Gene mbk-2 (Nematode worm)

mbk-2

Species: Nematode worm
Alias: aSWK175, CE19878, F49E11.1b, mbk-2, F49E11.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 13009110-13035035, WormBase Genetic Map location: n/a,

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
mbk-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 314 Kinase domain by global Sugen HMM Fasta, JSON
mbk-2.AA Protein Genbank 817 None Fasta, JSON

Protein domain

Protein domains of mbk-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mbk-2.AA DYRK2 461-774 65 3e-237 779.69 In-house 1-318 (318) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-318/318
Sequence Identity: 65% (208 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFS
||.|.||||||||||.|..|||..|.||.|..||.||||.|| ||||||.|.|||| |.|.|..|||||| |||| ||||||||.||||.||.|.|||||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQ-RIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYP
|.|||.||.|.| ||..|.||..|||||||||.||||..||||||||||||||..| |||||||||||||||||||.||||.|||||.|||.|||.||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LLPGEDENDQLALIIELLGMPPPKSLETA-----KRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRC
|.|||.||||.|...|.|||||.| ..|.     .|...|..|.....||  |.|.|.|... . ...|...|.||.|.||...||...||.|.||.|||
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYC--TFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRC

LDWDPETRMTPAQALKHKWL
..|||..||||.|||||.|.
FEWDPSERMTPSQALKHPWI
Kinase mbk-2.AA DYRK 461-774 55 1.1e-204 686.27 In-house 1-320 (320) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-320/320
Sequence Identity: 55% (181 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGF-
||.|..|||||||||.|..||| ...||.|..||.||||||| .||.||..|..||.| .....||.|||..||| ||.|||||.||||..|.|.|||| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

SLMLVRKFAYSMLLCLDLLQKN-RLIHCDLKPENVLLKQQ-GRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTG
|| ||||||...|.||..|.|| ..|||||||||..|||. ..|.||||||||||| .||||||||||||||||||||..|...|||||||||||||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLLPGEDENDQLALIIELLGMPPPKSLETA--KRARTFITSKGYPRYCTATSMPDGSV------VLAGARSKRGKMRGPPASRSWSTALKNMGDELFVD
.||.|||.|.||||.|.|.|||||.. ....  .|...|...   ..||. ........      .... ..|| ..|.|| .|.|  ...   |..|.|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKD

FLKRCLDWDPETRMTPAQALKHKWL
|.|.||.|||. |.||.|||.|.|.
FIKKCLQWDPHKRITPSQALQHPWF
Kinase mbk-2.AA CMGC 461-774 21 2e-124 411.1 In-house 1-513 (513) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-513/513
Sequence Identity: 21% (111 aa)

YEVLKVIGKGSFGQVIKAFD--------------HKYQQYVALKLVRNEKRFHRQAD-------------EEIRILDHLRRQDSDGT-----------HN
||..|.||.|..|.| |..|              |.....||.| ..|.. ...||               ||.|| ||....               ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-IIHMLDYFNFRN-----------------HKCITFELLSINLYELIKRNK--------------------------FQGFSLMLVRKFAYSMLLCLD--
 |....|.| ..|                 | .. ||..  .||..||.|.                           . |.. ..| ..| .| .|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

LLQKNR--LIHCDLKPENVLLKQQGRS------------------GIKVIDFGSSCFDDQR------------------------IYTYIQSRFYRAPEV
 . ...   ||.||||||.|. .....                   .|..|||.... ...                        ...|...|.|||||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGTK----------YGMPIDMWSLGCILAELLTG--------YPLLPGEDE-----------NDQLALIIELLGMPPPKSLETAK-------RARTFIT
.|| |          |. ||||||.|||.||..||        .|| ||..|            |||..|...||.|. . ....|       . .....
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGYPRYCT---------ATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKN-------------------------------MGDELFVDFLKRCLD
 ...|.| .          |.  . .. ..  . .| ... |.  ...   ..|                               . |....|.||..| 
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WDPETRMTPAQALKHKWL
.||. |.|..|||.| ..
YDPDKRITAEQALQHPYF
Kinase mbk-2.AA DYRK1 461-774 47 8.60000000001e-112 377.69 In-house 1-321 (321) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-321/321
Sequence Identity: 47% (151 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFS
||.   |||||||||.||.||. |.|||.|...| | |  ||  |||.|. . ..| .   .|.|.   | |||| |. ||||| |||.|..  .|.| |
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LMLVRKFAYSMLLCLDLLQKNRL--IHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGY
| |.||||  |.  |  .    |  |||||||||.||    || ||.|||||||  .|||| ||||||||.|||.||..| | |||||||||| |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITS-KGYPRYCTATSMPDGSVVLAGARSKR---GKMRGPPASRSWSTALKNMGDEL-FVDFLKR
||  | .| ||.  |.| ||||| . .. | .|. . .  .    ||  |       .  ..|  .   |   | | .|    .   . | | | | .||
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLIKR

CLDWDPETRMTPAQALKHKWL
 |..||..|.|| .||.|...
MLQYDPKQRITPYYALQHSFF
Kinase mbk-2.AA YAK 461-681 45 1.4e-88 300.64 In-house 1-225 (347) Show / Hide 
Range on Protein: 461-681
Range on HMM: 1-225/347
Sequence Identity: 45% (103 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQ-DSDGTH---NIIHMLDYFNFRNHKCITFELLSINLYELIKRNKF
| || . |.| ||||.|         .| | . |   .  ||  ||.||  |  | | .. .    |. |.|.| ..|| |. ||.||.||||..| |||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

QGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLT
 |||  |.| .  . |  .  |.  ..|||||||||..|..  .  ||.|||||||   . .|||||.|.||.||.|... |   |||||||||.|||  
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLLPGEDENDQLALIIELLGMPP
| |. ||  | .|.  ||. || ||
GLPIFPGNSEYNQIKRIIDMLGYPP
Kinase mbk-2.AA S_TKc 461-774 25 3.3e-85 290.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-231/231
Sequence Identity: 25% (84 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSI---NLYELIKRNKFQ
||.|..||||.||.| |. ..| ...||.| ..      ...  ||.|| .       .  ||....|.|   .| .. .|...    .|...||... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGM-PIDMWSLGCILA
|    |.   .|...| ... |. . ... ||.||||||.|| .     ||..|||....     .|.. ...|.||||.   .||  ..|.||.||||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELLTGYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWSTALKNMGDELFVDFLK
|.|.|||. |      |........|                                                                 .. . ||..
EMLCGYPPFP------QMQMMFKKIG-----------------------------------------------------------------SPEAKDFIR

RCLDWDPETRMTPAQALK-------HKWL
.||..||| |.|  .||.       | |.
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase mbk-2.AA HIPK 461-694 40 6.7e-71 222.39 In-house 1-236 (329) Show / Hide 
Range on Protein: 461-694
Range on HMM: 1-236/329
Sequence Identity: 40% (97 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNKFQGFS
|||| ..|.| ||||.|.  .  .  ||.|. .|.  . ||   |..||  |. ...|   ... ....|. .|| |. ||.|  |||.  | |||    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSG--IKVIDFGS-SCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTG
|  .|      |  |  | .  ||| ||||||..|  . |    .||||||| | . .    ||.|||.|||||.||| ..   .|||||||..|||  |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTF
 || || || ||   |..  . | .  |. | ..  |
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRF
Kinase mbk-2.AA Pkinase 461-774 26 1.2e-65 229.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-293/293
Sequence Identity: 26% (89 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADE-----EIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSI-----NLYEL
|.....||.||||.| |. ...... ||.| .. ... . .  .     ||.|. .|.        ||. ..|.|  ..| .. .|..        |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

IK---RNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSG--IKVIDFGSSCF---DDQRIYTYIQSRFYRAPEVIL-GTKYGMP
|.   ...|  ||   .....| .|  |. . ... ||.||||||.|....|  .  .|..|||....    ..  .|.  ...|.|||||. |..|| .
ISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCILAELLTGYPLLPGE----DENDQLALIIELLGMPPPKSLETA--KRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSW
.||||.||||.|.|.|.|. ||.    . .||...| . .| |.. . ..   .. .. ..    .                               .  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------------------------F-H

STALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL
.|  .|. .| . ||.|.||..||. | |..|.|.|.|.
WTF-HNW-SEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase mbk-2.AA CDK 461-774 25 3.7e-58 184.61 In-house 1-284 (284) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-284/284
Sequence Identity: 25% (89 aa)

YEVLKVIGKGSFGQVIKAFDHKYQ-----QYVALKLVRNEK--------RFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRN---------HKCI
|| |. || |..|.| || |.. .     |.|||| .| |.         |   |  || .| .|        .||.  .| .   |          . .
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

T--FELLSINLYELIKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQG---RSGIKVIDFGSSCFD--------DQRIYT-YIQS
.  || .   |.....           .. . . .|  |. . .|. .| |||| | |.  .|   .  .|. ||| ..           .| ||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRAPEVIL-GTKYG--MPIDMWSLGCILAELLT---GYPLLPGEDENDQLALIIELLGMPPPKSLETAKRARTFITSKGYPRYCTATSMPDGSVVLAG
. |||||. |  ..|.   ||||||.|||.||..|   . ||.||. | ||| .|....| | ...    .    .                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

ARSKRGKMRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL
                              |.| ..|  ||. |..  |||.|...
------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase mbk-2.AA DyrkP 461-657 41 1.5e-56 184.42 In-house 1-201 (323) Show / Hide 
Range on Protein: 461-657
Range on HMM: 1-201/323
Sequence Identity: 41% (84 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQDSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRNK----F
| ..  .|   | . |.  | .  | . .|.. | | .  |. .||..|  .         |.... |||  . |  |  |||  ||||  | |.     
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

QGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLT
. | .  . |    .|. || .   |||||||||||.|.| . .  .|.||||||||    .  |.||| |||||||.| ||   ||||||||||||| |
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

G
|
G
Kinase mbk-2.AA PRP4 461-678 37 1.5e-54 187.57 In-house 1-222 (320) Show / Hide 
Range on Protein: 461-678
Range on HMM: 1-222/320
Sequence Identity: 37% (83 aa)

YEVLKVIGKGSFGQVIKAF-DHKYQQYVALKLVRNEKRFHRQADEEIRILDHLRRQ--DSDGTHNIIHMLDYFNFRNHKCITFELLSINLYELIKRN-KF
|.|   .|.| |. |...    . .. || | .||    |.    |. ||  |  .  |..    .. | . ||.|.| |. || .| || |..|.  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGS-SCFDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELL
 |..|  || .|. ..| | .| |.  .| |.|| |.|     .. .| .|||| |   .. |  | .||||||||.|.| .|   ||||| || |.|| 
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLLPGEDENDQLALIIELLG
||  . ||   |. | |. .. |
TGKIMFPGKTNNHMLKLFMDYKG
Kinase mbk-2.AA CLK 461-595 31 3e-44 130.12 In-house 1-147 (350) Show / Hide 
Range on Protein: 461-595
Range on HMM: 1-147/350
Sequence Identity: 31% (46 aa)

YEVLKVIGKGSFGQVIKAFDHKY-QQYVALKLVRNEKRFHRQADEEIR-ILDHLRRQ-DSDGTHN--IIHMLDYFNF-RNHKCITFELLSINLYELIKRN
||.... | | || | .  |||.  .||||| .|| ...  .|  ||. |. ..    |.....   ...|.|.|..  .| || |||.  ..|...| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLL
.      .... .  .|..||  .  .  | ...|.| |||||| ..
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase mbk-2.AA CLK 603-684 47 1.2e-28 82.38 In-house 186-270 (350) Show / Hide 
Range on Protein: 603-684
Range on HMM: 186-270/350
Sequence Identity: 47% (40 aa)

IKVIDFGSSC---FDDQRIYTYIQSRFYRAPEVILGTKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLGMPPPKS
|.||||||     ||.   .| ...| |||||||||  .  | | || |||| || ||. | .. |. . ||.. ...||| |..
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQW
Kinase mbk-2.AA TyrKc 461-774 16 7.9e-09 -79.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 461-774
Range on HMM: 1-280/280
Sequence Identity: 16% (59 aa)

YEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKRFHRQADEEIRILDHL--RRQDSDGTHNIIHMLDYFNFR-------NHKCITFELLS-INLYEL
 . .|..| | ||.| |.      . || | .....  ..   .|.||. .|  .        ||. .. .              .| .|. .  .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH------HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKRNKFQGFSLMLVRKFAYSMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFGSSCFDDQR-------IYTYI----QSR-----FYRAPEVIL
..... . ...    .|..      . | ....|| ||   |.|.. ..   .|. ||| | . .          |       ...        |||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GTKYGMPIDMWSLGCILAELLT-GYPLLPGE----DENDQLALIIELLGMPPPKSL----ETAKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGK
  |.    | || |  . |..| | .  ||.     .|...   ..  ...|.                                               
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------------

MRGPPASRSWSTALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL
          .     . ||..    |.| . ||| | | ..   |. .
----------F---VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase mbk-2.AA HIPK 747-774 42 1e-07 19.82 In-house 302-329 (329) Show / Hide 
Range on Protein: 747-774
Range on HMM: 302-329/329
Sequence Identity: 42% (12 aa)

FVDFLKRCLDWDPETRMTPAQALKHKWL
||. ||. . ||.. |.||..||.|.. 
FVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase mbk-2.AA CLK 745-774 30 2.2e-07 17.45 In-house 321-350 (350) Show / Hide 
Range on Protein: 745-774
Range on HMM: 321-350/350
Sequence Identity: 30% (9 aa)

ELFVDFLKRCLDWDPETRMTPAQALKHKWL
. . | ....|  ||  |.| ..||.| . 
RQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase mbk-2.AA DyrkP 744-774 41 5e-07 18.46 In-house 293-323 (323) Show / Hide 
Range on Protein: 744-774
Range on HMM: 293-323/323
Sequence Identity: 41% (13 aa)

DELFVDFLKRCLDWDPETRMTPAQALKHKWL
| .|.|| ..||  |   | |   ||.| |.
DHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase mbk-2.AA PRP4 747-774 46 8.2e-07 21.06 In-house 293-320 (320) Show / Hide 
Range on Protein: 747-774
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FVDFLKRCLDWDPETRMTPAQALKHKWL
| |.| .||  ||. | |. .||||  .
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase mbk-2.AA YAK 745-774 33 3.1e-05 13.31 In-house 318-347 (347) Show / Hide 
Range on Protein: 745-774
Range on HMM: 318-347/347
Sequence Identity: 33% (10 aa)

ELFVDFLKRCLDWDPETRMTPAQALKHKWL
..|.||.   |. .|  | .| || .|  .
DCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase mbk-2.AA APH 582-615 28 0.004917 11.23 Pfam 171-206 (248) Show / Hide 
Range on Protein: 582-615
Range on HMM: 171-206/248
Sequence Identity: 28% (11 aa)

RLIHCDLKPENVLLKQQGRSG-IK---VIDFGSSCFDD
...|.|..| ||.. .  |..  .   |||.. .|..|
CWCHGDFHPGNVMWDP--RPDGGRVTGVIDWDDACWGD
Kinase mbk-2.AA APH 463-516 18 0.809416 3.67 Pfam 1-52 (248) Show / Hide 
Range on Protein: 463-516
Range on HMM: 1-52/248
Sequence Identity: 18% (10 aa)

VLKVIGKGSFGQVIKAFDHKYQ-QYVALKLVRNEKRFHRQADEEIRILDHLRRQD
 ...|. |  ...    . . . .|| |.. .   . .... .|.|.|.||....
WWRPISGGWSNRTYYRTTDD-RPRYV-LRRYPPP-WWAEELHREHRWLRHLAAHG