Gene Y50D4B.6 (Nematode worm)

Y50D4B.6

Species: Nematode worm
Alias: Y50D4B.6, Y50D4B_4.a, aSWK393, CE26136
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: V:-19.02, WormBase Physical Map location: V: 1083951-1086950

Classification

Group: TK
Family: KIN16

Sequence

Name Sequence Type Origin Length Description Download
Y50D4B.6.AA Protein Genbank 412 None Fasta, JSON
Y50D4B.6.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 282 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Y50D4B.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y50D4B.6.AA KIN16 106-393 48 6.9e-218 646.03 In-house 1-332 (332) Show / Hide 
Range on Protein: 106-393
Range on HMM: 1-332/332
Sequence Identity: 48% (162 aa)

FYNLSFLGNGYYGKVFKERMHKKQKNG-LDSENSLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIR-WIRTNE------ILIVSEFVEKGD
  ... ||.|..|.|.|...|.|....  ...|.||||||....|.|...|.....||.|||..|||||.|||.. ......      ..||.|.||.||
LEFEEPLGSGHFGVVRKGLLHMKNPKNEKEHKNRLEVAVKSPANPHDICQQKMIYDELKVMCAIGKHPNVLALVGAVTKNMRQGGRHMLMIVTEYVECGD

LVEYLRARRRYFNKDIVCVEDNGR-------------------------------LLCPTDLLSFAFQIANGMKFLGNVAC-VHRDLALRNVFVKRNRII
|...||..|..|....|| ... .                                ||..||||||.||||||..|..|.| ||||||.||||.|||.||
LRKFLRQHRNNFQNHQVCWDNERQSGYNINNKERKHYVFKNFCENEQLVIKDIFDSLCTSDLLSFAYQIANGMEWLAHVPCCVHRDLACRNVFIKRNKII

RIADFGLARWHENKEYYRKK--TDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDF---RPDYFQGLMKYVRDGNQLPS
||||||||||||||.|||.|  .|...||.|.||||||.|||| ..||..|||.||||||||||||||..||. ...   |.||||..|.|.|.||.||.
RIADFGLARWHENKDYYRMKSSMDTPLPMRWMAPECFEEEQER-KMKFTEKSDVWSYGVCLYEIFSLGETPYPNCPNNNCRDDYFQYVMEYLRKGNRLPQ

PEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
|||....||.||..|||..|.||| ||||..||
PEHCHPEIYDFMKMCWNFDPEKRPTFSECVEFF
Kinase Y50D4B.6.AA TyrKc 106-393 32 1.9e-94 321.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 106-393
Range on HMM: 1-280/280
Sequence Identity: 32% (104 aa)

FYNLSFLGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPEDPSEQQLMCEELNVMCVVG-KHPNILALIRWIRT--------NEILIVSEFVEKG
   .  ||.| .|.|.| ..             ..||||          .. ...|...|| .| .||||..|.  ...          ..|| |....|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLVEYLRARRRYFNKDIVCVEDNGRLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENK-------EYYRKKT--D
|| .|||..|.               ||. |||||..|||.|| .|    |.||||| ||. |..|....|.||||.| ....       .|||||.  .
DLKDYLRKHRPK--------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKG

VG--FPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEH--------GSDKIYEFMQSCWN
    .| .|.||||.         || .|||.||.|||..|||..| .||.|  ...   | ...||..|. .| |..         .|..|. |..||.
GKTMLPIRWMAPECI------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

LNPDKRPVFSECRDFF
 .|..|| |||....|
EDPEDRPTFSEIHECF
Kinase Y50D4B.6.AA Pkinase_Tyr 112-393 35 3.8e-92 312.72 Pfam 7-270 (270) Show / Hide 
Range on Protein: 112-393
Range on HMM: 7-270/270
Sequence Identity: 35% (103 aa)

LGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPEDPSEQ---QLMCEELNVMCVVGKHPNILALIRWIR--TNE--ILIVSEFVEKGDLVEYLRA
|| | .|.|.| ...      ..... ..||||   ..   .||   . . .|...|.  |.||||. |.  .        |.|| |....||| .|||.
LGEGAFGEVYKGTWKG-----DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

RRRYFNKDIVCVEDNGRLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKEYY-RKKTDVGFPMKWLAPECFEFE
.|           .... |.. |||....|||.|| .| .  |.||||| ||. |..|....|.|||||| ..|..|| ||...  .| ||.||||. . 
HR-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

QERENIKFDSKSDIWSYGVCLYEIFSLGVSP-YEGLDFRPDYFQGLMKYV-RDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
       | .|||.||.||...|||..| .| |.|..        ...|. .||...| ||. .|.||. |..||. .|..|| |||.. ..
K------FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEE-----VYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Y50D4B.6.AA TK 112-393 22 1.8e-88 296.6 In-house 7-486 (486) Show / Hide 
Range on Protein: 112-393
Range on HMM: 7-486/486
Sequence Identity: 22% (107 aa)

LGNGYYG---KVFKERMHKKQKNGLD----------------SENSLEVAVKRALRPEDPSEQ-QLM---------------CEELNVMCV-VGKHPNIL
|| | .|   .|.| ... . ... .                ...  .||||      . |.. ...               .||. .||  .|.||||.
LGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIV

ALIRWIRTNE-------------ILIVSEFVEKGD----LVEYLRARRRYFNKDIVCVE-----------------------------------------
 |.  .  .|             ..|| |....||    | .|||..|..|..   | .                                         
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

DNGRLLCPTDLLS-------------------FAFQIANGMKFLGNVAC------VHRDLALRNVFVKRNRI-----------IRIADFG--------LA
| .  |. .|||.                   ...|||.|| .|    |      |||||| ||. | .| .           ..|||||        ||
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA

RWHENKEYYRKKTDVG------------------------FPMKWLAPECFEFEQEREN---IKFDSKSDIWSYGVCLYEIFSLG-VSPYEGLDF-----
| ......|..|.. |                        .| .|.||||..  ...|     || .|||.||.||...|||..| . .|.|..      
RDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWK

-RPDYFQGLMKYVRDG--------------NQLPSPEHGS--------------DKIYEFMQSCWNLNPDKRPVFSECRDFF
    . | .|.|.|.|              ...| |.| .              . .|..||.||...|..|| ||......
DG--DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Y50D4B.6.AA TK-Unique 106-393 30 7.1e-63 215.19 In-house 1-294 (294) Show / Hide 
Range on Protein: 106-393
Range on HMM: 1-294/294
Sequence Identity: 30% (92 aa)

FYNLSFLGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRW-IRT-NEILIVSEFVEKGDLVEYLR
. ... .| | .| |..  . ..     ...    ||||   ..... ..| .  |...|  .|.||||. ..   ... .  .|. |....|.|  |||
LEVGDVIGEGAFGQVWRGEVWGIW---KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

ARRRY---------FNKDIVCVEDNGRL--LCPTDLLSFAFQIANGMKFLGN--VACVHRDLALRNVFVKRNRIIRIADFGLAR-WHENKEYYRKKTDVG
 .|..          . |   ..|  |.  . | ||..||.|||.||..|      .|||||. |||.. .. .. |.|||.||  . |..| ....   
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

FPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHG-SDKIYEFMQSCWNLNPDKRPVFSE
 | .|.||| .      ... . .|||.||.|| ..|||.||  || |.. .      .|. .|||  .| |||  |. .|..|.|||...|..|| |..
IPIRWMAPESLKCY---HGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-----IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQ

CRDFF
... .
IKHRL
Kinase Y50D4B.6.AA Src 137-393 32 5.5e-58 195.58 In-house 22-255 (255) Show / Hide 
Range on Protein: 137-393
Range on HMM: 22-255/255
Sequence Identity: 32% (84 aa)

NSLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRWIRTNE--ILIVSEFVEKGDLVEYLRARRRYFNKDIVCVEDNGRLLCPTDLLSFAFQ
.. .||||  |.| . | ...  .| ..|  . .|.....|   . . |  |.|| |. ..| | .||..            .. || |  ..|...| |
GNTKVAVK-TLKPGTMSPEAFL-QEAQIMKKL-RHEKLVQLYA-VCSQEEPIYIVTEYMSHGSLLDYLKK------------DGEGRHLHLPQLIDMAAQ

IANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHE-NKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVS
.|.||..|.    .||||| ||| |  | .  .|||||||  . ... |  ...  ||.|| |||.. .       .|  ||| ||.|. |.||.. |  
VAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYG------RFTIKSDVWSFGILLTEIVTYGRV

PYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYE-FMQSCWNLNPDKRPVFSECRDFF
||.| . .       .. |  |  .| |..  |..||  |. ||.  |..|| |   ..|.
PYPGMTNH-----EVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Y50D4B.6.AA UTK 141-393 28 5.4e-52 176.15 In-house 32-296 (296) Show / Hide 
Range on Protein: 141-393
Range on HMM: 32-296/296
Sequence Identity: 28% (82 aa)

VAVKRALRPEDPSEQQLMC------EELN---VMCVVGKHPNILALI-RWIRTNEILIVSEFVEKGDLVEYLRARRRYFNKDIVCVEDNGRLLCPTDLLS
|||| .   .. . || ..      || .   .|  .  |||.| |.    .   ..||.|. |.|||. |||  |. ..       ... .|  ...|.
VAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP-------ACPHWLTLHQRLC

FAFQIANGMKFLGNVACVHRDLALRNVFVKRNR-------IIRIADFG---LARWHE---------NKEYYRKKTDVGFPMKWLAPECFEFEQERENIKF
.| .||.|| .| .  .|||||| ||..| ..|       ...|||||   ..|            . .||..  .   |..| |||..         .|
MAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHT-----RF

DSKSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDG--NQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
 .|||.||.|| ..||.. |  ||.|.       . . . |..|   ..|.|.. .. .|. |..||. .|..|| | . ....
TTKSDVWSFGVVCWEIWTWGRLPYPGM-----SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Y50D4B.6.AA FGFR 161-393 35 4.3e-51 172.35 In-house 54-293 (293) Show / Hide 
Range on Protein: 161-393
Range on HMM: 54-293/293
Sequence Identity: 35% (88 aa)

ELNVMCVVGKHPNILALIRWIRTNE--ILIVSEFVEKGDLVEYLRARR---RYFNKDIV--------CVEDN-----GRLLCPTDLLSFAFQIANGMKFL
|. .| ..|||.||. |.    | |    .. |. ..| | ..|||||   .   ||.           |.         |   || |.|.|.| || .|
EMEMMKMIGKHKNIINLL-GCCTQEGPLYVIVEYCHHGNLRDFLRARRPPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYL

GNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDFRP
    |.||||| ||| |  . .. |.||||||   . .||||.|.   | || |||     ..|   .....||.||||| | ||. .| .|| .    .
ASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEAL---FDR---VYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVE

DYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
.    | || . |  .  |.. |  ||  | .||  .|. || | .  . .
E----LYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase Y50D4B.6.AA PDGFR 208-393 39 3.9e-50 158.97 In-house 181-358 (358) Show / Hide 
Range on Protein: 208-393
Range on HMM: 181-358/358
Sequence Identity: 39% (75 aa)

YFNKDIV--CVEDNGRLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFEFEQE
|...|.     ||. . |  .|||.|..|.|.|| ||    ||||||| ||| .   ... | ||||||   |   |  |     | || |||   |   
YIEQDVKNELMEDDSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESI-F---

RENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
 ... .  .||.||||. | ||||||..|| |.     ..    | ...| .  .|.| .. ||| ||.||.. | ||| |..   | 
-DCV-YTTQSDVWSYGILLWEIFSLGGNPYPGMPVDSKFY----KMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase Y50D4B.6.AA TKL 112-393 18 5.2e-49 169.14 In-house 1-364 (364) Show / Hide 
Range on Protein: 112-393
Range on HMM: 1-364/364
Sequence Identity: 18% (74 aa)

LGNGYYGKVFKERMHK-----KQKNGLDSENSLEVAVKRALRPE-----------------------DPSEQQLMCEELNVMCVVGK--HPNILALIR-W
.| | .|.|.| . .      .      |  . .||||.  . .                       ||  .... .| ... .  .  ||||. ..   
IGSGGFGEVYKGKWRGWGGKCP------SDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYC

IRTNE-------------ILIVSEFVEKGDLVEYLRARRRYFNKDIVCVEDNGRLLCPTDLLSFAFQIANGMKFLGN--------VACVHRDLALRNVFV
.. .              . || |....|.| .||                      .  ....| .|| || .| .         . .||||  .|..|
CCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV

KRN--------------RIIRIADFGLARWHENKE-----------------YYRKKTDVGFPMKWLAPECFEFEQEREN----------IKFDSKSDIW
..|              . . |.||||.|......                 .  ..  ..    |.|||... ... ..           ... |.|..
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

SYGVCLYEIFSLGVSPYEGLDFRPDYFQ----GLMKYVRD-GNQLPSP------------EHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
|.|..|.||..  . ||......| .||      ...| | |...| |            ..  . . . || ||. .|.||| |.|. . .
SFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Y50D4B.6.AA KIN6 151-393 33 1.8e-48 158.17 In-house 58-305 (305) Show / Hide 
Range on Protein: 151-393
Range on HMM: 58-305/305
Sequence Identity: 33% (86 aa)

DPSEQQLMCEELNVMCVVGKHPNILALIRWIRTNE-ILIVSEFVEKGDLVEYLRARRRYFNK------DIVCVEDNG-----RLLCPTDLLSFAFQIANG
.......|  | . |   | || .  .  ..  ..  ..| |. ...||  ||| |..|  .      .  |   |        .   ||..||.||..|
EMAHHDFM-HEIAFMKQLGHHPHLVNMLGCVTNSYKPCLVVEYCCHMDLLKYLRNRCQYMMNLDDLGINYHCPDENSRYDDMMCIRHKDLYMFAWQICDG

MKFLGNVACVHRDLALRNVFVKRNR---IIRIADFGLAR-WHENKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSP
| .| .  |.||||| ||| |          | ||||.|     .  |  | .   | ||.||||.      .  .|  |||.||.|| ..|.|||| .|
MEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECL------KHYEFSYKSDVWSFGVLMFEMFSLGDVP

YEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
|...  ||     ..   | |  .  |.  ...||. |||||.  || || |.| |  |
YPEMQ-RP---TEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase Y50D4B.6.AA VEGFR 227-393 39 5.6e-44 152.42 In-house 174-332 (332) Show / Hide 
Range on Protein: 227-393
Range on HMM: 174-332/332
Sequence Identity: 39% (67 aa)

DLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARW--HENKEYYRKKTDVGFPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCL
||....||.|.|| ||    |.||||| ||. .  | .. | ||||||     .  | ||      |.||.|||       .... . ..||.||||| |
DLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESI-----FDKV-YTTYSDVWSYGVFL

YEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRDFF
 |||||| ||| | .   . .. |.    ||. .  |.     ||. |..||  .|  || |||    .
WEIFSLGGSPYPGVQIDEEFCNRLK----DGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase Y50D4B.6.AA S_TKc 106-393 21 5.9e-34 120.04 SMART 1-231 (231) Show / Hide 
Range on Protein: 106-393
Range on HMM: 1-231/231
Sequence Identity: 21% (65 aa)

FYNLSFLGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRWIRTNEILIVSEFVEK--GDLVEYLR
.  |  .| | .|||.| | .|            .||.|.          . .. |....    .||||  |. ....... .| |...   ||| .|..
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIK

ARRRYFNKDIVCVEDNGRLLCPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFEFE
 |.|         . ... . . .  ... ||....... .   .||||   |... .   | |.||||||           | .     ..||| .   
KRGR---------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---

QERENIKFDS-KSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYFQGLMKYVRDGNQLPSPEHGSDKIYEFMQSCWNLNPDKRPVFSECRD---------FF
      ...  |.|.|| |..||| .. |  |..        |. ..               |.   .|.. |.. .|.|||   |.           .|
------GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y50D4B.6.AA Pkinase 106-393 20 5.9e-27 96.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 106-393
Range on HMM: 1-293/293
Sequence Identity: 20% (67 aa)

FYNLSFLGNGYYGKVFKERMHKKQKNGLDSENSLEVAVKRALRPEDPSEQQ-----LMCEELNVMCVVGKHPNILALIRWIR-TNEILIVSEFVEKG---
.  .. .| | .|.|.| . .. .|         .||||.  .... |...     |   |. .|  . .||||. |..| .  ..| .| |..|.|   
YHIGRKIGSGSFGCVYKCHHKGTGK---------IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYV

-DLVEYLRARRRYFNKDIVCVEDNGRLL--CPTDLLSFAFQIANGMKFLGNVACVHRDLALRNVFVKRNRII----RIADFGLARWHENKEYYRKKTDVG
 || .|...             .... .   . .. ... ||. |.... .  ..|||| . |.....|  |    .|.|||||. ..    ..  |.. 
MDLFDYIST-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFC

FPMKWLAPECFEFEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGL------DFRPDYFQGLMKYVRDGNQLPSPEHGS---------------DKI
    ..|||        .. . ..|.|.||.|. ||| .. |  |. |       | .  ... ... ..   . ....  .               .  
GTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

YEFMQSCWNLNPDKRPVFSECRDF--F
 .|. .|....| ||| . ..     |
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Y50D4B.6.AA VEGFR 185-210 34 0.009465 6.44 In-house 80-105 (332) Show / Hide 
Range on Protein: 185-210
Range on HMM: 80-105/332
Sequence Identity: 34% (9 aa)

EILIVSEFVEKGDLVEYLRARRRYFN
. .. .|.. .| |  |||. | ||.
PLMVIVEYCCFGNLSNYLRTKRMYFV