Gene T15B12.2 (Nematode worm)

T15B12.2

Species: Nematode worm
Alias: CE01404, T15B12.2, aSWK112
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: III:-1.94, WormBase Physical Map location: III: 5297370-5295308

Classification

Group: CK1
Family: CK1-Unique

Sequence

Name Sequence Type Origin Length Description Download
T15B12.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 320 Kinase domain by global Sugen HMM Fasta, JSON
T15B12.2.AA Protein Genbank 423 None Fasta, JSON

Protein domain

Protein domains of T15B12.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase T15B12.2.AA CK1-Unique 51-372 48 1.5e-206 692.43 In-house 1-337 (337) Show / Hide 
Range on Protein: 51-372
Range on HMM: 1-337/337
Sequence Identity: 48% (162 aa)

WCVQAHIGSGGFGDVYRVYDEPNP-----KMEYAMKTEVHGAQQR--RLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVR
|||..|||.||.|.|.||....|.     ...|.||||.|..|..  ||.||....|.|.......|..|||||..|..|..|..|||||..|||.|...
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RMLKR-QYTKS------CVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPP-QDDHVLYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSSRA
.|.|. |.|..      |.|....|.|...|.||..||.||..||.|.|...|. |..|..|.||.||.||||..|..|..|..|...||.|........
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

CHQEKDQGRKDDMETYLYTILDLFHNERGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKKMAPSDSSDETMDWTGKLEQLLKEANKN
|||....||.||||...|....|.||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||.|.|.|...|......||
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKKMAPSDSSDEKMCWKGLRRQNAYDKHKN

KAVGTPKGEETLLYERLKAKRDRDMTTDAVKTVEMRA
........|...|....|...|..|.........|  
YQNSKQFNEKPCLFCKIKPHNDMKMYCCMSEYFYMFN
Kinase T15B12.2.AA CK1 51-298 26 3.1e-87 296.13 In-house 1-339 (339) Show / Hide 
Range on Protein: 51-298
Range on HMM: 1-339/339
Sequence Identity: 26% (91 aa)

WCVQAHIGSGGFG-DVYRV-----YDEPNPK----MEYAMKTEV-HGAQQRRLSIEKSILKEIDTYTTTHKK-----SRHFCE----------LIDSGQT
| |  .||.|||| ..|.|     .|..|.|     |||||.|  . . | .. .| ...... .. .   |     ..|||.          ....| .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE

KDYS-WIVMTLIGPSLESVRR--ML-KRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPP------------QDDHVLYVLDFGISR-RV
.||  ..|||| ||.||..|.  .. .|  ....... |.|.|.|.|.||. ||||||.||.|.| |  .            .. ...|..|||..| . 
DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY

FKSSKCH----------ELRNKRE---RVPFFG-TRKFSSRACHQEKDQGRKDDMETYLYTILDLFHNERGLSWKLDKI---------------------
 ......          ..| .||   ...| | | .. |..||. |.|||.||... .|......  ..|| |. .|                      
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK

---------------IPSGIDNIIVYLRGLKFEDPVDYRQI
               .|.    |. |.|.||..|  ||  |
MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase T15B12.2.AA Worm6 51-260 36 9.3e-71 241.39 In-house 1-216 (279) Show / Hide 
Range on Protein: 51-260
Range on HMM: 1-216/279
Sequence Identity: 36% (81 aa)

WCVQAHIGSGGFGDVYRVYDEPNPK-MEYAMKTEV--HGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKD--YSWIVMTLIGPSLESVRRM
| | . ||.||||.|| | |. . |  ..||| |    ... . | .| ..||..     .|.|.||||...| |...   . .|||||.|..|.  |. 
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAV-----KHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKN

L-KRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTP----PQDDHVLYVLDFGISRRVFKSSKCHELRNKR-ERVPFFGTRKFSSRACHQE
. .| .. .. .  |.| |.|.|..| .||||||.||.| | | .      . | .| ||||..|| ..  |  |||. | ....| || .. ..|||. 
RPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKG

KDQGRKDDMETYLYTILDLFH
..|.||||.|. .| ......
QEQCRKDDCESWFYMMVEMIV
Kinase T15B12.2.AA TTBKL 51-248 32 3.4e-58 195.09 In-house 1-212 (288) Show / Hide 
Range on Protein: 51-248
Range on HMM: 1-212/288
Sequence Identity: 32% (71 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQ--QRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVRRMLKR
| ..  ||.|||| ||.| |  ..| ..||| |.       .|. .|  .|..        ..|.||.....||..|||...|||| ||.|  .|.|...
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQ-----PNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPN

Q--YTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTP---PQDDHVLYVLDFGISRRVFKSSK-C--------HELRNKRE---RVPFFGTRKF
.   ... .  .. |.|.|.  ||..||||||.||.|.|.|       . ...|..|||..|. ..... .         ..| .|.   ..|| || ..
KKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRY

SSRACHQEKDQGRKDDM
 | . |. |.|||.||.
CSPNMHDRKEQGRHDDL
Kinase T15B12.2.AA Dual 51-268 32 4.5e-50 166.53 In-house 1-226 (282) Show / Hide 
Range on Protein: 51-268
Range on HMM: 1-226/282
Sequence Identity: 32% (76 aa)

WCVQAHIGSGGFGDVYRVYDEPN---PKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTT---HKK---SRHFCELIDSG--QTKDYSWIVMTLIGPSL
| |   .|||||.|||.| ..      .  |..|||  . . . |     .. ..   .       |    ..| |..| |  ..    ..|| . ||||
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLK--VEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSL

ESVRR-MLKRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFK-SSKCHELRNKRERVPFFGTRKFSSRACH
. .|| ..  | ...|  | |.| |.|.   | .|..||. ||||   |    |   .| .||.| |     . | |  | .|  | ..|.  . .||| 
QEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL-GMDETTVYMQDFRIVRKYIDPENKKH--RTARKKVKMYGCGRYACRACM

QEKDQGRKDDMETYLYTILDLFHNERGLSWK
 .||||||||.|.  |.. ||. .| |.||.
MQKDQGRKDDLECWIYMVFDLMDPEHGMSWR
Kinase T15B12.2.AA CK1-Unclassified 51-249 29 1.6e-33 96.28 In-house 1-200 (244) Show / Hide 
Range on Protein: 51-249
Range on HMM: 1-200/244
Sequence Identity: 29% (60 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHK--KSRHFCELIDSGQT--KDYSWIVMTLIGPSLESVRRML
  |   ||.| ||..| ...  .  .|.|.| |   . .. | .|  |...             ...  .. .||    ||  .||.| |||||.   | 
YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNC-DNFI-KGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC

KRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVF--KSSKCH-ELRNKRERVPFFGTRKFSSRACHQEKDQG
.|. .   | . | |... .|..|. .|||||.|| |.. |   .  |..|  |||.| | .  .. . | . |...   .. ||  ..|   |. . |.
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENK---NLTGTARYASINAHLGIEQS

RKDDME
|.||.|
RRDDLE
Kinase T15B12.2.AA TTBK 51-248 33 2.9e-32 111.35 In-house 1-190 (257) Show / Hide 
Range on Protein: 51-248
Range on HMM: 1-190/257
Sequence Identity: 33% (67 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVRRMLKRQ-
| | . || |||| .|   |  | . . |.| |   ..   | .|  .||             | |  |  |   .. ..||.| | .|   ||   |. 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQG-------CDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGC

YTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSSRACHQEKDQGRKDDM
.. |  . . .|||...|  |.||| ||| || |   |  |.     | ||||  |.   .  | | |  ||   | ||  . |   |. .. ||.||.
FSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA--CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDL
Kinase T15B12.2.AA CK1 51-249 31 1.9e-28 95.17 In-house 1-200 (271) Show / Hide 
Range on Protein: 51-249
Range on HMM: 1-200/271
Sequence Identity: 31% (63 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKME--YAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQT--KDYSWIVMTLIGPSLESVRRML
  |   ||.| |||.| ...  . . |  .|.| |   . .  | .|  |.|.         .. ..  .. .||   .||  .||.| |||||.   . 
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGH-NCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC

KRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSSRACHQEKDQGRKD
.|. .   |.. | |... .|..|. .|||||.|| |.. |.  .. |..|. |||.. | .. .| |.    ||  .. ||  . |   |. . |.|.|
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKR-YRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD

DME
|||
DME
Kinase T15B12.2.AA CK1-A 51-267 31 8.4e-27 91.63 In-house 1-205 (261) Show / Hide 
Range on Protein: 51-267
Range on HMM: 1-205/261
Sequence Identity: 31% (68 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVRRMLKRQY
. .  .|||| |||.|      | . | |.| | . |.   |  |  . . .       ..   . ..   |. |||  .|| |.||||| .  . ||..
YRLVRKIGSGSFGDIYLGINITNGE-EVAIKMESNKARHPQLIYEAKVYRIL-------QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRF

TKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHV--LYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSSRACHQEKDQGRKDDM
|   |. .| |..  .| .|| .|||||.|| |   |.   . |   |...|||.... .. |. ..    ||     || .. |   |.  .| |.|||
TMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI---GRHCNKLFLIDFGLAKK-YRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDM

ETYLYTILDLFHNERGLSW
|   | .  .. | . | |
ESMGYVM--MYFNRGKLPW
Kinase T15B12.2.AA CK1-D 51-256 30 4.5e-24 81.72 In-house 1-196 (261) Show / Hide 
Range on Protein: 51-256
Range on HMM: 1-196/261
Sequence Identity: 30% (63 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVRRMLKRQY
. .   |||| |||.|   .  .   | |.| |   ..   | ||  . | .              |.   ||  ||  .|| |.||||| .    .|..
YRIGRKIGSGSFGDIYHGTNI-QTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIG-------IPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKF

TKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSSRACHQEKDQGRKDDMET
    |. .|.|..  .| .|   |||||.|| |   |   .  .. |..|||...| .. .. |.    ||     || .. |   ||  .| |.||.| 
SLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL-GKRGNMVYIIDFGLAKR-YRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLES

YLYTIL
  | ..
LGYVLM
Kinase T15B12.2.AA Pkinase 51-216 22 1.2e-16 59.93 Pfam 1-171 (293) Show / Hide 
Range on Protein: 51-216
Range on HMM: 1-171/293
Sequence Identity: 22% (42 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSI------EKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGPSLESVRR
...   ||||.|| ||. ..  ..| ..|.|.     .     .      | .|.|...        . . ..|.|. ..||. ..|| . .  |. |  
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMD

ML-------KRQY--TKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRR--VFKSSKCHEL
         .. .  .   ......||| ..| .|. |.|||||||.||     .. |  . . |||...     ..| .. .
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF
Kinase T15B12.2.AA S_TKc 51-385 14 1.4e-13 22.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-385
Range on HMM: 1-231/231
Sequence Identity: 14% (54 aa)

WCVQAHIGSGGFGDVYRVYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTKDYSWIVMTLIGP---SLESVRRMLK
. .  .||.|.|| ||....    . ..|.|              ..|..||.       .  . . |.|. |. |. ..|| ...    .| .. .  .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

RQ-----YTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFKSSKCHELRNKRERVPFFGTRKFSS--RACHQEK
|.     ..   .  .. ||..|.| .|. |.|||||||.||   .      .. . |||..|..                 | ||. . .         
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL---------------TTFCGTPWYMAPEVL-----

DQGRKDDMETY-----------LYTILD---LFHNERGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKKMAPSDSSDETMDWTGKLE
         ..           ||  |    .|.    .   ..||                                                      
-------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------------------------------------------

QLLKEANKNKAVGTPKGEETLLYERLKAKRDRDMTTDAV--------KTVEMRATINRDVD-----ASEGMF
                                  . .|         |  | | |.          ..   |
----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase T15B12.2.AA TyrKc 51-273 14 6e-06 -126.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-273
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

WCVQAHIGSGGFGDVYR-VYDEPNPKMEYAMKTEVHGAQQRRLSIEKSILKEIDTYTTTHKKSRHFCELIDSGQTK-------DYSWIVMTLIGP-SLES
      .|.| || ||. ...     .. | |.  ..|       .. ...|.   .   ..  .   |.    ..       .  .||| .    .| .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VRRMLKRQYTKSCVINMALQILDAVEVMHEVGFIHRDLKPANICTGTPPQDDHVLYVLDFGISRRVFKS--------SKCH----ELR------------
  |  ... . .  .....|| .  |  |. ..|||||   |.  | .     .  . ||| || .            . .      .            
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

-NKR---------------------ERVPFFG---TRKFSSRACHQEKDQG----RKDD--------METYLYTILDLFHNE----RGLSWKLDKII
 |..                        |  |     . | .  ..  .||    . ..        . . .|.|     .|    |   . . ...
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase T15B12.2.AA Worm6 271-298 24 0.007542 6.46 In-house 251-279 (279) Show / Hide 
Range on Protein: 271-298
Range on HMM: 251-279/279
Sequence Identity: 24% (7 aa)

KIIPS-GIDNIIVYLRGLKFEDPVDYRQI
...|  . . |  |. .....| .||..|
GPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase T15B12.2.AA CK1 283-296 50 0.025678 4.02 In-house 258-271 (271) Show / Hide 
Range on Protein: 283-296
Range on HMM: 258-271/271
Sequence Identity: 50% (7 aa)

YLRGLKFEDPVDYR
| |.|.||.  ||.
YCRQLHFEEKPDYM
Kinase T15B12.2.AA CK1-A 268-298 32 0.031868 3.45 In-house 231-261 (261) Show / Hide 
Range on Protein: 268-298
Range on HMM: 231-261/261
Sequence Identity: 32% (10 aa)

KLDKIIPSGIDNIIVYLRGLKFEDPVDYRQI
.| |  |.    .. | |.|.||.. ||  .
QLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase T15B12.2.AA CK1-D 274-298 40 0.07072 2.21 In-house 237-261 (261) Show / Hide 
Range on Protein: 274-298
Range on HMM: 237-261/261
Sequence Identity: 40% (10 aa)

PSGIDNIIVYLRGLKFEDPVDYRQI
||   . . | | |||.|  ||  .
PSEFQQYMNYCRNLKFDDKPDYCYL