Gene spe-6 (Nematode worm)
spe-6
Sequence
Protein domains of spe-6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | spe-6.AA | Worm6 | 26-288 | 40 | 6.1e-150 | 504.42 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 26-288 Range on HMM: 1-279/279 Sequence Identity: 40% (113 aa) WKVLRNIYSGPFSDVYVVADTVTNE--KYAMKCERQ-EGNSRPVLKLDVMVLMATKGLR--GFPNFVAAGRTDV--YRYCIMQLVGPDLGRLRRTRPERK |||...|..|.|..||.| |. ... ..|||||.| |...|..||...|||.|.| . .|.... .|..| ..|..|.|||..|..||..||.|| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGV-----GENESTVYILDFGFAR--KFVDKEGKIIPPR-TAAALMGTFQYCAVSAHSHKDQCA ||..|.|.| |.|...|||||||...||||..|||||. ....|.|.||||..| |. .|......|| ||.. .||..|.....|....||. FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLESWFYMGIELLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFFEGVPK-QFNEILTILDQTSYFDRPNYKKL .||.|||||| .|...| |||.....|........... ...|....||...|| .||.|....||.||.|||.||.. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | spe-6.AA | CK1 | 26-288 | 30 | 2.6e-108 | 366.11 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 26-288 Range on HMM: 1-339/339 Sequence Identity: 30% (103 aa) WKVLRNIYSGPFS-DVYVV-----ADTVTN-----EKYAMKCERQEGNSR-PVLKLDVMVLMATKGL----------RGFPN----------FVAAGRTD ||| . | .| | ..| | |. .| |.||||.|. . . . |.|. .. ......|. ..|.. .. .|..| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED VYR-YCIMQLVGPDLGRLRR--TRPERKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGV-------------GENESTVYILDFGFAR-KFV | | .|.|.||.|..||. . . ||||..|.|.| |.| .||..|.||.. ||.|. |||.|. .... .||..|||.|| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DK------------EGKIIPPRT---AAALMG-TFQYCAVSAHSHKDQCARDDLESWFYMGIELLKGP--LPWANIDGHK---NHKQIGEAKVAIRSEPL || .....|||. .. ..| |. || ...| .|.|. ||||.||||| ||.||| ||| |.. .. .|. ....| ....|.. DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK RSEFFE--------GVPKQFNEILTILDQTSYFDRPNYKKL | |. ..|..| .|...... .|.|||.|... MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | spe-6.AA | TTBKL | 26-292 | 32 | 1.4e-72 | 244.34 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 26-292 Range on HMM: 1-288/288 Sequence Identity: 32% (94 aa) WKVLRNIYSGPFSDVYVVADTVT-NEKYAMKCERQE-GNSRPVLKLDVMVLMATK--GLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERK-FS |.. . | .| | || | |... ....||| | .. .. ..|. | |||. | . ||.....|... |.. .|.|.||.|. ||.. | .| || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGEN----ESTVYILDFGFARKFVDKEG-----------KIIPPRT---AAALMGTFQYCAVSA |.. | |.| | ..| ||.. |||| |.|.|. .. . .||..|||.||....|.| .. .||. | ..||..|| . . DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HSHKDQCARDDLESWFYMGIELLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFF--EGVPKQFNEILTILDQTSYFDRPNYKKLGDLL | .|.| ||| ||.|| |||..| ||| |. .....|...|.. | | .. . . |..| .. . | . .| |||.| .. .. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM---EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | spe-6.AA | TTBK | 26-288 | 35 | 1.7e-59 | 203.96 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 26-288 Range on HMM: 1-257/257 Sequence Identity: 35% (93 aa) WKVLRNIYSGPFSDVYVVADTVTN-EKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERKFSLPTA |||.. | | | .| | ... |. |.| | . . |||. | || | |. || | . | .||| | | ||| |. .||| |. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQ-QPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT LQILGQTLRRLEDLHNCGWLCRDVKAPNFCIG-VGENESTVYILDFGFARKFVDKEGKIIPPRTAAALMGTFQYCAVSAHSHKDQCARDDLESWFYMGIE |.. | | .| |. |.| ||.| || .| . .. .|.|||| ||... .| . ||| .| || | .. || .. .||| | ||| .| LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE LLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKL ..| ||| | | |.|| | | . .|..| . . |.|||.|. . FVQGQLPWRKI---KDKDQVGEMKEKYDHRML----LKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | spe-6.AA | CK1-D | 26-288 | 31 | 3.9e-38 | 132.09 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 26-288 Range on HMM: 1-261/261 Sequence Identity: 31% (83 aa) WKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERKFSLPTAL ... | | || | |.| .. ||| |.| | | |... . .| | |. |. | .|.|.|| | | .||||| | | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTK-HPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVL QILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVDKE-GKIIPPRTAAALMGTFQYCAVSAHSHKDQCARDDLESWFYMGIEL . | ..|.| .| .. ||.| || .|.| ..|||.||| |... | . . || | | || | .. | .| |||||| |. . MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF LKGPLPWANIDG---HKNHKQIGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKL .| ||| . .. .| | |. .. . | .| |..| . . . . |.|.| | NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTL----CKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | spe-6.AA | CK1-A | 26-288 | 28 | 1.5e-35 | 123.04 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 26-288 Range on HMM: 1-261/261 Sequence Identity: 28% (77 aa) WKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGPDLGRLRRTRPERKFSLPTAL ....| | || | |.|. . | |.| |... | | . | .| |.|. |. | .|.|.|| | | .|.|.. | | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKAR-HPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVL QILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVDKEGKI-IPPRTAAALMGTFQYCAVSAHSHKDQCARDDLESWFYMGIEL . | . |.| .|. ... ||.| || .|.| ....||| |.|. |.. .. || |. |.|| | .. || .| |||.|| |. . MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF LKGPLPWANIDGHKNHKQ---IGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKL .| ||| . ... | | |... | | | | .| ... . . . |.| | NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQL----CKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | spe-6.AA | Dual | 26-220 | 32 | 3.1e-35 | 115.86 | In-house | 1-212 (282) | Show / Hide |
Range on Protein: 26-220 Range on HMM: 1-212/282 Sequence Identity: 32% (68 aa) WKVLRNIYSGPFSDVYVVADTVT----NEKYAMKCERQEGNSRPVLKLDVMVLMATKGL----------RGFPNFVAAGR--TDVYRYCIMQLVGPDLGR ||| . . || | ||| | . |..|..| | || . . ..| .| . . . |. || | .| | .| ..|| | WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRRTRPERKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVD-KEGKIIPPRTAAALMGTFQYCAVSAHSHKDQ || .| ... . |.|| . |||. |.| |..| || .|.|. |.||| .||. .||..| . .| ..|. |. | ||| IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQ CARDDLESWFYM ||||.| || GRKDDLECWIYM |
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| Kinase | spe-6.AA | CK1-Unclassified | 26-234 | 36 | 2.2e-34 | 98.88 | In-house | 1-219 (244) | Show / Hide |
Range on Protein: 26-234 Range on HMM: 1-219/244 Sequence Identity: 36% (81 aa) WKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLR-------GFPNFVAAGRTDV--YRYCIMQLVGPDLGRLRRTRPE .|.. | .| | ..| . .. |||..|.| |. | |. . .... .. |.|. |. . | . .| | ||.| | YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCN RKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIG-VGENESTVYILDFGFARKFV--DKEGKIIPPRTAAALMGTFQYCAVSAHSHKDQCARDD ||||| | | | | . |.| |||.. ..|| | ||..| | | .||| |||.. ... ||.|| || | | || | . || . | ||| RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD LESWFYMGIELLKGPLPWANI ||| | | .||| ||| || LESLGYVLIYFLKGSLPWQNI |
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| Kinase | spe-6.AA | CK1 | 26-286 | 30 | 2.9e-33 | 111.95 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 26-286 Range on HMM: 1-271/271 Sequence Identity: 30% (86 aa) WKVLRNIYSGPFSDVYVVADTVTNEK---YAMKCERQEGNSRPVLKLDVMVLMATKG------LRGFPNFVAAGRT--DVYRYCIMQLVGPDLGRLRRTR .| | | .| | |.| . .. ||.. .|.| |.. | |. . ... .| |.|. |. | . .| | ||.| | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNF PERKFSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGV-GENESTVYILDFGFARKFVD-KEGKIIPPRTAAALMGTFQYCAVSAHSHKDQCARD ||||| | | | | ..|.| .||.. ..||.| ||..|. | .. .||| |||.| ...| |... || |. | || | . .| . | || CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD DLESWFYMGIELLKGPLPWANIDGHKNH---KQIGEAKVAIRSEPLRSEFFEG-VPKQFNEILTILDQTSYFDRPNYK |.|| |. . .|.| ||| .. .. .|.| | . | | ..| |..|.. |.. | .....|.|. DMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQL----CKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | spe-6.AA | CK1-Unique | 26-231 | 23 | 3.2e-25 | 84.41 | In-house | 1-232 (337) | Show / Hide |
Range on Protein: 26-231 Range on HMM: 1-232/337 Sequence Identity: 23% (56 aa) WKVLRNIYSGPFSDVYVVADTVTN------EKYAMKCERQEGNSRP-----VLKLDVMVLMATK--GL--RGFPNFVAAGRTDVYRYCIMQLVGPDLGRL |.| | .| . .|. | . . .|.|| | | . ... ..... . . | |. . . .... . .|...|| . . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTE-QHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC RRTRPER-KFSLP------TALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGE--NESTVYILDFGFARK--FVDKEGKIIPPRTAAALMGTFQYCA .. . . .| | .|.| |.| .| | | . |. | |.| . . . |.||.| |. ||.. . | .|| . |. || CMM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCP VSAHSHKDQCARDDLESWFYMGIELLKGP--LPW | | ... .|||.|||||| . |. . | | CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW |
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| Kinase | spe-6.AA | S_TKc | 26-296 | 16 | 5.7e-11 | -16.06 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-296 Range on HMM: 1-231/231 Sequence Identity: 16% (48 aa) WKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNSRPVLKLDVMVLMATKGLRGFPNFVAAGRTDVYRYCIMQLVGP---DLGRLRRTRPERK---- ...|| | .| |. || . .. |....|.|. . .. . .|. . .. . .. . | .| ... || .. . |. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FSLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIGVGENESTVYILDFGFARKFVDKEGKIIPPRTAAALMGTFQYCA---VSAHSHKDQCARDDLE |. .| .. |... || .|. | . ||.| | . .. | |||.||.. . || |.| . FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL--------------- SWFYMG------------IELLKGPLPWANIDGHKNHKQIGEAKVAIRSEPLRSEFFEGVPKQFNEILTILDQTSYFDRPNYKKLGD-----LLSQAA | . .|.| | |. . .. |.|| .... ... . | .|| .. . . --GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | spe-6.AA | Pkinase | 113-199 | 30 | 0.000707 | 14.79 | Pfam | 97-179 (293) | Show / Hide |
Range on Protein: 113-199 Range on HMM: 97-179/293 Sequence Identity: 30% (27 aa) TRPERKF--SLPTALQILGQTLRRLEDLHNCGWLCRDVKAPNFCIG-VGENESTVYILDFGFARKFVDKEGKIIPPRTAAALMGTFQYCA |. ...| | .. .. |.|| || .|..| . ||.| |. | |.....| | |||.|..| . . . . . || |.| TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |
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| Kinase | spe-6.AA | Pkinase | 26-63 | 26 | 0.961821 | 3.71 | Pfam | 1-38 (293) | Show / Hide |
Range on Protein: 26-63 Range on HMM: 1-38/293 Sequence Identity: 26% (10 aa) WKVLRNIYSGPFSDVYVVADTVTNEKYAMKCERQEGNS ....| | || |. || . |....|.|. . .... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEK |
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