Gene mek-2 (Nematode worm)

mek-2

Species: Nematode worm
Alias: Y54E10B_152.b, Y54E10BL.6, mek-2, let-537, aSWK322, CE25437, Y54E10B_152.bY54E10B_152.c, glv-1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 3013446-3006030, WormBase Genetic Map location: I:-5.45249,

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
mek-2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
mek-2.AA Protein Genbank 387 None Fasta, JSON

Protein domain

Protein domains of mek-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase mek-2.AA MEK1 73-360 68 2.7e-203 681.64 In-house 1-297 (297) Show / Hide 
Range on Protein: 73-360
Range on HMM: 1-297/297
Sequence Identity: 68% (202 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVG
....|||||||||||.||.||.||.||||||.||||||..|.||..||.|||.||||.||||||||.....||||||||||.|||.||||.||.|||..|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

RISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPAPS
..||||.||||||.|..||.||||||||.||||.||||||||||||.||||||||||||||||.||||.|.|||..|||||.||||||..|||||.|.|.
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

QAEYATMFN-----VAENEIELADSLEEPNYHPPS----NPASMAIFEMLDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSLTADVFF
|.||.|||.     ..|.|....|..|.|||||.|    .|..||||||||||||.|||.||.|.|..|...||.|||.|.|.|||.||.|....|.
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPISHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase mek-2.AA STE7 73-360 47 8.20000000001e-169 567.12 In-house 1-288 (288) Show / Hide 
Range on Protein: 73-360
Range on HMM: 1-288/288
Sequence Identity: 47% (148 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIK-PSVRQQIVKELAVLHKCN-SPFIVGFYGAFVDNND--ISICMEYMDGLSLDIVLKKV-----
|.. |||||||.|||.|..|...|.|||.|...|... |. ..||..|| |||||| .|.||.|||||....|  |.|||||||| .|| ..|.|     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSM--ANSFVGTRSYMAPERLTG--SHYTISSDIWSFG
    ||.||...|.|.|||..||.||... || ||||||||.||||.|..||||||..|.|.|||  |..|||...||||||..|  .||.. ||.||.|
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VELLIGRYPVP-----APSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLDYIVNG-PPPTLPKRFFTDEVIGFVSKCLRKLPSER
... .|. .|||| |     .|.|..|..||.                      |. |||||.|..|||. |||.||   |..| . ||.|||.| |.||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ----------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNER

ATLKSLTA-DVFF
.... |..   |.
PKYHQLMKEHPFI
Kinase mek-2.AA STE7-Unclassified 73-355 34 1.8e-111 376.61 In-house 1-295 (301) Show / Hide 
Range on Protein: 73-355
Range on HMM: 1-295/301
Sequence Identity: 34% (113 aa)

LQTEGELGHGNGGVVNKCVHRK------TGVIMARKLVHLEIK-PSVRQQIVKELAVLHKCN-SPFIVGFYGAFVDNND---ISICMEYMDGLSLD---I
|.. ..||||..|.| ||.| .      .|.||| | . ...  .. ..||..|| .||||. .|.||..|||...      | |||||||. |||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VLKKV--------GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSM--ANSFVGTRSYMAPERLTGS-----
..||.        |..||. .|.|  .| .|| ||... .| |||.||.| ||||.|..|.|||||.| |....  |...||. .||.|||. |      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYTISSDIWSFGLSLVELLIGRYPVP----------APSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLDYIVNGPPPTLPK-R---FF
 |.. |||||.||.. |. .|.|| .           ...                                 | ..| |..||| | |.||. .    .
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP-------------------------------ENMSFWELLSCIVNFPVPRLPDDPEDIIW

TDEVIGFVSKCLRKLPSERATLKSLT
  | . |.|||. | | ||..   |.
SKEFMDFISKCCKKHPRERPDIHQLL
Kinase mek-2.AA STE 73-360 28 1.9e-100 340.04 In-house 1-359 (359) Show / Hide 
Range on Protein: 73-360
Range on HMM: 1-359/359
Sequence Identity: 28% (110 aa)

