Gene R151.4 (Nematode worm)

R151.4

Species: Nematode worm
Alias: aSWK411, R151.4, CE00747
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 7215435-7216647, WormBase Genetic Map location: III:-0.76,

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
R151.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
R151.4.AA Protein Genbank 276 None Fasta, JSON

Protein domain

Protein domains of R151.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R151.4.AA TK-Unique 2-256 43 6.2e-138 464.54 In-house 6-294 (294) Show / Hide 
Range on Protein: 2-256
Range on HMM: 6-294/294
Sequence Identity: 43% (127 aa)

LLGEGAFGQVFKGILRGPN---GQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQ-LQCMIMEYVPYGDLKHYLQNMRKE---
..||||||||..| ..|..   .. . ||||.||.|| |... .| .|||||. .|.| |||...|.|.. .  ...||||.|.|.| |||...|..   
VIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQ

----------------KDSDSAIDSKEFLSFTNQIACGMAHLES--VGIIHRDLAARNILVGTGKVLKISDFGMSR----PGVYIKM-SKGVIPLRWLSP
                |.....|..| ...|  ||||||..|.|   .|.||||.|||.|.. .||.||.||||.|    .|||..| |.| ||.||..|
HQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAP

EAIK--DNTY-SNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKC-SDDMYILMKSCWNLKAEDRPSFLAILSKI
|..|  ...| . |||||.||||.|||.|||..||... .|||......|.|..||..| |..|| ||||||....|.|||| .|....
ESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase R151.4.AA TyrKc 2-256 39 2.4e-131 443.56 SMART 6-280 (280) Show / Hide 
Range on Protein: 2-256
Range on HMM: 6-280/280
Sequence Identity: 39% (116 aa)

LLGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVG-QHDNIVTMYGYCMDE-------QLQCMIMEYVPYGDLKHYLQNMRK
 |||||||.|.||...      |.|||| ||..|    ||.| ||...|  .| .|.||| .||.|...       .  ...|||.|.||||.||.. |.
KLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

EKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPG----------VYIKM-----SKGVIPLRWLSPEAIKDNT
.      .  |..|||  ||||||..|.| ..|||||||||.||| ... ||||||.|| .           |...     .|...|.||..||.|....
K------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSNKSDVWAFGVLLWEIATLGGFPYNN-----VADKDILNQLTEGMRLEQPAK--------CSDDMYILMKSCWNLKAEDRPSFLAILSKI
.. |||||.|||..||| |.|. || .     . ........ .|.|..||.         |.|.|| .||.||. ..||||.| .| ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase R151.4.AA Pkinase_Tyr 3-256 42 4.4e-126 427.63 Pfam 7-270 (270) Show / Hide 
Range on Protein: 3-256
Range on HMM: 7-270/270
Sequence Identity: 42% (114 aa)

LGEGAFGQVFKGILR-GPNGQVIPVAVKQLKANAIDEE--REEFVREIQMMQTVGQHDNIVTMYGYCM-DEQL--QCMIMEYVPYGDLKHYLQNMRKEKD
|||||||.|.||...  | .. |||||| || .| .|.  ||.| ||...| . |.|.||| .|| |. ...    ...|||.|.|||..||.. |   .
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR---E

SDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPG----VY-IKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVL
.. ... |. |..  |||.||..||| ..|||||||||.||. ..| ||.|||..|       |  | ..| .| .|..||.|... .. |||||.||||
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVL

LWEIATLGGFP-YNNVADKDILNQL-TEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
.||| |.|. | | .. . ......  .| |...| .|.|..| |||.||. ..||||.| .|....
MWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase R151.4.AA TK 3-256 23 2.9e-113 381.23 In-house 7-486 (486) Show / Hide 
Range on Protein: 3-256
Range on HMM: 7-486/486
Sequence Identity: 23% (114 aa)

LGEGAFG---QVFKGILRGPN----------------------GQVIPVAVKQLKANAIDEERE----------------EFVREIQMMQT-VGQHDNIV
||||.||   .|.||..||.|                      |...|||||.||. . ....|                |...|..||.  .|.|.|||
LGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIV

TMYGYCMDE------------QLQCMIMEYVPYGD----LKHYLQNMRKE-------------------------------------------------K
 .||.|...            .  ...|||.|.||    |..||.. |..                                                 |
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

DSDSAIDSKEFLS-------------------FTNQIACGMAHLESV------GIIHRDLAARNILVGTGKV-----------LKISDFGMSR-------
|. .... |..|.                   .  ||||||..|.|       ...||||||||.||| ..|            ||.|||.||       
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

-----------------------------PGVYIKMSKGVIPLRWLSPEAIK---------DNTYSNKSDVWAFGVLLWEIATLG-GFPYNNVAD-----
                                | . |.| .|.||..||...         ..... |||||.||||.||| |.| . .| .. .     
RDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWK

----KDILNQLTEG--------------MRLEQPAKCS--------------DDMYILMKSCWNLKAEDRPSFLAILSKI
    ......|..|              ||..||. |.              ...|.||..||....||||.| ......
DGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase R151.4.AA UTK 2-256 31 1.1e-89 304.29 In-house 6-296 (296) Show / Hide 
Range on Protein: 2-256
Range on HMM: 6-296/296
Sequence Identity: 31% (93 aa)

LLGEGAFGQVFKGILRGPN--GQVIPVAVKQLKANAIDEEREE----FVREIQ---MMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMR
.||.||||.|.|. .. ..  ...  ||||.... | ..  .|    | .| .   ||. .  | |.. ..|.|..|.  ....|| . ||| .||.. |
QLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHR

KEKD-SDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTG-------KVLKISDFG---MSRPGV------------YIKMS-KGVIPLRW
.. .  . . .. . |.. ..||.||..|.| |..||||||||.||.          | ||.|||   |||               | ...  . .|.||
PTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRW

LSPEAIKDN-TYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEG--MRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
 .|||. .. ....|||||.|||..||| | |  || . .. ... |...|   |...|. |....| ||..||.   ..||.|  .....
MAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase R151.4.AA RTKB 3-256 35 1.1e-80 271.69 In-house 7-264 (264) Show / Hide 
Range on Protein: 3-256
Range on HMM: 7-264/264
Sequence Identity: 35% (92 aa)

LGEGAFGQVFKGILRGPNGQ-VIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAI
||.||||.||.. .| .       .|.|.||. |  ||| .|  |. .| ..|.| |.. . | |. .  .    |.  .| |  ||   |  .     .
LGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRASQHNPQSL

DSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR--PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKS-DVWAFGVLLWEIATL
 ..  ..|  |||||||.|.. ..|||||.|||.||...   ||.||||.|   .   .      | .|. || ...  |..|| |||.|||  ||| .|
KQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEIFSL

GGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
|| ||   .  ||.. |  |.||..|   .  .. .|. || . |..||.| ....  
GGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase R151.4.AA FGFR 1-256 36 1.4e-80 274.05 In-house 5-293 (293) Show / Hide 
Range on Protein: 1-256
Range on HMM: 5-293/293
Sequence Identity: 36% (106 aa)

MLLGEGAFGQVFKGILRGPNGQ----VIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMR---K
  ||||.|||| ..   |   .     | |||| ||.|. |..    |.|. ||  .|.| ||.   | |  |     | || . | |. .|.  |   .
KMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARRPPGM

EKDSDSA---------------------IDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGV-----YIKMSKGVIPLR
. ..||                      . .|.  |.. |.| ||  |.|  .|||||||||.||. . |.||.||| .| ..     | | . |  |  
DYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLAR-DIHCIDYYRKTTNGRLPIK

WLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVA-DKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
|  |||  |. |  .|||| .||||||| |.|| ||  ..   ..   | || |.| |..|| ..|..| .||  |...||.|  .   .
WMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase R151.4.AA Tie 5-256 38 1.3e-79 241.83 In-house 1-267 (267) Show / Hide 
Range on Protein: 5-256
Range on HMM: 1-267/267
Sequence Identity: 38% (103 aa)

EGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMR---------KEK
|| ||||.|  ..   | .. ||.|..|  | .... .|. |. .|  ||.| ||. . | | .  .  . .|| ||| |  .|   |         .|.
EGNFGQVMKAMIKK-DGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREH

DS------DSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPG-VYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAF
 .       |.. |.  | |   .| || .|   ..||||||||||||.   | ||.|||.||   ||.|   | .| ||.  |..    |  |||||..
TTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSY

GVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
||||||| .||| ||  ..  .. ..| .| |.|||  | |..| ||. ||  .  .||.|  |. ..
GVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase R151.4.AA Fer 3-257 36 1.6e-77 263.51 In-house 7-283 (283) Show / Hide 
Range on Protein: 3-257
Range on HMM: 7-283/283
Sequence Identity: 36% (102 aa)

LGEGAFGQVFKG-----ILRGPNGQV--IPVAVKQLKAN-AIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKE
||||||| |.||     ...| . .|  ..|.|| .|.. |..|...|| .| ..|..  .|.|.|  ||.| |||    .||... |.|. ||.   ..
LGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNK

KDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLK---ISDFGMSRP----GVYIKMS--KGVIPLRWLSPEAIKDNTYSNKSDV
     ..  .| . .. |.||||..|.| ..||||.||||.|.. .|| |   ||||||||     |.  ||      .| |||.||.... .|| |.||
-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDV

WAFGVLLWEIATLGGFPYNN---------VADKDILNQLTEGMRLEQPAKCSDDMYILMK-SCWNLKAEDRPSFLAILSKIE
|.|||..||| | |  || .         |.. .. .  ..| ..  |  . .... .|. .||. . ||||..  |  |..
WSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase R151.4.AA CTKA 3-256 33 3e-73 245.43 In-house 7-290 (290) Show / Hide 
Range on Protein: 3-256
Range on HMM: 7-290/290
Sequence Identity: 33% (96 aa)

LGEGAFGQVFKGILRG-PN------GQVIPVAVKQLKANAIDEEREEFVREIQMMQ-TVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKE
.||| .||||. .|.. |        .   |||| ||..| .|.|..|  |  .       | |..   | |  ..   ||||. .||||. ||.  |  
IGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYLRACR--

KDSDS-------------------AIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR---PG--VYIKMSKGVIPLRWLS
  ...                   ..   |  . . ||| ||  | . |..|||||.||.|.| . . ||.||| .|    .   |.  |..|.| || .
--PADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMA

PEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEG--MRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
|||.. ...|  |||||||||||||.. |  |.    |. . .  | .   ||  |  | . .| .|. ||      ||.|  ..   
PEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase R151.4.AA KIN6 25-256 33 1.1e-72 239.43 In-house 46-305 (305) Show / Hide 
Range on Protein: 25-256
Range on HMM: 46-305/305
Sequence Identity: 33% (88 aa)

PVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMR----------------KEKD---SDSAIDSKE
..||| | . | . .. .| .||  | . | |. .| | |.  . .. | . ||   .|| .||.| .                 | .    .. |  |.
QCAVKMLPSHADEMAHHDFMHEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKD

FLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGK---VLKISDFGMSR---PGVYIKMSKGVI--PLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIAT
...|  ||. ||  | | ..|||||||||.|| .|      ||||||. |   .      |||    |..|..||..|   .| ||||| ||||..|. .
LYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLMFEMFS

LGGFPYNNVA-DKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
||. ||  .    ...  .  | |...| .|..  |  |.|||. | .||| |  .  ..
LGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase R151.4.AA VEGFR 97-256 39 3.2e-55 189.78 In-house 166-332 (332) Show / Hide 
Range on Protein: 97-256
Range on HMM: 166-332/332
Sequence Identity: 39% (66 aa)

SDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGVYIK---MSKGV---IPLRWLSPEAIKDNTYSNKSDVWAFGV
... ..... ...  |.| ||  |.|  .|||||||||||.   .|.||.||| .| | |       ||     |..|..||.| |. |. .||||..||
WKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGV

LLWEIATLGGFPYNNVA-DKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI
.|||| .||| ||  |  | .  | | .|.|.. |  |   .|  | .||    | ||.| .   . 
FLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase R151.4.AA Pkinase 3-256 25 5.5e-52 183.82 Pfam 7-293 (293) Show / Hide 
Range on Protein: 3-256
Range on HMM: 7-293/293
Sequence Identity: 25% (76 aa)

LGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDE-EREEFVR--EIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYG----DLKHYLQNMRKEK
.|.|.||.|.|.. .| .     ||||..|   ... .... .|  |||.|. . .|.|||..|....|..  .|.|||.. |    ||..|..      
IGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-----

DSDSAI--DSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVG-TGKV---LKISDFGMSR---PGVYIKMSKGVIPLRWLSPEAIK-DNTYSNKSDV
... ..  . .|  ..  ||..|.... | |||||||   |||.  .| .   .||.||| ..      .  |.  .  .....|| |. .. |. |.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGVLLWEIATLGGFPYNNV-----ADKDILNQLTEGMRLEQP--AKCS-------------------DDMYILMKSCWNLKAEDRPSFLAILSK--I
|..|..|.| .. | .|. .      .|.. . ... | .|. .   .||                   ...  ..|.|.... ..||..  ||    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase R151.4.AA S_TKc 1-260 25 1.3e-51 178.68 SMART 5-231 (231) Show / Hide 
Range on Protein: 1-260
Range on HMM: 5-231/231
Sequence Identity: 25% (69 aa)

MLLGEGAFGQVFKGILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPY--GDLKHYLQNMRKEKDSD
 ..|.||||.|.|.. ..  |..  ||.|..|        | . ||||...   .|.|||..|... | .  .|.|||..   |||..|........  .
RKIGKGAFGKVYKCRHKK-TGRI--VAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG-LR

SAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSRPGVYIKMSKGVIPLRWLSPEAIKDNTYSN-KSDVWAFGVLLWEIAT
. ..  .  ... ||.|..... | |||||||   |||. .  ..||.|||..|       .  .  . ...|| .    |.  |.|.|..|..|.| ..
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

LGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILS-----KIEQIA
 |  |.    .. .....            |...  ... |..   |.||.   .|      |. .  
-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase R151.4.AA VEGFR 3-94 34 8.4e-16 56.23 In-house 7-103 (332) Show / Hide 
Range on Protein: 3-94
Range on HMM: 7-103/332
Sequence Identity: 34% (34 aa)

LGEGAFGQVFK----GILRGPNGQVIPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCM---DEQLQCMIMEYVPYGDLKHYLQNMRKE
||.|||||| .    || .... ..  ||||.||..|  .|  . . |. |.  .|.| | | . | |          .|.||...| |  ||   |..
LGRGAFGQVHEASAFGIRKMETCTT--VAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMY
Kinase R151.4.AA KIN6 1-18 50 1.3e-05 14.29 In-house 5-22 (305) Show / Hide 
Range on Protein: 1-18
Range on HMM: 5-22/305
Sequence Identity: 50% (9 aa)

MLLGEGAFGQVFKGILRG
 .||.|||. |.||.. |
HKLGHGAFCNVYKGKIKG