Gene T01H8.1a (Nematode worm)

T01H8.1a

Species: Nematode worm
Alias: CE18169, T01H8.1aN, aSWK024, T01H8.1a
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: No interpolated position., WormBase Physical Map location: I: 8588175-8581927, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
T01H8.1a.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
T01H8.1a.AA Protein Genbank 797 None Fasta, JSON
T01H8.1a.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of T01H8.1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T01H8.1a.AA AGC 104-363 34 1.6e-189 495.42 In-house 1-395 (395) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-395/395
Sequence Identity: 34% (137 aa)

FELLKVLGQGSFGKVFLVRKVRGR---DSGHVYAMKVLKKAT---LKVR-DRQRTKLE------------RNILAHIS----------HPFIVK-LHYAF
||.|||.|.||||||.||||. |    |.|..||||||||..   .| . . ..|. |            ||||....          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEDDVKFYLAE-------LTLALEHLHS-LGIVYRD-LKPENILLDADGHIKVTDFG
|.. .  ||......          || .||..|    ||  |.|. ..||.||       ..||||.||| .||..|| |||||||||.||||| ||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEAIDSE--------------------------------------------------KKTYSFCG--TVEYMAPEVINRRGHSMAADFWS--LGVLMF
|.|| ....                                                  ..|..|||  | ||||||..    .. |.| ||  ||.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGHLPFQGR----------DRNDTMTQIL------KAKLSMP----------HFLTQEAQSLLRALFKRNSQNRLGAGPD-----GVEEIKRHAFF
|||||. ||.|           ...... .|.      . |. .|           ....||..|.. |....  .|||.|..     |.||||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase T01H8.1a.AA RSK 104-363 53 9.90000000001e-183 613.35 In-house 1-271 (271) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-271/271
Sequence Identity: 53% (145 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....|||||.||....|....|... ||||..||||..|.||.... ||.||... |||||||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

DDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDAD----GHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGVLMFEMLT
..||||.||..||.|.|||.|||.|||||||||.|..    ||||..|||..|...| ......||.|..||||||..|.||..|.|.||.||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GHLPFQGRDRNDTMTQILKAKLSM-------PHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
|..|||...|...|..|...|| |       ..|...||..|||....|. .|||||||.|||.||.|..|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase T01H8.1a.AA RSK 107-363 54 3.3e-169 568.41 In-house 1-278 (278) Show / Hide 
Range on Protein: 107-363
Range on HMM: 1-278/278
Sequence Identity: 54% (151 aa)

LKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDR-QRTKL-ERNILAHIS-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||..|||||.||....|.|..|||||||||....|.. .|... |||||...  |||||.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDA---DGHIKVTDFGLSKE-AIDSEKKTYSFCGTVEYMAPEVIN----RRGHSMAADFWSLGV
|.||...||.||..||.||||..||..|||||||||.|    .||||.||||..|.  .| ...|..||.|.||||||...    ..||. |.| |||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGHLPFQG---RDRNDTMTQILKAK--LSMP--HFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
||.|||||..||||    .|...|..|.|.|  |.||  ..|.|||..|.|....|. ..|||.||...||||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase T01H8.1a.AA p70 104-363 48 2.5e-145 489.12 In-house 1-299 (299) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-299/299
Sequence Identity: 48% (145 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKA--TLKVRDRQRTK-------------------------LERNILAHISHPFIVKLHYAFQTE
||||||||.| .||||.|||| |.|.| .||||||.||  .   .| . |.                          |||||  . ||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKK----------TYSFCG
|||||||..| || ||. | .. .. || ..|||.| ..||||||..||.||||||||..|.. ||.. |||||.|| |   ..          |..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAK--LSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
| ||||||.. | ||. | | ||||.||. ||||  || |  | .|.  |||.|  |..|  ||.|.  |...| ||. . |.||||. ...|..|.||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase T01H8.1a.AA Akt 104-363 49 5.5e-145 466.45 In-house 1-264 (264) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-264/264
Sequence Identity: 49% (133 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVY-AMKVLKKATLKVRDR-QRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.|||||||||.|    |.. .| |||||||  .  ..  . || ||||| |. |||||.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEDDVKFYLAELTLALEHLHSLGIVYRD-LKPENILLDADGHIKVTDFGLSKEA-IDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWS-LGVLMFEML
.||  .|| ||. ||.||||| .|.||| |||||||.|.||||..|||||.||  |    ||..|||| ||.|||..|  ||..|.|.|. ||..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGHLPFQGRDRNDTMTQILKAKLSMP--HFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
.| .||  .|.   . .|. ... .|  ... .|...|.. | ...  .|||.||....||||| .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase T01H8.1a.AA AktR 104-363 45 1.9e-120 406.48 In-house 1-268 (268) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-268/268
Sequence Identity: 45% (122 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKK-ATLKVRDRQRTKLERNILA-HISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|...|.||.| ||||.||.| |  |.. .||||..||    . . ...| .||||.. ...|||||||||.|||. ||..|... .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEDDVKFYLAELTLALEHLHSL-GIVYRDLKPENILLDADGHIKVTDFGLSK-EAID-SEKKTYSFCGTVEYMAPEVINR-RGHSMAADFWSLGVLMFEM
.|....|| |.  ||||.||.   |.|||||||||||| |||.| ||||||| . ..  . |.||||||.||||||.|..  ||  ..|.|..|.. .||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGHLPFQGRDRNDTMTQILKAK-LSMPHF--LTQEAQSLLR-ALFKRNSQNRLGAGPDGVEEIKRHAFF
.||. ||.  ..|.    |..   .. |    .......|.   |...| ..||| .  | ||||.| .|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase T01H8.1a.AA MSK 107-358 39 4.1e-107 362.15 In-house 1-277 (277) Show / Hide 
Range on Protein: 107-358
Range on HMM: 1-277/277
Sequence Identity: 39% (109 aa)

LKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKAT--LKVRDRQRTKLERNILAHI-SHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|. ||.|..||....|.| .||||.|.|||  .| .    |. || .| .. .||.||.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

DDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDAD---GHIKVTDFGLSKEAIDS-EKKTYSFCGTVEYMAPEVINR-----RGHSMAADFWSLGVLM
. . ....|| .|..|.|..||..|||||||||.| .   ||.|..|||....   . |....|.|.| .|||||...|      |.. | | |||||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGHLPFQ--GRDRN-------DTMTQILKAKLSMP----HFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIK
..||||. |||  ..||        . |  |.|.. | |        ..|. |.. |  .. . |||... ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase T01H8.1a.AA S_TKc 104-363 34 5.6e-106 359.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-231/231
Sequence Identity: 34% (93 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|.||||...|...   .|...|.|..|         .... |..|| .  ||.||||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSM-AADFWSLGVLM
     |.| ...||.... .|||..||.||..|||||||||||   |||..||||...        ..|||| .||||||.   |..  ..| ||.|...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGAGPDGV--EEIKRHAFF
.|||.|  ||.      .| ...|  .      ..|| ...| ..... ..|..|       ..|| | .|
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T01H8.1a.AA Pkinase 104-363 29 2.4e-94 324.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKL--ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||||.|.. ...  ..   ..|.|..|| . |   .|.  .  |  |.....||.||.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHI----KVTDFGLSKEA-IDSEKKTYSFCGTVEYMAPEVIN-RRGHSMAADF
 ..  |  .|...|||. ..  .||..|| ||..|||||||||.| .|||    |..||||.| . . .   ...|||| .|||||||. ..... ..| 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSLGVLMFEMLTGHLPFQGR------DRNDTMTQILKAKLSMPHFLT---------------------QEAQSLLRALFKRNSQNRLGAGPDGVEEIKRH
||.|....|||.|..||.|.      | .  . .|....|. . . .                     .|...... ..... . |..      |.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

AFF
 .|
PWF
Kinase T01H8.1a.AA CAMK 109-363 21 7.9e-89 286.29 In-house 1-425 (425) Show / Hide 
Range on Protein: 109-363
Range on HMM: 1-425/425
Sequence Identity: 21% (94 aa)

VLGQGSFGKVFLVRKVRGR----------DSGHVYAMKVLKKATLK--------------------------VRDRQRTKLERNILAH-------ISHPF
.||.||||||.|..  .            . |. .|.|...|  ||                           .||.. . | .|. .       ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEDDVKFYLAELTLALEHLHSL
|.||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .  |....||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIVYRDLKPENILLDAD-----------------GHIKVTDFGLSKEAIDSE-----------------------KKTYSFCGTVEYMA-PEVINR----
.|| ||||||||||| .                 . ||..|||.... ...|                       .| . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMT-------------QILKAKLSMPHF------------------------LTQEA
          .... ..| ||.||... ||.|..||.| ..|...              .|.|.| ..|..                        ..||.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
..|.| . ... ..|. .     |....| ..
KDLIRKMLQVDPEKRMTI-----EQCLNHPWM
Kinase T01H8.1a.AA Ciliate-E2 104-363 25 5.4e-87 295.33 In-house 1-365 (365) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-365/365
Sequence Identity: 25% (96 aa)

FELLKVLGQGSFGKVFLV--RKVRGR------------------DSGHVYAMKVLKKATLKVRDRQRTKL-----------ERNILAHISHPFIVKLHYA
....|..|||.||.|...  .||. .                  . .  ||||..||  ..   .    .           |.||| ...||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEDDVK-------FYLAELTLALEHLHSLG-IVYRDLKPENILLDADGHI
||  .. ..||..... ||||| ..                   ||.  ...  ..       ||.|.. ||||.||| . |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KVTDFGLSKEAIDSEK-------------------------------KTYSFCGTVEYMAPEVINRRG---------HSMAADFWSLGVLMFEMLTGHLP
|..||||||.. |...                                ....||| .|||||..|. .         .. ..|.|||||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGRDRNDTMTQILKAKLSMPHF------------------LTQEAQSLLRA----LFKRNSQNRLGAGPDGVEEIKRHAFF
|        . ||.. |.. | .                  ..||.. |..     ..... ..|..    | |.|. | .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase T01H8.1a.AA Ciliate-E2-Unclassified 104-363 26 2.4e-85 289.87 In-house 1-352 (352) Show / Hide 
Range on Protein: 104-363
Range on HMM: 1-352/352
Sequence Identity: 26% (93 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTK---------LERN--------------ILAHISHPFIVKLHYAFQTEGKLY
....|..|||.||||.....   .. . .|||| .||.  . .  ...|         ....              || .. ||||||..|.||.. ..|
YKIIKQIGQGGFGKVYKCQH---KKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LILDFLRGGDLFTRLSKE-----------------VMFTEDDVK-----FYLAELTLALEHLHSLG-IVYRDLKPENILLDADG---HIKVTDFGLSKEA
.......||||.  ..|                   .|||  .|     ||.|.. ..||.||. . |..||.||||||.| .|   .||..|||.||. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

IDS---------------EKKTYSFCGTVEYM----APEVINRRGHS----MAADFWSLGVLMFEMLTGHLPFQGRDRND----------------TMTQ
...               ......|||| .||    ||||. . ...     ..|.|||||...|||.| .||.......                   .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

ILKAKLSMPHFLT--------QEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF
|.. ... |.|          .||. ... |.... .....  . . |.|. | .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI-TFEQILNHPWF
Kinase T01H8.1a.AA S_TK_X 364-425 39 6.3e-22 80.09 SMART 1-79 (79) Show / Hide 
Range on Protein: 364-425
Range on HMM: 1-79/79
Sequence Identity: 39% (31 aa)

AKIDFVKLLN--KEIDPPFKPALS----TVDSTSYFDPEFTKRTPKDSPALPASANGHEI-----------FRGFSFVS
..||. ||.|  ||| ||||| ..        ||.||||||. ||...|. |.. |..             ||||..| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase T01H8.1a.AA Pkinase_Tyr 104-316 26 1.6e-20 70.09 Pfam 1-228 (270) Show / Hide 
Range on Protein: 104-316
Range on HMM: 1-228/270
Sequence Identity: 26% (61 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVY--AMKVLKKATLKVRD--RQRTKLERNILAHI-SHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRL
 ...|.||.|.||.|.. .     .... .  | |.| | .   ..  |.    | .|. .. .|| ||.|. .    ..   .|... .  .||| . |
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SK----EVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCG----TVEYMAPEVINRRGHSMAADF
 |    .  .|  |   . ..   ..|.|.| ... |||   |.|.. ....|..||||..   . .   |   |     .  ||||.|| .  . . | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSLGVLMFEMLT-GHLP-FQGRDRNDTMTQI
|| ||||.|..| |  | ..| . .. . .|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase T01H8.1a.AA TyrKc 104-362 24 5.2e-17 52.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 104-362
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHI--SHPFIVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | ||.|.. .           | |.||. .     |.    | .|. ..  .|| ||.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEDDVKFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDS-----EKKTYSF----CGT----VEYMAPEVINRRG
| |    .. .|   .        |.||| ... |||   |.|.......|..|||||..  |      .|..|.     .|     .  ||||.|| . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HSMAADFWSLGVLMFEMLT-GHLPFQGR----DRNDTMTQILKAKLSMPHFLT----------QEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAF
 . . | || ||.|.|..| |  |  |       |. . . .|.   ||              .|  .. .   ...  .|        .|| .. |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTF-----SEI-HECF
Kinase T01H8.1a.AA Pkinase_C 383-427 38 4.1e-12 45.88 Pfam 1-46 (46) Show / Hide 
Range on Protein: 383-427
Range on HMM: 1-46/46
Sequence Identity: 38% (18 aa)

ALSTVDSTSYFDPEFTKRTPKDSP--ALPASANGHEIFRGFSFVSNA
 ..  . ||.||||||. .|.|.|      |.. .| ||||..|.  
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase T01H8.1a.AA RSK 454-712 51 8.70000000001e-176 590.28 In-house 1-271 (271) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-271/271
Sequence Identity: 51% (141 aa)

YEILEKIGNGAHS---VVHKCQMKATRRKYAVKIVKKAVFDAT-----EEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGS
||..|.||.|..|   |..|||.|.|...||.||.|||..|..     ||..|.||..||.|.|||..|..||...|||.....||.|.|.|...|.. |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMF-S

EKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTML
|.||...||....|..|||||...||||...|||.. ..|.|....|.|||||||.|.|||||||.||||...|||||..||.|..||.||.|||...||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTA-----KQALQHKWI
||||||...|.|||..|.||...|..||||..||.||||||||.|.||..||..|..|     .|..||.|.
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase T01H8.1a.AA RSK 456-712 39 7e-140 471.0 In-house 1-278 (278) Show / Hide 
Range on Protein: 456-712
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

ILEK--IGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDAT--------EEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLG-
. ..  .|.|......||....|.. ||.|..|||.....        .|..||.|. .|.|.|.|......|. .|.| |.|.||||...| ..|..| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-SEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAE-NGMLMTPCYTAQFVAPEVLR---KQG-YDRSCDVWSLG
 ||.|....||..  ||..||.|.. ||||   |||.. .. .. .....||||.||.|.. |...||.|||....|||.|.   .|| .|..||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLLHTMLTGCTPFAMGPND-TPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVT-----AKQALQHKWI
||...|||||.||.. ||| ....|..|.. ||.|.|.| |...|.|||||.|||| .||..| .     |.. .||.|.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase T01H8.1a.AA AGC 454-712 22 6.7e-102 263.65 In-house 1-395 (395) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

YEILEKIGNGAHSVVHKCQMK------ATRRKYAVKIVKKAV---------FDAT-------------EEVDILLRHSH---------HQFVVK-LFDVY
.|.|  || |. . |. ...|      .| . ||.|..||..          . |             || .|| . .|         |.|.|| |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EDETA--IYMIEELCE---------GG-ELLDKLVNK-KSLGSEKEVAAIMAN--------LLNAVQYLHS-QQVAHRD-LTAANILFALKDGDPSSLRI
.|..   .|.. |...         || ||.  | .. |.   . |.| ..|         .. |..|||| . . ||| |   |||.  .      ...
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

VDFGFAKQSRAE-----------------------------------------------------NGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWS--L
.|||..|. . .                                                     .  .  || |....|||.|    |...|| ||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GVLLHTMLTGCTPFAMGPND-------TPDQILQRVGDGKISMTHPVW------------DTISDEAKDLVRKMLDVDPNRRVT----------AKQALQ
|.|.  ||||..||   ...       .|... |.. .|.. ....|             . .|.|||||..|.| .||..| .          |..  .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HKWI
|.| 
HPWF
Kinase T01H8.1a.AA CAMK 459-712 23 3.4e-96 310.45 In-house 1-425 (425) Show / Hide 
Range on Protein: 459-712
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

KIGNGAHSVVHKCQMKATR------------RKYAVKIVKKA-------------------------------VFD-ATEEVDILLRHS------HHQFV
..| |. ..|..|. | |             .|.|.||..|                                  .    |..|. . .      .|  .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLFDVYED-------------------ETAIYMIE---ELCEGGEL----LDKLVNKKSLG--------------SEKEVAAIMANLLNAVQYLHSQQV
.||..||||                   .. .||.    |.|.||||    .|..| ... |              .|.|.. ..  .. ||.|.||. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDLTAANILFALKDGDP-------------SSLRIVDFGFAKQSRA-----------------------ENGMLMTPCYTAQFVA-PEVLRK------
.||||   |||.  ...|                . |.|||||.. .                        |. .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDRSCDVWSLGVLLHTMLTGCTPFAMGPND----------TPDQILQRVGDGKISMTHPV------------WDTISDE--------AKD
        ..|...||.||.||.| .||.|. ||    ..          .. ......  || .. .|             || ||||        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVRKMLDVDPNRRVTAKQALQHKWI
|.|||| |||..| |..|.|.|.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase T01H8.1a.AA S_TKc 454-712 35 1.4e-95 324.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEG--GELLDKLVNKKSL-----GSE
||||.||| || ..|.||. | | |..|.||.|    ..  |..|| .  || ..|||.||..| . .||. |.|.|  |.|.| ......       .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

KEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENGMLMTPCYTAQFVAPEVLRKQGYDR-SCDVWSLGVLLHTML
 ... .|. ...|..|.||... ||||  .|||.         . | |||.|.|        .| | |  ..|||||   ||.. .||.||.|..|  ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

TGCTPFAMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQ-------HKWI
.|..||      .........|              |.||||..||.|..||..| || .|||       | |.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T01H8.1a.AA Pkinase 454-712 33 7.8e-89 306.22 Pfam 1-293 (293) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATE--------EVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGG----ELLDKLV--N
|.|..||| |. ..| ||. | |....||||.||   .  .        |. |..|  .| ..|.|.|..||.. |||. |.||||    .| | .   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKSL-GSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDP-SSLRIVDFGFAKQS-RAENGMLMTPCYTAQFVAPEVLR-KQGYDRSCDVW
.... .||.|.  .|  .| ...|.||. . ||||  .|||.  ..|.. ....| |||.|||     |. ..|.| |  ..||||.|  |.|....|.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SLGVLLHTMLTGCTPFAMG----PNDTPDQILQRVGDGKISMTHPVWDTIS-----------------DEAKDLVRKMLDVDPNRRVTAKQALQHKWI
|.|..|. ||.| .||       . ....|...|.......   | |..||                 .|.||.....|..||..| ||.|.|||.|.
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase T01H8.1a.AA Ciliate-E2 454-712 25 4.4e-84 285.66 In-house 1-365 (365) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YEILEKIGNGAHSVVHKCQMKATRRK-----------------------YAVKIVKKAVFDATEEVDILLR----------------HSHHQFVVKLFDV
|....|||.|....| ||. . ....                       ||.||.||    ... .. ..|                .  | ...|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--DETAIYMIEELCEGGELLDKLVNKKSLG----------SEKEVAAIMANLLN---------------AVQYLHSQQ-VAHRDLTAANILFALKDGD
..  |.. ||.. |.|.||.|.| . |.|             .|||.. ||. .|.               |..||||.  . |||.   ||||      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PSSLRIVDFGFAKQSRAENG-------------------------------MLMTPCYTAQFVAPEVLR---------KQGYDRSCDVWSLGVLLHTMLT
   . |.|||..|.   .|                                |  | |.|. ..|||.|.         ..||| .||.|||||.|. ||.
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GCTPFAMGPNDTPDQILQRVGDGKISMTHP--------------VWDTISDEAKDLVRK----MLDVDPNRRVT-AKQALQHKWI
| .||           .|   ..||.   |               |. .|.|.||| .|    ||..||. | | ..|.|.|.|.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase T01H8.1a.AA MSK 454-712 31 1.7e-78 264.94 In-house 1-277 (277) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-277/277
Sequence Identity: 31% (88 aa)

YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVK------KAVFDAT--EEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGS
 . | ..|.|. ....||  . |   ||.||..      |. . ..   |. .|..   | ..|.|.... |..  |.. |.| ||||. ..  ..   .
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHF-D

EKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAE-NGMLMTPCYTAQFVAPEVLR----KQG-YDRSCDVWSLGV
|.|.. ||. |  ||...|.  . ||||   ||||. .. |   ....|||||.   .. .  . .||.| .. |||.||    ..| || .||.|||||
ESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEE-DNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV

LLHTMLTGCTPFA---MGPN---DTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWI
.| |||||. ||.    .      .   | .|.  |. | .   | ..| .||||....| .||..| ..   ..| |.
ILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase T01H8.1a.AA Ciliate-E2-Unclassified 454-712 26 9.3e-67 228.09 In-house 1-352 (352) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-352/352
Sequence Identity: 26% (94 aa)

YEILEKIGNGAHSVVHKCQMKATR-----------RKYAVKIVKKAVFDATEEVDILLRH------------------SHHQFVVKLFDVYEDETAIYMI
|.|...||.|....|.||| | .            ..|..|....   .   | ... ..                  . | |.||.|.. .|.  ||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

EELCEGGELLDKLVNKKS----------------LGSEKEVA-----AIMANLLNAVQYLHSQQ-VAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSR
 |.||||.|.. . ..|.                  .|....      ..| .|.. .|||... . |||..  ||||  . .    ..| |||..|.. 
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQ

AENG---------------MLMTPCYTAQFV----APEVLRKQGYDRS----CDVWSLGVLLHTMLTGCTPFAMGPNDTPDQ--------------ILQR
  |.               |. | | | ..     |||||..|.|| |    ||.|||||.|. ||.|  ||  ..|.. .|              ..| 
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF-YDNNCEQHQQLITQWINNAYRKQLYQN

VGDGKISMTHPVW----DTISDEAKDLVR----KMLDVDPNRRVTAKQALQHKWI
  ...|.  .  |    ...|.||||...    |||...|| | |..|.|.| |.
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase T01H8.1a.AA AktR 454-712 27 3.6e-37 129.82 In-house 1-268 (268) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-268/268
Sequence Identity: 27% (77 aa)

YEILEKIGNGAHSVVHKCQMK-ATRRKYAVKIVKK-------AVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGS
..... .|.|| . |  .| |  . ..|| |..||       .   .  | .|.  .. | | |||..  .... .. | | |.||||.. | .|| . |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF-S

EKEVAAIMANLLNAVQYLHSQ-QVAHRDLTAANILFALKDGDPSSLRIVDFGFAK--QSRAENGMLMTPCYTAQFVAPEVLRK-QGYDRSCDVWSLGVLL
|...  ..|  | |..|||..  .  |||   |||   .||    ..|.||| .|    .... .  . | | . .|||...| .|...|.| |..|...
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLD-EDGH---VKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFI

HTMLTGCTPFAMGPNDTPDQILQRVGDGKISMT-HPVWDT--ISDEAKDLVR-KMLDVDPNRRVT-----AKQALQHKWI
  |.|||.||        ..  ..  . ... .  .. ..  .|...|||.  | |. .|| | .     ...   |.| 
YEMVTGCPPFY-------HKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase T01H8.1a.AA p70 505-712 27 3.8e-23 80.71 In-house 87-299 (299) Show / Hide 
Range on Protein: 505-712
Range on HMM: 87-299/299
Sequence Identity: 27% (61 aa)

HQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAE
| |...|.  . ..   | | |   ||||   |  ...   |  .   ..    | ..||.. .  |||   |..  .. |    .   |||  |.|  .
HPFICDLHYAFQTNGKLYLILEYLHGGELFMHL-ERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQ-GH---VVLTDFGLCKESIHD

NGM----------LMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPF-AMGPNDTPDQILQRVGDGKISMTHPVWDTISDEAKDLVRKML
  .          . | | |  . |||.|.. |... .|.||||.|.  ||||  || .  . .| | ||.    ||  .. |     . |..||..|.|
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILK----GKQGLKLPPY--LTHEMRDLIKKLL

DVDPNRRVT-----AKQALQHKWI
  .|  | .     |..  .|.. 
KRHPTQRWGAGPEDAADIQEHPFF
Kinase T01H8.1a.AA TyrKc 454-712 20 1.6e-14 11.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 454-712
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YEILEKIGNGAHSVVHKCQMKATRRKYAVKIVKKAVFDATEEVD---ILLRHS--HHQFVVKLFDVYEDE-------TAIYMIEELCEGGELLDKLVNKK
 . ..|.|.||  .|.|...|   .. ||| .|.      |.      ....   ||. .|.|. |  ..         .... |....| |.| | ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

SLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAE------NGMLMT----PC---YTAQFVAPEVLRKQGY
   . |.   ..    .  .||||... |||| | |.| . .       .| ||| ..    .        . ..     .         |||....  .
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DRSCDVWSLGVLLHTMLTGCTPFAMGP---NDTPDQILQRVGDGKISMTHPV-----WDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWI
    |||| ||..  ..| . .   |.     ........| .|.  .  |        . .||  .. ..  . ||. | | ..   |. .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase T01H8.1a.AA Akt 590-651 31 3.4e-14 41.68 In-house 140-203 (264) Show / Hide 
Range on Protein: 590-651
Range on HMM: 140-203/264
Sequence Identity: 31% (20 aa)

LRIVDFGFAKQS-RAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWS-LGVLLHTMLTGCTPF
... ||| .|.    .. . .| | |.   |||.| ..|.....| |. ||...  |..|  ||
ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase T01H8.1a.AA Pkinase_Tyr 454-641 26 2e-12 42.7 Pfam 1-204 (270) Show / Hide 
Range on Protein: 454-641
Range on HMM: 1-204/270
Sequence Identity: 26% (56 aa)

YEILEKIGNGAHSVVHKCQMK----ATRRKYAVKIVKKAVFDATE--------EVDILLRHSHHQFVVKLFDVYE-DETA--IYMIEELCEGGELLDKLV
 ....|.| ||  .|.|. .|     |. . |||.. |   .  .        |. |.    ||. .|.|  |   ..    ||.. |....| ||| | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

NK---KSLGSEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQS-------RAENGMLMTPCYTAQFVAPEVLRKQGY
..   |   . |.   . .   .. .||.|..  |||| | |.| .    ..   .| ||| |.         |.  |  .    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DRSCDVWSLGVLL
    |||| |||.
TTKSDVWSFGVLM
Kinase T01H8.1a.AA Akt 679-700 50 0.000117 10.72 In-house 226-247 (264) Show / Hide 
Range on Protein: 679-700
Range on HMM: 226-247/264
Sequence Identity: 50% (11 aa)

DTISDEAKDLVRKMLDVDPNRR
|.||.|.|||....|  ||..|
DWISPECKDLISGLLNKDPKKR