEPFEG-V
     |.|. .    |..|.                        ..|.||.|.|||.|.         .  |. ..||.|.||...|.|  |.||. | .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------ATIKADIMA------------NNFYPMP--SMTP--------------DEVKEYMSSCIFVEESRRATIPLAVAEF
||         . .   . .             . ..||     |              .|. . | .|   . ..| |    . ..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase M176.9.AA UTK 174-402 30 6.4e-69 234.91 In-house 1-271 (296) Show / Hide 
Range on Protein: 174-402
Range on HMM: 1-271/296
Sequence Identity: 30% (82 aa)

VTVGDVLGEGAFGKVCAGELRLKD--GSSAEVAIKMTKASAFLSKMKI--KEMMNEAR---FIRNFN-HKNVVRLYGVAHDEQPLYILLELVKGGSLQDY
|  |. ||.|||| |. ....  .  .  . ||.|  ...|.  . .    . |.|||   .  .|. | ||.||.||  .|.|..|..|. ..|.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

MK--------QTKSVPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHEN--------EVKITDFG---LSRAGPS-----------YTTKT-SCK
.         .. .. | .|. ...  | |..|||. ...|||.||||||.|..         .|| |||   .||. ..           | ...  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPIKWLAPETLATL-SFSYATDVYSWGVTCYEVFVDGAEPFEGVSNATIKADIMANNFYPMPS--MTPDEV
.||.| ||| |.    |. ..||.|.||.|.|..  |. |..| ||. . . ... . | ||.    |..|
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPV
Kinase M176.9.AA TK-Unique 174-427 28 2.6e-53 182.17 In-house 1-294 (294) Show / Hide 
Range on Protein: 174-427
Range on HMM: 1-294/294
Sequence Identity: 28% (83 aa)

VTVGDVLGEGAFGKVCAGELRLKD---GSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFN-HKNVVRLYGVAHDEQ-PLYILLELVKGGSLQDYMKQ
..||||.|||||| |. ||.. ..   .    ||.|| |..|  .. . .....|... ..   |.|.|...|.  . . | .|..| . .|.||.| ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNA--TDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

TKS--------------------------VPLADRINFCLGAAKGLAYLHQ--NNCIHRDIAARNCLLHEN-EVKITDFGLSR---AGPSYTTKTS-CKI
..                           . . | ..|. . |.|..||..   ...|||..|||.|| |. ..||.|||..|   ..  | ...|  .|
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRI

PIKWLAPETLA--TLSF-SYATDVYSWGVTCYEVFVDGAEPFEGVSNATIKADIMANNFYPMPSMT-PDEVKEYMSSCIFVEESRRATIPLAVAEF
||.|.||| |   .  . .. .||.| ||. .|.|  || |. |.... |  .| .    | |.   ..|. . |.||.  |.. | ..   . ..
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase M176.9.AA S_TKc 174-431 24 2.5e-51 177.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 174-431
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKG--GSLQDYMKQTKS
 ......|.||||||. .  .    .  .||||. |          . ...| .  .. .|.|.|.||.| .| . ||. .|.. |  |.| ||.|. ..
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------VPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHENEVKITDFGLSRAGPSYTTKTSCKIPIKWLAPETLATLSFSY-ATDVYSWGVTCY
       |  .   ..   ...|.|.|... ||||.   | || | ..||.||||.|        |..     ..||| |   .... . |..| |.. |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKEYMSSCIFVEESRRATIPLAVAEF-----ERFA
| .. |  ||.   .     ...           ..|.|. .. |  .. ..| |.  | ..        . 
EMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase M176.9.AA Ack 174-382 35 3e-49 164.29 In-house 1-220 (266) Show / Hide 
Range on Protein: 174-382
Range on HMM: 1-220/266
Sequence Identity: 35% (78 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYMKQTKS--
.|..  ||.| || |  ||  .  | . .||.|  .     .   . . . |.    . .| ..||||||  |   |    ||  .||| | ... ..  
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVLDQPMLMMVTELAPCGSLLDCLRKHCRTA

VP-LADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHENE--VKITDFGLSRA---GPS-YTTKTSC--KIPIKWLAPETLATLSFSYATDVYSWGVT
 . ..   .||.  |.|..||.. .||||| |||| ||   .  ||| ||||.||   .   |...     |.|. | ||| | .. || | || . |||
FFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVT

CYEVFVDGAEPFEGVSNATI
  |.|  | ||. |.. . |
LWEMFSYGEEPWAGCNGYQI
Kinase M176.9.AA Src 174-409 33 5.7e-48 161.04 In-house 1-237 (255) Show / Hide 
Range on Protein: 174-409
Range on HMM: 1-237/255
Sequence Identity: 33% (82 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYMK---QTK
..  . ||.| || |  |  .     . .||.|  |.      |. .    ||    .. |...|.|| |  .| | ||  |. . |||.|| |   ...
IKLCRKLGQGQFGEVWMGYWN----GNTKVAVKTLKPGT----MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

SVPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHE-NEVKITDFGLSRAGP----SYTTKTSCKIPIKWLAPETLATLSFSYATDVYSWGVTCYE
...| . | .    |.| ||| ..| |||| |||| |  | | .|. |||| |        |. ..  |.|||| ||| .   .|.  .|| | |.  .|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

VFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKE-YMSSC
..  |  | .| .|.     ....   |.|.  |||. |  |  |
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQC
Kinase M176.9.AA Frk 174-431 30 1.4e-45 155.84 In-house 1-260 (260) Show / Hide 
Range on Protein: 174-431
Range on HMM: 1-260/260
Sequence Identity: 30% (81 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGGSLQDYMK----QT
. .   || | ||.|  |    .    . ||.|  |. .    |  .... ||. ...  |  ...|| |   |.|.||. ||.. ||||.|..    . 
IQLIRRLGSGQFGEVWEGLWNNT----TPVAVKTLKPGT----MDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKG

KSVPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHE-NEVKITDFGLSR---AGPS--YTTKTSCKIPIKWLAPETLATLSFSYATDVYSWGVTC
... .   ..     | |.||| . | ||||.|||| |. | | .|| |||| |         | ...  ..|||| |||   . .|.   ||.|.|.  
RQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILL

YEVFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKEYMSSCIFVEESRRATIPLAVAEFERFA
.|.   |  |. |. || .   . ..   | |.  | .. | |  |  ..  .| |       .| . 
TEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase M176.9.AA Axl 174-425 32 4.1e-45 156.21 In-house 1-267 (267) Show / Hide 
Range on Protein: 174-425
Range on HMM: 1-267/267
Sequence Identity: 32% (87 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMMNEARFIRNFNHKNVVRLYGVAHDEQP------LYILLELVKGGSLQDYM-
...| .|||| || |  |.|.  |||.  ||.|| |. . ...  | | . ||  ...|.| ||.|| ||.   .         ..|  .| | |  .. 
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKI-DICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLL

-----KQTKSVPLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLHEN-EVKITDFGLSR---AGPSYTTKTSCKIPIKWLAPETLATLSFSYATDVY
     .| . .||   . | .  | |. || . | ||||.|||||.|.|.  | . |||||.   .|  |      |.|.||.| | ||   .    ||.
YSRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVW

SWGVTCYEVFVDGAEPFEGVSNATIKADIMANNFYPMPSMTPDEVKEYMSSCIFVEESRRATIPLAVA
..||| .|.   |  |. || |. .   ..  .    |    ||. . |..|  ..   | .      
AFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase M176.9.AA MLK 174-409 27 3.8e-44 151.05 In-house 1-273 (291) Show / Hide 
Range on Protein: 174-409
Range on HMM: 1-273/291
Sequence Identity: 27% (75 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMK----IKEMMNEARFIRNFNHKN----VVRLYGVAHDEQP-LYILLELVKGGSLQD
 ..  ..|.|.||||. |. | ||..  .||.|. .|..| .| .    ....  |.|  | ..|.|    ....||| ..... ..|..| . |||| .
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

YMKQTKS--------------VPLADRINFCLGAAKGLAYLHQNN---CIHRDIAARNCLLH-------ENEVKITDFGLSRAGPSY-TTKTSCKIPIKW
. .  .|              ....  .|..|  |.|..|||..     ||||.  .| |..       .  .||.|||.||   .  |...| .    |
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAW

LAPETL---ATLSFSYATDVYSWGVTCYEVFVDGAEPFE-GVSNATIKADIMANN-FYPMPSMTPDEVKEYMSSC
 ||| .       .| . ||.||||  .|..  . .|.. ......| . . .|.   |.||  |.  |. |. |
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQC
Kinase M176.9.AA Pkinase 174-427 21 3.9e-44 157.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 174-427
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

VTVGDVLGEGAFGKVCAGELRLKDGSSAEVAIKMTKASAFLSKMKIKEMM-NEARFIRNFNHKNVVRLYGVAHDEQPLYILLELVKGG----SLQDYMK-
 ..| ..|.|.||.|. .  .       .||.|  | .   |....     .|..  ...||.|.||||.. .|.. .|. .|.. ||    .| ||.. 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-QTKSV--PLADRINFCLGAAKGLAYLHQNNCIHRDIAARNCLLH-ENEV----KITDFGLSRA--GPSYTTKTSCKIPIKWLAPETLA-TLSFSYATDV
 . ...  .  . .....  ..||.|.|....||||.   |.|.. ....    ||.||||..     ...  |.    . ..||| .      ... |.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

YSWGVTCYEVFVDGAEPFEGV-------SNATIKADIMANNFYPMPSMTP-------------------DEVKEYMSSCIFVEESRRATIPLAVAE--F
.| |...||..  |  || |         .. |. . .. . .. |   .                   .| |. ...|. .  ..| |.. ..    |
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase M176.9.AA TKL 180-367 21 9.8e-44 151.61 In-house 1-283 (364) Show / Hide 
Range on Protein: 180-367
Range on HMM: 1-283/364
Sequence Identity: 21% (64 aa)

LGEGAFGKVCAGELRLKDGSS------AEVAIKMTKASAFLSKMKIK---------------------EMMNEARFIRN---FNHKNVVRLYGVAHDEQP
.|.|.||.|. |..|  .|         .||.|. |     ...|.                      ..  | . |.    ..| |.|...|.. ....
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LYILLELVKGGSLQDYMKQTKSVPLADRINFCLGAAKGLAYLHQNN--------CIHRDIAARNCLLHENE---------------V
             |.|  |...|||| .|.       .  |....|..|.|..|||..|         ||||.  .|.|..||                .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KITDFGLSR---------------------AGPSYTTKTSCKIPIKWLAPETLATL----------------SFSYATDVYSWGVTCYEVF
||.||||||                     .  . .|. ..   . |.||| |                   ..| ..||||.|.  .|..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL