Gene T05C12.1 (Nematode worm)

T05C12.1

Species: Nematode worm
Alias: CE02312, T05C12.1, aSWK103
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:0.78, WormBase Physical Map location: II: 8173621-8174743

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
T05C12.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
T05C12.1.AA Protein Genbank 325 None Fasta, JSON

Protein domain

Protein domains of T05C12.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T05C12.1.AA TTBKL 46-305 40 1.6e-144 486.4 In-house 1-288 (288) Show / Hide 
Range on Protein: 46-305
Range on HMM: 1-288/288
Sequence Identity: 40% (117 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATT-ND-SQRMILESKVLDDML--GSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIRKMMPNKK-IS
....|||..|||||||...........|...|  .. .. ..||..| .||  .   ||.|||.... | ...|||.||...|.|..|.|||||||| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

ILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEK----RKTVYLVDFGMSRKFRNDNGSL-----------RESRT---YCGFRGTTRYCSYRM
  ...|||||...|| ..|..|..|||.||.|||.|. ..    ...|||.||||.|......|..           |. |.   ...|||||||||..|
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HDRREQGPVDDLWCLYYSLGELIEGCLPWRDIESADEMAHVKKILKHEDIF------HSMPSKFASFGRNLRRLRPANTPDYTKFQNIL
|||.|||..||||...|.. || .| |||...|...|..|.|| .|.||.|      |..|| |..| ..||.||.. .|||.......
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase T05C12.1.AA CK1 46-301 29 4.5e-107 362.01 In-house 1-339 (339) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-339/339
Sequence Identity: 29% (99 aa)

FVVEKMIAGGGFG-QVYRA-----RNTETQ-----EEVAVKVERATTN--DSQRMILESKVLDDMLG---------SKHFPN----------VYYIGPYH
. |.|.|..|||| |.|..     ......     ||.|.|||.....  ..|.|...  ..    |         .|||..          ..| |  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

S-YNFIVMQMLGKNIGDIRK--MMPNKKISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGL-------------DEKRKTVYLVDFGMSR-KFR
  ||..||..||.|..|.||  .|.|.|.|  ....|.||..|||  .|..|..|||.||.|.|.|.             ......||..||||.| |.|
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NDNGSL------------RESRT---YCGFRG-TTRYCSYRMHDRREQGPVDDLWCLYYSLGELIEGC--LPWRDIESADE-----MAHVKKILKHEDIF
...|.             |. |.    .|||| |.|||| ..|...|||..||||.. | | |.. |.  |||..... ..     . . |.  ..|. .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

------------HSMPSKFASFGRNLRRLRPANTPDYTKF
            |..|. |  .   .| |..  .||| ..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase T05C12.1.AA TTBK 46-301 36 3.1e-69 236.32 In-house 1-257 (257) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-257/257
Sequence Identity: 36% (95 aa)

FVVEKMIAGGGFGQVYRARNTETQ-EEVAVKVERATTNDSQRMILESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIRKMMPNKKISILSS
  | | | ||||| .| | .  .. |.||.||| | .   | . .|  ||  . | .|    .  |    .|..|||..|||  | |   |  . |. . 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPK-QVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT

VRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLD-EKRKTVYLVDFGMSRKFRNDNGSLRESRTYCGFRGTTRYCSYRMHDRREQGPVDDLWCLYYSLGE
.|.|.||....   || |.|||| || |  .|.  .... .|..|||. |.. |  |  |  |   ||||| || |   |  || |  |||| |.| | |
LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LIEGCLPWRDIESADEMAHVKKILKHEDIFHSMPSKFASFGRNLRRLRPANTPDYTKF
 ..| |||| |   |.  ..|.   | ..   .|. |  |   .. |  . .|||  .
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase T05C12.1.AA Worm6 46-269 36 2.9e-66 226.48 In-house 1-240 (279) Show / Hide 
Range on Protein: 46-269
Range on HMM: 1-240/279
Sequence Identity: 36% (87 aa)

FVVEKMIAGGGFGQVYRARNTETQE--EVAVKVERA-TTNDSQRMILESKVLDDM--LGSKHFPNVYYIGPYHS--YNFIVMQMLGKNIGDIRKMMPNKK
. |.| |. |||| || . .... .  ..|.|.|.   .. .|   .|  ||      ...||...   | . .  .|.|||...||| .|.||  |..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

ISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGL-----DEKRKTVYLVDFGMSR--KFRNDNGSLRESR-TYCGFRGTTRYCSYRMHDRREQGP
.|   . .|.|| .||.  ||. |..|||.|| | | |      |....|.|..||||.|  |..|....||  | | ||||||.||..   |...||..
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

VDDLWCLYYSLGELIEGCLPWRDIESADEMA-HVKKILKH
 ||. .  | . |.| |||||| ..  |. . | |.. ..
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRR
Kinase T05C12.1.AA CK1-Unclassified 46-234 31 1e-46 135.9 In-house 1-199 (244) Show / Hide 
Range on Protein: 46-234
Range on HMM: 1-199/244
Sequence Identity: 31% (63 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDSQRMILESKVLDDMLGSK-------HFPNVYYIGPY--HSYNFIVMQMLGKNIGDIRKMMPN
. |.. |  | ||..| . |..|.||||.|.|....  .     | |.. .. . .       ..|..|. |      ||..||  ||... |. .|. |
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-N

KKISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLG-LDEKRKTVYLVDFGMSRKFR--NDNGSLRESRTYCGFRGTTRYCSYRMHDRREQGPVDD
.| |.     |. |.|. . .||.|. .|||.|| | . | |  ....||..||| | ...    .|.  . |   .. ||.|| | ..|   ||.  ||
RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD

L
|
L
Kinase T05C12.1.AA CK1 46-234 28 8e-40 134.83 In-house 1-199 (271) Show / Hide 
Range on Protein: 46-234
Range on HMM: 1-199/271
Sequence Identity: 28% (58 aa)

FVVEKMIAGGGFGQVYRARNTETQEE---VAVKVERATTNDSQRMILESKVLDDMLG------SKHFPNVYYIGPY--HSYNFIVMQMLGKNIGDIRKMM
. |.. |  | ||..| . |. |..|   ||.|.|....  .     |.|..  . |      ....|..|. |.     ||..||  ||..  |  ...
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC

PNKKISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGL-DEKRKTVYLVDFGMSRKFR-NDNGSLRESRTYCGFRGTTRYCSYRMHDRREQGPVD
 |.| |.   . |. |.|. .  .|.|. .|||.|| | . |.   . ..||..|||.. ..|  ....  . |.  .. ||.|| |  .|  .||.  |
-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD

DL
|.
DM
Kinase T05C12.1.AA CK1-D 46-301 29 3.5e-38 132.25 In-house 1-261 (261) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-261/261
Sequence Identity: 29% (77 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDSQRMILESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIRKMMPNKKISILSSV
. . . | .| ||..|   | .| ||||.|.| . |   | . .|||.   | |    |.. ..|    || .||..||  . |.     ..| |.   .
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQ-LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVL

RIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRKTVYLVDFGMSRKFRNDN-GSLRESRTYCGFRGTTRYCSYRMHDRREQGPVDDLWCLYYSLGEL
 .. |.|  .  .|.. ..|||.|| |  .||  . ..||..|||.....|  .       |      || || |   |   ||   |||  | | |   
MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

IEGCLPWRDIESADEMAHVKKILKH------EDIFHSMPSKFASFGRNLRRLRPANTPDYTKF
  | |||  .  |       .|         ... . .||.|. .    |.|.  . |||. .
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase T05C12.1.AA CK1-A 46-301 26 5.3e-35 121.06 In-house 1-261 (261) Show / Hide 
Range on Protein: 46-301
Range on HMM: 1-261/261
Sequence Identity: 26% (71 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDSQRMILESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIRKMMPNKKISILSSV
. . . |  | || .| . |..  ||||.|.|..     | .| |.||   . |   .|.. . |  . || .||..||  . |.  .  ... ..   .
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQ-LIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVL

RIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRKTVYLVDFGMSRKFRNDNGSLR-ESRTYCGFRGTTRYCSYRMHDRREQGPVDDLWCLYYSLGEL
 .  |.|  .  .| |...|||.|| |  .|..     ..|.|||...|.|  .     . |.     || || |   |   ||   ||.  . | .   
MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

IEGCLPWRDIESADEMAHVKKILKH------EDIFHSMPSKFASFGRNLRRLRPANTPDYTKF
  | |||  .. .       ||.        | .   .|. |. .    | ||  ..|||.  
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase T05C12.1.AA CK1-Unique 46-252 23 2.8e-23 77.58 In-house 1-233 (337) Show / Hide 
Range on Protein: 46-252
Range on HMM: 1-233/337
Sequence Identity: 23% (55 aa)

FVVEKMIAGGGFGQVYRARNTETQ-----------EEVAVKVERA---TTNDSQRMILESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIR
. | | | .||.| |.|     .             .  . . .    ...    |   .|.    . ..||. |  ..   .. .|||.|.|...  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KMMPNKKISIL------SSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDE--KRKTVYLVDFGMSRK--FRNDNGSLRESRTYCGFRGTTRYCSYR
 || | ..           .. | |. ...   |  | .||..|| | |..     . .. |  |.| .|.  |   |...|  |    |||. .||.  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

MHDRREQGPVDDLWCLYYSLGELIEGC--LPWR
 |  ||.|  ||.  ..|.|  |. .   | |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase T05C12.1.AA Dual 116-234 33 1.8e-22 72.28 In-house 87-206 (282) Show / Hide 
Range on Protein: 116-234
Range on HMM: 87-206/282
Sequence Identity: 33% (40 aa)

NFIVMQMLGKNIGDIRKMMPNKKISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRKTVYLVDFGMSRKFRN-DNGSLRESRTYCGFRGT
...||   |  . .||. . ..  |   |  ..|| ..|.  ||| |.|||. || |   ||...  |||. ||.. ||.    |.  |  |.   . |.
KYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGC

TRYCSYRMHDRREQGPVDDL
 || .      ..||  |||
GRYACRACMMQKDQGRKDDL
Kinase T05C12.1.AA Pkinase 46-275 20 2.5e-19 69.4 Pfam 1-239 (293) Show / Hide 
Range on Protein: 46-275
Range on HMM: 1-239/293
Sequence Identity: 20% (51 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDS-QRMIL----ESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKN---IGDIRKMM--P
..... |  |.||.||....  |...||||. .  ...| .....    | ...  . ....    |..  ....  .||  ...    .   . ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NKKI--SILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRK--TVYLVDFGMSRKFRNDNGSLRESRTYCGFRGTTRYCSYRMHD-RREQGP
....  |     ..  ||...|  .||.| .|||||| |. .  ..     .| . ||| ...|.     .  .. . .| || .|..   .  ... ||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

VDDLWCLYYSLGELIEGCLPWRDI----ESADEMAHVKKILKHEDIFHS
  | | .   | |.. | .|...     . .|.|. ...|.. .  |..
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDW
Kinase T05C12.1.AA S_TKc 46-321 17 3.1e-15 46.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-321
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDSQRMILESKVLDDMLGSKHFPNVYYIGPYHSYNFIVMQMLGKNIGDIRKMMPNKK-------
. . . |  |.||.||..|...|...||.|. .      .... | ..|    . ..  . |..    .. ..|| ... . || .... ...       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

ISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRKTVYLVDFGMSRKFRNDNGSLRESRTYCGFRGTTRYCSYRMHDRREQGP-VDDLWCL
..     ..  ||..||  .||.| .|||||| |  |       .. . |||..|..               | ||  |..  .      |.   | | .
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

YYSLGELIEGCLPWRDIESADEMAHVKKILKHEDIFHSMPSKFASFGRNLRRLRPANTPDYTKFQNILAYCVKF-------VDDNAE-------FEWD
   | |.. |. |..      .|. . |...                                . ...  | ..       . .  .        .| 
GCILYEMLCGYPPFP------QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T05C12.1.AA TyrKc 46-290 18 1.2e-07 -99.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-290
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

FVVEKMIAGGGFGQVYRARNTETQEEVAVKVERATTNDSQRMILESKVLDDMLGSKHFPNV-----YYIGP-----YHSYNFIVMQMLGKNIGDIRKMMP
 . .|..  | ||.||... .   ..||||. .. .   . .. | ...  .|| .| ||.     . . .     |    .|||    .  || ..   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIM-CKLG-GHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLR

NKK--ISILSSVRIGIQIIEALSLLHSKGWLHRDLKPTNCCLGLDEKRKTVYLVDFGMSRKFRND--NGSLRESRTYC-----GFR--GTTRYCSYRMHD
...  ..    . . .|| .  . ||||.  ||||   || .| .    ||   |||.||.  .|  .|   .. .|      | .     | ..    .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECIN

RREQGPVDDLW----CLY--YSLGELIEGC-----LPWRDIESADEMAHVKKILKH-----------------EDIFHSMPSKFASFGRNLRRL
 ..  .  | |    |..  ...|.          ......    .  .  .. ..                 ..  |  |..  .|    ...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase T05C12.1.AA CK1 264-299 27 0.026893 3.95 In-house 235-271 (271) Show / Hide 
Range on Protein: 264-299
Range on HMM: 235-271/271
Sequence Identity: 27% (10 aa)

KKILKHEDIFHS-MPSKFASFGRNLRRLRPANTPDYT
|  . .|. .    |. || . .  |.|. ...|||.
KMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase T05C12.1.AA Dual 295-305 63 0.033477 3.05 In-house 272-282 (282) Show / Hide 
Range on Protein: 295-305
Range on HMM: 272-282/282
Sequence Identity: 63% (7 aa)

TPDYTKFQNIL
||||  | | |
TPDYDYFRNCL