Gene W06F12.3 (Nematode worm)

W06F12.3

Species: Nematode worm
Alias: aSWK104, W06F12.3, CE16557
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: III:23.56, WormBase Physical Map location: III: 13730071-13731492

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
W06F12.3.AA Protein Genbank 318 None Fasta, JSON
W06F12.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of W06F12.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase W06F12.3.AA TTBKL 38-295 38 3.5e-136 458.71 In-house 1-288 (288) Show / Hide 
Range on Protein: 38-295
Range on HMM: 1-288/288
Sequence Identity: 38% (110 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSV-E--SGRIVLELHILVELA--HSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRC-FS
....||.|.|||||.....||..|  .|...|.| . |  . |. .|.|.|..|.  .|||.||.|.||....|||.||.|.| |. ||||  . .. ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

AETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEH----KRVLYIVDFGMARQIRFPSGAF-----------RPERP---YASFRGTTRYVSLAA
..|..|.|||||..|||.|. |.||||.||.|.|.|. .|     |..|..|||||||.. ..| .           |..|.   .|.|||||||.|...
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HERKEQGFADDIWCLFFSLLELAEGLPWKNVVDQDQVYHAKQLLLRNFQSRK------MGQNFGTFPRALELIKRTETPNYENFIVIL
|.|||||  ||.|...... ||..||||.|..|.....|.|. .. .  . .      . . |. | ..|.  .  ..|.|| .. ..
HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase W06F12.3.AA CK1 38-291 30 3.7e-103 349.02 In-house 1-339 (339) Show / Hide 
Range on Protein: 38-291
Range on HMM: 1-339/339
Sequence Identity: 30% (102 aa)

FQVEKMVGGGGFG-QIFRA-----VDMETK-----LVVAVKVEPKSVESGRIVLELHILVELA----------------------HSPHIPKVHYSGEIG
..|.|. |.|||| ||...     .||...       .|.|||||. . .  .|.  ... ..                      ..||.....|.|| .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

G-YNFIVMQLLGSNITDLRK--FQKGRCFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEH-------------KRVLYIVDFGMAR-QIR
. ||..||.||| |. ||||  .. .|.||  |. ...||.||.|...|. |.|||||||.|.|.|..|.             .|..|..|||||| . |
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

FPSG------------AFRPERP---YASFRG-TTRYVSLAAHERKEQGFADDIWCLFFSLLELAEG---LPWKNVVDQDQ-----VYHAKQLLLRNFQS
...|              || |.    ..||| |.||.|...|..||||  ||.|..|. |.|.  |   |||.|. |...     | ..|.   ...  
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

RK------------MGQNFGTFPRALELIKRTETPNYENF
              . | | ..   ..  |. ..|.||..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase W06F12.3.AA TTBK 38-291 38 1.2e-66 227.71 In-house 1-257 (257) Show / Hide 
Range on Protein: 38-291
Range on HMM: 1-257/257
Sequence Identity: 38% (98 aa)

FQVEKMVGGGGFGQIFRAVDMETK-LVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTA
 .| | .|||||| |. | || ..   ||.|||          .|  .|  |   .|. .    |    .|..||||.| |  |||  |   |||  || 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RVGIQCLEGLKQIHELGYIHRDIKPSNICVG-IGEHKRVLYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLEL
|.|.| |.....||..|. ||||||||  .|   .  |  |..|||.|||    .|  || |. | |||| || |  ||  .| |  || | ||. | | 
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

AEG-LPWKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPRALELIKRTETPNYENF
..| |||  . | ||| . |.          . ..| .|   .. ..  ..|.|  .
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase W06F12.3.AA Worm6 38-291 31 2e-66 227.01 In-house 1-279 (279) Show / Hide 
Range on Protein: 38-291
Range on HMM: 1-279/279
Sequence Identity: 31% (87 aa)

FQVEKMVGGGGFGQIFRAVDMETKL--VVAVKVEP--KSVESGRIVLELHILVELAHSP--HIPKVHYSGEIGG--YNFIVMQLLGSNITDLRKFQKGRC
..|.| .| |||| .. . | ..|    .|.|.|   .. ...   .|. .| ...|..  | .|.   | ..   .|.|||.|.| |  ||||.. .|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGI-----GEHKRVLYIVDFGMAR--QIRFPSGAFRPER-PYASFRGTTRYVSLAAHERKEQGF
||  |. ...|||||.. . |  |.||||.||.| |.|       .  . .|..||||.|  . .   .  |. | . . ||||.|| .||.| ..||. 
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

ADDIWCLFFSLLELAEG-LPWKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPR--------ALELIKRTETPNYENF
 ||. . |  ..|.  | |||... | |.|   |    |. ... | . ||..|.         .  ... ..|.|.. 
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase W06F12.3.AA CK1-Unclassified 38-220 31 1.8e-53 156.17 In-house 1-194 (244) Show / Hide 
Range on Protein: 38-220
Range on HMM: 1-194/244
Sequence Identity: 31% (62 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSP-------HIPKVHYSGEI--GGYNFIVMQLLGSNITDLRKFQKGR
..|.. .| | ||.|. ...|.|. .||.|.| | ...  .. |  |. .| .         .|||....|    |.||..|| |||... || .. ...
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNRK

CFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVG-IGEHKRVLYIVDFGMARQIRFP--SGAFRPERPYASFRGTTRYVSLAAHERKEQG
 ||  |.   . | .. . ..|. ..||||||| |...|  | .. ..||.||| .   . .   |   | |   .. ||.|| |. ||  .||.
-FSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQS
Kinase W06F12.3.AA CK1 38-220 31 4.3e-45 153.22 In-house 1-194 (271) Show / Hide 
Range on Protein: 38-220
Range on HMM: 1-194/271
Sequence Identity: 31% (62 aa)

FQVEKMVGGGGFGQIFRAVDMETKLV---VAVKVEPKSVESGRIVLELHILVELAH------SPHIPKVHYSGEI--GGYNFIVMQLLGSNITDLRKFQK
..|.. .| | ||.|. . .| |. .   ||.|.|..  .   .. |  |. .| .      ...||.....|    | ||..|| ||| .  || .| .
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCN

GRCFSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGI-GEHKRVLYIVDFGMARQIR-FPSGAFRPERPYASFRGTTRYVSLAAHERKEQG
.. ||  |.  .. | .. .  .|. ..||||||| |...|. | |. ..||.|||.| . |   ..   | |   .. ||.|| |. .|  .||.
RK-FSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQS
Kinase W06F12.3.AA CK1-D 38-242 31 1.2e-34 119.63 In-house 1-206 (261) Show / Hide 
Range on Protein: 38-242
Range on HMM: 1-206/261
Sequence Identity: 31% (66 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTAR
. . . .|.| ||.|.   ...|   ||.|.|.   .   . .| ..   .     ||.... |. | || .||.|||  . ||  . . | ||  |   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCH-RKFSLKTVLM

VGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIRFPS-GAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLELA
.. | .  .. ||   .||||||| |  .|.| .  . ||.|||.|.. | .      | |   .  || || |.  |   ||   ||.  | . |.  .
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

EG-LPWK
 | |||.
RGSLPWQ
Kinase W06F12.3.AA CK1-A 38-242 31 2.2e-32 111.68 In-house 1-206 (261) Show / Hide 
Range on Protein: 38-242
Range on HMM: 1-206/261
Sequence Identity: 31% (66 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTAR
... . .| | || |. .. ..    ||.|.| . .    .. |  .   |.  . ||.... |.   || .||.|||  . ||  | | | |.  |   
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCK-RRFTMKTVLM

VGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIR-FPSGAFRPERPYASFRGTTRYVSLAAHERKEQGFADDIWCLFFSLLELA
.  | .  .  .|| ..||||||| |  .||| |   |...|||.|.. |   .    | |      || || |. ||   ||   ||.  . . ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

