Gene Y39G10AR.4 (Nematode worm)

Y39G10AR.4

Species: Nematode worm
Alias: Y39G10A_244.a, Y39G10AR.4, Y39G10A_244.a=Y74C10A_156.a, CE23001, aSWK230
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:-9.51, WormBase Physical Map location: I: 2357884-2365249,

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
Y39G10AR.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
Y39G10AR.4.AA Protein Genbank 579 None Fasta, JSON

Protein domain

Protein domains of Y39G10AR.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y39G10AR.4.AA NEK1 112-126 46 0.292953 0.33 In-house 111-125 (276) Show / Hide 
Range on Protein: 112-126
Range on HMM: 111-125/276
Sequence Identity: 46% (7 aa)

SQICLAVQSVSKKKI
.|||||.. ....||
CQICLALNHIHDRKI
Kinase Y39G10AR.4.AA NEK 113-126 31 0.320111 0.53 In-house 122-140 (286) Show / Hide 
Range on Protein: 113-126
Range on HMM: 122-140/286
Sequence Identity: 31% (6 aa)

QICLAVQSVSKK-----KI
|.|||.. . ..     ||
QMCLALKYMHDRKGPQRKI
Kinase Y39G10AR.4.AA NEK8 171-423 56 5.8e-231 666.82 In-house 1-275 (278) Show / Hide 
Range on Protein: 171-423
Range on HMM: 1-275/278
Sequence Identity: 56% (155 aa)

YERIRTVGKGAFGSAVLYRRREDS--SLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQN--LL
|||||.||.||||...||||.||.  .|||.|.|||.......|..|.||...||...|||||.|||.|.|...|||||||||||||.||....||  ..
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

DEE----------------QIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRD-SFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYN
.|.                .|.....||||||...|....|||||||.|.|.||. ..||||||||||||.|....|..|||||||||.|||||.|..||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

EKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTC-AYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALKM
.|||||||||.||||||||.|||..||||||..||.| ||.|....||.||.|.....||.||..||||.|...|
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAM
Kinase Y39G10AR.4.AA NEK 171-423 42 4.2e-143 481.7 In-house 1-283 (286) Show / Hide 
Range on Protein: 171-423
Range on HMM: 1-283/286
Sequence Identity: 42% (121 aa)

YERIRTVGKGAFGSAVLYRRREDSSL-----VIIKEINMYDLDSSQRRLAL-NEVSLLSRIEHPNIIAYYDSFEEEG--VLMIEMEYAD-GGTLAQM---
||.|...|.|.||.. ..||..|..      ...|.|||  ... ... |. ||| .|... ||||..|||||.||.   |.|.|||.. ||.|.|.   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LSRTQN---LLDEEQIGDMMIQMCSAVAYLHEN-----SVLHRDLKTANVFLTRDS----FVKIGDFGISKIMGTETLAQGAKT-VVGTPYYISPEMCSG
. . ..   ...|||| |..||||.|. |.|..      .||||.|..|.|||..     .||||||||||.....| .  |.| .||||||.|||.|..
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDM--AYTTQVGTPYYMSPEVCQN

VSYNEKSDMWALGCILYEMCCL--KKAFEGD--NLPALVNSIMTC-AYTPVKGP--YSAEMKMVIRELLQLDPQKRPSAPQALKM
 .||.|||.|.|||.|||||.|  |..||..  |.|.|.. || .  | |.     || .....|. .|| ||..|||. | |.|
KPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEM
Kinase Y39G10AR.4.AA NEK1 171-422 39 1.9e-100 340.03 In-house 1-272 (276) Show / Hide 
Range on Protein: 171-422
Range on HMM: 1-272/276
Sequence Identity: 39% (108 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGV--LMIEMEYADGGTLAQMLSRT---QNL
|..|...|.|.|| |.| ...||...  |||||     .. |  ..||| .|.. .||||..|..||||.|   | | |||.||| |.|   |     .|
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

LDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLT--RDS---------------FVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSY
  | || .  .|.| |. . |   .||||.|. |.|||  ..                .||.|||||....  ...   |.|..|||||.|||.|    |
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEY--ACTCIGTPYYLSPEICQNKPY

NEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALK
| |||.|.|||.||| | || .||. |...||. |    |.|.   || | .  .  ... .|. |||. | |.
NNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILE
Kinase Y39G10AR.4.AA S_TKc 171-424 31 3.1e-83 283.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 171-424
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADG--GTLAQMLSRTQNL---
|| .|..||||||.  . | ...  .| ||.|.         . ...|...|..  ||||. .||.|.. . | . |||.||  |.| ... . .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNE-KSDMWALGCILY
  ..| ..  .| |.|.|..|.|.. ..||||| .|..|..   .||.|||.....         .|..|||.|..||..   .|.  |.|.|..|||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALK---------ML
||.| .  |.  .. .. . |.           | |.|  || .|| ||.|||.| .||.          .
EMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y39G10AR.4.AA NEK4 171-426 38 2.8e-82 279.67 In-house 1-257 (257) Show / Hide 
Range on Protein: 171-426
Range on HMM: 1-257/257
Sequence Identity: 38% (99 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFE-EEG-VLMIEMEYADGGTLAQMLSRTQN-LLD
|. .. |||| .|   | | | |    ..| ...   .. .|. |. |. |||.  ||||. | .|.| |.|  | | | . .|| | . | .  | .|.
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCL
|.|. .  .|   |  |.||  .||||||| |.|||.   .||||||||...  .  .. |||..|||||.|||. .   |. |||.|.||| .|||  |
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVL--NNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITL

KKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSAPQALKMLRP
| ||.  ... |.  |.     |.   || ...  ....|.  |.||||  . ..|   
KHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase Y39G10AR.4.AA Pkinase 171-424 27 1.2e-78 272.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 171-424
Range on HMM: 1-293/293
Sequence Identity: 27% (81 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALN--EVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGG----TLAQMLS-RTQ
|...|..|.|.||.  . ... .. .| .|.|.  . .|.... ...  |.... |. ||||. .||.||... . . |||..||     |. ..| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

NLL--DEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFV----KIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCS-GVSYNEKSDMWA
. .  .|... ..| |......|.|.....||||| .|... ..  .    ||.|||..| .  .   . ..|..|||.|..|| .  |  |  |.|||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGCILYEMCCLKKAFEGD------NLPALVNSIMTCAYTPVKGPYS--------------------AEMKMVIRELLQLDPQKRPSAPQALKM--L
.|||||||.| .  | |.      .  .... || . .       .                     |.| .|. .|..||.|||.|.|.|.   .
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Y39G10AR.4.AA NEK-Unclassified 171-417 37 1.3e-63 209.32 In-house 1-249 (258) Show / Hide 
Range on Protein: 171-417
Range on HMM: 1-249/258
Sequence Identity: 37% (95 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNL---LD
|..| |.|.|  | ||   |   |   ... |        ...   | . .|| . || |. | ||| |   |    .| ||| | . . .       .|
YDKITTLGQGG-GGAVYLVRHQISKRHLVQQISKRK----KKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCL
|  |    |||  ||.| |   ..|||||. |.||| |  | .||||||.||  .     |.| |||. ..||| |    ||..|| |.||||.||||  
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDFGISRIM--DHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC

KKAFEGDNLPALVNSIMTCAY------TPVKGPYSAEMKMVIRELLQLDPQKRPSA
  .|   |.  .   |            ||   ||. .  ||| .|. ..|.||||
EPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSA
Kinase Y39G10AR.4.AA CAMK 176-422 21 5.6e-62 198.21 In-house 1-421 (425) Show / Hide 
Range on Protein: 176-422
Range on HMM: 1-421/425
Sequence Identity: 21% (89 aa)

TVGKGAFGSAVLYRRREDS------------SLVIIKEINMYDLDSSQ--------------------------RRLALNEVSLLSR-------IEHPNI
| |.|.||   | .....               | || |.   |...|                          |.  ..|......       . ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IAYYDSFEEEGV-------------------LMIEM---EYADGG----TLAQMLSRTQNL--------------LDEEQIGDMMIQMCSAVAYLHENSV
|  |. .| . .                   . . |   ||..||     | ... .  .               ..|..   .. |.||||.|.|.. .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKTANVFLTRDS----------------F-VKIGDFGISKIMGTETL---------------------AQGAKTVVGTPYYIS-PEMCSG------
 |||||  |. |. ..                . .|| ||| ....                           |  ||..|||.|.. ||. .|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------VSYNEKSDMWALGCILYEMCCLKKAFEGD-------------NLPALVNSIMTCAYTPVKGP-----------------------YSAEMKM
          |..|.|||..|.||| | | .  |.||             |.. |   ||.. |.    .                        |.| | 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VIRELLQLDPQKRPSAPQALK
 || .|| ||.||... |.|.
LIRKMLQVDPEKRMTIEQCLN
Kinase Y39G10AR.4.AA STE 171-424 23 1.3e-61 210.98 In-house 1-359 (359) Show / Hide 
Range on Protein: 171-424
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)

YERIRTVGKGAFGSAVLYRRR------EDSSL---------VIIKEINMYDLDS---------------SQRRLALNEVSLLSRIE--HPNIIAYYDSFE
.|.|. .||||||. .. ...      .   .         . ||..|. . ..               ...   |.|......    ||||. ||....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EEG-------VLMIEMEYADGGTLAQMLS---RTQNLLD----------EEQIGDMMIQMCSA-VAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISK
 ||        | | ||| |||.| ...     ... |.          |.||. .  | . .  .|||.. . |||.| ||..|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

IMGTE--------------TLAQGAKTVVGTPYYISPEMCSG------VSYNEKSDMWALGCILYEMCCLKKAF-EGDNLPALVNSIMT-----------
..  .              | .|  .|.|||| . .||. ..        |..|.|.| ||| . ||.. |  . .. .. |. . ..            
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---CAYTPVKGP-------------------YSAEMKMVIRELLQLDPQKRPSAPQALK----ML
       | . .                   .| |.|  |.  || ||.|||.| | ||     .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Y39G10AR.4.AA NEK6 171-417 36 3e-59 193.54 In-house 1-252 (252) Show / Hide 
Range on Protein: 171-417
Range on HMM: 1-252/252
Sequence Identity: 36% (93 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDL-DSSQRRLALNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQML---SRTQNLL
..  . .||| |      .   |   | .| . .... |   |.  . |. || ...|||.| ||.|| |.  | | .| || | ...|.    . . |.
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

DEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCC
 |  |    .|.|||.. .|.  |.|||.| ||||.| .  ||.|| |. .    .| |  |  .||||||.|||      || |||.|.|||.||||  
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTA--AHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAA

LKKAFEGD--NLPALVNSIMTCAYTPVKGP-YSAEMKMVIRELLQLDPQKRPSA
|.  | ||  || .|   |  | | |. .  || ...  .   .. ||..||  
LQSPFYGDKMNLYSLCKKIEQCDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase Y39G10AR.4.AA Ciliate-E2 171-422 22 4.3e-59 201.5 In-house 1-361 (365) Show / Hide 
Range on Protein: 171-422
Range on HMM: 1-361/365
Sequence Identity: 22% (83 aa)

YERIRTVGKGAFGSAVLYRRREDSSL------------------VIIKEINMYDLDSSQRRLALNEVSLLSRIE----------------HPNIIAYYDS
|. |.  |.|.|||  . .....  .                  | ||...|  .  .| .  ..| ... .|.                ||||| .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--EEGVLMIEMEYADGGTLAQMLS-----RTQNLL-----DEEQIGDMMIQMCS---------------AVAYLHENS-VLHRDLKTANVFLTRDSFV
|.   .  . . |||..||.| . .      |....      .|..|...| | ..               |. |||..  ..|||.|  |...     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KIGDFGISKIMGTE-------TLA----------------------QGAKTVVGTPYYISPEMCSGVS---------YNEKSDMWALGCILYEMCCLKKA
|| |||.||.  ..        ..                      . ..|..|||.| .||. .| .         |..|.|.|.||.|||||.. |  
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGDNLPALVNSIMTCAYTPV-----------------KGPYSAEMKMVIRE----LLQLDPQKRPS-APQALK
|         . |. | .                    .   | |.|  |.     .|| ||.||.. . |.|.
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase Y39G10AR.4.AA NEK2 171-416 30 6.6e-59 196.96 In-house 1-309 (319) Show / Hide 
Range on Protein: 171-416
Range on HMM: 1-309/319
Sequence Identity: 30% (94 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSF--EEEGVLMIEMEYADGGTLAQMLSRTQN---L
||   | |.| ||.    || .|  . . |||.   ...  . .  .|...|.   ||||. |||    ... .| | |||  || |.|| ..  .    
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

LDEEQIGDMMIQMCSAVAYLHE-------------------N--SVLHRDLKTANVFLTRDSF-------------------------------------
..|| |   | |.|.|    |                    .   .||||.| ||.||  |                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--VKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRE
  || ||||  ..  ..|.   |.| |||||| |||  .| .|||||| |..||..|||| |.  |.. |  .|   |    . ..   || .   .|  
VVVKLGDFGLARMLNHDTSF--AHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHF

LLQLDPQKRPS
 . .|...|||
MINVDHYHRPS
Kinase Y39G10AR.4.AA Pkinase_Tyr 171-367 22 1.5e-24 83.8 Pfam 1-210 (270) Show / Hide 
Range on Protein: 171-367
Range on HMM: 1-210/270
Sequence Identity: 22% (47 aa)

YERIRTVGKGAFGSAVLYRRR----EDSSLVIIKEINMYDLDSSQ--RRLALNEVSLLSRI-EHPNIIAYYDSFE-EEGV--LMIEMEYADGGTLAQMLS
 . ... |.||||. .. . .    ..   | .| ..  . ...|  |.  ..|..... .  ||||. .|     ...   ..| |||. .| |   | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RT---QNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIM-GTETL-AQGAKTVVGTPYYISPEMCSGVSYNEKSDMW
.    .. |. ... .| .| ... .||...   |||| . |. .|.. .|||.||| .. .  ...   .. .. .  . . .||  .   ...||| |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVW

ALGCILYEMCCL
. |  ..|.. .
SFGVLMWEIFTY
Kinase Y39G10AR.4.AA TyrKc 171-424 20 1.9e-16 43.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 171-424
Range on HMM: 1-280/280
Sequence Identity: 20% (59 aa)

YERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDLDSSQRRLALNEVSLLSRI--EHPNIIAYYDSFEEE-------GVLMIEMEYADGGTLAQMLSR
 . ... | ||||  .. . .     | .| .. .      |.  ..| ......  .||||.. |    ..       . ||| |||...| | . | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TQNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTE--------TLAQ----GAKTVVGTPYYISPEMCSGVSYN
... |  ..  ....| ..  .|||.. . |||| . |. ....  |||.||| |.  . .        .  .    |.||..      .||      ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI-RWMAPECINYGKFT

EKSDMWALGCILYEMCCL-KKAFEG-----DNLPALVNSIMTCAYTPVKGP--------YSAEMKMVIRELLQLDPQKRPSAPQALKML
.||| |. |  ..|.. . ..  .|      .   ... ...  . |             ..|| .....  . || .||.  .  . .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
RCC1 Y39G10AR.4.AA RCC1 445-482 28 1.007123 5.23 Pfam 20-52 (52) Show / Hide 
Range on Protein: 445-482
Range on HMM: 20-52/52
Sequence Identity: 28% (11 aa)

TTLYDLHVPT-ITLSSIPDLPSRISIKQVALSKTHTMVL
..  . |||. | ...  .   .....|||   .|||.|
GDT-NCHVPQQI-VEFL-G---NVRVVQVACGWQHTMAL
RCC1 Y39G10AR.4.AA RCC1 485-534 24 2e-06 23.72 Pfam 1-52 (52) Show / Hide 
Range on Protein: 485-534
Range on HMM: 1-52/52
Sequence Identity: 24% (13 aa)

DNELFGFGDNSCGQLG-FGKFSKMENG-RL-VESLKG-RDIQSVGVGNYFSVIC
| .....| |. ||||  .. .  ..  .. ||.| | . ...|  |.......
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 Y39G10AR.4.AA RCC1 537-569 24 9.471687 2.07 Pfam 1-35 (52) Show / Hide 
Range on Protein: 537-569
Range on HMM: 1-35/52
Sequence Identity: 24% (9 aa)

RGTLLTFGTAKNLGLG---KDAKDSAKPML-LEQLLR
 | . |.|   .  ||   .|  .  .|.. .| | .
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-G