Gene ver-4 (Nematode worm)

ver-4

Species: Nematode worm
Alias: ver-4, CE03440, aSWK388, F59F3.5
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: X: 10986159-10991623

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
ver-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 306 Kinase domain by global Sugen HMM Fasta, JSON
ver-4.AA Protein Genbank 1199 None Fasta, JSON

Protein domain

Protein domains of ver-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG ver-4.AA IG 37-126 14 0.073395 7.11 SMART 1-58 (58) Show / Hide 
Range on Protein: 37-126
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

GDYVELVEGKNRDISLTCYGQHKNLKIEPPKREEHAGFPEIGIRTSAEWKKNEYWFLLKNVRQCDT---GSYYCVSDEFKESMLQN--TVHIFVR
   |. .|    ...|||  .                        .  |.     . . ||.  |.   | |||.       . .   .... |.
PP-VTVKE--GETVTLTC-VS------------------------QIWWY-----LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ
V-set ver-4.AA V-set 94-125 25 0.080842 8.1 Pfam 97-128 (128) Show / Hide 
Range on Protein: 94-125
Range on HMM: 97-128/128
Sequence Identity: 25% (8 aa)

LKNVRQCDTGSYYCVSDEFKESMLQNTVHIFV
..|..  |.| |||..  . |   .. ..  |
ISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG ver-4.AA IG 170-355 7 0.005367 16.96 SMART 1-58 (58) Show / Hide 
Range on Protein: 170-355
Range on HMM: 1-58/58
Sequence Identity: 7% (15 aa)

KNMYTMKPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSA
   .| |. .|| ..| ..                         ..|                                                     
PP-VTVKEGETVTLTC-VS------------------------QIWWY----------------------------------------------------

HEIEKRSSGLRFGDPSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDS---GIYRCTWRNRSKTNIVLDYDLNFNQ-KGTQIKII
                                           .. |.. |||   |.|.|. .             .  . .||.... 
------------------------------------------LTI-NVQPEDSQQHGTYYCQAT-----------HGQYWSIQGTTLTVQ
IGc2 ver-4.AA IGc2 176-334 9 0.010038 1.03 SMART 1-56 (56) Show / Hide 
Range on Protein: 176-334
Range on HMM: 1-56/56
Sequence Identity: 9% (15 aa)

KPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKR
..  .| ..|. |.. . .   |  ..  .                                                                      
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----------------------------------------------------------------------

SSGLRFGDPSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDSGIYRCTWRNRSK
                                .. |....| | ||||.|.|. ||.  
--------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set ver-4.AA V-set 311-327 41 0.09877 7.8 Pfam 94-110 (128) Show / Hide 
Range on Protein: 311-327
Range on HMM: 94-110/128
Sequence Identity: 41% (7 aa)

TVNFQNLTSEDSGIYRC
... .||...|||.| |
SLTISNLQPSDSGTYYC
I-set ver-4.AA I-set 314-328 33 1.401169 4.48 Pfam 62-76 (92) Show / Hide 
Range on Protein: 314-328
Range on HMM: 62-76/92
Sequence Identity: 33% (5 aa)

FQNLTSEDSGIYRCT
..| ...|.|.|.|.
ISNVQPDDEGKYTCV
IG ver-4.AA IG 587-676 18 2.1e-09 38.51 SMART 1-58 (58) Show / Hide 
Range on Protein: 587-676
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

EPSDIIFEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFT---GTYYCIVKNKEFEHRF--ETSISVE
 |     ||..|.||| |.       ..|.                          |.. |.. . .   ||||| ..    ..    .| ..|.
PP-VTVKEGETVTLTC-VS------QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 ver-4.AA IGc2 593-665 21 0.0003 15.62 SMART 1-56 (56) Show / Hide 
Range on Protein: 593-665
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

FEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYCIVKNKEF
 ||..|.|||    |. . .. |..   ..|               ..  |...|.| .  |.| |.. |.  
HEGQSVTLTCP-ATGNPDPNIHWYK--GQPLP--------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set ver-4.AA V-set 594-677 20 0.00096 14.74 Pfam 20-128 (128) Show / Hide 
Range on Protein: 594-677
Range on HMM: 20-128/128
Sequence Identity: 20% (23 aa)

EGDNVRLTCVVPYGA----VEFDVFWKF-ENP--------KMLKYTTFP-AMHPVKDRYK-RVI-----------LNVRNITIDFTGTYYCIVKNKEFEH
||..|.|.| .  .      .|...| .  .|        . . . ...  .. ...|.| ||            |. .|.. . .||||| |.|   |.
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC-NED

RFETSISVEK
 |.... .  
YFGHGTRLTV
IGc2 ver-4.AA IGc2 695-755 27 2.8e-10 41.39 SMART 1-56 (56) Show / Hide 
Range on Protein: 695-755
Range on HMM: 1-56/56
Sequence Identity: 27% (17 aa)

SNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAG
  || . ..|...| |.|. .|.| | |       .. |... ... | |. .|.|.|..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP----WNWTLTIKNVTPEDSGYYTCYARNPWG
IG ver-4.AA IG 689-766 14 6.2e-09 36.92 SMART 1-58 (58) Show / Hide 
Range on Protein: 689-766
Range on HMM: 1-58/58
Sequence Identity: 14% (12 aa)

RSIISASNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDN---GIFWCSATNRAGTTID--YIEVKVA
 . .... |.   ..| |.      ..|.               |.. .... |    |...| ||  .|..     ....| 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set ver-4.AA I-set 701-765 29 8.9e-05 18.72 Pfam 19-92 (92) Show / Hide 
Range on Protein: 701-765
Range on HMM: 19-92/92
Sequence Identity: 29% (22 aa)

DINCKVNGVPTPDYTWFKDGYPYTK----GKVIGNA-----LHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKV
. .|.| | |.|. .||||| | .      ..  .      | .|.....| |.  | |||..|.    .|..|
RFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set ver-4.AA V-set 681-765 11 2.915197 2.73 Pfam 1-128 (128) Show / Hide 
Range on Protein: 681-765
Range on HMM: 1-128/128
Sequence Identity: 11% (15 aa)

PFLLNNNSRS----IISASNGQMFDINCKVN-----GVPTPDYTWFKDGYPY--------------------------TKGKVI--------GNALHVSK
.. .   . .     .... ||.  ..|..        .. ...|...  |                            ||.|            |. |.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

AEKRDNGIFWCSATNR-AGTTIDYIEVKV
..  |.|. .| ..|   ..    ... |
LQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase ver-4.AA KIN16 853-1158 52 2.4e-241 716.13 In-house 1-332 (332) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-332/332
Sequence Identity: 52% (174 aa)

LEILETLGSGQFGIVKKGYLNMASSKN-FGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGE---LFIVTELIDGGN
||..|.||||.||.|.||.|.|...|| .....||.||.||........ |||...|||.||||.||||||.|||||||||..|.   |.||||....|.
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LREFLRERRDVFANELVEKGYIFLTN-------VRENVPKREVEKEQLLIDE-FNSLCTSDLLSIGLQIANGMDWLANIPC-VHRDLACRNVLISKTKII
||.|||..|..| |..|.. . ....       ....|.|...|.|||.|.. |.|||||||||...||||||.|||..|| ||||||||||.|...|||
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITD-----LTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFS--------LVEYIKTGNINKRP
||||||||..|..|.|||...| |||||.|||..|.. .     ..||.||||||||.||||||.||.||||.|||..        ..||...|| ...|
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQERKMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQP

SNCHKDVYKIMKMCWQASPDDRPTFAECIKLF
 .||...|..|||||...|..|||| ||...|
EHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase ver-4.AA TyrKc 853-1158 33 3.4e-130 439.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-280/280
Sequence Identity: 33% (111 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAI-PKHPNVLSLVGAVTKN----MEIGELFIVTELIDGG
.. ...||.|.||.| || ..            . ||.|.  ...    ...| .|...|| . ..|||.. |.|..|.     |.|. |.||.|. ..|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

NLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLA
.|...||..|.                                      ||..||||. .|||.||. |.  .|.|||||.||.|... ....|.||||.
DLKDYLRKHRPK-------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS

KKHTDK-------AYYRVRE--SLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPD-----CPNFSLVEYIKTGNINKRPSN-----
....|.        |||..|  . .|.||.|||..|.| . .|| ||||||.|.|..||||.|..|||.     ..|. ..||.|.|.  ..| |     
RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS

---CHKDVYKIMKMCWQASPDDRPTFAECIKLF
   |....|.|||.||.. |.|||||.|....|
FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ver-4.AA Pkinase_Tyr 853-1158 32 2.2e-128 435.46 Pfam 1-270 (270) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-270/270
Sequence Identity: 32% (102 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMEL--QKMFFEELKLMCAIPKHPNVLSLVGAVTKNME-IGELFIVTELIDGGNL
......||.|.|| |.||....      . . .. ||.|.  ...  |   ...|..|.|.|. ...|||...|.|..|.  | . ...||.|.  .|.|
ITFGKKLGEGAFGEVYKGTWKG-----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDL

REFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKK
...||..|                                  .. ..|...|||.. .|||.||..|....|.|||||.||.|........|.|||||. 
LDYLRKHR----------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD

HTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTP-YPDCPNFSLVEYI-KTGNINKRPSNCHKDVYKIMKMCWQASPDD
.... || .| . ...||..||..|.| .  || ||||||.|....||||.|..| ||...|. ..||| . |.  ..| ||....|..||.||.. |.|
IYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPED

RPTFAECIKLF
||||.|..  .
RPTFSEIHEQL
Kinase ver-4.AA TK 853-1158 22 5e-109 366.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-486/486
Sequence Identity: 22% (109 aa)

LEILETLGSGQFG---IVKKGYLNMAS---SKNF-------------GFESRLSVAIKSST--DSSNMELQKM--------------FFEELKLMCA-IP
......||.||||    | || ... .   .|.|             . . .  ||.|  .  |....| ...              . ||.|.||. . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNVLSLVGAVTKNME---------IGELFIVTELIDGGN----LREFLRERRDVFANELVEKGYIFLTNVRE-------------------NVPKREV
.|||...|.|..|.. .          . . ||.|. ..|.    ||..||..|. | .|. ...    .....                   . |  . 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

EKEQLLIDEFNSLCTSDLLS-------------------IGLQIANGMDWLANIPC------VHRDLACRNVLISKTKI-----------IRIADFG---
 ...|. |....|.|.|||.                   . .|||.|| .|.  .|      ||||||.||.|... ..           ..|||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LAKKHTDKAYYRVRESLDT----------------------PLPVRWMPLESIT---------DLTFTQKSDVWSYGICLYEIFTLG-GTPYPDC
     ||... .. .|....| .|                       ||.|||. |...         . .|| ||||||.|....||||.| ...|.. 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PN---------FSLVEYIKTG--------------NINKRPSNCH--------------KDVYKIMKMCWQASPDDRPTFAECIKLF
.|           ..||...|              .  ..| .|.              ...| .|..||.. |.|||||... . .
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ver-4.AA UTK 853-1153 27 1.4e-60 205.97 In-house 1-291 (296) Show / Hide 
Range on Protein: 853-1153
Range on HMM: 1-291/296
Sequence Identity: 27% (90 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQK-MFFEELK--LMCAIPK-HPNVLSLVGAVTKNMEIGELFIVTELIDGGN
......||.|.||.| |. .. .|        .. |. .....  ..|     | || .   | . .. ||||| ||| .|. .    . ||||.  .|.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEP-YPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGD

LREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSD-LLSIGLQIANGMDWLANIPCVHRDLACRNVLISKT-------KIIR
|| .||  |. .                                ..  . |.. .|.  ..||.||  |..  .||||||.||.|. .         ...
LRSYLRRHRPTPP-------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCK

IADFG---LAKKHT-------DKAYYRVRESLDTPLPVRWMPLESITDL-TFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTG--NINKRPS
|||||   ...          .. .| .. . ....|.|||  |..|.  .||.||||||.|. ..||.| | .|||.  |  ... .  |     ..| 
IADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPW

NCHKDVYKIMKMCWQASPDDRPTFAE
 |  .||..|. ||...|..||.| .
DCPHPVYRLMHRCWHYDPQERPDFED
Kinase ver-4.AA TK-Unique 1001-1158 39 1.9e-60 207.1 In-house 132-294 (294) Show / Hide 
Range on Protein: 1001-1158
Range on HMM: 132-294/294
Sequence Identity: 39% (65 aa)

DLLSIGLQIANGMDWLANIPC--VHRDLACRNVLISKTKIIRIADFGLAKK-HTDKAYYRVRESLDTPLPVRWMPLESIT--DLTF-TQKSDVWSYGICL
||.... |||.||  ||  ..  |||||. ||||..  |.. |.|||.|.. .|...|  ...    ..|.|||..||.   . .. | ||||||.|. .
DLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVY--SMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLM

YEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNC-HKDVYKIMKMCWQASPDDRPTFAECIKLF
.||||||..|||. |. ...| |. | . ..|..|  ...|..|| ||| .|..||.|..... .
WEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase ver-4.AA Src 853-1158 28 3.5e-59 199.69 In-house 1-255 (255) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-255/255
Sequence Identity: 28% (89 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREF
.  .. ||.|||| | .|| |           .  ||.|.    . |. ...| .| ..|    .|.....|   ...       .||||.   |.| ..
IKLCRKLGQGQFGEVWMGYWNG----------NTKVAVKTLKPGT-MS-PEAFLQEAQIMKKL-RHEKLVQLYAVCSQEE---PIYIVTEYMSHGSLLDY

LRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHT-
|..                                    .|  .|   .|.... |.|.||. |     .||||| ||||.... .  .||||||.    
LKK-----------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKE

DKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYK-IMKMCWQASPDDRPT
|.  |  |.  .  .|..|.  | |.  .||.||||||.|| |.||.| | .|||   |   .. .. |    .|.|| . .|. ||..||...|..|||
DDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPT

FAECIKLF
|.   . .
FEYLQWFL
Kinase ver-4.AA FGFR 1001-1158 42 2.5e-57 193.96 In-house 137-293 (293) Show / Hide 
Range on Protein: 1001-1158
Range on HMM: 137-293/293
Sequence Identity: 42% (68 aa)

DLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTL
|| |.  |.| ||..||   |.||||| ||||..   .. |.|||||    .  ||| .   .  ||. || .|.  |  .| .|||||||. | ||.|.
DLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTT--NGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTY

GGTPYPDCP-NFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLF
||.|||  |    | .| |.|    .|.|| ...| .|  || ..|..||||.. .  .
GGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase ver-4.AA Met 992-1152 35 1.4e-56 183.85 In-house 96-271 (271) Show / Hide 
Range on Protein: 992-1152
Range on HMM: 96-271/271
Sequence Identity: 35% (63 aa)

DEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKH-TDKAYYRVRESLD-TPLPVRWMPLESIT--------DLT-
.. | .|  ||.. ..|.| ||  .|    ||||||||| ....  .. .|||||. .   || || ...  .   |||.||..|.          .   
NPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQ

FTQKSDVWSYGICLYEIFTLGGTPYPDCPN-FSLVEYIKTG--NINKRPSNCHKDVY-KIMKMCWQASPDDRPTFA
|| |||||| |. . | .| | .|||.  | | .  . ..|  .   .|  |   .|  .|  ||.|.| |||.| 
FTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase ver-4.AA InsR 853-1160 29 1.9e-55 184.66 In-house 1-278 (278) Show / Hide 
Range on Protein: 853-1160
Range on HMM: 1-278/278
Sequence Identity: 29% (92 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRL-SVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGE-LFIVTELIDGGNLR
....  .| | || |  | ..   . .   |.|   .|||.  ..  |.    |  |   | .. .. .|  | | ...    |.   .| |. . |.|.
IVLIRECGQGSFGMVYEGIAKGIVPDE---EWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSR----GQPMYVVMEMMTYGDLK

EFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKH
 .|| ||                             .  ... .   | .....   .|. || .|| .  ||||||||| ....   . |.|||..   
SYLRSRRPEEEF-----------------------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDI

TDKAYYRV-RESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYI-KTGNINKRPSNCHKDVYKIMKMCWQASPDDR
 .  |||  . ..   ||||||. ||..|  || .|||||.|. |.|. |||  ||    |    .|| . ||. ..| || . ....|.|||| .| .|
YEHDYYRKGGKGM---LPVRWMAPESLKDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMR

PTFAECIKLFKN
||| . |.. ..
PTFLDIIHYLCD
Kinase ver-4.AA VEGFR 999-1158 41 1.8e-49 170.67 In-house 172-332 (332) Show / Hide 
Range on Protein: 999-1158
Range on HMM: 172-332/332
Sequence Identity: 41% (67 aa)

TSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKK--HTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYE
. ||..  .|.|.||. ||   |.||||| ||.|..  ... | |||||.    .|  |  ||    . || .|| .||| |  .| .|||||||. | |
MEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDY--VRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IFTLGGTPYPDCP-NFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLF
||.||| |||    .  .   .| |.  ..|  |   .|.||  ||   |  ||.|.|  . .
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase ver-4.AA Fer 999-1159 30 1.1e-47 160.48 In-house 110-283 (283) Show / Hide 
Range on Protein: 999-1159
Range on HMM: 110-283/283
Sequence Identity: 30% (54 aa)

TSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISK-TKIIR--IADFGLAKK-HTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICL
. ... . .|.|.||. |    |.|||.| ||.|..|    .   |.|||....  ...  |. .|   . .|.||.. |.... ... |.||||.|. .
DNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE-KACKVPIRWLAPETWQTGIYSPKTDVWSFGVMC

YEIFTLGGTPYPD------CPNF--SLVEYIKT-GNINKRPSNCHKDVYKIMK-MCWQASPDDRPTFAECIKLFK
.|||| | .|||.      . |   .... | . |.  . |.........||. .|||. |.||||..| .. .|
WEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase ver-4.AA S_TKc 853-1164 20 6.5e-27 96.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 853-1164
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDG--GNLR
 |||...|.| || |.|.. .          .   ||||           ...  |....    .|||.  | ..       ..|..|.|..||  |.|.
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLF

EFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKH
.....|.    .                                  .   .  ..  ||..... . .   .||||   |.|...   | |.|||||.. 
DYIKKRGRHGLR--------------------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL

TDKAYYRVRESLDTPLPVRWMPLESITDLTFTQ-KSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRP
                   .|. | .    ..  |.|.|| |..||| .. | .|.|    . . . |.            ...  ... |.|  |..||
-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRP

TFAECIK---LFKNHIQY
|  |. .   . |.|   
TA-EALQDEWDIKCHPWF
Kinase ver-4.AA Pkinase 853-1158 18 1.1e-21 77.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 853-1158
Range on HMM: 1-293/293
Sequence Identity: 18% (65 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIK-SSTDSSNMELQKMFFE--ELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGG--
..|....||| || |.|..    .           ||.|  . .. ... ..  .   |...|  . .|||.. | ....     ... .|.|. .||  
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLY

--NLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSL--CTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKII----
   | ....                                     .. ...     .. .. .||. |.. . .  ..||||   |.||...  |    
VMDLFDYIST------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV

RIADFGLAKKHTDKAYYRVRESLDTPLP-VRWMPLESIT-DLTFTQKSDVWSYGICLYEIFTLGGTPYPDC------PNFSLVEYIKTGNINKRPS----
.|.||||||..     |   . ..|.    ..|. | |  .   ..|.|.||.|. ||| .. | .|.|..          ... |. . .    .    
KICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCS

----------------NCHKDVYKIMKMCWQASPDDRPTFAECIKL--F
                | ...  ...| |..  | .|||.... .   |
ISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ver-4.AA TK-Unique 853-959 27 2.1e-21 70.64 In-house 1-102 (294) Show / Hide 
Range on Protein: 853-959
Range on HMM: 1-102/294
Sequence Identity: 27% (29 aa)

LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREF
||.....|.|.|| | .|   ...... ... . .||.|   |... . ...|. |...| ....|||.....|. ||.   .  .|. | . .|||. .
LEVGDVIGEGAFGQVWRG---EVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHY

LRERRDV
||..|..
LRTCRPA
Kinase ver-4.AA VEGFR 908-963 37 4.9e-10 34.23 In-house 52-107 (332) Show / Hide 
Range on Protein: 908-963
Range on HMM: 52-107/332
Sequence Identity: 37% (21 aa)

ELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANE
|||..  | .| || .. |..|||.  |.|..  |    |||  .||  |. |  .
ELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTKRMYFVPY
Kinase ver-4.AA FGFR 908-957 42 4.6e-08 23.52 In-house 54-100 (293) Show / Hide 
Range on Protein: 908-957
Range on HMM: 54-100/293
Sequence Identity: 42% (21 aa)

ELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERR
|.  |  | ||.|.. | |. | .   | |... |.   ||||.|||.||
EMEMMKMIGKHKNIINLLGCCTQE---GPLYVIVEYCHHGNLRDFLRARR
Kinase ver-4.AA Fer 853-966 26 1.4e-07 22.04 In-house 1-115 (283) Show / Hide 
Range on Protein: 853-966
Range on HMM: 1-115/283
Sequence Identity: 26% (32 aa)

LEILETLGSGQFGIVKKG-YLNMASSKNFGFE-SRLSVAIKSS-TDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGE--LFIVTELIDGG
 .. . ||.| ||.|.||    .   |  ...   . |. |   ......| .| |. | ..|    .||||  . |     .   |  . || |...||
VTLGKKLGEGAFGEVYKGRR-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYG-----VCVDEQPIMIVMEFCNGG

NLREFLRERRD--VFANELVE
.|...|..  .  |  ||...
SLDSYLKKNKNKTVSDNEKIR
Kinase ver-4.AA Met 917-926 80 0.066164 1.7 In-house 59-68 (271) Show / Hide 
Range on Protein: 917-926
Range on HMM: 59-68/271
Sequence Identity: 80% (8 aa)

KHPNVLSLVG
.|||||||.|
DHPNVLSLIG