LQTEGELGHGNGGVVNKCVHRK---------------TGVIMARKLVHLEIK----------------PSVRQQIVKELAVLHKCN--SPFIVGFYGAFV
..  ...|.|..|.| |....|               ||.||| | ..|| .                .. .||| ||. ...|||  .|.|| .||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-------NDISICMEYMDGLSLDIVLKKV--------------GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSG
..       ... |||||||| ||| ..|..              .|.||. ...| .....|| |.. . .| |||.||.| |.     .|||||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

MLIDS------------------MANSFVGTRSYMAPERLTG------SHYTISSDIWSFGLSLVELLIGRYPV--PAPSQAEYATMFNVAENEIELADS
 |.||                  . |.||||  .||||....      ..|....||||.|. ..|.. |..|     | .| ....|| .  . .    
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ-Q----

LEEPNYHPPSNPASMAIFEMLDYIVNGPPPTLPK------------------RFFTDEVIGFVSKCLRKLPSERATLKSLTA--DVFF
                 ||.| .|||||||.||                   . ...| . |..|||.| |..|.| . |      |.
-----------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase mek-2.AA MEK5 73-270 51 2.1e-84 286.75 In-house 1-193 (254) Show / Hide 
Range on Protein: 73-270
Range on HMM: 1-193/254
Sequence Identity: 51% (102 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRLPEKFVG
..    ||||||| | |  |  .| |.| |.. |.|   ...||. || .|.|| ||.|.||||||   | |||| |.||| |||.  .    .||. .|
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC----IPEHILG

RISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTISSDIWSFGLSLVELLIGRYPVPA
|..||.|.||.||  ..||.|||||||||||| .|.|||||||||  |..|..  ..||  ||||||. | .| | ||.|| |....|. .||.| |.
RMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQ
Kinase mek-2.AA S_TKc 73-360 27 3.4e-78 266.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 73-360
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDG--LSLDIVLKKVGR-----
 .   ..|.|  |.| ||.|.||| |.| | ..        ..| .|...|.| . |.|| .|..|.| ... ..|||.||   .|  ..|| ||     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSFVGTRSYMAPERLTGSHYTI-SSDIWSFGLSLVELLI
 .||  . ..   ....| |. .  .|.|||.||.| |...  .||.||||..  |     ..|.||. ||||| |   .|.  ..|.||.|  | |.| 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GRYPVPAPSQAEYATMFNVAENEIELADSLEEPNYHPPSNPASMAIFEMLDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSLTA-------
|. | |     ....||..                                               ..|.. |..|||.| |..| |   . .       
GYPPFP-----QMQMMFKKIG---------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

DVFF
. .|
HPWF
Kinase mek-2.AA MEK4 73-267 42 6.4e-64 207.46 In-house 1-211 (275) Show / Hide 
Range on Protein: 73-267
Range on HMM: 1-211/275
Sequence Identity: 42% (90 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVH-LEIK-----PSVRQQIVKELAVLHKC-NSPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKV--
|| .||.| |. |.||| .|...|.||| | .    .          ..  .|. |  |  | | || ||||     |  |||| || .|.|   | |  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

---GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSF-VGTRSYMAPERLTG--SH--YTISSDIWSFG
    |.||  .|.| |..|. | ||| . || |||||||| |..  | .||||||..| | ||.| .  .| | ||||||..   .   | | ||.|| |
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVELLIGRYP
  ..|.  |..|
ITMYEVATGKFP
Kinase mek-2.AA MEK7 73-267 41 6.8e-64 215.65 In-house 1-206 (269) Show / Hide 
Range on Protein: 73-267
Range on HMM: 1-206/269
Sequence Identity: 41% (85 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCN-SPFIVGFYGAFVDNNDISICMEYMDGLSLDIVLKKVGRL-----
|.  |..|||  | | |. |...||||| |             |   | |  .|. .|.||  .|.|. . |. |||| | .  .|  ||..        
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANS-FVGTRSYMAPERLTG-----SHYTISSDIWSFGLSLVE
||. .|...||..  | |||.   |.||||||||.|    | |||||||.|| ..||.|..   |   ||||||..      . | | .|.||.| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

LLIGRYP
|  |.||
LATGQYP
Kinase mek-2.AA Pkinase 73-360 24 3e-63 221.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 73-360
Range on HMM: 1-293/293
Sequence Identity: 24% (80 aa)

LQTEGELGHGNGGVVNKCVHRKTGV-IMARKLVHLEIKPSVRQQIVK--ELAVLHKCNSPFIVGFYGAFVDNNDISICMEYMDGL----SLDIVLK--KV
..... .| |. |.| ||.|..||      ..   ..|....|. ..  |.......|.|.|| .|..| |...| ..|||..|     .|  ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--PEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEI----KLCDFGVSG---MLIDSMANSFVGTRSYMAPERLT-GSHYTISSDIWS
|..  .|. . ..   ..||| |. .  .|.|||.||.| |...||.|    |.||||..       .| ...|.||. ||||| .  |..|. ..|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

FGLSLVELLIGRYPVPAP----SQAEYATMFNVAENEIELADSLEEPNY-------HPPSNPASMAIFEMLDYIVNGPPPTLPKRFFT---DEVIGFVSK
.|. | |.| || | |      .  ... .... . ...   . . ...       |                       . ...| .   .| . |...
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH-----------------------F-HWTF-HNWSEECKDFIKW

CLRKLPSERATLKSLTADVFF
||.| |..| | . .  . .|
CLCKDPKKRPTAEQILQHPWF
Kinase mek-2.AA MEK3 73-267 39 5.3e-57 192.39 In-house 1-205 (264) Show / Hide 
Range on Protein: 73-267
Range on HMM: 1-205/264
Sequence Identity: 39% (81 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKCNS-PFIVGFYGAFVDNNDISICMEYMDGLSLD----IVLK-KVGRL
. .  ||| |  |.| |  || .| ||| | .   .      ... .. .       |. | ||||     |. |||| ||  .||     |.| .  . 
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDT-CLDKFYRHVYKPHGMHI

PEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDSMANSF-VGTRSYMAPERLTG---S-HYTISSDIWSFGLSLVEL
|| . |.|.. .|..| |..   |. |||||||| |.| .| .|.||||.|| |.||||     | . ||||||  .   .  | . ||.||.|  ..|.
PEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEM

LIGRYP
 |||||
AIGRYP
Kinase mek-2.AA TKL 79-267 21 2.2e-43 150.43 In-house 1-288 (364) Show / Hide 
Range on Protein: 79-267
Range on HMM: 1-288/364
Sequence Identity: 21% (62 aa)

LGHGNGGVVNKCVHRK--------TGVIMARKLVHLE-IKPS-------------------------VRQQIVKELAVLHKCNSPFIVGFYGAFVDNND-
.| |  |.| | ..|         ||  .| |  . .  . .                          |.....|. ...... | || |.|.  .... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------ISICMEYMDGLS-LDIVLKKVGRLPEKFVGRISVAVVRGLTYLKDEIK-------ILHRDVKPSNMLVNSNGE--------------I
            . | |||..| | |....            |..  . ||. ||  ..        |.||| |..| ||..|..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KLCDFGVSGMLIDS---------------------MANSFVGTRSYMAPERLTGS----------------HYTISSDIWSFGLSLVELLIGRYP
|.|||| | ..  |                     . .. .||  .|||| | |.                 |. ..|..|||. | |.| .. |
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase mek-2.AA STE20 73-255 32 4.8e-42 145.99 In-house 1-214 (288) Show / Hide 
Range on Protein: 73-255
Range on HMM: 1-214/288
Sequence Identity: 32% (70 aa)

LQTEGELGHGNGGVVNKCVHRKTGVI----MARKLVHLEIKP---SVRQQIVKELAVLHKCNSPFIVGFYGAFVDN----NDISICMEYMDGLSLDIVLK
 .   ..|.|. |.| |. |..|| .     | | . || .      .. |.||  .. .|..| || .||... .    ... |.|||..| ||  ..|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---KVG------RLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLID----SMA---NSFVGTRSYMAPERLTG---
   | |      .. |. .  |   |..|| ||  . .| |||.|  | |....||.||.||||...|..    .|.   |.||||  .|||| . .   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--SHYTISSDIWSFG
  . |.  .||||.|
PDKGYDYKCDIWSLG
Kinase mek-2.AA TyrKc 73-358 21 4.2e-13 -10.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 73-358
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

