Gene W01B6.5 (Nematode worm)

W01B6.5

Species: Nematode worm
Alias: CE03757, aSWK351, W01B6.5
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:4.51, WormBase Physical Map location: IV: 10076303-10078627

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
W01B6.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 275 Kinase domain by global Sugen HMM Fasta, JSON
W01B6.5.AA Protein Genbank 553 None Fasta, JSON

Protein domain

Protein domains of W01B6.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 W01B6.5.AA SH2 107-243 20 2.1e-19 71.72 SMART 1-87 (87) Show / Hide 
Range on Protein: 107-243
Range on HMM: 1-87/87
Sequence Identity: 20% (30 aa)

MPCFHGFIGREDLMSVLKNV----GDFLIRTSVQPNKHEVEKMKKNQADVKVLGNLSREKCAKKEKEKEEKLAGMGDVGRREFVISVYCKDKEKPATDKP
.|..||.| ||.  . |||.    ||||.| | .                                             ....|.|| .|          
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES--------------------------------------------NPGDYVLSVRWK----------

QYTPIRNLVIKRDN-GMVHVEP--LRKFKTLTEFFGYYQKNSGI
    ... .|.|.. |.....    ||| .| |   .||.|.. 
--GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase W01B6.5.AA Fer 268-543 36 1.6e-131 443.24 In-house 1-283 (283) Show / Hide 
Range on Protein: 268-543
Range on HMM: 1-283/283
Sequence Identity: 36% (110 aa)

ALQQKKLGEGAFGEVRIG--KMKLKSTKKTVE--VAVKMLRN-AEVVIREQVGELLHEARVMRM-MDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYL
   .|||||||||||. |  ..|.|  |. |   ||||. .. .|....||  |..||||.||. .||.|| . ||..|...|.... |.| .|.|..||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RENQE-TVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKI----SERYEMK-EQCKIPVRYLA
..|.. ||...||. .. ....| .||||.. ||||.| ||.|. .. .                 .||||||...      ..|.|| ..||.|.|.||
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKK--------------CKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLA

PETLESFIFTTKTDVFSFGCVIWEIYENGN-----QPHDG-KNAQT----IRNLTKKNQFLKLTNSAPSELRKLIEERVFTSDPENRCSMTTIVQCAE
|||....|...||||.|||...|||..||      ||| | |....    ... .||. .....|..|.|........... |||.|..|..|.|. .
PETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPH-GMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase W01B6.5.AA TyrKc 271-542 30 5.9e-86 292.79 SMART 4-280 (280) Show / Hide 
Range on Protein: 271-542
Range on HMM: 4-280/280
Sequence Identity: 30% (93 aa)

QKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMM--DHKNVLRSYGIAVLK-------EPLYLMTEMCACGALREYL
 |||||||||||. |..|       ..||||||..        . ....|||.|..   .|.|..| ||... .       |||.. .| .. |.|..||
GKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RENQETVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKISERY-------EMKE-----QCK-
|...........| | .  ..| .||||.. |||||| ||.|. ...                 . |||||||..  . .       ...      ..| 
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-IPVRYLAPETLESFIFTTKTDVFSFGCVIWEIYENGNQPHDG-----KNAQTIRNLTKKNQFLKLTNS--------APSELRKLIEERVFTSDPENRCS
 .|.| .|||..   .||||.||.||| ..|||. .| ||. |     ...| .... |.   ..   .        .|.|. . | ..    |||.|..
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPT

MTTIVQCA
...|..| 
FSEIHECF
Kinase W01B6.5.AA TK 268-542 18 3.2e-73 244.6 In-house 1-486 (486) Show / Hide 
Range on Protein: 268-542
Range on HMM: 1-486/486
Sequence Identity: 18% (93 aa)

ALQQKKLGEGAFG---EVRIG---------------------KMKLKSTKKTVEVAVKMLRN-AEVVIREQVGELLH----------EARVMRMMD----
    ||||||.||   ||. |                     |.| ........||||||.  ..   .|.  | .|          ||..| ||.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNVLRSYG-------------IAVLKEPLYLMTEMCACGA----LREYLRENQET-------------------------------------------
 |.|..| ||             . |..||.....|....|     ||.|||.. ..                                           
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VTLAEKLFFVVGSSRGVQYLHSQ------KTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKI
                                .|....| . .  ..| .||||.      . .||||| ||.|. .. ..  . .     . . .. ||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWH-F-----DGCGPVCKI

SDFGLAK-----------ISERYEMKE------------------------QCKIPVRYLAPETLESFI---------FTTKTDVFSFGCVIWEIYENG-
.||||..            .. |  |.                        ..|.|.|..|||.|.. .         ||||.||.|||...|||. .| 
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQ

NQPHDGKNA---------QTIRNLTKK------------NQFLKLT--NSAPS-------------ELRKLIEERVFTSDPENRCSMTTIVQCA
 ... | .          | . .. ..             . . .     .|.             |.  ..  . .  ||| | ........ 
EPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Pkinase_Tyr W01B6.5.AA Pkinase_Tyr 267-504 33 8.1e-69 233.7 Pfam 1-233 (270) Show / Hide 
Range on Protein: 267-504
Range on HMM: 1-233/270
Sequence Identity: 33% (84 aa)

IALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQ--VGELLHEARVMRMM-DHKNVLRSYGIAV-LKEP--LYLMTEMCACGALREY
| .  |||||||||||. |..| .  .....||||||   |    ||    ....||..|. . .|.|..| ||. .  .||  .|. .| ...| |..|
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML--KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LREN---QETVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKIS---ERY-EMKEQCKIPVRY
||..   .. .|. ..| . .  ..| .||.|.. |||||| ||.|. .                  .. ||.|||||.     . |  ... .|.|.. 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----------------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKW

LAPETLESFIFTTKTDVFSFGCVIWEIYENGNQP-HDGKNAQTIRNLT-KKNQ
.||| .   .||||.|| ||| ..|||.  | ||   |   . . ..  ....
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
Kinase W01B6.5.AA UTK 270-487 33 1.6e-47 160.67 In-house 3-240 (296) Show / Hide 
Range on Protein: 270-487
Range on HMM: 3-240/296
Sequence Identity: 33% (84 aa)

QQKKLGEGAFGEVRIGKMKLKS-TKKTVEVAVKMLRNAEVVIREQVG--ELLHEAR---VMRMMD-HKNVLRSYGIAVLKEPLYLMTEMCACGALREYLR
. ..||.||||||. .. .  |   ... |||| ... ..  .|. .  ... |||   .| . . | |||| .|. .  ||... ||... | || |||
LGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLR

ENQET-------VTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFG---LAKISER-----------Y
 . .|       .|| ..| ...  .||.|||||.. .||||| ||.|. . |           |.. . . ||.|||   ...   .           |
RHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHR---------M-MWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYY

EMKE-QCKIPVRYLAPETLESF-IFTTKTDVFSFGCVIWEIYENGNQP
.|.  |...|.|  ||| | .   ||||.||.||| | |||. .|..|
YMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLP
Kinase W01B6.5.AA TK-Unique 268-542 26 3e-46 157.47 In-house 1-294 (294) Show / Hide 
Range on Protein: 268-542
Range on HMM: 1-294/294
Sequence Identity: 26% (83 aa)

ALQQKKLGEGAFGEVRIGKMKL--KSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMD-HKNVLRSYGIAVLK-EPLYLMTEMCACGALREYLRE
   ....||||||.|  |...   |.  |.. ||||||.  . .  ... ..| |...|.  . |.|... .|. . . || ... | |.|| |. |||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK--DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRT

NQET-----------------------VTLAEKLFF--VVGSSRGVQYLHS--QKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAK
.. .                        .. .|...   ..  .| .||.|  .| .||||. ||.|| .                  .. ||.|||.|.
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----------------DKVCKICDFGMAR

---ISERYEMK-EQCKIPVRYLAPETLE--SFIF-TTKTDVFSFGCVIWEIYENGNQPHDGK-NAQTIRNLTKKNQFLKLTNSAPSELRKLIEERVFTSD
     . |.|. .| .||.|..||| |     .. |||.|| |||...|||  .| .|  |  ... ......    ..  .... |...|... .....
DVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKS-CWQWE

PENRCSMTTIVQCA
|| | | ..|..  
PEERPSFRQIKHRL
Kinase W01B6.5.AA Src 267-499 29 2.1e-41 138.37 In-house 1-213 (255) Show / Hide 
Range on Protein: 267-499
Range on HMM: 1-213/255
Sequence Identity: 29% (71 aa)

IALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLR--EN
| |  .|||.| ||||  |.      .....|||| |. .      ..  .| || .|  ..|..... | .   .|| |  ||  . | | .||.  . 
IKL-CRKLGQGQFGEVWMGYW-----NGNTKVAVKTLKPGT----MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGE

QETVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKISE----RYEMKEQCKIPVRYLAPETLE
  .. | . . .    ..| .|| |.. |||||| ||.|  ..                    |. |||||.. .     |....  |.|..  ||| . 
GRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-----------------VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAIN

SFIFTTKTDVFSFGCVIWEIYENGNQPHDG-KNAQTIRNL
   ||.|.|| |||  ..||   |  |  | .|.......
YGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQV
Kinase W01B6.5.AA Ack 267-496 32 2.1e-40 134.02 In-house 1-220 (266) Show / Hide 
Range on Protein: 267-496
Range on HMM: 1-220/266
Sequence Identity: 32% (77 aa)

IALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPL-YLMTEMCACGALREYLRENQ
| |  .|||.| || |. |  .. .  |...|||| ||  ..   .  ...| |. .|  .|| ...| ||. ||  |.  . ||.. ||.| . ||. .
ITL-CEKLGDGCFGVVWRGEWTN-PGGKHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGV-VLDQPMLMMVTELAPCGSLLDCLRKHC

E--TVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLA---KISER-YEMKEQC--KIPVRYLAPE
     ...  . | .    | .||...  |||||| |||||  .                    ||.||||    .. |  | |...   |.|    |||
RTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD----------------RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPE

TLESFIFTTKTDVFSFGCVIWEIYENGNQPHDGKNAQTI
 |    |. . || .||  .||    | .|  | |.  |
CLRHRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQI
Kinase W01B6.5.AA TKL 274-522 18 6.4e-33 115.69 In-house 1-345 (364) Show / Hide 
Range on Protein: 274-522
Range on HMM: 1-345/364
Sequence Identity: 18% (67 aa)

LGEGAFGEVRIGKMKL-----KSTKKTVEVAVKMLRNAEV------------------------VIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEP
.|.|.||||  || .      .|  .  .||||...  ..                         ..    ..  |...|.. .| |... .|..   ..
IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LYLMTEMCACGALREYLRENQETVTLAEKLFFVVGSSRGVQYLHSQK--------TIHRDLAVRNILLIHKRH--DPAITNSTVSMG
             |.. .| | .| |..||        .  .. .. . .||..||||..         |||||  .|||.  . .  .  .        
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM-------

TFLFQ-------PKISDFGLAKISERYE--------------------MKEQCKIPVRYLAPETLE----------------SFIFTTKTDVFSFGCVIW
            .||.||||..  .. .                    ..  .    |..||| |.                .| ...|.||.||| |.|
----YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

EIYENGNQPHDGKNAQTI---------RNLTKKNQFLKLT------------NSAPSELRKLIEE
||.      .| .. . |             .|.. . .             ...| ...||...
EILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQD
Kinase W01B6.5.AA S_TKc 268-550 21 4.8e-31 110.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 268-550
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

ALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCAC--GALREYLRENQ
    .|.|.||||.|. .. |        .||.|...            .. | ..... .|.|. . |.. .  . ||. .|.|    | |..|.....
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

E-----TVTLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKISERYEMKEQCKIPVRYLAPETLE
        .  .  |..    ....|.||.. |||||   |||| .                   . ||.|||||..         .     |.||| | 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------------HIKICDFGLARQL------TTFCGTPWYMAPEVL-

SFIFTT-KTDVFSFGCVIWEIYENGNQPHDGKNAQTIRNLTKKNQFLKLTNSAPSELRKLIEERVFTSDPENRCSMTTIVQ-CAEKIEKPPV
   ... | |. |.||...| .  |  | .  . |.. .. .           ..|.. .| .. .. |||.| .   . | . .    | .
--GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFI-RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase W01B6.5.AA Pkinase 268-540 22 1.1e-28 102.52 Pfam 1-289 (293) Show / Hide 
Range on Protein: 268-540
Range on HMM: 1-289/293
Sequence Identity: 22% (70 aa)

ALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELL-HEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACG----ALREYLR
    .|.|.|.||.|.... |  .     .|||| ..  .    ...  ..  |...|....|.|..| |..   |  .|. .| | .|     | .|..
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

-ENQETV--TLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILLIHKRHDPAITNSTVSMGTFLFQPKISDFGLAKI--SERYEMKEQCKIPVRYLAPE
 ... ..  .  |  |..    ||..|.||.. |||||   |||. .. | .|               ||.||||||     ...         .|.|||
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE

TLE-SFIFTTKTDVFSFGCVIWEIYENGNQPHDGK-----------NAQTIRNLTKKNQFLKLTNS---------------APSELRKLIEERVFTSDPE
 .  .   ..| |..|.||...| .  |. | .|.            ... .  .. . . . ..|               ...|....| .. .. ||.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI-KWCLCKDPK

NRCSMTTIVQ
 |.. . |.|
KRPTAEQILQ
Kinase W01B6.5.AA EGFR 270-404 33 4.8e-23 73.21 In-house 3-134 (258) Show / Hide 
Range on Protein: 270-404
Range on HMM: 3-134/258
Sequence Identity: 33% (45 aa)

QQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLRENQETVT
. |.|| |||| |  |    .  .  . ||.|.||  |   ...  |.| || ||  .||....|  |. . .. . | | .   |.| .|.|...... 
KVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLR--EQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-MQLVTQYMPYGCLLDYVRQHKDNIG

LAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILL
  . | . |   .| |||  .. .||||| ||.|.
SQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLV
Kinase W01B6.5.AA Abl 269-404 35 6.3e-23 72.88 In-house 2-130 (252) Show / Hide 
Range on Protein: 269-404
Range on HMM: 2-130/252
Sequence Identity: 35% (48 aa)

LQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLRENQETV
  ..||| | .|||  |  |    .    |||| |.   .    .| | |.|| .|. | |.|. .  |.     | |..||  . | | .||||.... 
MMKHKLGGGQYGEVYEGVWK----RHDCTVAVKTLKEDTM----EVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREE

TLAEKLFFVVGS-SRGVQYLHSQKTIHRDLAVRNILL
  |  | ..    . |..|| ... |||||| || |.
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLV
Kinase W01B6.5.AA Frk 272-404 32 9.5e-19 61.3 In-house 5-131 (260) Show / Hide 
Range on Protein: 272-404
Range on HMM: 5-131/260
Sequence Identity: 32% (44 aa)

KKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVGELLHEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLR---ENQETV
..|| | ||||  |.        |. |||| |.   .  .    ..| ||..|. . |  ... | .  ..||.|..||.   |.| |||.   .. . .
RRLGSGQFGEVWEGLW-----NNTTPVAVKTLKPGTMDPN----DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQC

TLAEKLFFVVGSSRGVQYLHSQKTIHRDLAVRNILL
 . . .        |. || ||  |||||| ||.|.
QMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLV
Kinase W01B6.5.AA EGFR 428-502 37 2.9e-15 46.95 In-house 141-218 (258) Show / Hide 
Range on Protein: 428-502
Range on HMM: 141-218/258
Sequence Identity: 37% (29 aa)

KISDFGLAKI--SERYEMKEQC-KIPVRYLAPETLESFIFTTKTDVFSFGCVIWEIYENGNQPHDGKNAQTIRNLTKK
|| ||||||.  ..  |.. |  |.|.. .| | ..  ..| . || |.|  .||.   | .|.||  |. | .| .|
KITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEK
Kinase W01B6.5.AA Frk 428-546 28 1.9e-13 42.64 In-house 138-260 (260) Show / Hide 
Range on Protein: 428-546
Range on HMM: 138-260/260
Sequence Identity: 28% (35 aa)

KISDFGLAK---ISER--YEMKEQCKIPVRYLAPETLESFIFTTKTDVFSFGCVIWEIYENGNQPHDGKNAQTIRNLTKKNQFLKLTNSAPSELRKLIEE
|| |||||.     .   || . . ..|... |||  ..  ||.| ||.||| .. ||   |  |  |   . . .  ...  .      | .| ... |
KIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLE

RVFTSDPENRCSMTTIVQCAEKIE
  . |||..|    |.    |.  
-CWHSDPMKRPTFETLQWKLEDYF
Kinase W01B6.5.AA Abl 428-542 26 6.8e-12 35.46 In-house 137-252 (252) Show / Hide 
Range on Protein: 428-542
Range on HMM: 137-252/252
Sequence Identity: 26% (31 aa)

KISDFGLAKI--SERYEMKEQCKIPVRYLAPETLESFIFTTKTDVFSFGCVIWEIYENGNQPHDGKNAQTIRNLTKKNQFLKLTNSAPSELRKLIEERVF
|. |||||..   . |  .   | |... ||| |    | .| ||. || ..|||   |  |  | . . . ..  |.  .   .  | .  .|.  . .
KVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELM-RQCW

TSDPENRCSMTTIVQCA
  ..  | | . | .  
QWSHTDRPSFKEIHHAM
Kinase W01B6.5.AA UTK 526-542 29 0.264706 0.22 In-house 280-296 (296) Show / Hide 
Range on Protein: 526-542
Range on HMM: 280-296/296
Sequence Identity: 29% (5 aa)

TSDPENRCSMTTIVQCA
..||..|... ..||  
HYDPQERPDFEDLVQQM