Gene R166.5 (Nematode worm)

R166.5

Species: Nematode worm
Alias: aSWK055, R166.5, CE03584
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 10548812-10544112, WormBase Genetic Map location: II:2.66,

Classification

Group: CAMK
Family: MAPKAPK
Subfamily: MNK

Sequence

Name Sequence Type Origin Length Description Download
R166.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 291 Kinase domain by global Sugen HMM Fasta, JSON
R166.5.AA Protein Genbank 761 None Fasta, JSON

Protein domain

Protein domains of R166.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase R166.5.AA MNK 201-490 65 1.8e-229 768.64 In-house 1-292 (292) Show / Hide 
Range on Protein: 201-490
Range on HMM: 1-292/292
Sequence Identity: 65% (192 aa)

KLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTEEEA
||||||||.|||.||.||..|.||.||||||.||||..|||||..|||..|..|..|.||.||..||||...||||.||||||||||||.|||.|||.||
KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA

RRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVG-DSLKYDKKCD
..|.|||..||.|||..||||||.||||.||..||||.|||.||.||.|.|||.|..|..||....|.|..|.|||||||||||||.|. ....|||.||
SQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVYDEAHYYDKRCD

TWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVN-PFA
.|||||||||||.||.||.|.|.||||||..|..|.|||..|||.||.|.|||||.||..||||||||.||||.||...||......| |..
LWSLGVILYIMLCGYPPFVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV
Kinase R166.5.AA MAPKAPK 201-490 52 6.00000000001e-207 647.35 In-house 1-292 (292) Show / Hide 
Range on Protein: 201-490
Range on HMM: 1-292/292
Sequence Identity: 52% (156 aa)

KLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFED----ETNFYLVMEKMRGGPLLQHILQ--RKY
||..|.||.|.||.|.||.....| ||||||...| ..|||....|||.....|..||||||..||||.    ...||||||.|.||.|.||| |  .|.
KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQ-PGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKH

FTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKY
|||.||....|||..|..|.|...|||||.||||.||||.||..||||||...|..   .|..|........|.|..|......||||||.|.. ....|
FTEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKE---IHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTY

DKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVN-PFA
||.||.||||||.||||.||.||...|.||||.|..|..|.|||...|||||.|.||||.||| .||||||||...||.|||..||......| |..
DKSCDMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI
Kinase R166.5.AA CAMK 206-480 25 1.4e-106 344.55 In-house 1-414 (425) Show / Hide 
Range on Protein: 206-480
Range on HMM: 1-414/425
Sequence Identity: 25% (106 aa)

HLGSGAYGSVTTCKSIKSG------------VEYAVKIVDKQGET---------------------------HSRKRILREVNIFKTCK------DHPNI
 ||.|..| |  |. ....            ...|.||.||.  .                           ..||...||..| |...      |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLLDWFED-------------------ETNFYLVM---EKMRGG----PLLQHILQR---------------KYFTEEEARRVTKDISLALKFMHDRGI
..|....||                   ....|.||   | . ||     |...| ..               ..|||.||||. . |  |....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDVKPENVLCTDPN--------------HVSPVKLCDLDLASQRPPQHERHPL------------SQVASEPDLASPVGSAEFMA-PEVVDAYVGD--
.||| ||||.|..| |              .. ..|..|  .| . .| .. . .            ..... . .  ..|. |.|| |||.    ..  
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------SLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEE------------WGMISEE--------
          |..||| ||.|||||||| || ||.| ||.|.|. . . .  .....||..|. | |.||...            |. ||.|        
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D-E-WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

AKDLVSNLLKRDPVDRL
.|||....|..|| .|.
CKDLIRKMLQVDPEKRM
Kinase R166.5.AA CAMK1 200-480 32 6.3e-98 285.25 In-house 1-265 (276) Show / Hide 
Range on Protein: 200-480
Range on HMM: 1-265/276
Sequence Identity: 32% (97 aa)

YKLTDEHLGSGAYGSVTTCKSIKS---GVEYAVKIVD-KQ-GETHSR---KRILREVNIFKTC--KDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHI
|....| .|.|| . |. |. ...   | .||.|. | |.  .....   .....|..| |..   |||||... .|.|... |||||| . || |.  |
YEFGKE-IGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LQRKYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVK--LCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAY
......||..||.. | |  |...||..||.||| |||| |. |.   |..|  ..|  |. .  .. .            .  ..|. ...||||.   
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN-----------LMKTACGTPGYVAPEVLECK

VGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEE-AKDLVSNLLKRDPVDRL
      |||.|| || |||.||.| || ||..               |. .. ||  |  . ||||. .|. ||.. |||.....|. ||  |.
K--DKPYDKACDMWSIGVITYILLCGYPPFYD---------------ENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase R166.5.AA S_TKc 201-490 30 1.4e-92 314.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 201-490
Range on HMM: 1-231/231
Sequence Identity: 30% (94 aa)

KLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRG--GPLLQHILQRKY----
    ...|.||.|.|  |. .|.| ..|.||..        ..|.||..| |   .|||||.|.|.|.| ...|.||| . |  | |...| .|..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSL
  |.| .||.... | .||...|..|| |||.||||.|...      .|.||  || |                    . .|. ..|||||.        
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------------------TTFCGTPWYMAPEVL--------

KYDK-KCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVN----
.|.| ||| ||.|.|||.||.|| ||.                   .| .|..|               |.||||.....|..|| .|.      .    
GYGKCKCDWWSCGCILYEMLCGYPPFP------------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWD

----PFA
    |. 
IKCHPWF
Kinase R166.5.AA RSK 205-480 33 1.5e-85 290.49 In-house 2-262 (278) Show / Hide 
Range on Protein: 205-480
Range on HMM: 2-262/278
Sequence Identity: 33% (98 aa)

EHLGSGAYGSVTTCKSI---KSGVEYAVKIVDKQGETHSRK---RILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKY---F
. || |.||.| .|. .   ..| .||.|...|     . |   . ..|.|| ..|. ||.||.| . |..|. .||.|| .||| |. |....|.   |
KVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGCF

TEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHV-SPVKLCDLDLASQRPPQHERHPLSQVAS-EPDLASPVGSAEFMAPEVVD-AYVGDSL
.|.||. .   |.||....|..|| ||| ||||.| .| .     .||.| ... |.           ... .  . ......|.||||..  |.     
SEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQF-----------RCDHNQWTMTFCYTIEYMAPEMLKRAN---QQ

K-YDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRL
. .|| || |||||..| ||.|. ||||  .|            . ..... ||| | . .. ..|  .|.|||||.. .|.||| .||
GGHDKACDWWSLGVLMYEMLTGCPPFQG-PND------------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRL
Kinase R166.5.AA Pkinase 201-480 31 5.4e-77 266.9 Pfam 1-282 (293) Show / Hide 
Range on Protein: 201-480
Range on HMM: 1-282/293
Sequence Identity: 31% (97 aa)

KLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILR---EVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGG----PLLQHIL--Q
  . . .|||..|.|  |. ...| ..||||..|..| .. ....|   |. | | . .|||||.|.|||||... |.||| ..||     |  .|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RKYF--TEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHV-SPVKLCDLDLASQ-RPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAY
.. |  .|.|.... . |  .|...|..|| |||.||||.|. . .|. ..||.||  || | .             . . . ...|. ..|||||    
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWYMAPEV----

VGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMIS-----------------EEAKDLVSN
. .. .|..|.| ||.|.|||.|| |. ||.| | ..        .  ..|. .. || .. ..|....|  ||                 ||.||....
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WH--------DN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

LLKRDPVDRL
.|..|| .|.
CLCKDPKKRP
Kinase R166.5.AA MSK 202-480 36 1.9e-72 244.2 In-house 1-266 (277) Show / Hide 
Range on Protein: 202-480
Range on HMM: 1-266/277
Sequence Identity: 36% (103 aa)

LTDE-HLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILR---EVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTE
| .   .| |... .  |   ..| .||.||. |     .||.      |. . . |. |||||.| . | |.. .|||||  .|| |. || .|..|.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVD-AYVGDSLKYDK
.|.| .   . .|...||..|| ||| ||||.| .| .   .||| |  .|  .|.. |    |          | .. ..||||... .| .|.  ||.
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS----------PCFTLHYMAPEMLRRGYAQDG-GYDE

KCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRL
 || |||||||| || |  |||   ||.. .          ....  ||. |   || ..|  .|..||||.. || .|| .||
ACDWWSLGVILYTMLTGQVPFQQNEDDRQHS-------CNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRL
Kinase R166.5.AA CAMK-Unique 200-480 25 4.1e-66 217.19 In-house 1-352 (363) Show / Hide 
Range on Protein: 200-480
Range on HMM: 1-352/363
Sequence Identity: 25% (94 aa)

YKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRI-------------------LREVNIFKTCKDHPNIVQLLDW----FEDET-----
||.  . .|.|..| |  |. .. |...|.|.| ||.   ... .                    ||..| |.  |||||..|.||    |.|..     
YKMH-RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMV-DHPNIIKLYDWNNPIFCDRKYPLCD

----------NFYLVMEKMRGGPLLQHILQ--------------------RKYFTE--EEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNH---
          ..|.|||   || |.. |..                    . .|.|   .....   .  |...||. .| ||| |.||..   .     
LIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNN

----------VSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAP---------EVVDAYVGDSLKYDKKC----DTWSLGVILYIMLAG
           . .|||| .|. .         .... ... . . .|. ..|||         |   . |..  .|| .|    |.||||||.|.|| |
HHRDFPYDWSNWHIKLCDFGLCCH---------YNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCG

YAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYY-EFPEEEWGM---ISEEAKDLVSNLLKRDPVDRL
. || . |.| |         |     .| .|  | | .|... |.    ||.||||.| .....||. |.
CPPFDCECEDRD--------YENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRW
Kinase R166.5.AA RSK 200-480 33 2e-63 217.0 In-house 1-255 (271) Show / Hide 
Range on Protein: 200-480
Range on HMM: 1-255/271
Sequence Identity: 33% (96 aa)

YKLTDEHLGSGAYGSVTTCKSI---KSGVEYAVKIVDKQGETHS-RKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYF
| |  | .| |... |  || .    .. .||.||..|     . | .   | .|     .||.||.| . |.||.. |..|. |||| |. ..|  |.|
YELH-ECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYG-HHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF

TEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDP-NHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKY
.|.|.. .   | ||. . |  ||.||| ||||.|  |   . . .|.||. .| |             . .  | .. ..|..|||||.    |    .
SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQL-----------RDENGMLMTFCYTANYMAPEVLKRQ-G----H

DKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRL
|. || ||.||..|.||.|. |||.  .|.               ..  ||..| . .    |  ||.|||||.. .|.|||  ||
DQACDWWSFGVLMYEMLTGCTPFQNKPRDT-------------PMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRL
Kinase R166.5.AA RAD53 202-336 31 2.8e-47 138.56 In-house 2-147 (305) Show / Hide 
Range on Protein: 202-336
Range on HMM: 2-147/305
Sequence Identity: 31% (47 aa)

LTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDK-------QGETHSRKRILREVNIFKTCKDHPNIVQLLDWFED-ETNFYLVMEKMRGGPLLQHILQRK
.... ||||..|.|  ..  | .  .|.||.||         .. ..... .||.| |  . ||.|....|.|.. ....|.|.|.|.|| |.  |  .|
YMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLN-HPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

Y----FTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNH
.    |.| ....  . . .|.|  ||.||.||| ||||.|| ....
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDE
Kinase R166.5.AA MAPKAPK 201-344 33 4.8e-37 122.2 In-house 1-150 (268) Show / Hide 
Range on Protein: 201-344
Range on HMM: 1-150/268
Sequence Identity: 33% (52 aa)

KLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNF----------YLVMEKMRGGPLLQHIL
... . || |  | |  |   ...  .| |.         ...  |||.    |  ||.||| .| .| . .|            ||| | || |.. | 
QIWKQVLGIGINGKVMQCYHKRTQQKFALKVL------RDSPKARREVELHWMCSGHPHIVQIIDVYENMYQFPHEPSPRKCLLIVMECMEGGELFHRIQ

QR--KYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCD
.|  . ||| ||  ..|.|  |....|.. |||||.|||| |..| .  ...||.|
ERGDQHFTEREAAQIMKQICQAVQHCHSMNIAHRDLKPENLLYKDTQPNCVLKLTD
Kinase R166.5.AA MAPKAPK 380-490 43 4.5e-28 91.54 In-house 174-268 (268) Show / Hide 
Range on Protein: 380-490
Range on HMM: 174-268/268
Sequence Identity: 43% (49 aa)

APEVVDAYVGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDR
||||  .       ||| || ||||||.|||| || ||           |  ..      .  |||. |.||||..||  .||.||||. .||. || .|
APEVLGPEK-----YDKSCDMWSLGVIMYIMLCGYPPF----------YS--NHGQAISPGMKHRIMNGQYEFPHPEWSCVSEDAKDLIRKLLRTDPTER

LVTVSFVN-PFA
|    |.| |. 
LTIEEFMNHPWI
Kinase R166.5.AA RAD53 378-417 42 2.2e-13 35.7 In-house 192-241 (305) Show / Hide 
Range on Protein: 378-417
Range on HMM: 192-241/305
Sequence Identity: 42% (21 aa)

FMAPEVVD-----AYVGDS-----LKYDKKCDTWSLGVILYIMLAGYAPF
. ||||.       | ...       | ||.| ||.|.||||.|.|| ||
YVAPEVITSKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPF
Kinase R166.5.AA RAD53 438-480 43 3.9e-13 34.95 In-house 247-294 (305) Show / Hide 
Range on Protein: 438-480
Range on HMM: 247-294/305
Sequence Identity: 43% (21 aa)

Q----QDLFHRIQD-GYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRL
|     .||. |   |.|.|| ..|  ||||||||....|. ||  |.
QEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRY
Kinase R166.5.AA Pkinase_Tyr 200-324 25 4.1e-12 41.65 Pfam 1-137 (270) Show / Hide 
Range on Protein: 200-324
Range on HMM: 1-137/270
Sequence Identity: 25% (36 aa)

YKLTDEHLGSGAYGSVTTCKSI----KSGVEYAVKIVDKQGETHS---RKRILREVNIFKTCKDHPNIVQLLDWFE-DETN--FYLVMEKMRGGPLLQHI
 ..  . ||.||.|.|  ..      . ... |||.. |.| .|.   |.  .||..| |.  .|||||.|.     ..     |.||| | .| || . 
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

LQ----RKYFTEEEARRVTKDISLALKFMHDRGIAHRDV
 .    .. .| ..      .|. .. . ..... |||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase R166.5.AA TyrKc 200-489 20 4.9e-12 -28.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 200-489
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTC-KDHPNIVQLLDWFEDE-------TNFYLVMEKMRGGPLLQHILQ
 .| .. ||.||.| |  .. .   .. ||| . .      |. ..|| .| .   ..|||||.|.    ..          ..||| | .| |....  
ITLGKK-LGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RKY-FTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQ---HERHPLSQVASEPDLA--SPVGSAEFMAPEVVD
..  .. ..      .|.    . |.... |||    |.| ....    || .|  |.          |..    .... .     |.     ||||.  
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RWMAPECI-

AYVGDSLKYDKKCDTWSLGVILY-IMLAGYAPFQGM----CDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEE--WGM----ISEEAKDLVSNLLKR
    .  |.  | | || || .. |.  |  |  ||    ...               |........||.  . ..    |     ..|  .. .   ..
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSN---------------QEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHE

DPVDRLVTVSFVNPF
|| ||      .  |
DPEDRPTFSEIHECF
Kinase R166.5.AA Pkinase_Tyr 379-449 25 1.352148 2.64 Pfam 181-233 (270) Show / Hide 
Range on Protein: 379-449
Range on HMM: 181-233/270
Sequence Identity: 25% (19 aa)

MAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLA-GYAP-FQGMCDDEDCGWSEGKPCEDCQQDLFHRI-QDGY
||||.   ..     .  | | || || .. ..  |  | ..|| ..|.               ....| .|||
MAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEE---------------VYEYIYEDGY
Kinase R166.5.AA CAMK1 536-547 33 0.000294 8.21 In-house 265-276 (276) Show / Hide 
Range on Protein: 536-547
Range on HMM: 265-276/276
Sequence Identity: 33% (4 aa)

FNADQILSHRWL
....|.| |.|.
YTCEQCLNHPWI
Kinase R166.5.AA CAMK 536-547 33 0.002729 5.66 In-house 414-425 (425) Show / Hide 
Range on Protein: 536-547
Range on HMM: 414-425/425
Sequence Identity: 33% (4 aa)

FNADQILSHRWL
....|.|.| |.
MTIEQCLNHPWM
Kinase R166.5.AA RAD53 536-547 33 0.005186 4.23 In-house 294-305 (305) Show / Hide 
Range on Protein: 536-547
Range on HMM: 294-305/305
Sequence Identity: 33% (4 aa)

FNADQILSHRWL
...|..|.| |.
YTIDEALNHPWM
Kinase R166.5.AA RSK 538-547 40 0.224751 1.24 In-house 269-278 (278) Show / Hide 
Range on Protein: 538-547
Range on HMM: 269-278/278
Sequence Identity: 40% (4 aa)

ADQILSHRWL
|..|..| |.
AEEIKQHPWF
Kinase R166.5.AA Pkinase 537-547 54 3.424115 1.76 Pfam 283-293 (293) Show / Hide 
Range on Protein: 537-547
Range on HMM: 283-293/293
Sequence Identity: 54% (6 aa)

NADQILSHRWL
.|.||| | |.
TAEQILQHPWF