Gene pqn-25 (Nematode worm)
pqn-25
Sequence
Protein domains of pqn-25.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | pqn-25.AA | NEK10 | 431-697 | 69 | 3.4e-224 | 746.38 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 431-697 Range on HMM: 1-279/279 Sequence Identity: 69% (193 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTN----LNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVE--NHRLYIVMDLIQGC ||..|.||.|||||||.||||||.||||||||||.|||||.| .||.|.|||..|||||.||||.|.||||||||.|.||| |||.||||.||.|| YEVYDHLGTGAFGCVYKVRKKAQQHSENPAKLLAMKEIFMHNPAFGKNDKERDKSIEDMISELKIIKEQMRHPNIVRYYRTFVEPQNHRMYIVMELIEGC SLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFGLAKQKG--PEYLKSAAGTIIYSCPEIVQNLPYGEK .|......||||...|||..||.|..||.|||||||||||||||||.||||||....||.||||||||||. |....|..|||.||||||||..||||| PLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKMTSVVGTILYSCPEIVQSEPYGEK ADIWSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNE-MWSDDLRFLITSCLAPDPSARPDILKVSG---MCGV ||.|.||||.|.||.|||.|.|||||||||.|||..|||.|| |||||.||.||.||.|||.|||||.|||. | ADVWAFGCCLYQMCTLQPPFYSTNMLTLAMKIVEHFYDPVNEGMWSDDVRFTITRCLTPDPEARPDIVKVSSVLRMIQD |
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| Kinase | pqn-25.AA | NEK | 431-697 | 36 | 1.3e-119 | 403.72 | In-house | 1-286 (286) | Show / Hide |
Range on Protein: 431-697 Range on HMM: 1-286/286 Sequence Identity: 36% (107 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDK--SFGDMISEVKIIKQQLRHPNIVRYRRIFVENH--RLYIVMDLIQ-GCS ||.. ..| |.||.|| ||.| . .. .||...|.| |.|....| .. . . .|..||.|||||.|. |.|. .|.|||. | YEIIKKIGQGSFGKVYKVRRKSDGKHLV-EKLYVWKKINMGNMSEKEKQNAQN------NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGD LRDLIITMKEKKG---NFEEKKIWAMVVQMMLALRYLHKEK----QIVHRDLKPNNIMMTTDER----VVITDFGLAKQKGPE--YLKS-AAGTIIYSCP | ..| . |..|. .|||..|| . .|| |||.|.|..| |.|||.||.||..| . . | | |||..|. . . .... || | .| LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSP EIVQNLPYGEKADIWSFGCCIYEMCQLQP--VFHST--NMLTLAMQIVEA-KYDPLNEM--WSDDLRFLITSCLAPDPSARPDILKVSGMCGV |..|| ||..|.||||.||..|||| |.| | .. ||. |.|.|.. .|.|.... .|.||. ||...| .||. ||.. .. |. . EVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | pqn-25.AA | S_TKc | 431-703 | 29 | 1.1e-77 | 265.34 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 431-703 Range on HMM: 1-231/231 Sequence Identity: 29% (83 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVMDLIQG--CSLRD ||.|...| ||||.|| .|.| .. |.|.| ....|..| |. .|||||.. .|.. ..||.||... | .|.| YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFD LIITMKEKKGN--FEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFGLAKQKGPEYLKSAAGTIIYSCPEIVQNLPYGE-KADI .| .. .... | | .. .. |. .|| |.|. .|.|||||| ||.... .. |.|||||.| .. || | ||.. .|| |.|. YIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDW WSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARPDILKVSGMC-GVRLLEYL ||.||..|||. .| |. .| .. .|. |.... .| || ||. || . .. .. ... ... WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | pqn-25.AA | Pkinase | 431-688 | 27 | 7.7e-58 | 203.26 | Pfam | 1-284 (293) | Show / Hide |
Range on Protein: 431-688 Range on HMM: 1-284/293 Sequence Identity: 27% (81 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLND--RESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVMDLIQGC---- |... ..|.|.||||| ..| .. . |.|.| . .. .... ||..| | .||||||....| .. ..|.||.. .| YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM SLRDLIITMKEKKGNF--EEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERV----VITDFGLAK---QKGPEYLKSAAGTIIYSCPEIVQ .| |.| | ...|.| .|. . .. |. .| |.|. . |.|||||| ||.. . . |.|||||| . ... .||. | ||... DLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR -NLPYGEKADIWSFGCCIYEMCQLQPVFHST------NMLTLAMQIVEAKYDPLNEMWS--------------------DDLRFLITSCLAPDPSARPDI . .|| |.|.||.|| .|||. .| | . ... . .| ..... . |. .... .|..||..||. || . GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA |
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| Kinase | pqn-25.AA | STE | 431-687 | 23 | 8.5e-57 | 195.0 | In-house | 1-347 (359) | Show / Hide |
Range on Protein: 431-687 Range on HMM: 1-347/359 Sequence Identity: 23% (83 aa) YELLDQLGAGAFGCVYTVRKKAQS--HSENPAK--------LLALKEIFMTNLNDRESD------------KSFGDMISEVKIIKQQLR-HPNIVRYRRI .|.....| |||| ||. ... .. | .. . . | |.. . | | . . . . . . |.|| |. |||||.| WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC FVEN-------HRLYIVMDLIQGCSLRDLIITMKEKKGN----------FEEKKIWAMVVQMMLA-LRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFG .. . . |.|.| .. | ||.|.| . ...... |.|. | ....| . | |||. . |.|||.|| ||.. | ..||| YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFG LAKQKGPE------------------YLKSAAGTIIYSCPEIVQN------LPYGEKADIWSFGCCIYEMCQLQPVF---HSTNMLTLAM---------- ...| .. .. .|| . ||..|. .|..|.||||.||.| ||. .| . | . .. ... VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE --QIVEAKYDPLNE-------------------MWSDDLRFLITSCLAPDPSARPD .||. . || . ||.... | || ||. ||. QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT |
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| Kinase | pqn-25.AA | NEK8 | 431-687 | 31 | 1.2e-56 | 160.15 | In-house | 1-268 (278) | Show / Hide |
Range on Protein: 431-687 Range on HMM: 1-268/278 Sequence Identity: 31% (87 aa) YELLDQLGAGAFGCVYTVRKKAQS-HSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVMDLIQGCSLRDL || .| |||| . |.|. . | .| .|.| |. . .| . . .|. . . | ||||. | | |. | |.| | | .. YERIRVVGRGAFGICWLYRRKEDQSH-----HLVIWKQINMHRMSEKERQ----MAQNEIQVLS-MLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQM IITMKEKKGNFEEK----------------KIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTD-ERVVITDFGLAKQKGPEYLKSAA----GTIIY | . |. .||. | .. .|| .|....| .. |.|||||. || || . | | |||..| . .|. . . || | IQHQQNKL-FEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMH-QHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYY SCPEIVQNLPYGEKADIWSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEA-KYDPLNEMWSDDLRFLITSCLAPDPSARPD ||... || .| |.|. || .||||.| .| .| . | . |. .| |. . | ..| |...||. || ||. MSPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPS |
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| Kinase | pqn-25.AA | Ciliate-E2 | 431-688 | 23 | 1.4e-56 | 192.73 | In-house | 1-356 (365) | Show / Hide |
Range on Protein: 431-688 Range on HMM: 1-356/365 Sequence Identity: 23% (88 aa) YELLDQLGAGAFGCVYTVRKKAQSHSE-----------------NPAKLLALKEIFMTNLNDRESDKSFGDMIS---------EVKIIKQQLRHPNIVRY |... ..| |.||.|| .... . . . . .|. |.| . . |. |. |. ... . | |..|| ||||... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIM---KKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKM RRIFV--ENHRLYIVMDLIQGCSLRDLIITMKEKK-------GNFEEKKIWAMVVQMML---------------ALRYLHKEKQIVHRDLKPNNIMMTTD | .. .|.||...|| .|.|.|. .| |. ..| ||.| . | ||.|||... |.|||.||.||.. YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--- ERVVITDFGLAKQKGP------------EYLKSA----------------------AGTIIYSCPEIVQNLP---------YGEKADIWSFGCCIYEMCQ . |.||||.|. . .|. .|| | .|||... . |..|.||||.|...|||. --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF LQPVFHSTNMLTLAMQIVEA-KYD-PLNEM----------------WSDDLRFLITS----CLAPDPSARPD-I .| | .|. . |.| | .|. ||.. || .| ||. |.. . GKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGW |
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| Kinase | pqn-25.AA | CAMK | 436-688 | 20 | 2e-54 | 173.45 | In-house | 1-416 (425) | Show / Hide |
Range on Protein: 436-688
Range on HMM: 1-416/425
Sequence Identity: 20% (84 aa)
QLGAGAFGCVYTVRKK-AQ-------SHSENPAKLLALKEIFMTNLNDRE----------------------SDKSFGDMISEVKIIKQ------QLRHP
.|| |.|| |. .. | . ..| . | | | . | | . ..|. . .|..| |. .|.||
TLGRGSFGKVKLCIHKNTTGKERVHHI-YTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHP
NIVRYRRIFVENH-------------------RLYIVM---DLIQGC----SLRDLIITMKEKK-----------GNFEEKKIWAMVVQMMLALRYLHKE
||.. .. .| ..|.|| ....| | | |. . . | |.|. .. |. |..|.|.
NIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH
KQIVHRDLKPNNIMMTTDE-----------------RVVITDFGLAKQKGP-------------------------EYLKSAAGTIIYSC-PEIVQN---
. |||||||| ||...... . |.|||.|... | . .| || | . ||...
N-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH
-----------LPYGEKADIWSFGCCIYEMCQLQPVFHST-------------NMLTLAMQIVEAKYDPLNEMWSD-----------------------D
.||.|.|.|| |. | | | | . |. | .| ..||| ...|. .
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE
LRFLITSCLAPDPSARPDI
. || ..| .||. |. |
CKDLIRKMLQVDPEKRMTI
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| Kinase | pqn-25.AA | Ciliate-E2-Unclassified | 431-691 | 20 | 2.7e-50 | 172.65 | In-house | 1-346 (352) | Show / Hide |
Range on Protein: 431-691 Range on HMM: 1-346/352 Sequence Identity: 20% (71 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIF-MTNLNDRESDKSFGDMISEVKIIKQQ----------------LRHPNIVRYRRIFVENHR |... |.| |.||.|| ...| | .. |.|.. . . ... .. ... | |..... | ||...... ..... . YKIIKQIGQGGFGKVYKCQHKKQ-----K-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK --LYIVMDLIQGCSLRDLIITMKE-------------KKGNFEEKKIW-----AMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDE---RVVITDFGL .||||....| .|.. | .| .. |.|... . | ..| |||... |.|||.||.||... . .. |.|||. QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGI AKQKG-----------------PEYLKSAAGTIIYS----CPEIVQNLPYG----EKADIWSFGCCIYEMCQLQPVFHSTNMLT---------------- .|. . .. ... .||..| ||. |. |. .|.||||.|...|||. .. | ..| SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ LAMQIVEAKYDPLN-------EMWSDDLRFLIT----SCLAPDPSARPDILKV | .| . ... . ||. .|. ..| .|. |... .. LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQI |
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| Kinase | pqn-25.AA | NEK1 | 431-694 | 32 | 3e-48 | 165.48 | In-house | 1-276 (276) | Show / Hide |
Range on Protein: 431-694 Range on HMM: 1-276/276 Sequence Identity: 32% (94 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHR--LYIVMDLIQGCSLRD |. . |.| |.|| .. |..|. . .....||| .. . | .| ||.| . ..|||||.|. |.|| . |||||. | | YHYIKQIGEGSFGKAWLVKHKEDG------QHYVIKEINVMKMQEKEREES----MNEVAIL-AKMKHPNIVKYKESFEENGCGILYIVMEYCDGG---D LIITMKEK--KGN-FEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMT--TDE---------------RVVITDFGLAK--QKGPEYLKSAAGTI | ... ||. | | | .|. ||| . |..| | |||.|. || | . | . ||| |. . || . .|| LMQKINRQKRKGKLFSEDQIMHWFCQICLALNHIHDRK-ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTP IYSCPEIVQNLPYGEKADIWSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARP---DILKVSGM | ||| ||.|| | |||| || || | | | . |. .| . |... | |. | .|..|... . .|. || .||. . YYLSPEICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI |
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| Kinase | pqn-25.AA | NEK4 | 431-697 | 34 | 4.4e-46 | 159.42 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 431-697 Range on HMM: 1-257/257 Sequence Identity: 34% (95 aa) YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQLRHPNIVRYRRIF-VENH-RLYIVMDLIQGCSLRD |. . . | | .| |. ||.. | .| .|. | || . |... ||.||||| | . || ||||| | | YCHMKVVGKGSYGEVWLVRHRRD------KKQYVMKKMFLKNASRRERK----AAEHEAQLL-SQLKHPNIVEYKESWEIENGQFLYIVMGF---CEGGD LIITMKEKKGNF-EEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFGLAKQKG--PEYLKSAAGTIIYSCPEIVQNLPYGEKADI | ..|..|..| ||. . || .|| |.| ||.|.||||| || .| . | |||... .. | || | ||. | || | || LYRKLKQQKNQFLEEYQVVEWFVQIAMALQYMH-EKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDI WSFGCCIYEMCQLQPVFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSARPDILKVSGMCGV || |||.||| | | .| | ||.. . |. .| || |. | | || | . | . WSLGCCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI |
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| Kinase | pqn-25.AA | ULK | 431-685 | 24 | 1.5e-43 | 150.96 | In-house | 1-312 (324) | Show / Hide |
Range on Protein: 431-685 Range on HMM: 1-312/324 Sequence Identity: 24% (77 aa) YELLDQLGAGAFG-CVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKS----FGDMISEVKIIKQQL--RHPN--IVRYRRIFVENHR--LYIVMD |.| ..|| |.|| || |.| . . .. | | | . ..|. ... ..|..|.|. .||| ||.. .| . . .||.|. YCLNHCLGKGSFGVKVYKGRNKKTNT---QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIME LIQGCSLRDLIITMKE-----KKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDE------------RVVITDFGLAKQKGP-----E . .| |...| . |. .|....|... | . ....||| ..|.|||.|| ||... . .. |.|||.||. YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK-HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ YLKSAA------GTIIYSCPEIVQNL----PYG-EKADIWSFGCCIYEMCQLQPV----FHSTN----ML-------TLAMQIVEAKYDP--LNEMWSDD .... || .| .|.|.|.. ||. |.||||.|| .||| .. | ... | . .. .... . |.. MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPE LRFLITSCLAPDPSAR .. || .| |.. | CKDLIRRMLQYDEKDR |
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| Kinase | pqn-25.AA | TyrKc | 431-700 | 21 | 5.4e-16 | 35.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 431-700
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)
YELLDQLGAGAFGCVYTVRKKAQSHSENPAKLLALKEIFMTNLNDRESDKSFGDMISEVKIIKQQL--RHPNIVRYRRIFVEN-------HRLYIVMDLI
.|...|| |||| || . | | | . |...| .| . .| .|||||| . .. . |.||| .
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---------REDFMREARIMC-KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYM
QGCSLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFGLAKQKGPE--------YLK-----SAA--GTI
. .|.| . ..| . |. . .| .|||. ...|||| |.. . . .| |.||||.. . . | . .. |
PHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI
IYSCPEIVQNLPYGEKADIWSFGCCIYEMCQLQPVFHST-----NMLTLAMQIVEAK-YDPLNEM--------WSDDLRFLITSCLAPDPSARPDILKVS
|| . . .| |.|||| |..|.. . .. . ... |.. . | . .|.. ....| . ||. || .
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-
GMCGVRLL
....
----HECF
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| Kinase | pqn-25.AA | Pkinase_Tyr | 484-636 | 31 | 2.6e-11 | 38.92 | Pfam | 49-208 (270) | Show / Hide |
Range on Protein: 484-636 Range on HMM: 49-208/270 Sequence Identity: 31% (51 aa) DMISEVKIIKQQL-RHPNIVRYRRIFV-ENHR--LYIVMDLIQGCSLRDLIITMKEKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTT |...|.|| | || .||||||. . . . .|||| . .. .|.| . .| |... | . | .| .. ||. .|...|||| |.. | DFMREAKIMK-QLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTE DERVVITDFGLAKQK-GPEYL-KSAAGTII---YSCPEIVQNLPYGEKADIWSFGCCIYEMC . | |.|||||. .| ... |. . || .. . .| |.|||| ...|.. NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF |
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| Kinase | pqn-25.AA | APH | 549-591 | 21 | 0.000153 | 16.37 | Pfam | 159-202 (248) | Show / Hide |
Range on Protein: 549-591 Range on HMM: 159-202/248 Sequence Identity: 21% (10 aa) VVQMMLALRYLHKEKQIVHRDLKPNNIMMT--TDERVV--ITDFGLA . ....|.. . ...|.|..|.|.|.. |. | . |.. | LWAWLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDA |
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| Kinase | pqn-25.AA | Pkinase_Tyr | 431-446 | 50 | 0.026571 | 8.42 | Pfam | 1-16 (270) | Show / Hide |
Range on Protein: 431-446 Range on HMM: 1-16/270 Sequence Identity: 50% (8 aa) YELLDQLGAGAFGCVY ... .||.|||| || ITFGKKLGEGAFGEVY |
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| Kinase | pqn-25.AA | NEK10 | 831-845 | 66 | 0.000442 | 9.09 | In-house | 266-279 (279) | Show / Hide |
Range on Protein: 831-845 Range on HMM: 266-279/279 Sequence Identity: 66% (10 aa) DGLTVSSNVLRQIQD | . ||| |||.||| DIVKVSS-VLRMIQD |
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| WR1 | pqn-25.AA | WR1 | 1011-1049 | 35 | 1.5e-08 | 35.63 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1011-1049 Range on HMM: 1-48/48 Sequence Identity: 35% (17 aa) YECGSNSSP----QVSASGQVVTCSTNTQCASGYTCNN-----GACCP . | ....| .. ..||...|..|.|| |||.|.| | ||| PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYCCP |
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| EB | pqn-25.AA | EB | 1036-1047 | 58 | 2.159599 | 4.72 | Pfam | 1-12 (59) | Show / Hide |
Range on Protein: 1036-1047 Range on HMM: 1-12/59 Sequence Identity: 58% (7 aa) CASGYTCNNGAC |.||. |.|| | CPSGQVCVNGQC |
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| EB | pqn-25.AA | EB | 1064-1115 | 44 | 5.3e-19 | 70.55 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1064-1115 Range on HMM: 1-59/59 Sequence Identity: 44% (26 aa) CLAGQTMVNGQCYNS-VNIGSA-CQSTQQCL---GGSQC--QNNICQCYSGYVNVNQQC |. || ||||||.. |..|.. ||...||. |||.| .|..||| .|....|..| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1073-1105 | 22 | 0.0126 | 14.43 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1073-1105 Range on HMM: 1-48/48 Sequence Identity: 22% (11 aa) GQCYNS-----------VNIGSACQSTQQCLGGSQCQN-----NICQCY ..| | ... .|....|| |..||| ..| | PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1085-1108 | 25 | 6.414382 | 2.8 | Pfam | 1-32 (36) | Show / Hide |
Range on Protein: 1085-1108 Range on HMM: 1-32/36 Sequence Identity: 25% (8 aa) CQST-QQCLGGSQCQNN----ICQCYSG---Y |... |... .|.. ||| | | CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGY |
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| EB | pqn-25.AA | EB | 1123-1174 | 33 | 1.1e-17 | 65.96 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1123-1174 Range on HMM: 1-59/59 Sequence Identity: 33% (20 aa) CQLGTVSYNSQCITL-ASPGQN-CQTSSQCI---DNSVC--MNQMCTCNNNYRLVYGYC |. | |..|.||... ..||.. || . ||. .|.| ||..|.|.... ...|.| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1132-1164 | 18 | 0.042385 | 8.91 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1132-1164 Range on HMM: 1-48/48 Sequence Identity: 18% (9 aa) SQCIT-----------LASPGQNCQTSSQCIDNSVCMN-----QMCTCN ..| . ...|.|....|| ... |.| ..| | PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EB | pqn-25.AA | EB | 1182-1233 | 38 | 5.7e-18 | 66.92 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1182-1233 Range on HMM: 1-59/59 Sequence Identity: 38% (23 aa) CQQTQTLVNNQCVLL-SIVGET-CIANQQCV---GGAMC--NSGTCQCTNGATAMYGYC |...| .||.||. . . ||. | ...||. ||. | . ||||| .| |...|.| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1191-1223 | 20 | 0.102312 | 4.9 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1191-1223 Range on HMM: 1-48/48 Sequence Identity: 20% (10 aa) NQCVL-----------LSIVGETCIANQQCVGGAMCNS-----GTCQCT ..| . . .| .|.|| | |.. | | |. PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1203-1230 | 27 | 28.208333 | 0.65 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1203-1230 Range on HMM: 1-36/36 Sequence Identity: 27% (10 aa) CIAN-QQCVGGAMCNSG----TCQCTNG---ATAMY | | | ... |... ||||. | | . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EB | pqn-25.AA | EB | 1241-1284 | 32 | 4.7e-12 | 45.99 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1241-1284 Range on HMM: 1-59/59 Sequence Identity: 32% (19 aa) CNSNQVSINGMCYNT-VQVGGS-CSFSQQCL---NNAVC--TNNIC--------VSTFC | |.||..||.||.. || |.| |....||. ....| .|..| . ..| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1250-1281 | 16 | 0.0119 | 14.69 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1250-1281 Range on HMM: 1-48/48 Sequence Identity: 16% (8 aa) GMCYNT-----------VQVGGSCSFSQQCLNNAVCTN-----NICVS ..| | . ...|. ..|| .. |.| ..| . PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYCCP |
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| EB | pqn-25.AA | EB | 1288-1339 | 38 | 6.5e-17 | 63.16 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1288-1339 Range on HMM: 1-59/59 Sequence Identity: 38% (23 aa) CSTNQVCISNQCYNY-VSIGSQ-CVGSQQCL---SNSQC--ISSICQCPQGTQQSNGVC |...|||...|||.. |..|.. |. ..||. .|.| . ..|||| |..|.||.| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1297-1329 | 20 | 0.024308 | 11.44 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1297-1329 Range on HMM: 1-48/48 Sequence Identity: 20% (10 aa) NQCYN-----------YVSIGSQCVGSQQCLSNSQCIS-----SICQCP ..| | . ... .| ..|| |...| . ..| || PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1309-1336 | 22 | 0.296571 | 7.26 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1309-1336 Range on HMM: 1-36/36 Sequence Identity: 22% (8 aa) CVGS-QQCLSNSQCISS----ICQCPQG---TQQSN | |. . .|... ||||.| .. . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EB | pqn-25.AA | EB | 1349-1400 | 45 | 5.9e-21 | 77.48 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1349-1400 Range on HMM: 1-59/59 Sequence Identity: 45% (27 aa) CQPNQVLINNQCYNT-VSIGFQ-CQFPQQCL---GNSQC--MNSMCQCPTGSTNVNGYC |...||..|.|||.. |..| . ||. .||. |.|.| ||..||||.| |..||.| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1358-1390 | 20 | 0.025345 | 11.25 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1358-1390 Range on HMM: 1-48/48 Sequence Identity: 20% (10 aa) NQCYNT-----------VSIGFQCQFPQQCLGNSQCMN-----SMCQCP ..| | ... .|. .|| ...|.| ..| || PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1373-1397 | 26 | 2.88379 | 3.96 | Pfam | 3-36 (36) | Show / Hide |
Range on Protein: 1373-1397 Range on HMM: 3-36/36 Sequence Identity: 26% (9 aa) PQ--QCLGNSQCMNS----MCQCPTG---STNVN |. |... .|... .|||| | | . PNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EB | pqn-25.AA | EB | 1408-1459 | 44 | 3.6e-19 | 71.14 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1408-1459 Range on HMM: 1-59/59 Sequence Identity: 44% (26 aa) CNSNQVLINNQCYNT-VSIGFQ-CQFAQQCL---GNSQC--LNSICQCPSGSSNVNGYC | |.||..|.|||.. |..| . ||. .||. |.|.| |..||||.| ..||.| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1417-1449 | 20 | 0.016693 | 13.15 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1417-1449 Range on HMM: 1-48/48 Sequence Identity: 20% (10 aa) NQCYNT-----------VSIGFQCQFAQQCLGNSQCLN-----SICQCP ..| | ... .|. ..|| ...| | ..| || PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1435-1456 | 24 | 2.618534 | 4.1 | Pfam | 8-36 (36) | Show / Hide |
Range on Protein: 1435-1456 Range on HMM: 8-36/36 Sequence Identity: 24% (7 aa) CLGNSQCLNS----ICQCPSG---SSNVN |... .|... |||| | . . CHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| EB | pqn-25.AA | EB | 1467-1518 | 45 | 5.6e-20 | 74.02 | Pfam | 1-59 (59) | Show / Hide |
Range on Protein: 1467-1518 Range on HMM: 1-59/59 Sequence Identity: 45% (27 aa) CNSNQVYYNNQCYNT-VPIGSQ-CQITQQCL---GNSQC--MNSFCQCPSGTTNVNNFC | |.||..|.|||.. |..|.. || ..||. |.|.| ||. ||||.|.|..|..| CPSGQVCVNGQCYPKFVQPGESGCQYDEQCQAMWGGSHCHSMNGTCQCPEGFTQHNGRC |
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| WR1 | pqn-25.AA | WR1 | 1476-1508 | 20 | 0.019858 | 12.36 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1476-1508 Range on HMM: 1-48/48 Sequence Identity: 20% (10 aa) NQCYNT-----------VPIGSQCQITQQCLGNSQCMN-----SFCQCP ..| | .. .|....|| ...|.| ..| || PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSSGNQGYC-CP |
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| EGF | pqn-25.AA | EGF | 1488-1515 | 25 | 0.258379 | 7.46 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 1488-1515 Range on HMM: 1-36/36 Sequence Identity: 25% (9 aa) CQIT-QQCLGNSQCMNS----FCQCPSG---TTNVN |. . |... .|... .|||| | | . CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| WR1 | pqn-25.AA | WR1 | 1526-1569 | 30 | 7.6e-11 | 43.27 | SMART | 1-48 (48) | Show / Hide |
Range on Protein: 1526-1569 Range on HMM: 1-48/48 Sequence Identity: 30% (15 aa) NLCSAGQTV----QLDSSNQPINCL-VSTCPNNSFCQYSSSGQRYVCCR ..|. ||.. ......||..| ..||....||.|| |....||. PVCPNGQPPYFRYLDPNNGQPQRCTPNNQCPSGYSCQNSS-GNQGYCCP |
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