LQTEGELGHGNGGVVNKCVHRKTGVIMARKLVHLEIKPSVRQQIVKELAVLHKC--NSPFIVGFYGAFVDN-------NDISICMEYMDGLSLDIVLKKV
.. . .||.|. |.| |.. .   .  | | .. .     |. . .|. ...|   . | || .||. ..          . | ||||.. .|.  |.| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GR-LPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEIKLCDFGVSGMLIDS-----MANSFV-----GTRS-----YMAPERLTGSHYTI
.. |. |    ... . .|  || .  .. |||    | ||..|. .| .||| |  . |           .     |...      |||| .  . .|.
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

SSDIWSFGLSLVELL-IGRYPVPAPSQAEYATMFNVAENEIELADSLEEPNY----HPPSNPASMAIFEMLDYIVNGPPPTLPKRF--FTDEVIGFVSKC
 ||.||||  . |..  |  | | . |    . . | |. ..  . .. | .                                 |   .||.    ..|
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEY-VKQGYRMPQPPNDYPMS----------------------------FVCCPDEMYQIMKQC

LRKLPSERATLKSLTADV
 .  |..| | . .  . 
WHEDPEDRPTFSEIHECF
Kinase mek-2.AA MEK3 310-360 32 7.1e-10 29.76 In-house 213-264 (264) Show / Hide 
Range on Protein: 310-360
Range on HMM: 213-264/264
Sequence Identity: 32% (17 aa)

FEMLDYIVNGPPPTLPKRF-FTDEVIGFVSKCLRKLPSERATLKSLTADVFF
|. |  .| .||| ||.   |  ..  |...||.| . || . . | .  |.
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase mek-2.AA MEK7 310-360 33 3.9e-07 20.27 In-house 214-269 (269) Show / Hide 
Range on Protein: 310-360
Range on HMM: 214-269/269
Sequence Identity: 33% (19 aa)

FEMLDYIVNG--PPPTLPKRF---FTDEVIGFVSKCLRKLPSERATLKSLTADVFF
|||.  | |   .|| ||.     |  . . || |||.| . .|   . | .  | 
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase mek-2.AA MEK4 307-360 21 5.4e-07 18.68 In-house 216-275 (275) Show / Hide 
Range on Protein: 307-360
Range on HMM: 216-275/275
Sequence Identity: 21% (13 aa)

M--AIFEMLDYIVNGPPPTL-PKRF---FTDEVIGFVSKCLRKLPSERATLKSLTADVFF
.   .|. .  .|.| || | .  .   .... . |. .||.|  ..|.  . |    |.
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase mek-2.AA MEK5 301-360 25 1e-06 20.08 In-house 195-254 (254) Show / Hide 
Range on Protein: 301-360
Range on HMM: 195-254/254
Sequence Identity: 25% (15 aa)

PSNPASMAIFEMLDYIVNGPPPTLPKRFFTDEVIGFVSKCLRKLPSERATLKSLTADVFF
. .  ...  ..|  ||.  || ||   | .  . |. .|..| | .|   . |    | 
QRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase mek-2.AA STE20 315-360 35 1.1e-05 17.11 In-house 238-288 (288) Show / Hide 
Range on Protein: 315-360
Range on HMM: 238-288/288
Sequence Identity: 35% (18 aa)

YIVNG--PPPTLP---KRFFTDEVIGFVSKCLRKLPSERATLKSLTADVFF
.| ..  |||||    .. ...|   ||.||| | |..|.| . |    |.
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase mek-2.AA Pkinase_Tyr 202-255 32 0.000154 16.0 Pfam 143-201 (270) Show / Hide 
Range on Protein: 202-255
Range on HMM: 143-201/270
Sequence Identity: 32% (20 aa)

LVNSNGEIKLCDFGVSGMLIDSMANSFVGTRS-------YMAPERLTGSHYTISSDIWSFG
||..|. .| |||| .  .  .  .  . .|.        |||| .  . .|. ||.||||
LVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG
Kinase mek-2.AA Pkinase_Tyr 73-153 25 0.303009 4.84 Pfam 1-91 (270) Show / Hide 
Range on Protein: 73-153
Range on HMM: 1-91/270
Sequence Identity: 25% (23 aa)

LQTEGELGHGNGGVVNKCVHR----KTGVIMARKLVHLEIKPSV---RQQIVKELAVLHKC-NSPFIVGFYGAFV-DNND--ISICMEYMDG
..   .||.|. |.| |.. .    .|..  | | .  |   .    |.   .|......  . | || .||. . .     | | |||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH