Gene ver-3 (Nematode worm)

ver-3

Species: Nematode worm
Alias: CE03437, aSWK386, F59F3.1, ver-3
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: X: 10996240-11001096

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
ver-3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 317 Kinase domain by global Sugen HMM Fasta, JSON
ver-3.AA Protein Genbank 1227 None Fasta, JSON

Protein domain

Protein domains of ver-3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG ver-3.AA IG 37-127 14 2e-06 28.64 SMART 1-58 (58) Show / Hide 
Range on Protein: 37-127
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

GKFVELEEHTRLILKCSAHHNGDLKYNFPSMEGNVGYDENNFKKRMEEYYDDAFGDKVLTLNDVRESDT---GTYSCSSMEHSSLND--TIYVFVH
 . |.  |  .. |.| ..    ..                                 ||. .|...|.   ||| |    | .     .... |.
PP-VTVKEGETVTLTC-VS---QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set ver-3.AA V-set 72-126 26 0.00027 16.64 Pfam 72-128 (128) Show / Hide 
Range on Protein: 72-126
Range on HMM: 72-128/128
Sequence Identity: 26% (15 aa)

GYDENNFKKRMEEYYDDAFGDKVLTLNDVRESDTGTYSCSSME--HSSLNDTIYVFV
|| .. ||.| . . .   .|  ||......||.||| | ..   . .    . . |
GYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 ver-3.AA IGc2 43-117 17 0.009894 1.09 SMART 1-56 (56) Show / Hide 
Range on Protein: 43-117
Range on HMM: 1-56/56
Sequence Identity: 17% (13 aa)

EEHTRLILKCSAHHNGDLKYNFPSMEGNVGYDENNFKKRMEEYYDDAFGDKVLTLNDVRESDTGTYSCSSMEHSS
.| . ..|.| |  | |        .  .                   ... ||. .|...| |.|.|.   . .
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set ver-3.AA I-set 95-110 43 2.597962 3.57 Pfam 60-75 (92) Show / Hide 
Range on Protein: 95-110
Range on HMM: 60-75/92
Sequence Identity: 43% (7 aa)

LTLNDVRESDTGTYSC
||  .|  .|.|.|.|
LTISNVQPDDEGKYTC
IGc2 ver-3.AA IGc2 241-320 21 0.000793 11.58 SMART 1-56 (56) Show / Hide 
Range on Protein: 241-320
Range on HMM: 1-56/56
Sequence Identity: 21% (17 aa)

HVGYNFSLTCNLNYNGSKIFHGYTNKLSIECPQCSHDPGSHVHVDRHRIIGNKISTTVRIQHLELEDSGKYTCIWEHENK
| | ...|||  . |    .| |    ...                        . |..|.. ..||||.|||. .... 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-----------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG ver-3.AA IG 235-332 13 0.001039 19.57 SMART 1-58 (58) Show / Hide 
Range on Protein: 235-332
Range on HMM: 1-58/58
Sequence Identity: 13% (14 aa)

KGFQWPHVGYNFSLTCNLNYNGSKIFHGYTNKLSIECPQCSHDPGSHVHVDRHRIIGNKISTTVRIQHLELEDS---GKYTCIWEHENKETKYT--DYHL
 . ..  .| . .|||  .      .. |                                   .| ....|||   | |.|  .   . ...     .|
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------------LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTL

YVA
.| 
TVQ
V-set ver-3.AA V-set 280-331 24 0.003954 12.62 Pfam 75-128 (128) Show / Hide 
Range on Protein: 280-331
Range on HMM: 75-128/128
Sequence Identity: 24% (13 aa)

SHVHVDRHRIIGNKI--STTVRIQHLELEDSGKYTCIWEHENKETKYTDYHLYV
.... .| .. ||    . ...|..|...||| |.|   ..|. .  . ..| |
YPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set ver-3.AA I-set 276-314 30 0.612334 5.7 Pfam 36-76 (92) Show / Hide 
Range on Protein: 276-314
Range on HMM: 36-76/92
Sequence Identity: 30% (13 aa)

HDPGSHVHV--DRHRIIGNK-ISTTVRIQHLELEDSGKYTCI
.| |. ...  |||..  ..   .| .|.  . .|.|||||.
KD-GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV
IG ver-3.AA IG 577-668 16 3.3e-10 41.15 SMART 1-58 (58) Show / Hide 
Range on Protein: 577-668
Range on HMM: 1-58/58
Sequence Identity: 16% (16 aa)

EPSKIIYEGDNVKLTCVFPLDSDDWSVSWRFENSKSSDISSIPTTTETEIKQYSKHLILNLRDVTTSFT---GTYTCVVKNEDSEKL-LETSIDVK
 |     ||..|.||| ..      ...|.                            |.. .|. . .   |||.|...   . .   .| . |.
PP-VTVKEGETVTLTC-VS------QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set ver-3.AA V-set 570-667 14 7.5e-10 35.81 Pfam 1-128 (128) Show / Hide 
Range on Protein: 570-667
Range on HMM: 1-128/128
Sequence Identity: 14% (19 aa)

SSKATE-SEP----SKIIYEGDNVKLTCVFPLDS----DDWSVSWRF-ENS--------KSSDISSIPTTTETEIKQYSKHLI-----------LNLRDV
.|  |  ...    .    ||..|.|.| .  |.    .. ...| .  ..        ..    . .... .   ....              |.....
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TTSFTGTYTCVVKNE-DSEKLLETSIDV
. | .|||.|.|.|.       .|   |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 ver-3.AA IGc2 583-657 21 0.000112 19.72 SMART 1-56 (56) Show / Hide 
Range on Protein: 583-657
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

YEGDNVKLTCVFPLDSDDWSVSWRFENSKSSDISSIPTTTETEIKQYSKHLILNLRDVTTSFTGTYTCVVKNEDS
 ||..| |||     ..| ...|.. ... .                 .   |....|| .  |.|||.. |. .
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set ver-3.AA I-set 646-655 60 2.837511 3.44 Pfam 71-80 (92) Show / Hide 
Range on Protein: 646-655
Range on HMM: 71-80/92
Sequence Identity: 60% (6 aa)

GTYTCVVKNE
|.||||..|.
GKYTCVATNS
IGc2 ver-3.AA IGc2 687-747 29 1.6e-09 38.84 SMART 1-56 (56) Show / Hide 
Range on Protein: 687-747
Range on HMM: 1-56/56
Sequence Identity: 29% (18 aa)

DYDQYFEINCNMTGTPPPVYQWFKDGNPYTHGDVDGSILRVSRARGEDDGEFHCLATNRAG
  .| ....|  || | |  .|.| | |      ... |...... ||.|. .|.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set ver-3.AA I-set 673-757 29 9.2e-08 28.85 Pfam 1-92 (92) Show / Hide 
Range on Protein: 673-757
Range on HMM: 1-92/92
Sequence Identity: 29% (28 aa)

PSITGGNSNAVVIVDYDQYFEINCNMTGTPPPVYQWFKDGNPYT----HGDVDGSI-----LRVSRARGEDDGEFHCLATNRAGDKLNSIEVQV
|..|   ....| .  .  ||  |. ||.|||. .||||| | .    .  .. .      |..|..  .| |.  | |||..|    ..|..|
PKFTQKPKDVEVQEGETARFE--CQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG ver-3.AA IG 681-758 15 4.6e-05 24.07 SMART 1-58 (58) Show / Hide 
Range on Protein: 681-758
Range on HMM: 1-58/58
Sequence Identity: 15% (13 aa)

NAVVIVDYDQYFEINCNMTGTPPPVYQWFKDGNPYTHGDVDGSILRVSRARGEDD---GEFHCLATNRAGDKLN--SIEVQVN
   | |   .  ...|  .      ..|.               |.. ... ||    |.. | ||  .|..    .....| 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
Kinase ver-3.AA KIN16 847-1163 56 1.9e-257 764.3 In-house 1-332 (332) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-332/332
Sequence Identity: 56% (188 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQ---LYIVTEFIDGGN
||...|.||||||||.|||| |..||...|.|.|| |||||..||.. . |||...||||||||.|.||||||.||||||||||.   |.||||....|.
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVED-PDALCTSDLLSIGLQIAKGMAWLADVPC-VHRDLACRNVLITKT
||.||..|||.|.|..|...... .........   ..........|...|...| .|.||||||||...|||.|| |||.||| ||||||||||.|...
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKE---RKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRN

KIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEE-----FKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFN--------VIEFIRNGNRN
||.|||||||...|.||.|||.|.|.|||||.|||..||.||     .|||.||||||.|.||||||.||.||||||...|        |.|..|.|||.
KIIRIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRL

KQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFF
.|||.||.|||..||.||.|.|..||||..|..||
PQPEHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase ver-3.AA Pkinase_Tyr 847-1163 35 2.7e-131 445.31 Pfam 1-270 (270) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-270/270
Sequence Identity: 35% (114 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVEL--QKMMAEELKVMCAIPKNPNVLALIGAVT-KNMRQGQLYIVTEFIDGGN
....  .|.|.||.|.|| . .       ...|..|||||.  .    |   .... .|.|.|. ....||.. |.|..| .   . |.|||.|.  .|.
ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGD

LREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKI
|...|..||                                            ||...|...|||.. .||||||..|.. .|.|||||.||.|.|....
LLDYLRKHR--------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNV

VRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTP-YPNCDTFNVIEFI-RNGNRNKQPEYCHDEIYEL
|.|.||||.. ..|. || ..|.....||..||..||| . ||| ||||||||....||||.|..| ||... . |.|.| ..|.| ..||.|.||||.|
VKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL

MKVCWQFNPKDRPTFNDCITFF
|| ||...|.||||| ... ..
MKQCWHYDPEDRPTFSEIHEQL
Kinase ver-3.AA TyrKc 847-1163 32 6.30000000001e-127 428.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-280/280
Sequence Identity: 32% (112 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAI-PKNPNVLALIGAVTKN----MRQGQLYIVTEFIDG
.. .  .|.|.||.| || .              ..||||.  .      .... .|...|| . ...||...|.|..|.     |  ..|.||.|. ..
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKT
|.|...|..||..                                               ||..||||. .|||.||. |.. .|.|||||.||.|... 
GDLKDYLRKHRPK-----------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGEN

KIVRIADFGLSKKHTNK-------TYYRTKK--SKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPN-----CDTFNVIEFIRNGNR
..|.|.|||||......        |||.|.  ...|.||.|||..||| . ||| ||||||||.|..||||.|..|||.     .. . |||....|.|
HTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR

NKQPEY--------CHDEIYELMKVCWQFNPKDRPTFNDCITFF
 .||..        |.||.|..|| ||...|.|||||.... .|
MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ver-3.AA TK 847-1163 23 1.2e-112 379.16 In-house 1-486 (486) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-486/486
Sequence Identity: 23% (115 aa)

LEILNPIGSGHFG---VVKKG-LLGMAYPKSKI--------------ESKTRLPVAVKSST--NPFNVELQKM--------------MAEELKVMCA-IP
..... .|.|.||   .| || . |.   ..|               ..... |||||  .  .. . | ...               |||.|.||. . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KNPNVLALIGAVTKNMR---------QGQLYIVTEFIDGGN----LREFLQAHRNTFINELVEDEHVPVDDSYL----------VPNSVKKKIYKFDEKL
. ||.. |.|..|..           |. ..||.|. ..|.    ||..|...|..|..|. . .... .. .           .. |.... ..  |. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY-SHESNSPC-PEEQ

GEGTRLLVEDPDALCTSDLLS-------------------IGLQIAKGMAWLADVPC------VHRDLACRNVLITKTKI-----------VRIADFG--
   ..|. ..|..|.|.|||.                   . .|||.||..|.. .|      ||||||.||.|... ..           ..|||||  
DYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSKKHTNKTYYRTKKSKDT----------------------PLPVRWMPLECIEEFK---------FTQKSDVWSFGICLYEIFTLG-GTPYPN
      |.... ....|..|.|..|                       ||.|||. ||... .         || ||||||||....||||.| ...|..
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

CDT---------FNVIEFIRNG--------------NRNKQPEYCH--------------DEIYELMKVCWQFNPKDRPTFNDCITFF
 .            |.|..|.|              .| .||..|.              .|.|.||. ||...|.||||| ..  ..
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ver-3.AA Met 1001-1157 40 1.4e-67 220.51 In-house 100-271 (271) Show / Hide 
Range on Protein: 1001-1157
Range on HMM: 100-271/271
Sequence Identity: 40% (70 aa)

ALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKH-TNKTYYRTKKSKD-TPLPVRWMPLECIE--------EFK-FTQK
..|  ||.. ..|.||||  .|    ||||||||| .. .  .| .|||||. .    | ||  .   .   |||.||..|| .         .. || |
NPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTK

SDVWSFGICLYEIFTLGGTPYPNCDT-FNVIEFIRNG--NRNKQPEYCHDEIY-ELMKVCWQFNPKDRPTFN
|||||||. . | .| | .|||. |. | .  .   |  .|  ||||| | .| ..|  ||. || |||.| 
SDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase ver-3.AA UTK 847-1163 25 5.8e-67 228.1 In-house 1-296 (296) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-296/296
Sequence Identity: 25% (91 aa)

LEILNPIGSGHFGVVKKGLL----------GMAYPKSKIESKTRLPVAVKSSTNPFNVELQ---KMMAEEL-KVMCAIPK-NPNVLALIGAVTKNMRQGQ
.......|.|.||.| |. .          ..|... .             .. . . |     . | |    .| . ..  |||| |.| .|. .    
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-------------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---

LYIVTEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDL
..||||.  .|.|| .|. || |.                                         ..|..|   ..|.  ..|| ||. |.   .|||||
WMIVTEYMENGDLRSYLRRHRPTPP----------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDL

ACRNVLITKT-------KIVRIADFG---LSKKHT-------NKTYYRTKKSKDTPLPVRWMPLECIEEF-KFTQKSDVWSFGICLYEIFTLGGTPYPNC
|.||.|...         ...|||||   .|.           . .|  ... ....|.|||  |.. .  .||.||||||||. ..||.| | .|||. 
AARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGM

DTFNVIEFIRNG--NRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFF
 . .|.....||   | ..|. | ...|.||. ||. .| .||.| |   ..
SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ver-3.AA TK-Unique 1006-1163 42 2.1e-61 210.28 In-house 132-294 (294) Show / Hide 
Range on Protein: 1006-1163
Range on HMM: 132-294/294
Sequence Identity: 42% (70 aa)

DLLSIGLQIAKGMAWLAD--VPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIE--EFKF-TQKSDVWSFGICLY
||.... |||.||. ||     .|||||. ||||.|  |.. |.|||....  . . | ...|.  ..|.|||..| .   .  . | ||||||||. ..
DLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG-RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMW

EIFTLGGTPYPNCDTFNVIEFIRNGNRNKQPEYC-HDEIYELMKVCWQFNPKDRPTFNDCITFF
||||||..|||. .  ...| ||.| | .|||.|  .|.|.||| ||| .|..||.| ...  .
EIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ver-3.AA KIN6 1006-1163 42 1.1e-59 195.9 In-house 145-305 (305) Show / Hide 
Range on Protein: 1006-1163
Range on HMM: 145-305/305
Sequence Identity: 42% (69 aa)

DLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTK---IVRIADFGLSK-KHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYE
||...  ||. ||  |..  |.||||| ||||.|.        | ||||     . .  | .|  .   ||..|| .||..  .|  ||||||||. ..|
DLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRY--LPIKWMAPECLKHYEFSYKSDVWSFGVLMFE

IFTLGGTPYPNCD-TFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFF
.|.||. |||    .  .||..| | | |.|..| .|||. |. |||  | ||| ||.    |
MFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase ver-3.AA Src 933-1163 30 3.5e-59 199.71 In-house 70-255 (255) Show / Hide 
Range on Protein: 933-1163
Range on HMM: 70-255/255
Sequence Identity: 30% (72 aa)

YIVTEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLA
|||||.   |.| ..|..                                              ..  .|   .|.... |.|.||| |     .|||||
YIVTEYMSHGSLLDYLKK---------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLA

CRNVLITKTKIVRIADFGLSKKHT-NKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFIRNGNRNKQP
 ||||. .. .. .||||| .    ..  |  ..  .  .|..|.  |.| . .||.||||||||| |.||.| | .|||  .   |.. . .| |  .|
ARNVLVGENNVCKVADFGLARLIKEDDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCP

EYCHDEIYE-LMKVCWQFNPKDRPTFNDCITFF
. | ||.|| .|. ||.  |..||||     |.
HNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase ver-3.AA FGFR 1006-1163 41 1.1e-54 184.86 In-house 137-293 (293) Show / Hide 
Range on Protein: 1006-1163
Range on HMM: 137-293/293
Sequence Identity: 41% (66 aa)

DLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTL
|| |.  |.|.|| .||   |.||||| ||||.|   .  |.||||.    .  |||  |  .  ||. || .|   . ..| .|||||.|. | ||.|.
DLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYR--KTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTY

GGTPYPNCD-TFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFF
||.|||         .. . | |   |. |  ||| .|  || |.|..||||   .  .
GGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase ver-3.AA EGFR 1000-1164 37 6.9e-53 173.85 In-house 96-258 (258) Show / Hide 
Range on Protein: 1000-1164
Range on HMM: 96-258/258
Sequence Identity: 37% (62 aa)

DALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSK-KHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGIC
|..   .||  ..|||||| .| .   |||||| ||||. . . |.|.||||.|  . ... |. .  |   .|..|| ||||.. ..| .|||||.|. 
DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGK---MPIKWMALECIHHRCYTHQSDVWSYGVT

LYEIFTLGGTPYPNCDTFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFE
. |. | |. || .  . .. ... .|.| .||. |   .| .|  ||   .. ||||   .. |.
CWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase ver-3.AA VEGFR 1000-1163 38 3.8e-51 176.25 In-house 168-332 (332) Show / Hide 
Range on Protein: 1000-1163
Range on HMM: 168-332/332
Sequence Identity: 38% (65 aa)

DALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKK--HTNKTYYRTKKSKD-TPLPVRWMPLECIEEFKFTQKSDVWSFG
| | . ||..  .|.|.||  ||   |.||||| ||.|..  ..| | ||||..    ..  |   ... | . || .|| .| | .  .| .|||||.|
DPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDY---VRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYG

ICLYEIFTLGGTPYPNCD-TFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFF
. | |||.||| |||  .     . ....|.| . |.||  |||. |  ||  .|. ||.| .    .
VFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase ver-3.AA S_TKc 847-1163 18 2.4e-26 94.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 847-1163
Range on HMM: 1-231/231
Sequence Identity: 18% (62 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDG--GNL
 |||..||.| ||.|.|.              |   ||.|           ...  |....    . ||.  |...       . ||.|.|..||  |.|
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDL

REFLQAHRNTF----INELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITK
..... ..       ..| .                                                ..  ||..... . .   .||||   |.|...
FDYIKKRGRHGLRFPFPE-H----------------------------------------------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE

TKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQ-KSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFIRNGNRNKQPEYCHDEIY
   . |.||||...            .       .|. | .   ...  |.|.||.|..||| .. | .|.|  . . ... |.            .|  
--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAK

ELMKVCWQFNPKDRPTFNDCIT---------FF
.... |.|..|..|||  .. .         .|
DFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ver-3.AA Pkinase 1006-1163 20 6.1e-17 60.99 Pfam 109-293 (293) Show / Hide 
Range on Protein: 1006-1163
Range on HMM: 109-293/293
Sequence Identity: 20% (40 aa)

DLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIV----RIADFGLSKKHTNKTYYRTKKSKDTPLPV---RWMPLECIE-EFKFTQKSDVWSFGI
.. .. .||..|.. . .  ..||||   |.|| ..  .    .|.||||.|..       . ..  .  ..   ..|. | |    . ..|.|.||.|.
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGC

CLYEIFTLGGTPYPNC----DTFNVIEFIRNGNRNKQPEYCH-----------------------DEIYELMKVCWQFNPKDRPTFNDCITF--F
 ||| .. | .|.|..    .  . .. |..  . . .. .                        .|  ...| |....||.|||. ..     |
ILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ver-3.AA TK-Unique 847-952 25 2.6e-14 45.88 In-house 1-100 (294) Show / Hide 
Range on Protein: 847-952
Range on HMM: 1-100/294
Sequence Identity: 25% (27 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKI-ESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLR
||... ||.| || | .| .     .... ..  .  ||||    ... . ....  |...| .... ||.. ..|. ||.   .. .|. |.. .|||.
LEVGDVIGEGAFGQVWRGEV-----WGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQ

EFLQAHR
 .|.  |
HYLRTCR
Kinase ver-3.AA FGFR 903-952 40 9.4e-10 29.37 In-house 54-100 (293) Show / Hide 
Range on Protein: 903-952
Range on HMM: 54-100/293
Sequence Identity: 40% (20 aa)

ELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHR
|. .|  | |..|.. |.|. | .   | ||.. |.   ||||.||.|.|
EMEMMKMIGKHKNIINLLGCCTQE---GPLYVIVEYCHHGNLRDFLRARR
Kinase ver-3.AA Pkinase 847-958 22 7.5e-09 32.38 Pfam 1-107 (293) Show / Hide 
Range on Protein: 847-958
Range on HMM: 1-107/293
Sequence Identity: 22% (27 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAE---ELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGG-
..|. .|||| ||.|.|.          .. .|.  ||||    . . . ... .    |...|  . . ||.. |.....     . .|.|.|. .|| 
YHIGRKIGSGSFGCVYKC----------HHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGL

---NLREFLQAHRNTFI--NE
    | ......|.. .   |
YVMDLFDYISTWRHGCFYFSE
Kinase ver-3.AA VEGFR 903-958 33 1.3e-07 25.02 In-house 52-107 (332) Show / Hide 
Range on Protein: 903-958
Range on HMM: 52-107/332
Sequence Identity: 33% (19 aa)

ELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINE
|||..  | .  ||  . |..|||. .| | .  |.   |||  .| . |..|  .
ELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMYFVPY
Kinase ver-3.AA EGFR 847-954 25 1e-06 17.78 In-house 1-97 (258) Show / Hide 
Range on Protein: 847-954
Range on HMM: 1-97/258
Sequence Identity: 25% (27 aa)

LEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVKSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLRE
|  .   ||| || | ||.    .|. .   . . |||.|   .  . . .. | .| .||  . ..|... |.|     | .  . .|| ..  |.| .
LKKVKVLGSGAFGTVYKGIW---IPEGE---NVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVC---MHSQ-MQLVTQYMPYGCLLD

FLQAHRNT
... |...
YVRQHKDN
Kinase ver-3.AA Met 848-864 47 0.000377 9.18 In-house 1-17 (271) Show / Hide 
Range on Protein: 848-864
Range on HMM: 1-17/271
Sequence Identity: 47% (8 aa)

EILNPIGSGHFGVVKKG
  . .|| ||||.| .|
HFDDVIGQGHFGCVYHG