Gene R107.4 (Nematode worm)

R107.4

Species: Nematode worm
Alias: R107.4, aSWK267, YNH4_CAEEL, CE28842
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 9046135-9041495, WormBase Genetic Map location: III:0.12,

Classification

Group: Other
Family: Worm3

Sequence

Name Sequence Type Origin Length Description Download
R107.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 304 Kinase domain by global Sugen HMM Fasta, JSON
R107.4.AA Protein Genbank 827 None Fasta, JSON

Protein domain

Protein domains of R107.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R107.4.AA Worm3 21-324 86 6.7e-286 874.11 In-house 1-308 (308) Show / Hide 
Range on Protein: 21-324
Range on HMM: 1-308/308
Sequence Identity: 86% (266 aa)

LFNDESIGKGAYSEVYRGRTESGRLVAVKTACK----KLEVAAIGIEIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASSSLEAEMRRPK
|.|||...|||||.|||||||||||||||||||    |..|.|..|||.|||||||..|||||||||||||.|||||.||||||||.||.||.|||||||
LYNDEFMAKGAYSQVYRGRTESGRLVAVKTACKTASNKADVDAMCIEIDILKKLKGVANIVQYFGSNHTKMPPGSVTIETISFAMECASRSLDAEMRRPK

NHRGLSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAHEMVDPLMAQ
|||||.||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||||||||||.|||.|.|||||||||||..|.|
NHRGLPSNVLIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKAISENSSHEMRTIVGTKNFLHPFLAHEMVDDHMPQ

NRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNKSLYHKAVVALTQNPDAIAMVLVQKGRDPGRRTDIFEFQPVTELPAKFTRYPKWLVSTM
||||||||||||.|||||||||||||||||||||||||||.|.|||.|||.||||||||||.||||.|||.||.|||.||||||||||||||||||||||
NRHNWKTKSAYTPEQCDLWALGCTLYFCATGKFPFEHERNDKNLYHMAVVDLTQNPDAIAMNLVQKERDPVRREDIFNFQPVTELPAKFTRYPKWLVSTM

TCLLRSFF
||||||||
TCLLRSFF
Kinase R107.4.AA S_TKc 21-324 20 1.7e-23 85.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 21-324
Range on HMM: 1-231/231
Sequence Identity: 20% (68 aa)

LFNDESIGKGAYSEVYRGRTES-GRLVAVKTACKKLEVAAIGIEIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASS---SLEAEMRRPK
    . |||||...||..|  . ||.||.|          |  ||.||||  .  |||..... ..         . . . |||..    .|   ... .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKRG

NHRG---LSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAHEMVDPL
 |..   ..      ..     ||  . .|.| |||.|  ||||               |.|| | .. |        .|..|||.    ..| |..   
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL--------TTFCGTPW----YMAPEVL---

MAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNKSLYHKAVVALTQNPDAIAMVLVQKGRDPGRRTDIFEFQPVTELPAK------FTR
             |. . || |..||.|| ...|. ||.   . . ...| .                                    .||      ...
------------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------------------------SPEAKDFIRKCLQK

YPKWLVSTMTCLL-------RSFF
 |.   .   .|          .|
DPEKRPTA-EALQDEWDIKCHPWF
Kinase R107.4.AA Pkinase 21-263 21 2.2e-23 83.74 Pfam 1-229 (293) Show / Hide 
Range on Protein: 21-263
Range on HMM: 1-229/293
Sequence Identity: 21% (58 aa)

LFNDESIGKGAYSEVYRGRTESGRL-VAVKTACKKLEVAAIGI------EIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASS-----SL
.   . ||.|....||...  . .  ||||. .|. |     .      ||.|.|.| .  |||..... ..        .  | . |||.       .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDL

E----AEMRRPKNHRGL--SSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLF-PGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLL
     .     ..|...  | . ... .     .|  . ...| |||.|  |||.   |..         .|.|| |..| ... ... | |..|||.  
FDYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------CVKICDFGLAKQFDY-NNS-MTTFCGTPW--

HPFLAHEMVDPLMAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHE-----RNNKSLYHK
  ..| |    ..         .. | .  .| |..||.||  ..|..|| ..     .. . .. .
--YMAPEV---IR---------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICR
Kinase R107.4.AA Ciliate-E2 136-258 24 3.6e-16 52.0 In-house 172-301 (365) Show / Hide 
Range on Protein: 136-258
Range on HMM: 172-301/365
Sequence Identity: 24% (38 aa)

ALSALREHN-IAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSEN------------------------------SSHEMRTLVGTPNLLHPF
||  | . | | |||||  |||.               |..|.| || ....                              . .  .|..|||    ..
ALEYLHSKNNIIHRDIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTP----GY

LAHEMVD--PLMAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNK
.| |..   .   |      .|. . ...||.|.||..||.. .||.||  ....|
MAPEILNGKKYDNQ------QKQKGYDYKCDIWSLGVILYEMLFGKPPF--QQQIK
Kinase R107.4.AA STE 136-264 27 5.5e-16 53.04 In-house 163-281 (359) Show / Hide 
Range on Protein: 136-264
Range on HMM: 163-281/359
Sequence Identity: 27% (40 aa)

A-LSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSEN--------------SSHEMR-TLVGTPNLLHPFLAHEMVDPLMAQNRH
. |. | .|.| |||||  ||||               |||| |....|...              .. ..| |.||||     . | |....     | 
GLLYYLHSHHIIHRDIKPANILL--------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-----WMAPEVIQQNGQG-R-

NWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNKSLYHKA
     .   ...|| | ||||.   |||| |.  . . . .....
-----DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP
Kinase R107.4.AA IKK 21-263 23 5.8e-16 51.51 In-house 1-240 (297) Show / Hide 
Range on Protein: 21-263
Range on HMM: 1-240/297
Sequence Identity: 23% (61 aa)

LFNDESIGKGAYSEVYRGRTE-SGRLVAVKTACKKL---EVAAIGIEIEILKKLKGA------SNIVQYFGSNHTKMAPGSVTSETISFAMEYASS-SLE
 . ..  |.|| ..||..|   .|| ||||.. . .          |.|..|.|  .       ||.  ..   .       ..     .||| .. .| 
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQ---WQICKQPVIVMEYCTGGDLY

AEMRRPKNHRGLSS-NALIDLVVDCSMALSALR-EHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAH
     | |. ||    .   .  ||. ..  |. .  | |||||  || ..     .|       |. | |  . .  ..  .   ..||.. |||    
KYLNSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQ-----KGEDGKTIYKITDFGYAREWDDDE--MFMSFYGTEEYLHP----

EMVDPLMAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPF---EHERNNKSLYHK
.|. . .   .|.     .|.. . |.| .| |.| ||||. ||   . .|..... ..
DMYERAVLRKPHQ----KPYCA-TVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKH
Kinase R107.4.AA MSN 24-157 29 1.6e-13 40.82 In-house 4-137 (265) Show / Hide 
Range on Protein: 24-157
Range on HMM: 4-137/265
Sequence Identity: 29% (40 aa)

DESIGKGAYSEVYRGR-TESGRLVAVKT-ACKKLEVAAIGIEIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASSSLEAEMRRPKNHRGL
.| .|.|.| .||.|| .  |.|.|.|    .. |   |  || .|||     ||. |.|    |  ||    . . . ||. ..   ... .    . |
VEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG--HDHQLWMVMEFCGAGSVTDLVKMTKGQSL

SSNALIDLVVDCSMALSALREHNIAHRDIKHMNILL
  . .  .  .    |. | .| . |||||  |.||
KEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLL
Kinase R107.4.AA Ciliate-E2-Unclassified 136-258 25 5e-12 38.03 In-house 155-277 (352) Show / Hide 
Range on Protein: 136-258
Range on HMM: 155-277/352
Sequence Identity: 25% (36 aa)

AL-SALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSEN--------------SSHEMRTLVGTPNLL----HPFLAHEMV-DPLMA
.| .  ...|| |||||  |||.  .            |..| | || . .|              ....| | .|||| .     | .  .   |   |
GLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA

QNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNK
              ..|| |.||. ||.. .|..||. .  ..
--------------YKCDIWSLGVILYEMLFGYYPFYDNNCEQ
Kinase R107.4.AA ULK 21-80 26 2.5e-10 32.34 In-house 1-84 (329) Show / Hide 
Range on Protein: 21-80
Range on HMM: 1-84/329
Sequence Identity: 26% (22 aa)

LFNDESIGKGAYSEVYRGR---TE--SGRLVAVKTACKK--LEVA----------AIGIEIEILKKLK---GASN----IVQYF
   .. .|||..  ||.||   |.  .. .||.|  .|.   .             .  ||.|.||||   .  |    ||...
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLY
Kinase R107.4.AA ULK 21-80 28 5.3e-10 31.74 In-house 1-81 (324) Show / Hide 
Range on Protein: 21-80
Range on HMM: 1-81/324
Sequence Identity: 28% (23 aa)

LFNDESIGKGAYS-EVYRGR---TE-SGRLVAVKTACKKLEVA------------AIGIEIEILKKLK--GASN--IVQYF
   .. .|||..   ||.||   |. .. .||.|   ||                 .  ||.|.||||     |  ||...
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLY
Kinase R107.4.AA CAMK 227-263 26 2.4e-09 25.55 In-house 310-358 (425) Show / Hide 
Range on Protein: 227-263
Range on HMM: 310-358/425
Sequence Identity: 26% (13 aa)

YTSEQCDLWALGCTLYFCATGKFPFEHER------------NNKSLYHK
| ...|| |..|. ||.. .|..||...             | . |..|
YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEK
Kinase R107.4.AA STE 22-82 23 4e-09 28.48 In-house 1-98 (359) Show / Hide 
Range on Protein: 22-82
Range on HMM: 1-98/359
Sequence Identity: 23% (23 aa)

FND-ESIGKGAYSEVYRGRTE----------------SGRLVAVK--TACKKL-----------------EVAAIGIEIEILKKLKG-ASNIVQYFGS
. . | |||||. .||...                  .|...|.|    ...                  |.  |  ||.|.||..    |||.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC
Kinase R107.4.AA AGC 22-82 21 8.2e-09 17.38 In-house 1-99 (395) Show / Hide 
Range on Protein: 22-82
Range on HMM: 1-99/395
Sequence Identity: 21% (21 aa)

FNDE-SIGKGAYSEVYRGRT-------ESGRLVAVKTACKKL--------EVAAIGIE------------IEILKKLKG---------ASNIVQ-YFGS
|.    ||||....||  |         .|.. |.|   ||         .|. . .|             .||.|...           .||.  . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS
Kinase R107.4.AA TyrKc 21-301 18 1.1e-08 -82.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 21-301
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

LFNDESIGKGAYSEVYRGRTESGRLVAVKTACKKLEVAAIGIEIEILKKL-KGASNIVQYFGSNHTK----MAPGSVTSETISFAMEYASS-SLEAEMRR
.  .. .| ||. |||.|.    . ||||.  .   ....  |..|..|| .   |||. .|   ..    |      .| .   |||..  .|    |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFM-----YIEPLMIVMEYMPHGDLKDYLRK

PKNHRGLSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSEN-----SSHEMRTLV-GTPNLLHPF--LA
....  |.   |..  .. .   . | ..|. |||.   |.|.  .            | .| | |. . .      |.   |.   .  . . |   .|
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

HEMVDPLMAQNRHNWKTKSAYTSEQCDLWALGCTLY-FCATGKFPFEHE----RNNKSLYHKAVVA----LTQN---------PDAIAMVLVQK--GRDP
 |               .    ... | |. | ...  .  |. | . .     .|. ....          .|         ||.. . . ..   .||
PECI-------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDP

GRRTDIFEFQPVTEL
  |    |   . ..
EDRPTFSEI--HECF
Kinase R107.4.AA AGC 229-263 30 9.5e-08 14.57 In-house 281-326 (395) Show / Hide 
Range on Protein: 229-263
Range on HMM: 281-326/395
Sequence Identity: 30% (14 aa)

SEQCDLWA--LGCTLYFCATGKFPFEHE---------RNNKSLYHK
. .|| |.  ||| .|   ||. || ..         || . ...|
GKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQK
Kinase R107.4.AA ULK 136-198 31 1.1e-07 23.04 In-house 142-215 (329) Show / Hide 
Range on Protein: 136-198
Range on HMM: 142-215/329
Sequence Identity: 31% (24 aa)

ALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTH-----LFKLCDMGCSKSLSEN--SSHEMRTLV------GTP
.. .|..||| |||||  |||.  |.| .  .         .|..| | .|.....  .   | | |      |||
GFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK-KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTP
Kinase R107.4.AA ULK 136-198 31 9.4e-07 20.05 In-house 138-211 (324) Show / Hide 
Range on Protein: 136-198
Range on HMM: 138-211/324
Sequence Identity: 31% (24 aa)

ALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTH-----LFKLCDMGCSKSLSENS--SHEMRTLV------GTP
.. .|..||| |||||  |||.  |.| .  .         .|..| | .|.. .|.     . |.|      |||
GFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK-KVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTP
Kinase R107.4.AA CAMK 26-78 16 3e-06 15.44 In-house 1-102 (425) Show / Hide 
Range on Protein: 26-78
Range on HMM: 1-102/425
Sequence Identity: 16% (17 aa)

SIGKGAYSEVYRGRTE-SG------------RLVAVKT-----ACKKL-------------------------EVAAIGIEIEILKKLKG------ASNI
 .|.|....|....   ..            . ||.|      . .|                            . .  ||||.|||.|        ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQ
..
IK
Kinase R107.4.AA ULK 232-252 52 8e-06 16.45 In-house 237-257 (329) Show / Hide 
Range on Protein: 232-252
Range on HMM: 237-257/329
Sequence Identity: 52% (11 aa)

CDLWALGCTLYFCATGKFPFE
||.| ||| .| . .|| ||.
CDIWSLGCIFYEMLYGKPPFY
Kinase R107.4.AA ULK 232-252 52 1.3e-05 15.94 In-house 233-253 (324) Show / Hide 
Range on Protein: 232-252
Range on HMM: 233-253/324
Sequence Identity: 52% (11 aa)

CDLWALGCTLYFCATGKFPFE
||.| ||| .| . .|| ||.
CDIWSLGCIFYEMLYGKYPFF
Kinase R107.4.AA CAMK 142-198 20 5.7e-05 11.16 In-house 197-283 (425) Show / Hide 
Range on Protein: 142-198
Range on HMM: 197-283/425
Sequence Identity: 20% (19 aa)

EHNIAHRDIKHMNILLF---------------PGTPTRGRRSTHLFKLCDMGCSKSLSENS----------------------SHEMRTLVGTP
.|||.|||.|  ||||                .        ...  |..| | .. . ...                       . |.| .|||
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD-------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP
Kinase R107.4.AA Ciliate-E2-Unclassified 19-75 18 0.058941 2.6 In-house 1-63 (352) Show / Hide 
Range on Protein: 19-75
Range on HMM: 1-63/352
Sequence Identity: 18% (12 aa)

YTLFNDESIGKGAYSEVYRGRTESGRLV-AVKTACKKLEVA--------AIGIEIEILKKLKGASN
|..   . ||.|....||. . ..  .. | |...|. ...         |  |.......|. ..
YKII--KQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YH