EG-LPWK
 | |||.
RGKLPWQ
Kinase W06F12.3.AA CK1-G 38-225 35 3.2e-31 103.0 In-house 1-191 (266) Show / Hide 
Range on Protein: 38-225
Range on HMM: 1-191/266
Sequence Identity: 35% (69 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSP-HIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQKGRCFSAETTA
..| | .| | || .|    | . . ||.| ||   .     .|      |.  |  ||.|.| |  | || .|| |||    ||  .  .| ||  |..
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWC-DRKFSVKTVC

RVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKR--VLYIVDFGMARQIRFPS-GAFRPERPYASFRGTTRYVSLAAHERKEQGFADDI
 | || .. ....|.   | ||.|| |  .|    |.  |..|.|||||.| . |  .   | |   |  || || |   |  .||   ||.
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDM
Kinase W06F12.3.AA CK1-Unique 38-242 24 2e-28 95.7 In-house 1-233 (337) Show / Hide 
Range on Protein: 38-242
Range on HMM: 1-233/337
Sequence Identity: 24% (56 aa)

FQVEKMVGGGGFGQIFRAVDMETK------LVVAVKVEPKSVESG--RIVLELHILVELAHSP-------HIPKVHYSGEIGGYNFIVMQLLGSNITDLR
..| |  |.||.|   |  .  .          . | | ...     |   |. .. ..           | ..|| ..  . . .|||...| ..  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KFQKGRCFSAE------TTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGE--HKRVLYIVDFGMARQ--IRFPSGAFRPERPYASFRGTTRYVSLA
   |.  |         .  . | |||...   |. |..||..|| |.| .     | ...|. |.|  |   .  ...  |. || ..|||. .| . .
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHERKEQGFADDIWCLFFSLLELAE---GLPWK
 |. .|.|  ||   .|..|. |     || ||
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase W06F12.3.AA Pkinase 38-210 24 7.3e-19 67.78 Pfam 1-179 (293) Show / Hide 
Range on Protein: 38-210
Range on HMM: 1-179/293
Sequence Identity: 24% (46 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESG----RIVL--ELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGSNITDLRKFQ------
..... .| |.||. .....  |  .||||. .|. |.     . ..  |..|. .| ..|.| . ... | ...  .|| ...   . .          
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW

KGRCF--SAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRV---LYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVS
...||  | ..  ..  | |.||. .|. | ||||.||.|| .   ..  .   . | ||| |.|..       . . . .| || .|..
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase W06F12.3.AA S_TKc 38-302 20 1.2e-18 69.24 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-302
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVELAHSPHIPKVHYSGEIGGYNFIVMQLLGS---NITDLRKFQKG----RCF
... . .| |.||. ..... .|. .||.|. .      .|  |. || .  | |.| | ... .  .. ..|| ...    .  |. | ...    . |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQIRFPSGAFRPERPYASFRGTTRYVSLAAHERKEQGF-ADDIWCLF
.  .....  | ...|. .|..| ||||.||.|| .       .. | |||.|||.              .| ||  |..         |. . |.| . 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

FSLLELAEGLP-WKNVVDQDQVYHAKQLLLRNFQSRKMGQNFGTFPRALELIKRTETPNYE---NFIVILKSC-----SSRV
  | |.. | | .       |..   ....               | |...|..  . . |       .|...        .
CILYEMLCGYPPFP------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase W06F12.3.AA TyrKc 38-239 16 1.2e-05 -131.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-239
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

FQVEKMVGGGGFGQIFRAVDMETKLVVAVKVEPKSVESGRIVLELHILVEL-AHSPHIPKVHYSGEIG-------GYNFIVMQLLGSNITDLRKF-QKGR
 . .|. | | ||......     . ||||.  ..     .  |. |. .|  | |.| . .     .       .  .||| .      ||... .| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRKHR

C-FSAETTARVGIQCLEGLKQIHELGYIHRDIKPSNICVGIGEHKRVLYIVDFGMARQI-----------RFPS----GAF-------------------
  .. ..     .|  .|   .|. ..||||.   |. || .    .  | |||..| |              .    |.                    
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

-----------------RPERPY-------ASFRGTTRYVSLAAHERKEQG--------FADDI-----WCLFF------SLLELAEGL
                 . . ||        | .   .||      .. .           |..     .|  .      .  |. | .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF