Gene Y38H8A.3 (Nematode worm)

Y38H8A.3

Species: Nematode worm
Alias: Y38H8A.3, CE18365, aSWK121
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:9.48, WormBase Physical Map location: IV: 13472546-13473953

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
Y38H8A.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
Y38H8A.3.AA Protein Genbank 308 None Fasta, JSON

Protein domain

Protein domains of Y38H8A.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y38H8A.3.AA Worm6 17-276 49 2.1e-162 545.85 In-house 1-279 (279) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-279/279
Sequence Identity: 49% (138 aa)

WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEG--ANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQDLNKAGVGGH
|...||.||||||||| | |...|    .|||.|.  .|...|.||.|..||... ....||||||||.|...|  |||.|||||||.|.|| |.  ...
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGR---PELNEIRKVYILDFGMCR-KFTGNDGT-IRKPR-QAAGFRGTVKYAPISCHLQRELCR
.|||....|.||.|||.|||||.|..||||||||..|||    |.||....|.||||||| |.. |.|. .|.|| .|.||||||.|||..|| ..|.||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDLETWMYMQVELSHGTIPWQYISDMNQVG-QAKQAIRNN---LGSLFPPPCPH-QFQDIMRMVDAMKYYDAPNYQAI
|||.|.|.||.||. .|..||. ..|...|. ..|...|..   . ..|  |||. .|.||| ..| ..|.|.|.|. |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase Y38H8A.3.AA CK1 17-276 33 4.4e-117 395.26 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-339/339
Sequence Identity: 33% (115 aa)

WSIEKKLGEGGFG-AVYRV-----FDATGK-------YAMKVEGANEQIQ-VLKLEVSVLNKLSKRG---------NRHFCK----------IEDKGRFG
| ..||.|||||| ..|.|      | ...       |||||| ...  |  ...|.... |. ..|         ..||||          ....|. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

N-FNYVVMTLVGKSLQDLNK--AGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPE-----------LNEIRKVYILDFGMCR-KFT
. .||.||||.|..|.|| |  .  ....||.... |.|| |||||..|..|..|||.||.|. .|| |            || |.||..||||.| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

GNDGT------------IRKPRQ---AAGFRG-TVKYAPISCHLQRELCRKDDLETWMYMQVELSHGT--IPWQYISDMNQ-----VGQAKQAIRNN---
 .||.            .| ||    ..|||| |..|..|.|||..|..|.|||..|.|| .|.  ||   ||| ..| ..     |...|......   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

LGSLFPPPCPH-------QFQDIMRMVDAMKYYDAPNYQAI
. ..|  .||        .| .|| .....||||.|.|..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase Y38H8A.3.AA TTBKL 17-280 37 1e-87 296.2 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-288/288
Sequence Identity: 37% (110 aa)

WSIEKKLGEGGFGAVYRVFDAT--GK-YAMKVEGAN-EQI-QVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGH-MS
| |.|..||||||.||.| | .  .. .|||.|    | . ...|.|| ||.||...| .||.|. . |. ...|..||||.|..|||| |    .. .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELN--EIRKVYILDFGMCRKFTGNDG-----------TIRKPRQ---AAGFRGTVKYAPISC
 | .  |||| |.|| ..| .|..||||||.|. .|  . .  . | ||..||||.|..  .||           ..|.||     |.||||..|. .  
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLQRELCRKDDLETWMYMQVELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFP-PP----CPHQFQDIMRMVDAMKYYDAPNYQAIYGMM
|. .|. |.|||  |||| .||  |  ||....|  .....|..   ..  ||  .|    || .| ..|... ...||| |.|. ||  .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDED--LFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase Y38H8A.3.AA TTBK 17-276 42 6e-87 295.16 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-257/257
Sequence Identity: 42% (113 aa)

WSIEKKLGEGGFGAVYRVFDATGK---YAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGC
| . || | |||| .|   |   .    |.||| |. . ||||.|| || ||   |  | |.    ||  .|||.||.| ||.| ||  .   |  |.. 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

SIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
 . .|.| |...|  |..|.||||.|| |. .||    ..||.|.||||. |..|   | .| ||..||||||| || |  |. ||. |.|||    || 
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR-NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVDAMKYYDAPNYQAI
||  .|  ||  | | .|||. |.  . ..  |    |||.|.  |  .  ..| | |.|| |
VEFVQGQLPWRKIKDKDQVGEMKE--KYDHRMLL-KHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase Y38H8A.3.AA Dual 17-280 28 2.1e-47 157.44 In-house 1-282 (282) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-282/282
Sequence Identity: 28% (80 aa)

WSIEKKLGEGGFGAVYRVFDATG------KYAMKVEGANEQ--------IQVLKLEVSVLNKLSK-RGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQD
| . . || |||. ||.|..         .|..|.|  ...        .. .. ... . |..|  |...|    | |       .|.|| ..| |||.
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LNKAGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEI-RKVYILDFGMCRKFTG-NDGTIRKPRQAAGFRGTVKYAPISCHLQ
  .  . | .|| ||  ..|| |.|. |||.||||||..|| |. .|   |..   .|| .||.. ||.     .  | .|    . |.  || . | .|
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG---LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ

RELCRKDDLETWMYMQVELS-HGT-IPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVDAMKYYDAPNYQAIYGMM
..  ||||||.| ||   |  ..  ..|    | | . ..|..   . ..    . | .. ..  .|. . |  .| | ..  ..
KDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase Y38H8A.3.AA CK1-Unique 17-224 32 4.7e-46 157.64 In-house 1-233 (337) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-233/337
Sequence Identity: 32% (76 aa)

WSIEKKLGEGGFGAVYRVFD-ATG-------KYAMK--VEGANEQIQVLKLEVSVLNKLSKRG-----NRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLN
| . |..| ||.| |.|| . ..|       .|.||  . ..    | |. | .|.  ..|        ||||...| .  .   . |||..|.|.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KAGVGGHMSMG------CSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRK--FTGNDGTIRKPRQAAGFRGTVKYAPIS
 .  .  .  .      | |  | | |...|  |  |..||. ||.||  . |   . .  |.||.| ||.  |  | . ||.||  . |||. .|.|.|
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

CHLQRELCRKDDLETWMYMQVELSHGT--IPWQ
||. ||. |.||.|.| || . | |.|  . |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase Y38H8A.3.AA CK1-Unclassified 17-224 30 1.2e-25 72.7 In-house 1-217 (244) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-217/244
Sequence Identity: 30% (66 aa)

WSIEKKLGEGGFGAVYRVFDA--TGKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNR-----HFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVGG
  ...|.| | || .| . .     ..|.|.| .|  .  |. |. ... | .. |      .. |.   |.   |..|..||.| |.|| || .   ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-CNR

HMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFT--GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKD
  |.     |. | .. .| ||| ...||| || |. .| .   ..  .||| |||   ..    ..|.    |   .. ||  || |  ||  |  |.|
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLG--KNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD

DLETWMYMQVELSHGTIPWQ
|||  .|  . .  |. |||
DLESLGYVLIYFLKGSLPWQ
Kinase Y38H8A.3.AA CK1 17-224 28 1.2e-24 81.87 In-house 1-217 (271) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-217/271
Sequence Identity: 28% (62 aa)

WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEGANEQIQVLKLEVSVLNKLSK---RG-NRHFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVG
  ...|.|.| || .| . . | .    .|.|.| ..   . |. |. ... | .    .   .. ..   |.   |..|..||.| |.|| || .   .
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN

GHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFT-GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDD
.. |.   . |. | .. .| .|| ...|||.|| |. .||   ..  .||| |||.  ..   ....    |   .. ||. || |  || .|  |.||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LETWMYMQVELSHGTIPWQ
.|  .|. . .  |. |||
MESLGYVLMYFLRGSLPWQ
Kinase Y38H8A.3.AA CK1-D 17-276 26 6.8e-24 81.07 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-261/261
Sequence Identity: 26% (70 aa)

WSIEKKLGEGGFGAVY--RVFDATGKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS
. | .|.| | || .|      .    |.|.| .  .   |..|  .   ..  |     .|   |. |..| .|| |.| || ||     . . |.   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQ--GGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNY-CHRKFSLKTV

IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
. .. | .  .| .|   ..|||.|| |. .|     ..  |||.|||. ...         | |      || .|| |  |.  |  |.||||   |. 
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPC---PHQFQDIMRMVDAMKYYDAPNYQAI
.   .|..||| .  ...  .  . .   .       |   |..||. |  .  .|. | |.|  .
MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase Y38H8A.3.AA CK1-A 17-231 27 5.5e-23 77.94 In-house 1-213 (261) Show / Hide 
Range on Protein: 17-231
Range on HMM: 1-213/261
Sequence Identity: 27% (61 aa)

WSIEKKLGEGGFGAVYRVFDATG--KYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS
. . .|.| | || .|     |     |.|.| .. .   |  |  | . |.  |   . ...  |.  ..| .|| |.| || ||       . .|   
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNF-CKRRFTMKTV

IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
. .  | .  .| .|. ...|||.|| |. .|        |....|||. .|.  .   .  | |.     ||..|| |  ||  |  |.||.|   |. 
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

VELSHGTIPWQYISDMNQ
.    |..||| .  |..
MYFNRGKLPWQGMKAMTK
Kinase Y38H8A.3.AA S_TKc 17-268 17 2.4e-12 4.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-268
Range on HMM: 1-231/231
Sequence Identity: 17% (50 aa)

WSIEKKLGEGGFGAVYRVFDAT--GKYAMKVEGANEQIQVLKLEVSVLNKLSKRGNRHFCKIEDKGRFGNFNYVVMTLVGK---SLQDLNKAGVGGH---
. | .|.|.|.|| ||.. .     ..|.|.       . .. |...| |    .  . .|. |  .  .. |.|| ...    .| |. |   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLE
 ..      .  | ..||| .|. | .|||.|| |  . .        . | |||..|..               | ||  | .                
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------

TWMYMQ------------VELSHGTIPWQYISDMNQVGQAKQAIRNNLGSLFPPPCPHQFQDIMRMVD------------A-------MKYY
   |               |.  |  |..      |. .  . |.           |   . |... .            .       . . 
--GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Y38H8A.3.AA TyrKc 17-280 17 3e-05 -137.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

WSIEKKLGEGGFGAVYR-VFDATGKYAMKVEGANEQIQVLKLEVSVLNKL--SKRGNRHFCK-----IEDKGRF---GNFNYVVMTLVGK-SLQDLNKAG
 . .|||||| || ||. . .   . | |.  ..  .. .  | ... ||  .   . .  .     ......|   .   ..|| .. . .|.|  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPL-MIVMEYMPHGDLKDYLRKH

VGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGND--GTIRKPRQAA----GFR--GTVKYAPISCHL
 .   .|   . . .|  .  | ||  .. |||    |  .|..       | | |||..|. .  |  |  .|    .    | .    ..  ..    
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAP----

QRELCRKDDLETWMYMQVE---------------LSHGTIPWQY-ISDMNQVGQAKQAIRNNLGSLFPPP--------CPHQFQDIMRMVDAMKYYDAPN
          |...|                   .. |  |.   |  |    .. . ...      ||         ||    .||..  . .  | |.
----------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

YQAIYGMM
 ..|.  .
FSEIHECF
Kinase Y38H8A.3.AA Pkinase 17-45 32 4.2e-05 19.12 Pfam 1-31 (293) Show / Hide 
Range on Protein: 17-45
Range on HMM: 1-31/293
Sequence Identity: 32% (10 aa)

WSIEKKLGEGGFGAVYRVFDATGK--YAMKV
. |..|.|.|.|| ||.  .      .|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI
Kinase Y38H8A.3.AA CK1 251-274 16 0.001956 7.92 In-house 248-271 (271) Show / Hide 
Range on Protein: 251-274
Range on HMM: 248-271/271
Sequence Identity: 16% (4 aa)

CPHQFQDIMRMVDAMKYYDAPNYQ
.| .|.. .. .  ......|.|.
FPNEFAMYLNYCRQLHFEEKPDYM
Kinase Y38H8A.3.AA Pkinase 122-191 30 0.011555 10.5 Pfam 118-179 (293) Show / Hide 
Range on Protein: 122-191
Range on HMM: 118-179/293
Sequence Identity: 30% (22 aa)

LEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAP
|..|| .|. | .|||.|| |  |  ......  .| | ||| ...|      . . . . .| ||  |..
LRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA