Gene pek-1 (Nematode worm)

pek-1

Species: Nematode worm
Alias: aSWK237, CE18695, F46C3.1x=(qeked..cayly), F46C3.1, pek-1
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: X: 11418543-11418544,

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
pek-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 464 Kinase domain by global Sugen HMM Fasta, JSON
pek-1.AA Protein Genbank 1077 None Fasta, JSON

Protein domain

Protein domains of pek-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ pek-1.AA PQQ 54-91 28 1.8e-07 28.08 Pfam 1-37 (37) Show / Hide 
Range on Protein: 54-91
Range on HMM: 1-37/37
Sequence Identity: 28% (11 aa)

NIIITATLDGVVTALDGETGEMIWRYEDAPLLRGTLST
.... .| ||...||| .||...|...  |  ..   |
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ pek-1.AA PQQ 49-80 30 2.9e-07 31.37 SMART 1-33 (33) Show / Hide 
Range on Protein: 49-80
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

QNSQVN-IIITATLDGVVTALDGETGEMIWRYE
     . .....| || ..||| .||...|.|.
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ pek-1.AA PQQ 228-265 17 0.000716 16.1 Pfam 1-37 (37) Show / Hide 
Range on Protein: 228-265
Range on HMM: 1-37/37
Sequence Identity: 17% (7 aa)

DVKILLQPPDGVIVAVDKYN-REEWKTNVDGHIVSVWQV
.. ..  ..||.|.|.|  . .. ||......... ...
GDVYVH-TWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
Kinase pek-1.AA PEK 604-1076 25 1.1e-269 902.15 In-house 1-758 (758) Show / Hide 
Range on Protein: 604-1076
Range on HMM: 1-758/758
Sequence Identity: 25% (193 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVAD--------NDKARNRVLREARALAMFDHPGIIRYFYAWEERP----------------------
||.....|||||||||||....|||.||.|||....        ...||..|.||.|.|||.||..|.|||.||.|.|                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------------------------------------------PKGFQEKEDENLLGKIKAEKLAKLHEIKKAKKHTSEGKRVRSAD-------------
                                           ||..|||.|......|......|||..|...|........|..|             
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENEDDNPCNRFVNKIPKKWQEKMDKCWNNNISNNWKKKLHQLKYPFKMDDDISFIRNMDQTMQNDQSRYKMQ

---------------------------------------------------TASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGG
                                                   ...|.||..||.....|.|.|.||..|.......|.........|.|..
YSHDPFFKKFNKQIIIREPMRNSSFSKESYCDQDDSNDIYSNEVDFFFTPKKCYFSESQFMPSEFSGTDDEEQSWMDSNNDTMYNAQQKCMTKCFGHHKH

SDRTTAELKEESVAFSESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQEL
........|||...|....|.||....|.|...|......|..|..||.|..|..............|......|........|..|.........|...
MMDFSKDNKEEHTFFDCPSEASDYYSGSFSNNSSIIFEDSSCEDNKPKEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNN

EVRERNDTGDCAYLYIVMQLCAEKTLEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTH-------------------
.......||.|.|.||.||||...||.||.|...||||||...|..|..|...|..|.|.||.|||||||.|.|||.||.|                   
KNWKMHPTGNCIYMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDG

GHQILKIGDLGLAT--------------------------------------------------------------------------------------
||||.||||.||.|                                                                                      
GHQIIKIGDFGLVTDHTIVTPTPTPTPNNTPSTTPINTHITPIDQIININQQPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTTITTISVSPSKPSSIS

------------------------KTDGAPKITVRQDS-DSSAKHTKNVGTRSYMSPEQLKHQ----------------QYTEKVDIFALGLVATELIIS
                        ..|........|.| .|...||..|||..||||||..||                .|..||||..|||...|||..
TPPISSMQHQHQQQPCPIQTTSPTAIDQQMEWCTPQMSMPSCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHP

-FSTASERIHTFADFQKGDIPAILDN-VPESRDFLLQLTSLEPSERPTAHEVATHKFL
 |||..|||.|..|...|..|..... .|....|..|..|..|.||||| ..  | | 
GFSTQMERIRTMCDLRNGQWPKWFTQKYPQEYEFIQQMMSMNPDERPTADQISMHDFF
Kinase pek-1.AA PEK 604-1076 22 2.1e-186 625.53 In-house 1-655 (655) Show / Hide 
Range on Protein: 604-1076
Range on HMM: 1-655/655
Sequence Identity: 22% (151 aa)

FEVKKVIGHGGF-GVVFRAQSITDMNEYAVKRIAVADND----------------KARNRVLREARALAMFDHPGIIRYFYAWEERPPKGFQEKEDENLL
||.....|.||| |.|...|.. |...||.|||.. ...                |.. .||||...||...||.|.||..|| |.|....|...||...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

GKIKAEKLAKLHEIKKAKKHTSEGKRVRSADTASFAESFAMPPVV--GNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGS-----------------
.. .... ...| ..|..... ...... .| ....||..|.. .  .........||.|..... .... ..|.. ..|..|                 
LDSSTDWPNGKH-KSKDYNFH-PFEKEW-DD-EEAQESNVMSE-CEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTE

--------------------------------DRTTAELKEESVAFSESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNE
                                |.|... .|....||.|...|..|....|.|.||....|.....|...|..... .|..|.... ...
NENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDS

AVKETKKEIAVIE----------------ELSIHNRAMIVETENQELEVRERNDT--GDCAYLYIVMQLCAEKTLEDWIRRSK-----------------
.....||......                . | ....|  .|.|.. .......|  ..|.||||.|..|  |||.|||....                 
KNQSHKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHY

------------------------TMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLAT---------------
                        ......  .......|...||.|.|..|.|||||||.|.|.. |..|.....|||| ||||               
NNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQ

--------KTDGAPKITVRQDSDSS-AK----------------------HTKNVGTRSYMSPEQLKHQ-----QYTEKVDIFALGLVATELIISFSTAS
         .|... .. .|..... ..                      ||..||| .|||||||..|     .|..|||...||..  |... |.| .
DQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTM

-ERIHTFADFQK------GDIP-AILDN-VPESRDFLLQLTSLEPSERPTAHEVATHKFL
 ||..|. |...      ||.|  ..||  |. .||.....|. |..||.| .   |.|.
MERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase pek-1.AA S_TKc 604-1076 13 6.5e-49 169.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 604-1076
Range on HMM: 1-231/231
Sequence Identity: 13% (68 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLREARALAMFDHPGIIRYFYAWEERPPKGFQEKEDENLLGKIKAEKLAKLHEIKKA
.|. ..||.|.||.|.... . .  ..|.|.|                                                                    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KKHTSEGKRVRSADTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGSDRTTAELKEESVAFSESDEESDTTEDSSSSDESPSS
                                                                                                    
----------------------------------------------------------------------------------------------------

SSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQELEVRERNDTGDCAYLYIVMQLCAE--KTLEDWIRRSKT
                                        . .. |..|. .              .  ..    .||.|| .|     .| | |.. ..
----------------------------------------EHIRREIQILKK-----HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

MES---RPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTDGAPKITVRQDSDSSAKHTKNVGTRSYMSPEQLKH
       |  . . ...|....|||.|..|.||||||| |....         .||.| |||..                   |  .||. ||.|| |  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL--

QQYTE-KVDIFALGLVATELII---SFSTASERIHTFADFQKGDIPAILDNVPESRDFLLQLTSLEPSERPTAHEVAT-------HKFL
 .|.  |.|. ..| .  |..     |.      . .. |.|          || .||. ..   .|..|||| |. .       | ..
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase pek-1.AA STE 604-1076 11 2e-45 157.21 In-house 1-359 (359) Show / Hide 
Range on Protein: 604-1076
Range on HMM: 1-359/359
Sequence Identity: 11% (67 aa)

FEVKKVIGHGGFGVVFRAQSITDM-NE--------------YAVKRIAVADND----------------KARNRVLREARALAMFD--HPGIIRYFYAWE
.|  ..||.|.||.|..|  . .  ..              .|.|.. . ...                . ....|.| . .  ..  || |..|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ERPPKGFQEKEDENLLGKIKAEKLAKLHEIKKAKKHTSEGKRVRSADTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGSDRT
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

TAELKEESVAFSESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQELEVRE
                                                                                                    
----------------------------------------------------------------------------------------------------

RNDTGDCAYLYIVMQLCAEKTLEDWIR-RSKTMESRP----------LFTMKNWIKQLASG-LEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLG
   .... .|.|.| ...  .|.| |. . .. .. .              .  ..|.  | |.|||... ||||.||.|...           |. | |
---HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFG

LATKTDG-------------APKITVRQDSDSSA-KHTKNVGTRSYMSPEQLKH------QQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKG-
.... .                        .... | .  |||  .|.|| ..       ..|..|.||  ||... |..      ..  .. | |..  
VCGQLTDSMANIQSNNIIDCI---------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPF

----------------DIPAILDNV--------------------PESRDFLLQLTSLEPSERPTAHEVAT--HKFL
                ..| . |..                    || .||. .    .|..||||..     |.|.
NYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase pek-1.AA Pkinase 879-1076 24 5.9e-39 138.81 Pfam 74-293 (293) Show / Hide 
Range on Protein: 879-1076
Range on HMM: 74-293/293
Sequence Identity: 24% (58 aa)

YLYIVMQLCAEK----TLEDWIR--RSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFS----LDSTHGHQILKIGDLGLATKTDGAPK
..|.|| .|        | |.|.  |....   .  . |....|...||||.|..|.||||||| |....    .|.     ..||.| ||| . |    
HIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD----

ITVRQDSDSSAKHTKNVGTRSYMSPEQLK-HQQYTEKVDIFALGLVATELII---SFSTA----SERIHTFADFQKGDIPAILDNV--------------
        ..   |  .||. ||.|| .. .| |. |||....|..  |..     |. .    . . . .  ..... |   |                
------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------PESRDFLLQLTSLEPSERPTAHEVATHKFL
         .| .||.  .  . |..||||...  |...
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase pek-1.AA PKR 880-1074 36 4.5e-35 122.83 In-house 96-272 (272) Show / Hide 
Range on Protein: 880-1074
Range on HMM: 96-272/272
Sequence Identity: 36% (71 aa)

LYIVMQLCAEKTLEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTDGAPKITVRQDSDSSA
|.| |  |   ||| |.|. .         . .   |.  | .|.| |. |||||||.|.|   |  |    .|||| ||.|        ... |  |  
LFIQMEFCDKGTLEQWMRNRRQEKVDKVLIL-DLYEQIVKGVDYIHSKKLIHRDLKPSNIFL-VDERH----IKIGDFGLVT--------ALKNDGKS--

KHTKNVGTRSYMSPEQLKHQQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKGDIP-AILDNVPESRDFLLQLTSLEPSERPTAHEVATHK
  |.  ||  ||||||.  |.|   |||.||||.  ||.    |..|.|  | |  .||.   | ||    .  | .| |  | .||   |.    
-RTRRKGTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase pek-1.AA GCN2 879-1076 28 2.5e-33 113.84 In-house 281-511 (511) Show / Hide 
Range on Protein: 879-1076
Range on HMM: 281-511/511
Sequence Identity: 28% (69 aa)

YLYIVMQLCAEKTLEDWIRRS-KTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATK---------------
||||.|  |  ||| . |  .  .|... |..      |. .|| |.|..| ||||||| |.|  ||.   ..  |||| ||||                
YLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRY---FRQILEGLNYIHSQGMIHRDLKPSNIF--LDC---CGNVKIGDFGLATNNKMESQINRKQQKQQ

---------------TDGAPKITVRQDSDS----SAKHTKNVGTRSYMSPEQLKHQQYTEKVDIFAL-GLVATELIIS-FSTASERIHTFADFQKGDIPA
                |   ..........    .  || .|||  ||.|||.    |..|||...| |..  |..   |.|..||. .  .  .  .| 
QQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQ

ILD-----NVPESRDFLLQLTSLEPSERPTAHEVATHKFL
 .|       ....|.. ..... |..||.| .   |.||
DFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase pek-1.AA Ciliate-E2 879-1076 20 2.7e-33 111.65 In-house 108-365 (365) Show / Hide 
Range on Protein: 879-1076
Range on HMM: 108-365/365
Sequence Identity: 20% (57 aa)

YLYIVMQLCAEKTLEDWIR--RSKTMESRP------LFTMKNWIKQLAS---------------GLEYLHNKG-FIHRDLKPGNVFFSLDSTHGHQILKI
..|.|| .|  ..|.|.|.  . |  . ..      .. .|. .||...               .|||||.|.  ||||.|| |..|          .||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKI

GDLGLATKTD---------GAPKITVRQDSDSSAKHTKN------------VGTRSYMSPEQLK---------HQQYTEKVDIFALGLVATELIIS---F
 |.||..| |            |.     .| |   ...            .||  ||.|| |.         ...|..|.||..|| .  |..     |
IDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

STASERIHTFADFQKGDIP------------------AILDNVPESRDFLLQ----LTSLEPSERPT-AHEVATHKFL
         .   ....|                     ..  .|  |.. .    .   .|..|.| . ..  |...
---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase pek-1.AA CMGC 604-1011 12 2.9e-33 105.96 In-house 1-322 (513) Show / Hide 
Range on Protein: 604-1011
Range on HMM: 1-322/513
Sequence Identity: 12% (63 aa)

FEVKKVIGHGGFGVVFRAQS--------------ITDMNEYAVKRIAVADNDKARN----------RVLREARALAMF-----------------DHPGI
.|. |.||.| .|||....               . . ...|.|.|  . ..              | ||| . | ..                 .|. |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

IRYFYAWEERPPKGFQEKEDENLLGKIKAEKLAKLHEIKKAKKHTSEGKRVRSADTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLG
.. ..    . ..| ...  .                                                                               
VKLYDIFYHKNSDGNEYEDKHI------------------------------------------------------------------------------

LHGGSDRTTAELKEESVAFSESDEESDTTEDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETE
                                                                                               |    
-----------------------------------------------------------------------------------------------I-S--

NQELEVRERNDTGDCAYLYIVMQLCAEKTLEDWIRRSKT-MES---RPL-------------FTMKNWI------KQLASGLE--YLHNKG--FIHRDLK
             .  .||.|. .. ...| . |.. .. .     .||              . |. .      .|.  ||.  |.| ..  .||||||
-----------Q-HFNHLYLVFEYM-DHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLK

PGNVFFSLD----------STHGHQ---------ILKIGDLGLATKTDGAPKITVRQ-----------DSDSSAKHTKNVGTRSYMSPEQLKHQQ-----
| |. .. .          |    .         .|||.| |||....  .. .  |           | ...  .| .| || | .|| |   .     
PENILINHNCELITRMMWKS----EDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNH

-----YTEKVDIFALG
     ||...|. ..|
NYSMHYTTPIDMWSVG
Kinase pek-1.AA Ciliate-E2-Unclassified 879-1011 27 2.1e-27 92.11 In-house 95-257 (352) Show / Hide 
Range on Protein: 879-1011
Range on HMM: 95-257/352
Sequence Identity: 27% (45 aa)

YLYIVMQLCAEKTLEDWIRRSKT-----------MES---RPLFTMK-----NWIKQLASGLEYLHNKG-FIHRDLKPGNVFFSLDSTHGHQILKIGDLG
..||||..|  ..|...|. .|.           |..    . . .|     ....|. .|||||| |. .||||.|| |..|. .       .|| |.|
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK--NYYIKIIDFG

LATKTDGAPKIT----VRQDSDSSAKHTKNVGTRSYM----SPEQLKHQQYT----EKVDIFALG
.. | .  ....    ....  .. . . ..|| .||    .|| |. |.|     .|.||..||
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG
Kinase pek-1.AA HRI 879-1076 34 1.3e-25 86.88 In-house 393-613 (613) Show / Hide 
Range on Protein: 879-1076
Range on HMM: 393-613/613
Sequence Identity: 34% (77 aa)

YLYIVMQLCAEKTLEDWI--RRSK----TMESRPLFTMKN------WIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTD--
.|.| |||| | .| |||  |  .      |.   . | |         |.  |. | ||.. .|||.|| |.| . |   ||   |||| |||  .|  
MLHIQMQLC-ELSLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLH-DPDQGHPQVKIGDFGLA-CEDIL

GAPKITVR----QDSDSSAK-------HTKNVGTRSYMSPEQLKHQQYTEKVDIFALGLVATELIISFSTASERIHTFADFQKGDIPAILDN-VPESRDF
  ||  .|    || | . .       ||  |||  | |||||   ||  | | . .|..  ||   | |  ||         | ||  |    |    .
QEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQIPESLRKRCPVQAKY

LLQLTSLEPSERPTAHEVATHKFL
.  ||    | || |  .      
IQHLTRRNASQRPSAIQLLQSELF
Kinase pek-1.AA CAMK 879-1011 20 1.4e-22 68.97 In-house 131-321 (425) Show / Hide 
Range on Protein: 879-1011
Range on HMM: 131-321/425
Sequence Identity: 20% (40 aa)

YLYIVM---QLCAEK----TLEDWIRRS---------------KTM---ESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGH----
..|.||    .|        | |.|..                . .   | | .|        ..|...|.|... .|||||| |. .. ....      
HMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQ------ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEH

--------QILKIGDLGLATKTDGAPKITVRQDSDSSAKHTKN--------------VGTRSYMS-PEQLKHQQ--------------YTEKVDIFALG
          .|| | |.|.| |.  . .  .| ..     .|              .|| .||. || |. ..              |..|.|. ..|
DEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase pek-1.AA GCN2 604-673 29 5.5e-15 48.52 In-house 1-74 (511) Show / Hide 
Range on Protein: 604-673
Range on HMM: 1-74/511
Sequence Identity: 29% (22 aa)

FEVKKVIGHGGFGVVFR-AQSITDMNEYAVKRIAVA-DNDKARNR--VLREARALAMFDHPGIIRYFYAWEERP
||.  ..|.|||| |   ...  | . ||.|..... ...| . .   .||.  |.   |... ||..|| |..
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKC
Kinase pek-1.AA HRI 604-669 37 7.7e-15 48.04 In-house 1-67 (613) Show / Hide 
Range on Protein: 604-669
Range on HMM: 1-67/613
Sequence Identity: 37% (25 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKAR-NRVLREARALAMFDHPGIIRYFYAW
|| | .|| ||.| |.. .   |   ||.|.| .    |    ...|| . ||  .|. |.||  ||
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAW
Kinase pek-1.AA CAMK 609-670 18 3.7e-14 41.33 In-house 1-108 (425) Show / Hide 
Range on Protein: 609-670
Range on HMM: 1-108/425
Sequence Identity: 18% (20 aa)

VIGHGGFGVVFRAQSI-TDM-----------NEYAVKRIAVAD---------------------------NDKARNRVLREARALAM-------FDHPGI
..|.|.||.|.... . |              ..|.| |                               ..| | .|.|| . . .        ||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYFYAWE
|. . ..|
IKLYEVYE
Kinase pek-1.AA Pkinase 604-671 23 1e-13 49.55 Pfam 1-71 (293) Show / Hide 
Range on Protein: 604-671
Range on HMM: 1-71/293
Sequence Identity: 23% (17 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLR---EARALAMFDHPGIIRYFYAWEE
......|| |.||.|.... . .  ..|||.| . ....  .. .|   |.. .....|| |.|.....|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED
Kinase pek-1.AA TyrKc 604-1076 11 1.1e-13 -1.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 604-1076
Range on HMM: 1-280/280
Sequence Identity: 11% (60 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLREARALAMF--DHPGIIRYFYAWEE--------RPPKGFQE--KEDENLLGKIKA
 . .|..|.| ||.|.... .    . ||| .        |   .|||| . ..  .|| |.| . .  .         |.    |  .   .|.  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDYLRK

EKLAKLHEIKKAKKHTSEGKRVRSADTASFAESFAMPPVVGNTTDAENSWSTSAKPQEVGAKRTTSESKLGLHGGSDRTTAELKEESVAFSESDEESDTT
 .                                                                                                  
HRPK------------------------------------------------------------------------------------------------

EDSSSSDESPSSSSGSSIDDEPKKYNSSSGGIEFVDGSDDVDNEAVKETKKEIAVIEELSIHNRAMIVETENQELEVRERNDTGDCAYLYIVMQLCAEKT
                                                                                                    
----------------------------------------------------------------------------------------------------

LEDWIRRSKTMESRPLFTMKNWIKQLASGLEYLHNKGFIHRDLKPGNVFFSLDSTHGHQILKIGDLGLATKTDGA-PKITVRQDSDSSAK--HTKNVGTR
              .. .. ..  | |.| |||| |..|||||   |.  . .      . ||.| ||. . .    .  ...|  ....  ..| .   
-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPI

SYMSPEQLKHQQYTEKVDIFALGLVATELI---ISFSTA-----SERIHTFADFQKGDIPAILDN---------VPESRDFLLQLTSLEPSERPTAHEVA
  |.|| ...  .|.| |... | .  |.     .          . .. ... ..|. . . .|          .|  .  .|    .|..|||  |. 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-

THKFL
 |...
-HECF
Kinase pek-1.AA PKR 604-670 38 1.2e-10 34.17 In-house 1-62 (272) Show / Hide 
Range on Protein: 604-670
Range on HMM: 1-62/272
Sequence Identity: 38% (26 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLREARALAMFDHPGIIRYFYAWE
|.    || |||| ||.|.   |   |..||.    |.||     .| .|||  ||  |..|   |.
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKY-NNEKAE----HEVQALAKLDHVNIVHYHSCWD
Kinase pek-1.AA Ciliate-E2-Unclassified 604-668 17 1.1e-08 26.21 In-house 1-89 (352) Show / Hide 
Range on Protein: 604-668
Range on HMM: 1-89/352
Sequence Identity: 17% (16 aa)

FEVKKVIGHGGFGVVFRAQSITDMNEYAVKRIAVADNDKARNRVLR-----------EAR--------------ALAMFDHPGIIRYFYA
... |.||.||||.|...| . .  .|... ..   ...... ...           . .               | ...|| |...||.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC
Kinase pek-1.AA Ciliate-E2 604-671 17 3.4e-08 24.23 In-house 1-103 (365) Show / Hide 
Range on Protein: 604-671
Range on HMM: 1-103/365
Sequence Identity: 17% (18 aa)

FEVKKVIGHGGFGVVFRA-QSIT----------------------DMNEYAVKRIAVADNDKARN--RVLREAR----------ALAMFDHPGIIRYFYA
... |.|| |.||.|... .  .                      ....||.|..   .     .  ...|| .           |   .|| ||.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WEE
..|
FQE
Kinase pek-1.AA Pkinase_Tyr 912-934 52 8.3e-07 23.68 Pfam 115-137 (270) Show / Hide 
Range on Protein: 912-934
Range on HMM: 115-137/270
Sequence Identity: 52% (12 aa)

NWIKQLASGLEYLHNKGFIHRDL
..  | |.|.|||..|..|||||
QMCWQIAKGMEYLESKNCIHRDL
Kinase pek-1.AA CAMK 1047-1076 20 6e-06 14.34 In-house 396-425 (425) Show / Hide 
Range on Protein: 1047-1076
Range on HMM: 396-425/425
Sequence Identity: 20% (6 aa)

PESRDFLLQLTSLEPSERPTAHEVATHKFL
.| .|.. ..   .|..|.|....  |...
QECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase pek-1.AA CMGC 1047-1076 26 1.9e-05 12.87 In-house 484-513 (513) Show / Hide 
Range on Protein: 1047-1076
Range on HMM: 484-513/513
Sequence Identity: 26% (8 aa)

PESRDFLLQLTSLEPSERPTAHEVATHKFL
|. .|.| ..  ..|..|.|| .   | ..
PQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase pek-1.AA Pkinase_Tyr 604-665 24 0.001103 13.1 Pfam 1-69 (270) Show / Hide 
Range on Protein: 604-665
Range on HMM: 1-69/270
Sequence Identity: 24% (17 aa)

FEVKKVIGHGGFGVVFRAQSI----TDMNEYAVKRIAVADNDKA--RNRVLREARALAMF-DHPGIIRY
 .  |..|.| ||.|...        .  . ||| .     ...  |   .|||. .  . .|| |.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase pek-1.AA Ciliate-E2-Unclassified 1047-1076 23 0.002547 7.4 In-house 319-352 (352) Show / Hide 
Range on Protein: 1047-1076
Range on HMM: 319-352/352
Sequence Identity: 23% (8 aa)

PESRDFLL----QLTSLEPSERPTAHEVATHKFL
||  ||.     ..    |..|.|. ..  | ..
PEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF