Gene pmk-3 (Nematode worm)

pmk-3

Species: Nematode worm
Alias: F42G8.4, CE29318, pmk-3, aSWK199
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 8139204-8143124, WormBase Genetic Map location: n/a,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
pmk-3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 302 Kinase domain by global Sugen HMM Fasta, JSON
pmk-3.AA Protein Genbank 474 None Fasta, JSON

Protein domain

Protein domains of pmk-3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase pmk-3.AA p38 118-419 51 2.1e-189 635.54 In-house 1-289 (289) Show / Hide 
Range on Protein: 118-419
Range on HMM: 1-289/289
Sequence Identity: 51% (156 aa)

PNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTP--DEENDFRDVYVVTEFAGRSLYQILKQ
.......|.|..|.|.|........ ||||||||...||....||.|..||..||..|||.|.||.||..||  ...|||.|||.||.|.|..|..|.|.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADMWSL
||      |.|.||.|..|||.|.|||||||.||||||||.|.|...|..|.||||||||   ..|...|.||.|||||.||....... ||...|.||.
QR------LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR---HCDDEMTGYVATRWYRAPEIMLNWMH-YTQTVDIWSV

GCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQ
|||.|||.||..|||||....|.|||...||.||||...||.....   ...||||....||.|..||...||..  ||||||.|.|||.||||.|||.|
GCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEA---RNYIQSYPQMPRRDFHHVFMGANPQA--IDLLEKMLELDPDKRITAEEAMQ

HPYL
|||.
HPYF
Kinase pmk-3.AA MAPK 118-419 40 2.5e-155 522.31 In-house 1-328 (328) Show / Hide 
Range on Protein: 118-419
Range on HMM: 1-328/328
Sequence Identity: 40% (137 aa)

PNSIEYLGGGSFGNVIKTSAVCRDGL---RRYVAIKKMREPFFDPHHARRIFRETKLLQLM-RHDNIICALDIYTP----DEEN--DFRDVYVVTEFAGR
 . ....| |..| | .   .....     ..|||||.  || .|.|..|..|| |||. . .|.|||. |||.||    |...  .|.|.|.|.|. . 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

SLYQILKQQRDYGRRVLTDEHIKFIIYQIIRA--LKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDT--------------SLTQYVQTR
 |.||.|.|.      |.|.||....|||.|.  ||||||||.|||||||.|.... . || |.|||||||.. ...               .|.|| ||
DLHQIIKSQQ-----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRSPEVIYWKI-DSYTNLADMWSLGCIAAELLT-GEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSY---TTHKRRNFRDVFSAH
|||.||.. ..| . ||   ||||.||| ||.|| . |||||. .  | ..|....|.|.||.. .|..  |.. . .|||.   . .........|. .
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICM--SEHARNYIQSLGNLPKYPKKPWEKMFPNA

N--PSEDFIDLLEKLLVLDPEKRITVEEAIQHPYL
|   . . ||||||.||.||.||||||||.||||.
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase pmk-3.AA CMGC 118-419 23 3.2e-120 397.02 In-house 1-513 (513) Show / Hide 
Range on Protein: 118-419
Range on HMM: 1-513/513
Sequence Identity: 23% (124 aa)

PNSIEYLGGGSFGNVIKTSAVCRDGLR---------------RYVAIKKMREPFFDPHHAR----------RIFRETKLLQLMR----------------
   |...| |..|.| |    ||| ..               ..|||||...|| ....|.          |..|| |.|. ..                
YEIIKKIGEGTYGVVYK----CRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNK

-HDNIICALDIYTPDEEN------------DFRDVYVVTEFAGRSLYQILKQQRDY----GRRVLTDEH------------IKFII------YQIIRALK
 | ||.. .||.......            .|...| |.|. . .|||..|.....    ... |.. |            ||...      |||.|.||
HHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLK

--YIHSAN--IIHRDLKPGNLALTDDSDL--------------------MILDFGLARSLEKK---------------------DTSLTQYVQTRWYRSP
  |.||..  |||||||| |. .... .|                     | ||||||....                         .|.||.|||||.|
LKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAP

EVIYWKI--------DSYTNLADMWSLGCIAAELLTG--------EPLFPGDEP-----------NAQYQRITQLCGSP----------------DEELL
|..            . ||   ||||.||| ||..||        .|||||.               | ..| ...|.|                .||  
EILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWP

TKIEND-----------------NSSAIKAVIQS---YTTHKRRNFRDVFSAHN---------------------------------PSEDFIDLLEKLL
..|...                  |.  .  |||   . ..........|  |.                                  ....||||.|.|
NMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKML

VLDPEKRITVEEAIQHPYL
..||.||||.|.| ||||.
QYDPDKRITAEQALQHPYF
Kinase pmk-3.AA ERK 147-419 42 1.9e-91 310.12 In-house 32-307 (307) Show / Hide 
Range on Protein: 147-419
Range on HMM: 32-307/307
Sequence Identity: 42% (121 aa)

VAIKKMREPFFDPHHARRIFRETKLLQLMR-HDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHS
|||||  ..| .|  . |. || ||| . . |.|||| .||  |.  ... |.|.|.|.    | || . |       |.|.|... .|||...||||||
VAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQ-----ELSDDHCQYFMYQILCGLKYIHS

ANIIHRDLKPGNLALTDDSDLMILDFGLAR----SLEK----KDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAELLTGEPLFPGDEPNAQ
||.|||||||.|. .. . || | ||||||    | ..     .  .|.|| |||||.||..  .   ||   |.|| ||| ||.| . |||||     |
ANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIM-LSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQ

YQRITQLCGSP-DEELLTKIENDNSSAIKAVIQSYTT--HKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQHPYL
 .||.|. |.| .|| | .|...|    .  | ..     . ... ..|. .| . . ||||||.|| ||.|||||||...|||.
INRIFQIIGTPHSEEDLQYICSEN---AWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase pmk-3.AA S_TKc 118-419 28 1.9e-85 291.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 118-419
Range on HMM: 1-231/231
Sequence Identity: 28% (91 aa)

PNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEENDFRDVYVVTEFAGR---SLYQILK
   .. .| |.|| | |  .. ..   |.||||...         ..| || ..|.  .|.||.  .|..         ..|.|.|...    .|....|
YEILRKIGKGAFGKVYK--CRHKK-TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIK

QQRD-YGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTSLTQYVQTRWYRSPEVIYWKIDSYTN-LADM
...   .|....  |..|..|||..||.|.|| .|||||||| |. |..   ..| |||||| |       | .. |.||..|||.     .|.   .|.
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDW

WSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEE
||.||| .|.|.|.|.||      |.|.. ...|                                          |....|...|.|. |||||.|. |
WSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-E

AIQ-------HPYL
| |       ||..
ALQDEWDIKCHPWF
Kinase pmk-3.AA ERK7 114-419 36 5.2e-80 272.11 In-house 1-292 (292) Show / Hide 
Range on Protein: 114-419
Range on HMM: 1-292/292
Sequence Identity: 36% (115 aa)

YDVEPNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMR-HDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQI
|..    .. || | .| | |  |...   .  ||.||.   | ..  | | |||  .|| .. |.|||  ...     .|| ||.|.| ||    |  .
YEI----RKRLGKGAYGIVWK--AYDKRT-KQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR--ADND-RDIYLVFEFMETDLHAV

LKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKD------TSLTQYVQTRWYRSPEVIYWKIDSY
 ..      ..| | | ..|.||..||.||.||.|.||||||| |. |  .  . . |||||||. ...        || || |||||.||.       |
IRK-----GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLG-SHRY

TNLADMWSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEK
|   ||||.||| .|.|.| |.|||     |  .| .. . | .| .  |.   |.    ....  ..||. . ...   . ..| |||| .|||. |.|
TKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIG---SHYAWNMLEQMNQQKRKTLDQMMP--QCCDDAIDLLKRLLVFNPKK

RITVEEAIQHPYL
|.|.|.|.|||| 
RLTAEQALQHPYV
Kinase pmk-3.AA nmo 116-419 37 1.2e-73 225.72 In-house 1-292 (292) Show / Hide 
Range on Protein: 116-419
Range on HMM: 1-292/292
Sequence Identity: 37% (116 aa)

VEPNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQ
..|.    .| | || |. .    ||| |  ||.||| . | .   ..|.||| |.|   .|||.. ||||  | . . |...|||||     | .|.  
IQPD--RPIGYGAFG-VVWSVTDPRDGKR--VALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKII--

QRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDT-SLTQYVQTRWYRSPEVIYWKIDSYTNLADMWS
        |. .|.|  .|||.| |||.|||||.|||.||||| .  .  | | ||||||  |...   .|| | | .|| ||..      ||.  |.||
---VSPQHLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMG-ARHYTSAVDIWS

LGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPD-EELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEA
 ||| ||||    ||   .|  | | ||.| | |  |.. .  |   .  ...  .   ...      . |. .   . ..|| ..|. ||.||| ...|
VGCIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQV---LYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDA

IQHPYL
..||||
LAHPYL
Kinase pmk-3.AA Pkinase 124-419 27 1.7e-70 245.29 Pfam 7-293 (293) Show / Hide 
Range on Protein: 124-419
Range on HMM: 7-293/293
Sequence Identity: 27% (87 aa)

LGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFR--ETKLLQLMRHDNIICALDIYTPDEENDFRDVYVVTEFAGR-----SLYQILKQQ
.| |||| |      .. | .. ||.|... .  ..   .. .|  | .... ..|.||.  .|...       ...|.|.|...      .|. ...  
IGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST-

RDYGRRV-LTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDL----MILDFGLARSL-EKKDTSLTQYVQTRWYRSPEVIYWKIDSYTNLA
 ...... ......||..|||.|.|.|.|| .|||||||| |. . .. ..     | |||||. . . ... .| .. |.||..||||  .   |.  .
-WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKV

DMWSLGCIAAELLTGEPLFPGD----EPNAQYQRITQ-LCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPE
||||.||| .|.|.|.|.|||.    . . |.|.| . ... ....  ..... ... ..    .        |   .  || ||...|.....| .||.
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPK

KRITVEEAIQHPYL
||.| |.. |||..
KRPTAEQILQHPWF
Kinase pmk-3.AA ERK5 119-419 37 9.1e-70 238.09 In-house 2-295 (295) Show / Hide 
Range on Protein: 119-419
Range on HMM: 2-295/295
Sequence Identity: 37% (114 aa)

NSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEE-NDFRDVYVVTEFAGRSLYQILKQQR
. || .| | .| |  .||. |   .. |||||.   |     |.| ||| |.|.  ||||||   ||  | .   ...||||| .     | ||.    
KIIEKIGNGAYGVV--CSARRRKNGQQ-VAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQII----

DYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEK-----KDTSLTQYVQTRWYRSPEVIYWKIDSYTNLADM
      .| |||.. .|||.| |||.|||..||||||| ||   .  .| | |||.|| |       .   .|.|| ||||| ||...   . ||   |.
-HSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMF-SSHDYTQAIDV

WSLGCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQS-YTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVE
|| |||  |...   .|||  .  | | | .  | |   ..  .  |    ... .|. .  .. ...  |.    .    .||| ..|. .| .|||| 
WSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADH---VYNYFQKNFPNRQPKDWEKVYPKADR--QALDLLARMLRFEPSERITVN

EAIQHPYL
.|.|||.|
KALQHPFL
Kinase pmk-3.AA ERK1 119-419 40 2.6e-68 233.27 In-house 2-289 (289) Show / Hide 
Range on Protein: 119-419
Range on HMM: 2-289/289
Sequence Identity: 40% (124 aa)

NSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRD
  ..|.| | .| |       .   .. |||||.  ||    .  |  || |.|.  .|.|||   ||   |  . .||||.| .     ||..|| |. 
TNLQYIGEGAYGMVCSAYDTVH---KQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQH-

YGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLE-KKDTS--LTQYVQTRWYRSPEVIYWKIDSYTNLADMWSL
     |  .|| . .|||.| ||||||||..|||||| || |    || | ||||||  . ..|    || || ||||| || |      ||   |.|| 
-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPE-IMLNSKGYTKSIDIWSV

GCIAAELLTGEPLFPGDEPNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNPSEDFIDLLEKLLVLDPEKRITVEEAIQ
||| ||.|   |.|||     |   |  . ||| .. |  | |.     .. .||    ..  .. .|    .    .|||.|.|   |.||||||||. 
GCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEK---ARNYLQSLPHKPKVPWARLFPKADSKA--LDLLDKMLTFNPHKRITVEEALA

HPYL
||||
HPYL
Kinase pmk-3.AA JNK 143-357 36 8.2e-59 201.7 In-house 23-235 (309) Show / Hide 
Range on Protein: 143-357
Range on HMM: 23-235/309
Sequence Identity: 36% (82 aa)

LRRYVAIKKMREP--FFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEE-NDFRDVYVVTEFAGRSLYQILKQ--QRDYGRRVLTDEHIKFIIYQII
. . ||||||  |  | .  |..| .|| ... .  |.|||  . ..||.|   .|.|||.| |.   .| |.      .      |  | .....||. 
TNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTFME------LDHERMSYLFYQMC

RALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKKDTS--LTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAELLTGEPLFPGDEPN
.. |. ||. |||||||| |    .| .| |.|||.||   ..|..   | || ||.|| ||||    | |.   | ||.||| ||..... ||||    
CGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHAR---TEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMIRHHVLFPGKDHI

AQYQRITQLCGSPDEELLTKIE
 |. .| .. | || . . . .
DQWNKIIEFLGTPDPHFMMQMQ
Kinase pmk-3.AA MAPK-Unclassified 114-278 36 3e-45 156.66 In-house 1-160 (575) Show / Hide 
Range on Protein: 114-278
Range on HMM: 1-160/575
Sequence Identity: 36% (62 aa)

YDVEPNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLMRHDNIICALDIYTPDEEND--FRDVYVVTEFAGR---S
|..    ....| |..| | .  |.      ..|||||    | ..  ..|. ||  .|  . | |||   ||....|     | |.|.|...       
YEY----QKNIGSGAYGQVCR--AMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFD

LYQILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLE
|.||.|.  |     . ..||. ..||| | |||.|||.|||||||| || .. |  . | |||..|| |
LHQIIKSNQD----HWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIE
Kinase pmk-3.AA MAPK-Unclassified 284-419 29 1.1e-30 107.96 In-house 405-575 (575) Show / Hide 
Range on Protein: 284-419
Range on HMM: 405-575/575
Sequence Identity: 29% (52 aa)

LTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAELLTG-----------EPLFPGDE--------------------PNAQYQRITQLCGSPDEEL
.|||| ||||| || .    . |.   |.||.||| ||..              |||||.                        | . |    |.|.|| 
MTQYVVTRWYRAPEIMLSMHE-YDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHNP--------SEDFIDLLEKLLVLDPEKRITVEEAIQHPYL
.  |..|.   ..  |||    ..  | | . . .|          . ||.. |.|. .| |||| ..| .||| 
CNFITCDS---ARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase pmk-3.AA TyrKc 118-419 20 5.6e-13 -12.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 118-419
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

PNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHHARRIFRETKLLQLM--RHDNIICALDIYTPDEENDF---RDVYVVTEFA-GRSLYQ
   .. || | || | |  .       . ||.|...|        . . || ...     .|.||.. . . | ...| |     ...|.|.. . .| .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKD

ILKQQRDYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKK-------DTSLTQY-VQTR------WYRSPE
 |.  |.     |. ..   . .|| .   |.|| |.|||||   |  ....    | ||||.| .. .       |.  ..   ...      |. .||
YLRKHRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APE

VIYWKIDSYTNLADMWSLGCIAAELLT-GEPLFPG-----DEPNAQYQRITQL--CGSPDE--ELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAHN
.|  .   .|   | || |    |..| |..  ||      ..   .... |      |..  . .                             |    
CI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------------F--VC

PSEDFIDLLEKLLVLDPEKRITVEEAIQHPYL
 ...  .. ..    |||.| | .|   | ..
CPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase pmk-3.AA Pkinase_Tyr 124-253 28 2.3e-12 42.49 Pfam 7-137 (270) Show / Hide 
Range on Protein: 124-253
Range on HMM: 7-137/270
Sequence Identity: 28% (39 aa)

LGGGSFGNVIKTSAV-CRDGLRRYVAIKKMREPFFDPHH--ARRIFRETKLLQLM-RHDNIICALDIYT-PDEENDFRDVYVVTEFAGR-SLYQILKQQR
|| |.||.| |  .  . |. .  ||.|...|   ....   .  .|| |..  . .|.||.. . . |  .| |    .|.|.|..   .|.  |...|
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDYLRKHR

DYGRRVLTDEHIKFIIYQIIRALKYIHSANIIHRDL
  ... || ...  . .|| ... | .| |.|||||
-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase pmk-3.AA JNK 394-419 53 1.9e-10 35.06 In-house 284-309 (309) Show / Hide 
Range on Protein: 394-419
Range on HMM: 284-309/309
Sequence Identity: 53% (14 aa)

DLLEKLLVLDPEKRITVEEAIQHPYL
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DLLFRMLVINPDDRISVDDALQHPYI