Gene T08G5.2 (Nematode worm)

T08G5.2

Species: Nematode worm
Alias: aSWK352, T08G5.2, CE21175
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: V:5.77, WormBase Physical Map location: V: 14028104-14023800

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
T08G5.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 237 Kinase domain by global Sugen HMM Fasta, JSON
T08G5.2.AA Protein Genbank 728 None Fasta, JSON

Protein domain

Protein domains of T08G5.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T08G5.2.AA Fer 35-271 23 6e-83 281.88 In-house 1-283 (283) Show / Hide 
Range on Protein: 35-271
Range on HMM: 1-283/283
Sequence Identity: 23% (66 aa)

FEDDDILWLEDFCDSYRF------------------FTGNFHECAVKIDRNQKDPCVQDYLVNSPYFMPNVVKFFGIAASRDPFMIAIEFCAADSLENKL
......|.  .|.. |..                  .  . ..|..... ..|. . . ......| .||||||.|..... |.|| .|||  .||...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

KKVP---ITDFEKIRYLFQAANGLDYLHELGIVR------NCLLTDDDILK---IADFGLSAD----KGGTKHR--AEMVPVRYMAPEAVEKMISTKESD
|| .   ..|.||||...|||.|..|||. ...       |||...|.. |   |.|||.| .    .   |..  |..||.|..|||.....| ....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VYAFSVLIFEVFHKAYEPFGE---------Y-GPRERVPEALGKDEVRLLQFEEILYQFRCGNCQNMYFKFSTAELHFKNIFL
|..|.|...|.|....||...           ... .. .  |.     ... . ..|. ...| .....  .   ...... 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase T08G5.2.AA TK 85-230 16 5.8e-36 117.49 In-house 103-417 (486) Show / Hide 
Range on Protein: 85-230
Range on HMM: 103-417/486
Sequence Identity: 16% (51 aa)

PNVVKFFGIAASR------------DPFMIAIEFCAADS----LENKLKKVP------------------------------------------------
||.|...|.                 |.||  |...  .    | . |.| .                                                
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

-----------------------------ITDFEKIRYLFQAANGLDYLHELGI------------VRNCLLTDDDI-----------LKIADFGLS---
                             .|  ... . .|.|.|. |||....             ||||......            ||||||||   
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQG

---------ADKGGTKHR------------------------AEMVPVRYMAPEAVE---------KMISTKESDVYAFSVLIFEVFHKAYEPFGEYGPR
          |.  ....                          ..|.|.||||...         . . | .|||..| ||..|.|  . ||.... . 
SGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSN

---------ERVPEAL
         . | | |
QDVWKDGDNQEVMEYL
Kinase T08G5.2.AA Pkinase_Tyr 85-239 28 6.5e-28 95.16 Pfam 64-237 (270) Show / Hide 
Range on Protein: 85-239
Range on HMM: 64-237/270
Sequence Identity: 28% (50 aa)

PNVVKFFGIAA-SRDP--FMIAIEFCAADSLENKLKKV-----PITDFEKIRYLFQAANGLDYLHELGIV------RNCLLTDDDILKIADFGLSADKGG
||.|.. |.    ..|   .|  |...  .| . |.|      |.|  ... . .| |.|..||.. ...      ||||.|.. . ||.||||. |   
PNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYN

-----TKHRAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFEVFHKAYEP-FGEYGPRERVPEALGKDEVRLLQ
     .|.   ..|.. ||||.   .. | .|||..| ||..|.|    .| . .  . |.| |....|  |. .
DDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPC
Kinase T08G5.2.AA UTK 85-221 25 2.4e-25 83.64 In-house 70-245 (296) Show / Hide 
Range on Protein: 85-221
Range on HMM: 70-245/296
Sequence Identity: 25% (44 aa)

PNVVKFFGIAASRDPFMIAIEFCAADSLENKLKKVPITDF---------EKIRYLFQAANGLDYLHELGIV------RNCLLTDD-------DILKIADF
|||... |.  .  |.||..|...  .| . | . . | .         ... .  . |.|. |||. |.|      ||||....        . |||||
PNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADF

G---LSADKGG-------------TKHRAEMVPVRYMAPEAVEKM-ISTKESDVYAFSVLIFEVFHKAYEPFGEYG
|   .| . ..             ... ....|.| |||||. ..   |  |||..| |. .|... .  |.....
GRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMS
Kinase T08G5.2.AA TK-Unique 85-210 28 4.6e-21 69.47 In-house 64-233 (294) Show / Hide 
Range on Protein: 85-210
Range on HMM: 64-233/294
Sequence Identity: 28% (48 aa)

PNVVKFFGIAASRD-PFMIAIEFCAADSLENKLK------------------------KVP---ITDFEKIRYLFQAANGLDYLHE--LGIV------RN
||.|...|.  . | |.||..|.|.  .|.. |.                        |..   |. .  .....| |.|. ||..   .||      ||
PNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARN

CLLTDDDILKIADFGLSAD-----KGGTKHRAEMVPVRYMAPEAVE--KMIS-TKESDVYAFSVLIFEVF
.|||.| ..||.|||.. |     .  .. . ...|.|.||||.    . .  | .|||..| ||..|.|
VLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase T08G5.2.AA TKL 85-210 18 5e-20 68.82 In-house 85-283 (364) Show / Hide 
Range on Protein: 85-210
Range on HMM: 85-283/364
Sequence Identity: 18% (38 aa)

PNVVKFFGIAASRDP-------------FMIAIEFCAADSLENKLKKVPITDFEK-IRYLFQAANGLDYLHELG--------IV------RNCLLTDDDI
||.|.| |.. . ..             ..|  |.|   ||.. |       ... .|   ..| |..|||  .        |.      .|.|. ..  
PNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------LKIADFGLSADKGGTKH------------------RAEMVPV---RYMAPEAVEKM----------------ISTKESDVYAFSVL
              .||.||||| .. ....                   . | ..   |.||||. ...                  .. .|||.| ..
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

IFEVF
..|..
LWEIL
Kinase T08G5.2.AA CTKA 132-217 37 3.2e-17 54.3 In-house 139-235 (290) Show / Hide 
Range on Protein: 132-217
Range on HMM: 139-235/290
Sequence Identity: 37% (36 aa)

QAANGLDYLHELGIV------RNCLLTDDDILKIADFGLS-ADKGG----TKHRAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFEVFHKAYEPF
|.| | .|| |.|.|      |||||      ||||||.. . ...    .     . ||| |||||.     .  |||.|| ||..|..  .  |.
QIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPW
Kinase T08G5.2.AA TyrKc 46-264 20 7.8e-15 17.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-264
Range on HMM: 1-280/280
Sequence Identity: 20% (57 aa)

FCDSYRFFTGNF---------HECAVKIDRNQKDPCVQDYL----VNSPY--FMPNVVKFFGIAASR-------DPFMIAIEFCAADSLENKLKKVP--I
         |.|          ..|||  .. .   ..| .    . . .    ||.|...|.. .        .| ||  |...  .| . |.|    .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

TDFEKIRYLFQAANGLDYLHELGIV------RNCLLTDDDILKIADFGLSADKGGT--------KHRA-----EM--VPVRYMAPEAVEKMISTKESDVY
.  ... . .|.|.| .|||. ...      ||||.... . ||.||||| | .            |.     .   .|.| ||||.  . . | .|||.
CMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

AFSVLIFEVFHKAYEPFGEY----GPRERVPEALGKDEVRLLQFE----------EILYQFRCGNCQNM------YFKFSTAEL
.| |...|.|    .|  .      . ..| | . . . .    .          . .||     | .        |.    ..
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase T08G5.2.AA Abl 85-209 31 7.2e-14 42.16 In-house 55-191 (252) Show / Hide 
Range on Protein: 85-209
Range on HMM: 55-191/252
Sequence Identity: 31% (43 aa)

PNVVKFFGIAASRDPFMIAIEFCAADSLENKLKKVPITDFEKIRYLF---QAANGLDYLHELGIV------RNCLLTDDDILKIADFGLS---ADKGGTK
||.|.  |.     || |  || .   | . |..   .  . .  |.   | | |..|| .   .      ||||. ...|.|.|||||.    |   | 
PNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTA

HRAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFEV
|     |... |||..        |||.|| ||..|.
HAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEI
Kinase T08G5.2.AA RTKC 85-213 33 1.6e-13 40.85 In-house 61-204 (261) Show / Hide 
Range on Protein: 85-213
Range on HMM: 61-204/261
Sequence Identity: 33% (48 aa)

PNVVKFFGIAASRDPFMIAIEFCAADSLENKLKKV-PITDFEKIRYLFQAANGLDYLHELGIV------RNCLLTDDDILKIADFGLSADK---GGTKH-
||||.  |.     |  . .|||   ||   |..   .|.  |.|. .|.| |.   |..| .      || ||  |   |.|||||       ...   
PNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNPDCTEHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEA

----RAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFEVFHKA
    |   .|||  |||| .  . .. ||| || .| .|.. ||
YYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYEIYTKA
Kinase T08G5.2.AA Pkinase 85-210 20 1.9e-13 48.65 Pfam 60-206 (293) Show / Hide 
Range on Protein: 85-210
Range on HMM: 60-206/293
Sequence Identity: 20% (31 aa)

PNVVKFFGIAASRDPFMIAIEFCAAD----SLENKLK---KVPI--TDFEKIRYLFQAANGLDYLHELGIV------RNCLLTDDDIL----KIADFGLS
||.|.....  ..|   .  |.|  .    .|   ..   . ..  .. | ..|. | . ||.|.|. ||.       |.|. ... .    ||.||||.
PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA

A---DKGGTKHRAEMVPVRYMAPEAVE-KMISTKESDVYAFSVLIFEVF
.      ..      .  .||||| .      ....|.... ....|..
KQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML
Kinase T08G5.2.AA Tie 133-209 35 1.9e-13 36.61 In-house 123-206 (267) Show / Hide 
Range on Protein: 133-209
Range on HMM: 123-206/267
Sequence Identity: 35% (30 aa)

AANGLDYLHELGIV------RNCLLTDDDILKIADFGLS-ADKGGTKHRAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFEV
.|.|..|| . ...      || |  .  . |||||||| .|    |. .  .|||.|| |..   . | .|||... ||..|.
VARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEI
Kinase T08G5.2.AA CCK4 147-219 35 2.7e-13 41.18 In-house 145-221 (273) Show / Hide 
Range on Protein: 147-219
Range on HMM: 145-221/273
Sequence Identity: 35% (28 aa)

RNCLLTDDDILKIADFGLSADKGGT---KHRAEMVPVRYMAPEAV-EKMISTKESDVYAFSVLIFEVFHKA-YEPFGE
||||.  . . |.   ||. |.      .||  ..|.| |.||.. |   ||| |||.|. |.. ||| ..   |...
RNCLISPQMQVKVCYMGLCKDVYNREYHHHRQKWIPIRWMPPECIFEDEYSTK-SDVWAYGVFMWEVFNQGTKMPHEQ
Kinase T08G5.2.AA S_TKc 35-305 17 3.8e-11 -13.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-305
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

FEDDDILWLEDFCDSYRFFTGN-FHECAVKIDRNQKDPCVQDYLVNSPYFM----------PNVVKFFGIAASRDPFMIAIEFCAA--DSLENKLKKVP-
.|  ...    |   |.    .  ...|.|| .                ..          ||.||....  . | . .  |.|     .|   .|| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------ITDFEKIRYLFQAANGLDYLHELGIV------RNCLLTDDDILKIADFGLSADKGGTKHRAEMVPVRYMAPEAVEKMISTKESDVYAFSVLIFE
      ..  .  .|. | ...|.|.|..||.       | ||..   .||.||||..       .   .   ||||| .    .....|.... ....|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILYE

VFHKAYEPFGEYGPRERVPEALGKDEVRLLQFEEILYQFRCGNCQNMYFKFSTAELHFKNIFLKIPVDKSAW----QISLHNPE-RPQIQMEFE---IIF
 .   | ||                    . |. |.                               ...|.    ..   .|| || .   ..    | 
MLC-GYPPFP----------------QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

KHARF
.|  |
CHPWF
Kinase T08G5.2.AA DUF19 44-76 23 1.599029 3.81 Pfam 73-111 (194) Show / Hide 
Range on Protein: 44-76
Range on HMM: 73-111/194
Sequence Identity: 23% (9 aa)

EDFCDSYRFFTGNFHECAVKIDR-----NQ-KDPCVQDY
...||   |....| ||  |..      .  .  | .|.
RNYCDAIQFMHDDFAECMDKLYATIYNGKKPASECFKDW
DUF19 T08G5.2.AA DUF19 417-514 18 5.1e-09 31.91 Pfam 1-110 (194) Show / Hide 
Range on Protein: 417-514
Range on HMM: 1-110/194
Sequence Identity: 18% (21 aa)

CESLDTLVQSSQCYY-ALEGLDSSMSA--MSLTDPDVIQEINGYCSTFTDCYPEIEKC-----ADFDSYSIGIIKTFCDFYQFVTTKFFLPCSLILEG--
|.  | . ..  | .  .  ... |.     ....|  .... .| .|..|. .. ||      |   | .. |...||  ||.... | .|.  |.   
CTHQDGF-KAYKCLMIRFNDFMEKMDEYCLDMNNKDELKKFKKSCDSFMNCFETL-KCQGPNTDDEKKYMVKMIRNYCDAIQFMHDD-FAECMDKLYATI

---TS--TPCTDN
       . |...
YNGKKPASECFKD