Gene T25E12.4 (Nematode worm)

T25E12.4

Species: Nematode worm
Alias: T25E12.4a, T25E12.4, CE18967, aSWK064
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: No interpolated position., WormBase Physical Map location: V: 16750161-16791004

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
T25E12.4.AA Protein Genbank 1101 None Fasta, JSON
T25E12.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of T25E12.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF T25E12.4.AA PKD_Nterm_DUF 227-312 47 2.7e-53 175.59 In-house 1-87 (87) Show / Hide 
Range on Protein: 227-312
Range on HMM: 1-87/87
Sequence Identity: 47% (41 aa)

LTFRLQSGIHKKSIAVEGTEIALRDLRNEALQFIKEIYPEKGCSS-LEDYILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGSCP
..|..|.|.|.....|||.|..|..|...|.|||...||..||.. |.|.|.|..||..|.||||.||..||||.|.|.|.|...||
CHFHFQCGFHREMVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 T25E12.4.AA C1_1 322-374 43 8.2e-16 61.7 Pfam 1-55 (55) Show / Hide 
Range on Protein: 322-374
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HTLFVH-SYKVPTFCDFCGELLFG-LVKQGLKCFGCGLNYHKRCASKIPNNCNGS
|   .| ..| ||||. |||...| | .||.||  |..|.|.||..| |..| ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 T25E12.4.AA C1 320-371 26 6.4e-15 56.82 SMART 1-61 (61) Show / Hide 
Range on Protein: 320-371
Range on HMM: 1-61/61
Sequence Identity: 26% (17 aa)

HPHTLFVHSYKVPTFCDFCGELLFGLVKQ-----GLKCFGCGLNYHKRCASKIPN-------NC
|..    .    ||.|. |.....|. ||     |..|  |....||.|..|.|.       .|
HHWHWWRF---KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 T25E12.4.AA C1_3 333-364 25 1e-06 18.21 Pfam 1-30 (30) Show / Hide 
Range on Protein: 333-364
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TFCDFCGELLFGLVKQGLKCFGCGLNYHKRCA
 .|. ||. . .    . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1_1 T25E12.4.AA C1_1 474-526 40 1.5e-18 71.73 Pfam 1-55 (55) Show / Hide 
Range on Protein: 474-526
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HTFQVH-SYKLPTVCQHCKKLLKG-LIRQGMQCRDCKYNCHKKCSEHVAKDCSGN
| ...| ..| || | ||.... | |..||..|..|.||||..|...|.. | .|
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 T25E12.4.AA C1 474-523 33 1.1e-17 65.96 SMART 1-61 (61) Show / Hide 
Range on Protein: 474-523
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HTFQVHSYKLPTVCQHCKKLLKGLIRQ-----GMQCRDCKYNCHKKCSEHVAK-------DC
|... ...  || |.||.|...|. .|     |..|..|||.|||||...|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 T25E12.4.AA C1_3 485-516 18 0.438263 4.26 Pfam 1-30 (30) Show / Hide 
Range on Protein: 485-516
Range on HMM: 1-30/30
Sequence Identity: 18% (6 aa)

TVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCS
  |. |.. ...  . .  |  | .. |..| 
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH T25E12.4.AA PH 625-728 24 1.4e-13 52.39 SMART 1-82 (82) Show / Hide 
Range on Protein: 625-728
Range on HMM: 1-82/82
Sequence Identity: 24% (25 aa)

LLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDENTTRYYKEIPLNEILNVSMSPPDKTADYLFEIRTGVCVYFISGSPSDEKGSSLDAQSWTTAIQSA
..||||. ...     .||.. .|... .. |.|.   .. ..|||...  |.. |        |||..   .|... .      |. ..|.| .|||.|
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P-------CFEIHH-DRTYYFQCE------SEEEMQEWMQAIQKA

LMPV
. . 
IHNN
PH T25E12.4.AA PH 625-726 26 5.7e-08 31.4 Pfam 1-92 (92) Show / Hide 
Range on Protein: 625-726
Range on HMM: 1-92/92
Sequence Identity: 26% (27 aa)

LLKEGWIVHYTDQQNMRKKHYWRLDTKGITMYQDENTTRYYKEIPLNEILNVSMSPPDKTADYLFEIRTGVC-VYFISGSPSDEKGSSLDAQSWTTAIQS
. ||||.  .. .   .||..  | .. . .|.|..  |. . |||... .|   |.    .. |.|||    .|... .      |. ....| .||||
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN-KRPHCFQIRT-DRRTYYFQAE------SEEEMNDWMQAIQS

ALM
|. 
ACR
Kinase T25E12.4.AA PKD 770-1026 78 3.8e-223 747.59 In-house 1-260 (260) Show / Hide 
Range on Protein: 770-1026
Range on HMM: 1-260/260
Sequence Identity: 78% (205 aa)

IFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNK--EDLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSSEKGRLSE
||..|||||||||.|||||||..|.|||||.||||.||...  |...|.||.||..|.|||||....|.||.|||||||||..|||||||||||||||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

RTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSN-SDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSG
|.|.||..|||.||.||||.|||||||||||.||.|. ||||||||||||||||||||||||||||||||||||||||||.||||||||||||.||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQIWM
|||||||||||||||||.|||||.||||||||||..||.||||||.|||||.|..|..|.
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase T25E12.4.AA CAMK 775-1026 23 1.3e-104 338.1 In-house 1-425 (425) Show / Hide 
Range on Protein: 775-1026
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

VLGSGQFGTVYGGIHRRNG------------QHVAVKLIDKLKFP--------------------------PNKEDLLRAEVQILEK-------VDHPGV
.||.|.||.|. .||....            |.||.| ||| | .                          |.... .| |..|. |       .||| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VHFMQMLE------------TTDR--------IFVVM---EKLKG-----DMLEMILSSEK-------------GRLSERTTQFLVAQILEALRYLHHLN
... .. |            | ..        .. ||   |   |     |....| . ..             ||..|| ..... ||..|..|.| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENILLNSNSDFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRN-----
|||.|||||||||..|.|                ..|..|||||... .                            . ..|||.| | ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGFNRSLDMWSVGVIVYVSLSGTFPFNED---------------EDINDQIQNAEFMYPPTP------------WKEISEN--------AI
         .. ... ||||.||| |. |.|..||..|               ...  .|..... .|| .            |..||..        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

EFINGLLQVKMSKRYTVTKAQSQIWM
 .|...|||  .||.|.. . .  ||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase T25E12.4.AA RAD53 773-1026 32 2.8e-92 275.13 In-house 4-305 (305) Show / Hide 
Range on Protein: 773-1026
Range on HMM: 4-305/305
Sequence Identity: 32% (99 aa)

EEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFP------PNKEDLLRAEVQILEKVDHPGVVHFMQMLETT-DRIFVVMEKLKG-DMLEMILSSEKGR
 ..|||| ||||. .. ....| ||.| ||| ||       ..|.| .. || || |. || .. .    .|. .  . |.|.  | . .. | |. |..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN-KRC

---LSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNK-
   ..| |  ..  |...|..||| ..|.| ||||||||.|....                 ..|. ||| ....||.|| .   |||.|.||||...| 
QMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKG

--------------GFNRSLDMWSVGVIVYVSLSGTFPFNED-------EDINDQIQN-AEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQ
              | ... |.|| |.|.|..|.|. || .|        ....|| | . . .|.  |..|||.|  .|...|.|   ||||. .| . 
HNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNH

IWM
 ||
PWM
Kinase T25E12.4.AA S_TKc 770-1026 31 6.5e-89 302.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 770-1026
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

IFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKG---DMLEMILSSEKGR--
    ...|.| ||.|| ..|.. |..||.| |.         . .| |.|||.| .|| .|..  . .. |....||| . |   |....| .  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGFNR-SLDMWSVGVIVY
  ..| ...|...||..|| |.| ..|.|.|||||||||..     ..|.||||.||..      ....||| |.|||||   |... . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEDINDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQS-------QIWM
  |.|  ||    ...  ...             |. |..||...||.  .||.|. .|           |.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase T25E12.4.AA Pkinase 768-1026 31 5.3e-81 280.21 Pfam 1-293 (293) Show / Hide 
Range on Protein: 768-1026
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

YQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRA--EVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGD----MLEMILS-S
|.|  ....||| ||.|| ..|. .|. |||| |.| .  ..|.  .|   |.||. ...|| .| .  . |. |.| .||| . |.     |  ..| .
YHI--GRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

EKGRL--SERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDF-PQVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR-NKGFNRSLDMW
..|..  ||.. .| . |||..| |.|  .|.|.||||||||...| .  . ||.||||.|.   .  .|   ...||| |.||||.| ...  .. |||
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SVGVIVYVSLSGTFPFNED--------EDINDQIQNAEFMYPPTPWKEIS-----------------ENAIEFINGLLQVKMSKRYTVTKAQSQIWM
|.|.|.|  |.| .|| ..          . ..|  ......   | .||                 |....||...|.....||.| . .    |.
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase T25E12.4.AA CAMKL 768-1026 29 7.6e-77 244.73 In-house 1-297 (297) Show / Hide 
Range on Protein: 768-1026
Range on HMM: 1-297/297
Sequence Identity: 29% (88 aa)

YQIFAEEVLGSGQFGTVYGGIH-RRNGQHVAVKLID--KLKFPPNKEDL-----------LRAEVQILEKVD---HPGVVHFMQMLETTDR------IFV
|.|  ...|| | ||.|  ..| | .|..||.| ||  |..  |....            .| |.||.....   || ........|| .       |. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLKGD---MLEMILSSEK--GRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGE-----KSFRRSVVGTP
|||   |    ....| . ..  ||..|. ....  ||..|. |.| ..||| |.||||||| .| .  ..|..||||. .. .       . .   |.|
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

AYLAPEVLRN--KGFN-RSLDMWSVGVIVYVSLSGTFPFNEDEDI-------NDQIQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQI
.| |||..    | .. .  |.|| ||| |. . |..||..| .        .   .. .  | |..|...|  .. .| ..|||. .||.|.    .  
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WM
||
WM
Kinase T25E12.4.AA CAMK1 768-1020 34 4.2e-75 217.74 In-house 1-270 (276) Show / Hide 
Range on Protein: 768-1020
Range on HMM: 1-270/276
Sequence Identity: 34% (94 aa)

YQIFAEEVLGSGQFGTVYGGIHRRN---GQHVAVKLIDKLKFPPNKE----DLLRAEVQILEKV---DHPGVVHFMQMLETTDRIFVVMEKLK-GDMLEM
|...  ...|.| |..|| ..|...   |...|.| ||| ||  .|.    ..|. |..|. ||   ||| .. |    |... .  ||| .. |. .. 
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

ILSSEKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLRN---KGFNRS
|.  |||  .|.    .. |||.|. |.| ..|||.||||||.|. ....  ..|  ..||| ..|..... .   ..||| | ||||| .   |.   .
IV--EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKA

LDMWSVGVIVYVSLSGTFPFNEDE-D--INDQIQNAEFMYPPTPWKEISEN-AIEFINGLLQVKMSKRYTVTKA
 ||||.||| |. | |  ||...  |  . ..| ..|. .|   | .||.  | .||...| |  .||||....
CDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQC
Kinase T25E12.4.AA CAMK-Unique 770-1026 22 2.1e-65 214.82 In-house 1-363 (363) Show / Hide 
Range on Protein: 770-1026
Range on HMM: 1-363/363
Sequence Identity: 22% (83 aa)

IFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDL------------------LRAEVQILEKVDHPGVVHFMQM----LETTD-------
.   ...|.| || || .. | .|   |.|.. | .   .| ..                  |. |.||. .||||  .....      .. .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------RIFVVMEKL-KGDMLEMILS-SE-----------------KGRLSE--RTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSD-----
        ... ||| . .||... |.. .|                 .|..||  . |.|.....|.|. |.| ..||| |||.|||..... .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------FPQVKLCDFGFARIIGEKSFRR---SVVGTPAYLAP--------------EVLRNKGFNRSL----DMWSVGVIVYVSLSGTFPFN-EDED-
        .  .|||||| .. . ..  .    ...||| |.||              ||. . .  . .    | || ||| |  |.|  ||. |.|| 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

--------INDQIQNAEF-MYPPTPWKE---ISENAIEFINGLLQVKMSKRYTVTKAQSQIWM
        | . |  ...  ..   |     ||..|. |. ....|. ..| .   . . .| 
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase T25E12.4.AA ULK 770-1016 27 1.5e-64 220.73 In-house 1-314 (324) Show / Hide 
Range on Protein: 770-1016
Range on HMM: 1-314/324
Sequence Identity: 27% (86 aa)

IFAEEVLGSGQFG-TVYGGIHRRN---GQHVAVKLIDKLKFPPNKED--------LLRAEVQILEKVD---HPG--VVHFMQMLETTDR--IFVVMEKLK
.   ..||.|.|| .|| |.. ..   .|.||.| ||| |.  .| .        ||. |.||. | .   ||   .| .  ..||..   |. .||   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GDMLEMILSSEKG--------RLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSN----------SDFPQVKLCDFGFARIIGE----KSFRR
|  || ..   |.        ||||  ..    ||......||  ||.|.|.||.|||.. .          .  ...|..|||||... .    .  . 
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMCQ

SVV------GTPAYLAPEVLR----NKGFNRS-LDMWSVGVIVYVSLSGTFPFNEDEDINDQ----------------IQNAEFMYPPT-PWKEISENAI
. |      ||| | ||..|     .| .. .  |.||.|.| |  | |  ||...   ...                |.|  . .|.  . . ||.. .
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

EFINGLLQVKMSKRYT
..| ..||.. ..| .
DLIRRMLQYDEKDRIS
Kinase T25E12.4.AA ULK 770-1016 27 3.8e-63 216.09 In-house 1-319 (329) Show / Hide 
Range on Protein: 770-1016
Range on HMM: 1-319/329
Sequence Identity: 27% (87 aa)

IFAEEVLGSGQFGTVYGGIHRRN----GQHVAVKLIDKLKFPPNKED--------LLRAEVQILEKVD--------HPGVVHFMQMLETTDR--IFVVME
.   ..||.|.||.|| |.. ..    .. ||.| ||| |.  .. .        ||. |..|. | .        || .| .  ..||..   |. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLKGDMLEMILSSEKG---------RLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSN----------SDFPQVKLCDFGFARIIG----EK
   |  || ...  |.         ||||  ..    |||.....||  ||.|.|.||.|||.. .          .  ...|..|||||. .     |.
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

SFRRSVV------GTPAYLAPEVLR----NKGFNRS-LDMWSVGVIVYVSLSGTFPFNED-EDINDQIQNAEFMYPPTPW----------------KEIS
    . |      ||| | ||..|     .| .. .  |.||.|.| |  | |  ||..  .| ..||.. .. .||..                 . ||
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

ENAIEFINGLLQVKMSKRYT
.. ...| ..||.. ..| .
PECKDLIRRMLQYDEKDRIS
Kinase T25E12.4.AA Ciliate-E2 770-1026 20 3.2e-62 212.38 In-house 1-365 (365) Show / Hide 
Range on Protein: 770-1026
Range on HMM: 1-365/365
Sequence Identity: 20% (79 aa)

IFAEEVLGSGQFGTVYGGIHRRNGQH------------------VAVKLIDKLKFPPNKEDLLRAEVQIL----------------EKVDHPGVVHFMQM
.   ...|.|.||.|| . ......                   |..|.. .  . .|.   .  | .|.                |...|| .. .   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LE--TTDRIFVVMEKLKG-DMLEMILSS-----------------EKGRLSERTTQ-------FLVAQILEALRYLHHLN-IVHCDLKPENILLNSNSDF
 .  ... |. ||| ..| |... | ..                 | .....  .|       | .|.|..||.|||  | |.| |.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PQVKLCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRNKG---------FNRSLDMWSVGVIVYVSLSG
  .|..|||..... ... .|.                                ..||| |.|||.|..|.          . . |.||.||| |  |.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

TFPFNEDEDINDQIQNAEFMYPPT--------------PWKEISENAIEFING----LLQVKMSKRYT-VTKAQSQIWM
 .||       .||.. .. .|.                ||..|.... .|.     .||.. .||.|   ..    |.
KPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase T25E12.4.AA Ciliate-E2-Unclassified 773-1026 23 2.7e-58 200.01 In-house 4-352 (352) Show / Hide 
Range on Protein: 773-1026
Range on HMM: 4-352/352
Sequence Identity: 23% (81 aa)

EEVLGSGQFGTVYGGIHRRNGQHV-------AVKLIDKLKFPPNKEDLLRAEVQILEK------------------VDHPGVVHFMQMLETTDRIFVVME
 ...|.|.||.||  .|. ..  .        .. .....   .. .... . .. .|                   .|| .|... . .... |. |||
IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVME

KLKGDMLEMILSSEKG----------------RLSERTTQ-----FLVAQILEALRYLHHLN-IVHCDLKPENILLNSNS-DFPQVKLCDFGFARIIGE-
...|  |. .... |.                ...|. ..     |. ||||..| |||| | |.| |.||||||...|   . ..|..|||... ... 
YCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY-YIKIIDFGISKKYQQN

---------------KSFRRSVVGTPAYL----APEVLRNKGFNRS----LDMWSVGVIVYVSLSGTFPFN--EDED----------------INDQIQN
               .    ...||| |.    |||||.... . |     |.||.||| |  | |..||.   .|.                . ..|..
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

AEFMYPPTPW----KEISENAIEFIN----GLLQVKMSKRYTVTKAQSQIWM
 .. .|. ||    | .|..|..|||     .|.....||.|  ..    |.
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase T25E12.4.AA TyrKc 770-1024 20 3.9e-15 21.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 770-1024
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

IFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLIDKLKFPPNKEDLLRAEVQILEKV--DHPGVVHFMQMLETT-------DRIFVVMEKLKGDMLEMILSS
|  ...||.|.||.|| |. .   . |||| . . .     .  .. | .|. |.  .|| .| .     .        . ...|||  ..  |   | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRNKG
 ...|. ..      || .  .|||. |..| ||   |.|...|    .|| .||| .| |...          | .   |.        .|||... . 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FNRSLDMWSVGVIVY--VSLSGTFPFN------EDEDINDQIQNAEFMYPPTP-WKE-----ISENAIEFINGLLQVKMSKRYTVTKAQSQI
|.   | || ||  .   .. .. . .      .....  .... . | .|     .      ..   . .    . . ..| | .   ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase T25E12.4.AA Pkinase_Tyr 770-948 26 3.4e-14 48.69 Pfam 1-192 (270) Show / Hide 
Range on Protein: 770-948
Range on HMM: 1-192/270
Sequence Identity: 26% (53 aa)

IFAEEVLGSGQFGTVYGGIHR----RNGQHVAVKLIDKLKFPPN---KEDLLRAEVQILEKV-DHPGVVHFMQMLE-TTDR--IFVVMEKLKG-DMLEMI
|   ..||.|.||.|| |. .     ....|||| . | .  .    .||..| |..|. .  .|| .| ..       .   |..|||  .. |.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

LSS--EKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNSNSDFPQVKLCDFGFARIIGEKSFRRSVVGT-----PAYLAPEVLRNKGFN
 .   .|..|.  .     .|| ... ||.  |..| ||   |.|...  .. .|| |||| || | ...   .....        .|||..... |.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT