Gene spk-1 (Nematode worm)

spk-1

Species: Nematode worm
Alias: spk-1, aSWK206, B0464.5a, srk-1, B0464.5, CE02949, B0464.5x=(kmaqe..adlgn), B0464.5A
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: III: 9451994-9458391

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
spk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 550 Kinase domain by global Sugen HMM Fasta, JSON
spk-1.AA Protein Genbank 1160 None Fasta, JSON

Protein domain

Protein domains of spk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase spk-1.AA SRPK 519-1068 46 0.0 1085.58 In-house 1-554 (554) Show / Hide 
Range on Protein: 519-1068
Range on HMM: 1-554/554
Sequence Identity: 46% (266 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPN---------------------DIGCHKVVQLLDEFTVTGING
|||||||||||||||||.||.|..|.|||||||||.||||.|.|||||| .||..|||                     | ....||||||.|...|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

QHVAMVFEVLGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEIKIMAQHAVVARKMN-MKMSGSAVSTAPDHL
.|..|||||||.||||.|...||.|.....|..|.||||..| |.|.|||||||||||||||.......|| ||.......||. ...|.|.|.|||.|.
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

VKMAQENMTKNKKKKMKKKAKKQREKLEAELAGLEGLKMDAN----GLQEAYNNAPQNGVRMRPPSLLFNGPIPQLLQGSSCVNTPSSPRTVPPPPPSLY
....|..|.||||||||||.|.|.|..|.... .. ...|.|    . ||...|...|........ ..|..... .. ... |.............. .
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQ

PQVGCVCNQTYHLTQVILNANVGELENFNASQVEDVTMEDTVNENGNRNKVEIRSPDRFDRTTLTPFSDPESKFGDLASPSAEYLSSPMSQLPPGGILPA
........                 .||. ||. |..||...|...|............|.|...... ...|.|...|...|. |..|..    |....
NVQKQNND-----------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECESEDMQEQ--AGKFLV

PPVGPNIGDPYCDIDVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIP
....|.. |....|..|||||||||||.||.|.||||||||..||.||.||..||||||||||||||||||||||||.|..||||.||.||| ||.| ||
WWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIP

PSIYKKGKHWREFFHKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
......||..||||.|.|.| ||..||||.|..|| .|||||||.|.|||.||.|||....|||.||| .|.||.|
WHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase spk-1.AA CMGC 519-1068 15 1.2e-109 361.59 In-house 1-513 (513) Show / Hide 
Range on Protein: 519-1068
Range on HMM: 1-513/513
Sequence Identity: 15% (111 aa)

YHVIRKLGWGHFSTVWLAWD--------------TQDKRFVAMKIVKSAEHYTEAAL-------------DEIKLLLSVRSA---------DPNDIGCHK
|..|.|.|.|....|. ..|              ......||.|..|... |.| |.             .|||.|  .. .         ||..   . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLLDEFTVTGINGQ-------------HVAMVFEVLGCNLLKLIIRSN--YRG------------------------LHLEQVRKICRQVLEALG--Y
.|.|.| |.  . .|.             |. .||| ....|...| . .  |.|                        . . ..| ...|.|..|   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

MHEKCG-IIHTDIKPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKKKKMKKKAKKQREKLEAELAGLEGLKMDANGL
.| ..| |||.|.||||.||.   | |. | .   . ..   .                                                         
CHSHWGNIIHRDLKPENILINHNCELITRM-M---W-KS---E---------------------------------------------------------

QEAYNNAPQNGVRMRPPSLLFNGPIPQLLQGSSCVNTPSSPRTVPPPPPSLYPQVGCVCNQTYHLTQVILNANVGELENFNASQVEDVTMEDTVNENGNR
                                                                                                    
----------------------------------------------------------------------------------------------------

NKVEIRSPDRFDRTTLTPFSDPESKFGDLASPSAEYLSSPMSQLPPGGILPAPPVGPNIGDPYCDIDVKIADLGNACWVNHH------------------
                                                        |.    . .  .||.| |.|.|...|                  
---------------------------------------------------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKD

------YTDDIQTRQYRALEVLIGSG----------YGPPADIWSTACMAFELATG--------DYLFEPHQGD-----NYSRDEDHLAHISELLGAIPP
      ||....|| ||| |.|.|..          |..| |.|| .|. .|. ||        ..|| .| ..     |.... |.|..| ..|| .. 
DKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-

SIYKKGK-------HWREFFHKNGHLLHIHQLK-------------------------PWSLYEVLRQKYEWSHE-------------------------
.. .|||       | .|.. ... . .. ..|                         ||  .  ..... |...                         
WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFN

-------DAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
       . .|.  .|  || .| .|| ||. ||.||..
HQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase spk-1.AA S_TKc 519-1068 13 1.7e-50 175.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 519-1068
Range on HMM: 1-231/231
Sequence Identity: 13% (79 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGC---NLLKLI
|...||.| | |..|...... ..| ||.||.|      | .. ||..| .         ..  .|.|.| |       .|. ||.| ..    .|...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IRSNYRG----LHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEIKI----MAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKN
 . ...|    ..  ..|....|...|| |.|.. |||| |.||||.|..    .|||    .| .                                  
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL---------------------------------

KKKKMKKKAKKQREKLEAELAGLEGLKMDANGLQEAYNNAPQNGVRMRPPSLLFNGPIPQLLQGSSCVNTPSSPRTVPPPPPSLYPQVGCVCNQTYHLTQ
                                                                                                    
----------------------------------------------------------------------------------------------------

VILNANVGELENFNASQVEDVTMEDTVNENGNRNKVEIRSPDRFDRTTLTPFSDPESKFGDLASPSAEYLSSPMSQLPPGGILPAPPVGPNIGDPYCDID
                                                                                                    
----------------------------------------------------------------------------------------------------

VKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGP-PADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKGKHWREFF
                |  . |. |.| |||   |||. ..|.||  |. .|...|  .|.            ... . ...|                 
----------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG-----------------

HKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALK-------HPFL
                                ... .|.| .|..| ||| ||  ||.       ||..
-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase spk-1.AA CLK 519-668 27 8.4e-41 119.58 In-house 1-160 (350) Show / Hide 
Range on Protein: 519-668
Range on HMM: 1-160/350
Sequence Identity: 27% (46 aa)

YHVIRKLGWGHFSTVWLAWDTQD-KRFVAMKIVKSAEHYTEAALDEIK-LLLSVRSA-DPNDIGCHKVVQLLDEFTVTGIN-GQHVAMVFEVLGCNLLKL
| .. .|| | |..|   ||..  |..|| ||....| |.|||  ||.  . ..  . ||| .   ......| |     . . |...||| .| ..  .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD----YGHGHICIVFELYGLSIYDF

IIRSN------YRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMS-----REEIK
.   |      |... ....|.. .| .||.. .| . ...||| |||| ... |     . ..|
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFVDSRFTHFDCTFK
Kinase spk-1.AA DYRK 519-669 31 3.1e-31 110.11 In-house 1-148 (320) Show / Hide 
Range on Protein: 519-669
Range on HMM: 1-148/320
Sequence Identity: 31% (48 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLIIRS
| ..  .| | |. |  .||.. .  ||.||... . .   |..|||.|   . .||.|   . .|...| |.      .|. .||| |  ||  .. . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDK--YHCVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNN

NYRGL-HLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITM--SREEIKI
. .|. .|. |||...|.|..| ..|..  ||| |.||||...    .. .||.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKV
Kinase spk-1.AA DYRK2 519-659 30 1.7e-25 79.58 In-house 1-134 (318) Show / Hide 
Range on Protein: 519-659
Range on HMM: 1-134/318
Sequence Identity: 30% (43 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLIIRS
| .   .| | |  |  . |   | .|| |..     . . |. ||. |   |. |..  . . .| .|| |.  .    |. ..|| |. || ..| . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVL
.. |. |. ||. ....|..|   |.   ||| | ||||.|
HFQGFSLQLVRRFAHSILQCLRFLHKNN-IIHCDLKPENIL
Kinase spk-1.AA Pkinase 519-669 26 1.8e-25 91.12 Pfam 1-153 (293) Show / Hide 
Range on Protein: 519-669
Range on HMM: 1-153/293
Sequence Identity: 26% (45 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALD------EIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGC---
||..||.| | |..|... .  . . ||.||.|   |  .  .       ||.......        .  .|.|.| |.     ..|. ||.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY

--NLLKLIIRSNYRGL--HLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEI----KI
   |  .| .......    ........|.|..| |.|. .|||| |.||||.||  .. .|    ||
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKI
Kinase spk-1.AA CLK 905-1068 31 8.7e-25 70.62 In-house 183-350 (350) Show / Hide 
Range on Protein: 905-1068
Range on HMM: 183-350/350
Sequence Identity: 31% (54 aa)

DIDVKIADLGNAC---WVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLG-AIP-PSIYKKG
. .... | |.|      . | .. ..||.||| ||  | |.  | |.|| .|  ||| ||. ||  |         .||| . ...|  || . | .  
NTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTR

--KHWREFFHKNGHLLHIHQLKPWSLYEV---LRQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
  |  ...|..|. .   |  .  .  |    |.|  .  .....|.   .| || .|  || |.| ||.||| 
RFKVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase spk-1.AA DYRK 907-1068 27 8.5e-24 85.38 In-house 145-320 (320) Show / Hide 
Range on Protein: 907-1068
Range on HMM: 145-320/320
Sequence Identity: 27% (52 aa)

DVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKG--KHWRE
..|..| | .| .... .  || | ||| ||..|  |. . |.||  |   || ||  ||   .|.|.    | || | |.||..|. . .||  .. ..
TIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHK

FFHKNGHLLHIHQLKPWSLYEV------L-----------------RQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
|| .    .   ... |.  ..                         ....    | .||  |.. .|..| .|| |.. ||.||..
FFDC----FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase spk-1.AA DYRK1 519-670 33 3.7e-23 77.78 In-house 1-148 (321) Show / Hide 
Range on Protein: 519-670
Range on HMM: 1-148/321
Sequence Identity: 33% (52 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLIIRS
| ..  .| | |  |  |.|.|.. .||.||.|    . . |. ||.||  .  .|...    ..|.|   |        |. .|||.|  ||  |.   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMK--YYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYRGLHLEQVRKICRQVLEALGYMHE-KCGIIHTDIKPENVLITMS-REEIKIM
..||  |  .||. .|.. || .|      ||| |.||||.|.  . |  |||.
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKII
Kinase spk-1.AA CAMK 524-669 14 1.8e-21 65.3 In-house 1-237 (425) Show / Hide 
Range on Protein: 524-669
Range on HMM: 1-237/425
Sequence Identity: 14% (35 aa)

KLGWGHFSTVWLAWDTQDK------------RFVAMKIVKSA-----------------------------EHYTEAALDEIKLLLSVRSADPNDIGCHK
.|| | |..| |. .....            . ||.||..                               ..  .  . ||... .... .   .    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGN-KLDHPN

VVQLLDEFTVTGI--------NGQH--------VAMVF---EVLGCN-----LLKLIIRSNY-------------RGLHLEQVRKICRQVLEALGYMHEK
...|.. .  .          . ..        . ||.   |          |.  |..  .             . .. ...|.. ||...|. |.|..
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

CGIIHTDIKPENVLIT----------------MSREEIKI
  |.| |.||||.|..                ...  |||
N-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKI
Kinase spk-1.AA Pkinase 907-1068 23 6.3e-19 68.01 Pfam 150-293 (293) Show / Hide 
Range on Protein: 907-1068
Range on HMM: 150-293/293
Sequence Identity: 23% (40 aa)

DVKIADLGNAC---WVNHHYTDDIQ-TRQYRALEVLI-GSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKG--
.|||.| | |.   . | . ....  |. |.| ||.  |..|||..|.||  |. .|...|  .|  ... .  .  |... | . .|..... . .   
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

KHWREFFHKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
. ...|.|   |                .   .  |.  . . .|.. .|..| .|| ||. .|.||..
ISYFFFRH-W-H----------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase spk-1.AA Ciliate-E2-Unclassified 519-669 20 7.4e-17 55.02 In-house 1-188 (352) Show / Hide 
Range on Protein: 519-669
Range on HMM: 1-188/352
Sequence Identity: 20% (39 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFV-----AMKIVKSAEHYTEAALDEIKLL---LSVR-SADPND------------IGCHKVVQLLDEFTVTGING
|..|...| | |..|... . ..| ..     ..|| . . .. .    ||..    .  . . . ..            . .  .| ....|. .    
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDK----

QHVAMVFEVL-GCNLLKLIIRSNY---------------RGLHLEQVR-----KICRQVLEALGYMHEKCGIIHTDIKPENVLITMSRE--EIKI
|.. .| | . | .|.. |  ..                . .  .|..     ....|.|..| |.|.| .||| ||||||.|.. . .  .|||
QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI
Kinase spk-1.AA DyrkP 907-1006 37 6.2e-15 44.95 In-house 146-239 (323) Show / Hide 
Range on Protein: 907-1006
Range on HMM: 146-239/323
Sequence Identity: 37% (37 aa)

DVKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKGKHWREFF
.||| | | .|..  |    .| | ||| ||.||  |    |.||  |.  || ||  ||   | ||       || .  ..| .|  ... |.  . ||
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF---QNDNI---QGLLARVIGIIGPFPEWMMQEGRLVQNFF
Kinase spk-1.AA PRP4 519-669 32 1.2e-13 46.36 In-house 1-148 (320) Show / Hide 
Range on Protein: 519-669
Range on HMM: 1-148/320
Sequence Identity: 32% (51 aa)

YHVIRKLGWGHFSTVWLAW-DTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSA--DPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKLI
| |. . | | ||.|  .   |. .  || ||. . |      | |.  |     |  |.||   | .|.. . |       ||  .||| .  ||  ..
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDK-FH-CVRMFRHFNHR----QHMCLVFECMSMNLREVL

IR-SNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEIKI
 .     ||||. ||   .| . ||  .  ||.|.| |||| |.|.  |.. .|.
KKYGKDVGLHLKAVRSYAQQLFLALKHLK-KCNILHADIKPDNILVNESKNTLKM
Kinase spk-1.AA DYRK2 907-990 37 6.8e-13 37.94 In-house 142-220 (318) Show / Hide 
Range on Protein: 907-990
Range on HMM: 142-220/318
Sequence Identity: 37% (32 aa)

DVKIADLGNACWVNH-HYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGA
..|..| |  | ..  .   .||.| ||| || .|  || . |.||  | . || ||  ||    |.|.    | .| . |.||.
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGM
Kinase spk-1.AA DYRK1 908-1008 33 4.2e-12 38.31 In-house 145-239 (321) Show / Hide 
Range on Protein: 908-1008
Range on HMM: 145-239/321
Sequence Identity: 33% (34 aa)

VKIADLGNACWVNHHYTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPHQGDNYSRDEDHLAHISELLGAIPPSIYKKGKHWREFFH
.|| | | .| ...     || | ||. |||.|  |    |.||  |.  |. ||. ||    | |   . | . .| | ||  |  .  ..   . .|.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

K
|
K
Kinase spk-1.AA DyrkP 519-670 29 5.8e-11 31.64 In-house 1-150 (323) Show / Hide 
Range on Protein: 519-670
Range on HMM: 1-150/323
Sequence Identity: 29% (47 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEVLGCNLLKL--II
| ..  ||   ||      | |  . . |||.     | . ..||||||  .      |.    |..  | |        |. .. |.|  ||       
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNG--DVDEKNVLRYYDYF----YHKEHLFIITELLKDNLYEFYKFN

RSN--YRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLI-TMSREEIKIM
| |   |   .  . ||  |.| || |.|    .|| |.||||.|.   .. ..||.
RENEQQRYFTVGRLQKITQQILIALDYIHS-LRLIHCDLKPENILMKSYPKCQVKII
Kinase spk-1.AA PRP4 928-966 43 5.3e-07 21.76 In-house 167-205 (320) Show / Hide 
Range on Protein: 928-966
Range on HMM: 167-205/320
Sequence Identity: 43% (17 aa)

QTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLF
. | ||| |..||  |    |.||..|  .||.||  .|
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase spk-1.AA TyrKc 519-809 12 8.6e-07 -112.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 519-809
Range on HMM: 1-280/280
Sequence Identity: 12% (44 aa)

YHVIRKLGWGHFSTVWLAWDTQDKRFVAMKIVKSAEHYTEAALDEIKLLLSV--RSADPNDIGCHKVVQLLDEFTVTGING------QHVAMVFE-VLGC
 . ..||| |.| .|...  .   . || | .|.     |. ..|.... ..  .           .|.|.    |    |      . . .|.| . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGH--------HPNIVRLY---GVCTQQGRNFMYIEPLMIVMEYMPHG

NLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMSREEIKIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKK
.|.. . ..  . | ...  ..| |. .   | |.| ..|| |.   |.|..  .                                || .   .... .
DLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-------------------------------TVKISDFGLSRDIY

KK--------MKKKAKKQREK---------LEAELAG--------------------LEGLKMDA-----NGLQEAYNNAPQNGVRMRPPSLLFNGPIPQ
 .        ...|.... .|         .|.   |                    . .             ||....  | . ...||. .   |.  
DDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMS-

LLQGSSCVNTPSSPRTVPPPPPSLYPQVGCVCNQTYH-------LTQVI
            .    .  |. .|    . ..   .       . . .
------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase spk-1.AA Ciliate-E2-Unclassified 1025-1068 25 1e-06 19.11 In-house 302-352 (352) Show / Hide 
Range on Protein: 1025-1068
Range on HMM: 302-352/352
Sequence Identity: 25% (13 aa)

EVLRQKYEW------SHEDAQQFES-FLRPMLDFDQEKRSTAKIALKHPFL
..  .|..|      ... |. | . .|. ||. ...|| |.. .|.||..
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase spk-1.AA CAMK 1026-1068 20 5e-06 14.6 In-house 359-425 (425) Show / Hide 
Range on Protein: 1026-1068
Range on HMM: 359-425/425
Sequence Identity: 20% (14 aa)

VLRQKYEWSHEDA------------------------QQFESFLRPMLDFDQEKRSTAKIALKHPFL
... ||.. ..                          |.  ...| ||  | ||| |.. .|.||..
IMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase spk-1.AA DyrkP 1041-1068 46 1.3e-05 13.7 In-house 296-323 (323) Show / Hide 
Range on Protein: 1041-1068
Range on HMM: 296-323/323
Sequence Identity: 46% (13 aa)

FESFLRPMLDFDQEKRSTAKIALKHPFL
|  | | .|  |  .| ||| ||.||..
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase spk-1.AA DYRK1 1034-1068 37 2.6e-05 14.06 In-house 287-321 (321) Show / Hide 
Range on Protein: 1034-1068
Range on HMM: 287-321/321
Sequence Identity: 37% (13 aa)

SHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL
| || ..|.  .. ||..| ..| |   ||.|.|.
SVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase spk-1.AA PRP4 1039-1068 46 3e-05 15.26 In-house 291-320 (320) Show / Hide 
Range on Protein: 1039-1068
Range on HMM: 291-320/320
Sequence Identity: 46% (14 aa)

QQFESFLRPMLDFDQEKRSTAKIALKHPFL
.||  .|  .|  | .|| |   ||||||.
HQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase spk-1.AA Ciliate-E2-Unclassified 908-967 24 8e-05 12.69 In-house 186-271 (352) Show / Hide 
Range on Protein: 908-967
Range on HMM: 186-271/352
Sequence Identity: 24% (21 aa)

VKIADLGNA------------------CWVNHHYTDDIQTRQYR----ALEVLIGSGYGPP----ADIWSTACMAFELATGDYLFE
.||.|.|..                   | ...... ..| .|     | ||| | .|. .    .||||  . ..|. .| | |.
IKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFY
Kinase spk-1.AA DYRK2 1039-1068 33 8.9e-05 11.09 In-house 289-318 (318) Show / Hide 
Range on Protein: 1039-1068
Range on HMM: 289-318/318
Sequence Identity: 33% (10 aa)

QQFESFLRPMLDFDQEKRSTAKIALKHPFL
. |  |..  .. | ..| |.. |||||..
ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase spk-1.AA CAMK 907-951 20 0.002654 5.7 In-house 234-319 (425) Show / Hide 
Range on Protein: 907-951
Range on HMM: 234-319/425
Sequence Identity: 20% (18 aa)

DVKIADLGNACWVNHH--------------------------YTDDIQTRQYRA-LEVLIG--------------SGYGPPADIWS
..||.| | |. ...                           ...   |  | |  ||| |               .|||..|.||
NIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWS