Gene tpa-1 (Nematode worm)

tpa-1

Species: Nematode worm
Alias: CE17353, tpa-1, B0545.1a, aSWK015
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:-27.5208, WormBase Physical Map location: IV: 92016-110151

Classification

Group: AGC
Family: PKC
Subfamily: PKCd

Sequence

Name Sequence Type Origin Length Description Download
tpa-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
tpa-1.AA Protein Genbank 597 None Fasta, JSON

Protein domain

Protein domains of tpa-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD tpa-1.AA C2_PKD 18-54 28 5.3e-13 42.34 In-house 138-183 (183) Show / Hide 
Range on Protein: 18-54
Range on HMM: 138-183/183
Sequence Identity: 28% (13 aa)

KKVSDDDHPVED--------IMTSRSNSGPGIQRRRG-AIKHARVH
. . |..|....        .|.......||..|||| |..||..|
NEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C1_1 tpa-1.AA C1_1 59-111 41 7.3e-22 83.76 Pfam 1-55 (55) Show / Hide 
Range on Protein: 59-111
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HQFVAT-FFRQPHFCSLCSDFMWG-LNKQGYQCQLCSAAVHKKCHEKVIMQCPGS
|..|.. .|.||.||..| .|.|| | .||..|| |   .|..||.|| . |...
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 tpa-1.AA C1 59-108 33 3.8e-16 60.88 SMART 1-61 (61) Show / Hide 
Range on Protein: 59-108
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HQFVATFFRQPHFCSLCSDFMWGLNKQ-----GYQCQLCSAAVHKKCHEKVIM-------QC
|..... | .| .|..| ...||. ||     ||.|. |  ..|||||.||          |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 tpa-1.AA C1_1 131-183 43 5.7e-23 87.43 Pfam 1-55 (55) Show / Hide 
Range on Protein: 131-183
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HRFKTY-NFKSPTFCDHCGSMLYG-LFKQGLRCEVCNVACHHKCERLMSNLCGVN
|...   |||.||||.|||....| |..||..|..|.. |||.| ......|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 tpa-1.AA C1 131-180 33 1e-19 72.77 SMART 1-61 (61) Show / Hide 
Range on Protein: 131-180
Range on HMM: 1-61/61
Sequence Identity: 33% (21 aa)

HRFKTYNFKSPTFCDHCGSMLYGLFKQ-----GLRCEVCNVACHHKCERLMSN-------LC
|......| .||.|.||..|..|.|||     |.||..|...||.|| . ...        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase tpa-1.AA PKC 268-527 61 6.7e-200 653.86 In-house 1-262 (262) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-262/262
Sequence Identity: 61% (162 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEA
||.||||||||||||||.|.||..|.||.|.||||||..||| |||..|.||| ||...|||..|.|.|||...|||||||.||||||.||||...|.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP
..||||.||..||||||...||||||||||||||..||||.|||||.|..|...  ..||||||||||.|||...| |...||.|.||||||||..||||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG-DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

FHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECP---DGPIRQHCFF
|||| |||||.||....|..|...||||..........||..|||. ...   .. ||.|.||
FHGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase tpa-1.AA Delta 268-527 73 8e-188 630.26 In-house 1-259 (259) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-259/259
Sequence Identity: 73% (192 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEA
|...|||||||||||||.||||||..||.|||||||.|||||.|||..|||||.||...||||.|||.|||.|.||||||||||||||.||||...|||.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP
|.|||||||...|||||...||||||||||||||||||||.|||||.|..|..| ..|||||||||||.|||||||.||..||.|||||||||||.||||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGE-KKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSP

FHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFF
||||.|||||.||.|.||..|..|.|||..||..||.|.|..|||...||.|.|||||||
FHGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase tpa-1.AA AGC 268-527 31 6.4e-179 467.41 In-house 1-395 (395) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-395/395
Sequence Identity: 31% (125 aa)

FNLLKVLGKGSFGKVMLVELK------GKNEFYAMKCLKKDV-ILEDD--DTECTYIE------------RRVLILASQ---------CPFLCQ-LFCSF
|..|||.||||||||.||. |      . ...||||.|||.. |....  . |.|..|            |..| ....         .||... |..||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTNEY--LFFVMEYLN---------GG-DLMHHIQ---QIKKFDEARTRFYACE-------IVVALQFLHT-NNIIYRD-LKLDNVLLDCDGHIKLADFG
|....  |.|||||..         || .|..|.|   . ..||| |.||||.|       || ||..||  ..||.|| ||..|.||| ||||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MAKTEMNRE-------------------------------------------------NGMASTFCG--TPDYISPEIIKGQLYNEAVDFWS--FGVLMY
..|  ||..                                                 . ...||||  ||.|..|||.    |. |.| ||  .|.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLVGQSPFHGEG----------EDELFDSIL------NERPYFP----------KTISKEAAKCLSALFDRNPNTRLGMPECP-----DGPIRQHCFF
|||.|..||.|.           ..|.|..|.      |... ||          . .|.||   .. |. ..|. |||  .          |..| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase tpa-1.AA Alpha 268-527 58 1.4e-137 463.34 In-house 1-259 (259) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-259/259
Sequence Identity: 58% (152 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEA
|| |.|||||||||||| | || .| || | ||||||  ||| ||| .|.||| | .. ||| |.   |||   |.||||| |||||| ||||. || | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP
   ||| || ..| |||.  |||||||||||.|| .||||.||||| | .|. |.    ||||||||| ||||  | |  .|| |.||||.|||..|| |
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMW-EDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPP

FHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFF
| || ||||| .| .  . .|| .|||| .   ..  ..|| |||        ||.| ||
FDGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase tpa-1.AA Eta 268-527 57 7.1e-135 454.38 In-house 1-261 (261) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-261/261
Sequence Identity: 57% (151 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEA
|| .||||||||||||| |.||..| ||.| ||||||. ||| |||  |.|.| || . ||| ||.|.|||.. ||||||| |||||| .||. .||||.
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP
|.|||| |...||.|||....|||||||||.||| .|| ||||||| |  .. .. . .||||||||| |||.. . |  .||.| .|||||||. ||.|
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGM-TTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPP

FHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPE--CPDGPIRQHCFF
|  . ||.||.|||..   .|  ..|||   | | . .||. |||  .    .  |||| ||
FEADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase tpa-1.AA Akt 268-527 45 1.7e-119 383.64 In-house 1-264 (264) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-264/264
Sequence Identity: 45% (120 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFY-AMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDE
|..||||||||||||.||. |  ...| ||| ||||.|.. .  | |  ||..|     .||. .|  ||||...|.|||.| |||.|  |.|. ..|.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ARTRFYACEIVVALQFLHTNNIIYRD-LKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWS-FGVLMYEMLVG
 |.|||..||. |...|| .|||||| ||. |.|.| ||||.|.|||..| .   .. .. |||||| |..|||..|. .  |||.|. .|..||||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

QSPFHGEGEDELFDSILNERPYFP--KTISKEAAKCLSALFDRNPNTRLG-MPECPDGPIRQHCFF
. ||. .  ...|. |.|.   ||  ..||.|.   .| |  ..|. |||  |.  .  |..| .|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQE-IKRHPWF
Kinase tpa-1.AA SGK 268-527 38 2.5e-110 342.02 In-house 1-283 (283) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-283/283
Sequence Identity: 38% (110 aa)

FNLLKVLGKGSFGKVMLVELKGK------------------NEFYAMKCLKKDVIL-------EDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYL
| .|||.||||||||..|. |..                    ||||| |.|. |.              . .|| |..     ||. .|  .||| ..|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKG
.|||.|.|||..  |.|  |.| | | |||| ||| ||  ||  .||||||| .|.|||..||..| ||| .| ..  .|   .|||||| |  ||....
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGI-KTNDTTFTFCGTPEYLAPEVLRK

QLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMP-ECPDGPIRQHCFF
| .  .|| |. | ..|||..|  ||      ...| |.|.   .|. .| .|   .  |  ..|  |||      .  |..| ||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME--IKNHPFF
Kinase tpa-1.AA AktR 268-527 41 3.9e-106 358.92 In-house 1-268 (268) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-268/268
Sequence Identity: 41% (111 aa)

FNLLKVLGKGSFGKVMLVELK-GKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDE
| ..|.|||| ||||.||. |   ...|||| .||  | |    . |. || ...  .. ||. .|. .|||.|.|||.|||  ||.| .|....|||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ARTRFYACEIVVALQFLHTN-NIIYRDLKLDNVLLDCDGHIKLADFGMAK-TEMNRENGMASTFCGTPDYISPEIIKG-QLYNEAVDFWSFGVLMYEMLV
 ..|||...|. ||..|| . |||||||| .| ||| |||.|..|||..|   |. .. .| .||||| |..||.|.  . .| .||.|.||.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQSPFHGEGEDELFDSILNER-PYFPKT--ISKEAAKCLS-ALFDRNPNTRLG--MPECPDGPIRQHCFF
|. ||  .   ..|..|....  .||..  .|... . .   |...||| |||   .   .  |. | .|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEE--IKSHPWF
Kinase tpa-1.AA RSK 271-527 39 2.5e-105 356.22 In-house 1-278 (278) Show / Hide 
Range on Protein: 271-527
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

LKVLGKGSFGKVMLVELK---GKNEFYAMKCLKKDVILEDD-DTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKK---
|||||.|..||| |.  .    ..  |||| ||| .|   . ||. |  ||..| .  |.||...|. .|||...|. .|||..||.|  |.|. |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDC---DGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIK---GQL-YNEAVDFWSFGV
|.| . .||. |||.|...||.  ||.||||..|.|.|    .||||| ||| .|   ...|... |||.| .|. ||..|   .|  ...|.| ||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEMLVGQSPFHG---EGEDELFDSILNER--PYFP--KTISKEAAKCLSALFDRNPNTRLG-----MPECPDGPIRQHCFF
||||||.|..||.|   .  .|... |.. .  . .|  ...|.||   ..... |.|. |||     . |     |.||..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE-----IKQHPWF
Kinase tpa-1.AA PKN 268-527 46 2.7e-98 332.85 In-house 1-260 (260) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-260/260
Sequence Identity: 46% (122 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQC--PFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFD
| .. |||.| ||||.|...|. .|.||.| |||  |.  |. |  ..|.|..  ...   ||| .||  |||.|  .|||||. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHE-DVFS

EARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQ
|.|..|||  .|. ||.|| ..||||||||||.||| .|..|.||||. |  |       |||||||... ||..  . |  |||.|  |||.|||||| 
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGD-RTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGE

SPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFF
.|| |. |.|.||.|.|.   .|. .| || . .  |  .||. |||  |     |. . ||
CPFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAEDIKMQPFF
Kinase tpa-1.AA S_TKc 268-527 32 3.1e-91 310.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-231/231
Sequence Identity: 32% (87 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNG--GDLMHHIQQIKK--
. .|...|||.||||...  |. .. .|.|..|          | .. |...|    ..|....|. .||. ..|..||||..|  |||...|.. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNE-AVDFWSFGVLM
    |.| ..|||...|. ||...| ..||.|||| .|.|||   |||..|||.|.          .||||||.|..||..    |.  ..| ||.|...
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

YEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPD--GPIRQHCFF
||||.|. ||.   ....|. |.          |.||   .. .....|. |..  |.      |..| .|
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase tpa-1.AA Pkinase 268-527 28 6.8e-73 253.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 268-527
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTY-IERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGG----DLMHHIQ--Q
. .....|.||||.| .   || .. .|.|..||. . .. | . .   | ...    ..|. ..|...|... .. .||||..||    ||...|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

IKKF--DEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHI----KLADFGMAKT-EMNRENGMASTFCGTPDYISPEIIK-GQLYNEAVDFW
 ..|  .|   .||. .|. .|...| ..||.||||..|.|.| .|||    |..||| ||  . .  |. ..||||||.|..||.|. || |  .|| |
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLMYEMLVGQSPFHGE------GEDELFDSILNERPYFPKTIS---------------------KEAAKCLSALFDRNPNTRLGMPECPDGPIRQHC
|.|...|||| |. || |.       ...... |.  .. |.   .                     .|. . .. .....|. |.. ..     | || 
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ-----ILQHP

FF
.|
WF
Kinase tpa-1.AA S_TK_X 528-592 33 2.6e-24 88.0 SMART 1-79 (79) Show / Hide 
Range on Protein: 528-592
Range on HMM: 1-79/79
Sequence Identity: 33% (27 aa)

RGVDWKRFEN--RQVPPPFKPNIK----SNSDASNFDDDFTNEKAALTPVHDKNLLASIDPEA---------FLNFSYTN
||.||.. .|  ....|||||.||    |  |.||||..||.|..    ..|..|..|.. ..         |..|.| .
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase tpa-1.AA TyrKc 268-526 22 3.3e-16 39.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 268-526
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILA-SQCPFLCQLFCSFQTN-------EYLFFVMEYLNGGDLMHHIQ
  |.|.|| | ||.|.. ..|   .  | |.||.|        |  . | |..     . | . .|.    .        | |. ||||  .||| ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QIKK-FDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNR-------ENGMASTFCGTPD-----YISPEIIKGQLYN
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KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

EAVDFWSFGVLMYEML-VGQSPFHG-----EGEDELFDSILNE-RPYFPKT--------ISKEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCF
.. | |||||.|.|..  ||.|  |        .|..  . .  |.  |.          ..|  .  .   ...|. |  . |.       .||
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
Kinase tpa-1.AA Pkinase_C 547-594 43 8.3e-16 58.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 547-594
Range on HMM: 1-46/46
Sequence Identity: 43% (21 aa)

NIKSNSDASNFDDDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPH
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QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase tpa-1.AA Pkinase_Tyr 339-468 26 2e-14 49.45 Pfam 80-216 (270) Show / Hide 
Range on Protein: 339-468
Range on HMM: 80-216/270
Sequence Identity: 26% (38 aa)

NEYLFFVMEYLNGGDLMHHIQQ----IKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTE-------MNRENGMAST
| ... ||||  .||| .. ..     ....  .   .. .|  ....|. .|.| |||   |.|.......| .|||.|..          |..|.   
N-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LP

FCGTPDYISPEIIKGQLYNEAVDFWSFGVLMYEMLV-GQSP-F
   .    .|| |.   .... | |||||||.|..  |..| .
IKWM----APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase tpa-1.AA Pkinase_Tyr 268-284 41 0.006775 10.43 Pfam 1-17 (270) Show / Hide 
Range on Protein: 268-284
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FNLLKVLGKGSFGKVML
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ITFGKKLGEGAFGEVYK