Gene W06B3.2 (Nematode worm)

W06B3.2

Species: Nematode worm
Alias: W06B3.2a, CE31629, aSWK190, W06B3.2
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: No interpolated position., WormBase Physical Map location: X: 12005114-12001266,

Classification

Group: CMGC
Family: MAPK
Subfamily: MAPK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
W06B3.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 307 Kinase domain by global Sugen HMM Fasta, JSON
W06B3.2.AA Protein Genbank 472 None Fasta, JSON

Protein domain

Protein domains of W06B3.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase W06B3.2.AA MAPK 82-388 37 2e-143 482.78 In-house 1-328 (328) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-328/328
Sequence Identity: 37% (127 aa)

YEPTQNIGSGAFGIVCEAVETS------SNQKVAIKKVAHASATPTLARRTLREIRVLRYI-NHPNIVPLRDIFRTK-----GPLG--IDVFLVMDLMQN
|.. ..||.||.|.|| |. ..      ...||||||. ..  .||...||.|||. ||.. .|.||. |.|||. .     ..|.   |. .||.||. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLHHIIYGNEDPLEEHYINAFLGQLLRG--LEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADN-SSKKH--DDEEHC---YYMTQHVATLPYR
.||.||. .  ||... |  |. |.|||  | |.| |.. ||||||||.|||....|.|.|||.| ..|. ....|  ||. ||   ..||..|||  ||
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HCFQKMHMTEYVATRWYR

APELLFV--LPEHSTAVDMWAVGCIFGEMVI-RNEILPGRSVQGQIKMLLTMLGQPPQEVINEVR-CDRTRKLIQDFG--RKADAEWDDIMFCKARGDDQ
|||...   . ....|||||.|||||.||.  |  ..||.. . |... . .|| |..|.|. .  ... |..|| .|  .| .. . . ||..|..   
APEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF---

IVRGNCDTIDFVKQLFQYDAQKRINIQDALLHPYI
  . |.. ||..... . | .|||....|| |||.
--NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase W06B3.2.AA CMGC 82-388 23 2.3e-110 364.04 In-house 1-513 (513) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-513/513
Sequence Identity: 23% (121 aa)

YEPTQNIGSGAFGIVCEAVETSSNQK--------------VAIKKVAHASATPTLAR----------RTLREIRVLRYIN-----------------HPN
||  . ||.|..|.|.... . .|||              |||||.  .   .. |.          |.||||. |...|                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVPLRDIFRTKGPLGI-------------DVFLVMDLMQNNLHHIIYGNED--------PLEEHY------------INAFL------GQLLRGLE--YL
|| |.|||..|.. |              ...||...|...|...|. | .        ||.|              |  |.       |.||||.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HAAC--IAHRDLKPSNLLVNQD--------------------GTLRIADFGMAKCADNSSKKHD-------------DEEHCYYMTQHVATLPYRAPELL
| ..  | ||||||.|.|.|..                    |.|.|.|||.|.  .. |..|.             | ..   .|. |.|. |||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL

FVLPEHS---------TAVDMWAVGCIFGEMVIR--------NEILPGRSV-----------QGQIKMLLTMLGQP----------------PQEVINEV
.  .. .         |..|||.|||||.||. .          . ||.|            . |...   .|| |                ..| .| .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

R--------------------CDRTRKLIQD---FGRKADAEWDDIMFCKARGDDQIVR---------------------------GNCDTIDFVKQLFQ
                     ..  |. ||    |...    | ... .. ..|| . .                            . . ||..|...|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

YDAQKRINIQDALLHPYI
|| .||| ...|| |||.
YDPDKRITAEQALQHPYF
Kinase W06B3.2.AA MAPK-Unclassified 82-231 53 3.4e-104 352.47 In-house 1-157 (575) Show / Hide 
Range on Protein: 82-231
Range on HMM: 1-157/575
Sequence Identity: 53% (84 aa)

YEPTQNIGSGAFGIVCEAVETSS-NQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLG---IDVFLVMDLMQN---NLHHIIY
||...||||||.|.||.|..... ||.||||||.|.....|...|.|||||.|||.|||||....|||..|....   .|...|||.||.   .||.||.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

GNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAK
.|.|......|..|..|.||||.|||.|||.||||||||||.|||...||.||||..
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase W06B3.2.AA MAPK-Unclassified 232-388 41 1.4e-98 333.84 In-house 385-575 (575) Show / Hide 
Range on Protein: 232-388
Range on HMM: 385-575/575
Sequence Identity: 41% (79 aa)

CADNSSKKH---DDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVGCIFGEMVIR-----------NEILPGRS--------------------
|..|...||   .|..|||.|||.|.|..|||||......|..|.||.|..||||.||...           ....||..                    
CTKNKKQKHKQINDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHS

VQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINIQDALLHPYI
.|.||||....||.||.|..|...||..||.||.|..|......|.|||||.||||||||||..||||....|....|||....||.|||.
HQDQIKMIFDYLGMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase W06B3.2.AA ERK5 82-388 40 4.3e-89 302.28 In-house 1-295 (295) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-295/295
Sequence Identity: 40% (124 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLG--IDVFLVMDLMQNNLHHIIYGNEDP
|..   || ||.|.|| |..    |.|||||.  |    | |.||.||...||   | ||. .||| . | |..   ||. |.|||   || ||  |  |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQ-P

LEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAV
.    |  || |.|||| |.|.| . ||||||||||||    |.| |||||.     |     ..| ..||. |||  ||||||.| . .   |.|.|.|
FTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSP----DKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSV

GCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQD-FGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRIN
|||||||. |  . ||.    |..... .|| ||  .|  |  |. .  .|  |  .   .|. . . ||  | |       ..| . ..  ..  .|| 
GCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKV-YPKA--DRQ-------ALDLLARMLRFEPSERIT

IQDALLHPYI
.  || ||..
VNKALQHPFL
Kinase W06B3.2.AA ERK 82-388 35 1.4e-82 280.66 In-house 1-307 (307) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-307/307
Sequence Identity: 35% (114 aa)

YEPTQNIGSGAFGIVCEAVETS-----SNQKVAIKKVAHASATPTLARRTLREIRVLRYIN-HPNIVPLRDIFRTKGPLGI-DVFLVMDLMQNNLHHIIY
|. .. || ||.|.|| |. ..     ..|||||||.  |  .| .. ||||||. ||. . |.||. |.||.. . | .. |. .| .||.  || ||.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

GNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCAD-NSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTA
 .. .|..  .  |. |.|.|| |.| | . ||||||||.||| ...| |.||| | | |  ... |   .   .||. ||| .|||||..  ... ..|
-SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE--CNQNFMTEYVATRWYRAPEIMLSWQKYTKA

VDMWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQP-PQEVINEVRCDRTRKLIQDFGR--KADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQ
.|.|..|||| ||. |  ..||..  .||   .  .| | ..| ...   ....|.|  ..   ..   | .| | .|         | . ||  ... .
MDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENI-FPNAN-------CNPQAIDLLEKMLV

YDAQKRINIQDALLHPYI
 | .|||.. ..| ||| 
FDPDKRITVEECLEHPYF
Kinase W06B3.2.AA S_TKc 82-388 23 1.4e-78 268.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-231/231
Sequence Identity: 23% (77 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLGIDVFLVMDLMQN---NLHHIIYGNED
||  . ||.|||| |. .........||||..          ....|||..|.  .||||| | |.|..      ....||... .   .|...|  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

P-----LEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHST-
.     . |  .  .. |....|||.|   | ||||||.|.|...  .. |.|||.|.                  |  . |. |.|||.|     ... 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL----GYGKC

AVDMWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYD
..|.|..|||. ||. .    |      |..|.. ..|                                                 . .||.....|.|
KCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------------------------------------SPEAKDFIRKCLQKD

AQKRINIQDALL-------HPYI
 .||. . .||        ||..
PEKRPTA-EALQDEWDIKCHPWF
Kinase W06B3.2.AA Pkinase 82-388 26 1.1e-75 262.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-293/293
Sequence Identity: 26% (85 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLR--EIRVLRYINHPNIVPLRDIFRTKGPLGIDVFLVMDLMQN-----NLHHIIY
|.  . ||||.|| |..... .....||.|..   .. .   .. .|  ||.... .|||||| |.|.|..    . .. .||.....      |...| 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

-GNEDPL--EEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTL----RIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVL
  .. ..  .|. .  .. |.||||||.|.  | ||||||.|.|....|..    .|.||| ||..|        . .   ||  . |..|.|||..   
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGG

PEHSTAVDMWAVGCIFGEMVIRNEILPGR----SVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTID
......||||..|||. ||. .. . ||.    .   |..|.   .| |. . . . .. .... ...   .         |   .  . .   . . .|
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------F-HWTF-HNW---SEECKD

FVKQLFQYDAQKRINIQDALLHPYI
|.| ....| .||......| ||..
FIKWCLCKDPKKRPTAEQILQHPWF
Kinase W06B3.2.AA CDK 82-388 29 1.9e-73 234.29 In-house 1-284 (284) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-284/284
Sequence Identity: 29% (99 aa)

YEPTQNIGSGAFGIVCEAVETSSN-----QKVAIKKVAHAS-----ATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLG-------IDVFLVMDL
||  . || |..|.|  |  . ..     | ||.||.   .     .   .   ..|||  |. . ||||| |.|.. || .           ...|.. 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGT-----LRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYR
|   | ...           |  .. ||||||.|.|   | ||||||.|.|.| .|.     | ||||| |.   . ..   ..  .|  |  | || ||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTY--THEVVTLWYR

APELLFVLPEHS--TAVDMWAVGCIFGEMVI---RNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQI
|||||.   . |  |..|||.|||||.||.    |  ..||.| . |...   ..| |  ..  .|                                  
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------

VRGNCDTIDFVKQLFQYDAQKRINIQDALLHPYI
        |.  ....|| .|||. ..|| ||| 
--------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase W06B3.2.AA p38 82-388 33 1.1e-69 237.36 In-house 1-289 (289) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-289/289
Sequence Identity: 33% (104 aa)

YEPTQNIGSGAFGIVCEAVETSSNQK---VAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRT---KGPLGIDVFLVMDLMQNNLHHIIYG
|.  | .||||.| || |. . ..||   ||||| .    ..  |.|| ||.| |. ..| |.. | |.|           ||..|. .|.  |. |.  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

NEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVD
    | .  |   . |.|||| | |.| | ||||||||. || |  ||| ||| |         | |.|    ||..|||  ||||| ..   .   .||
QR--LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--------HCDDE----MTGYVATRWYRAPEIMLNWMHYTQTVD

MWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQK
.| ||||  |.. .    ||     |.. .. ..| |..|... .  .. |  ||        .  ..     .            ||    . . |. |
IWSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQA----------IDLLEKMLELDPDK

RINIQDALLHPYI
||  ..|. |||.
RITAEEAMQHPYF
Kinase W06B3.2.AA nmo 83-388 32 5.2e-69 211.15 In-house 2-292 (292) Show / Hide 
Range on Protein: 83-388
Range on HMM: 2-292/292
Sequence Identity: 32% (101 aa)

EPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGP-LGIDVFLVMDLMQNNLHHIIYGNEDPLE
.| . || ||||.|    .  . ..||.||. .       ..|  ||...| . .| |.. ..|| .   .    ... | .|||  || ||     .| 
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIV-SPQHLS

EHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVGC
   .  || |.|||| |||.| | |||.|| ||||| .  |.| |||.|.  .   .||        ||| | |  |||||.|      . |||.|.|||
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKH--------MTQEVVTQYYRAPEILMGARHYTSAVDIWSVGC

IFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINIQD
||.|.. |  .   .|   |..|.  .|| | .| .    |.  .  .   . |. .   . ..  .  |..    . . .. ....  .| .||| ..|
IFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYA-CEGAKAHMLRMPHKPPCL--QVLYTLSSPDHA----THEAVHLLCRMLHFDPDKRISCKD

ALLHPYI
|| |||.
ALAHPYL
Kinase W06B3.2.AA ERK7 82-388 33 5.6e-69 234.99 In-house 1-292 (292) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-292/292
Sequence Identity: 33% (103 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYIN-HPNIVPLRDIFRTKGPLGIDVFLVMDLMQNNLHHIIY-GNEDP
||  . .| ||.|||  |.   . | ||.||.  |   .| | || |||  |. .. ||||. | ...| .  .  |..|| . |   || .|  ||   
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR--DIYLVFEFMETDLHAVIRKGNI--

LEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAV
|..      . |||| . |.| . . ||||||||.|.. . .....|||.|    .  .    .|.   .|  |||  ||||| |    .   .|||| .
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY---DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINI
||| |||..   . || |   ||   |.....| || |. .  .   ....  ...   . |..|  ..           | || .|.| ..  .||. .
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCC---------DDAIDLLKRLLVFNPKKRLTA

QDALLHPYI
..|| |||.
EQALQHPYV
Kinase W06B3.2.AA ERK1 82-388 36 1.3e-64 221.02 In-house 1-289 (289) Show / Hide 
Range on Protein: 82-388
Range on HMM: 1-289/289
Sequence Identity: 36% (112 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYINHPNIVPLRDIFRTKGPLGI-DVFLVMDLMQNNLHHIIYGNEDPL
|   | || ||.|.|| |..|  .|.|||||..      |   ||||||..|   .| ||. ..|| |..    . ||..| .||   |  ..     .|
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQ-TYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLL--KTQHL

EEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYRAPELLFVLPEHSTAVDMWAVG
    |  || |.|||| |.|.| . ||||||||||.|.   |.| |||.|. ||       . .|  ..|  |||  |||||..        ..|.|.||
SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIAD------PEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVG

CIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINEVRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINIQ
||  ||.    | ||.    |.  .| .|| | |. .| .  .. |  .|    |.   |.  .| ||             .|.. ..  .  .|||.. 
CILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWAR-LFPKA---------DSKALDLLDKMLTFNPHKRITVE

DALLHPYI
.|| |||.
EALAHPYL
Kinase W06B3.2.AA Pkinase_Tyr 88-231 26 6.7e-16 54.47 Pfam 7-159 (270) Show / Hide 
Range on Protein: 88-231
Range on HMM: 7-159/270
Sequence Identity: 26% (42 aa)

IGSGAFGIVCEAVET----SSNQKVAIKKVAHASATPTL--ARRTLREIRVLRYI-NHPNIVPLRDIFR-TKGPLGIDVFLVMDLMQN-NLHHIIYGN--
.|.|||| |.... .    . ...||.|..   .|..     .  .||..... . .||||| |  .    ..|    ...|| .|.. .|..    .  
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHRE

-EDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAK
 ..||  . .  .  |  .|.|||..  . ||||   | ||. ... .|.|||.|.
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase W06B3.2.AA TyrKc 82-332 22 2.2e-13 -6.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 82-332
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYI--NHPNIVPLRDIFRTK-------GPLGIDVFLVMDLMQN-NLHH
 .  . .|.||||.|.... .   ..||.|.. . .      .  .||.|... .  .||||| |  . ...       .||    ..|| .| . .|..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPL----MIVMEYMPHGDLKD

IIYGNEDPLEEHYINAFLGQLLRGLEYLHAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNS-SKKHDDEEHCYYMTQH--VAT--LPYR--APELL
 .  ... |       |  |  .| ||||  .. ||||   | ||. ..| .|.|||...  ..  ..    |.. ||...    .   ||.|  ||| .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI

FVLPEHSTAVDMWAVGCI------FGEMVIRNEI---LPGRSVQGQIKMLLTMLGQPP-----------------QEVINEVRCDRTR--KLIQDF
    . .|. | |. |        .|..   ..|   .. . |  ..|    |   |                  ..  .|   || .   ....|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF