Gene Y59A8B.23 (Nematode worm)

Y59A8B.23

Species: Nematode worm
Alias: CE26212, Y59A8B.23, aSWK303, Y59A8A.bY59A8_00239
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: V:17.47, WormBase Physical Map location: V: 17967936-17956705

Classification

Group: STE
Family: STE20
Subfamily: FRAY

Sequence

Name Sequence Type Origin Length Description Download
Y59A8B.23.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 279 Kinase domain by global Sugen HMM Fasta, JSON
Y59A8B.23.AA Protein Genbank 545 None Fasta, JSON

Protein domain

Protein domains of Y59A8B.23.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y59A8B.23.AA FRAY 57-335 73 1.9e-245 770.92 In-house 1-277 (277) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-277/277
Sequence Identity: 73% (206 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQ-TSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQ
|.|.|.||.||||.|..|||.||.|..|||.||||||| ||.|||..|||||.||.|||||.|.|||...||||.|||.|.|||.|||.|.|.... .  
YELQEVIGEGATAVVHKAYCIPRQENCAIKRINLEKCQNTSMDELIKEIQAMCQCHHPNVVHYHTSFVVNEELWLVMRYLECGSCLDIMKFKMPQGEP--

AQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIW
...||.||..|||.|.||||||.||| ||||||||||||||...||||||||||||.|||. ||||||..||||||||||||||||||||.|||||||||
HKQGVFDEHVIATILKEVLKGLCYFHKNGQIHRDIKAGNILIGEDGTIQIADFGVSAWLAT-GGDLSRCCVRHTFVGTPCWMAPEVMEQVHGYDFKADIW

SLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
|.||.|||||||.|||||||||||||||||||||.|||....||.||.||.|||..|..||||||.||||||||||..||
SFGITAIELATGKAPYHKYPPMKVLMLTLQNDPPSLETDEDDKDMYKKYGHSFKKMIEKCLQKDPSKRPTASELLKHKFF
Kinase Y59A8B.23.AA STE20 57-335 45 1.7e-142 479.7 In-house 1-288 (288) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-288/288
Sequence Identity: 45% (134 aa)

YKLDESIGVGATATVFTAYCLPRNEK----VAIKCINLEKCQ---TSVDELSHEIQAMSQCNHPNVVSYYTSFIAQ----EELWVVMRLLNCGSMLDILK
|.| | || |.. .|..||. | .|.    |||| .|||||.    .....  ||. |.||.|||.|.||.|..      .|||.|| ... || .||.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

RKVKAIGKEQAQFG-VLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQ
...|  ..  .. | ...|. ||...||||.||.| | |..|||||||.|||| .|| ...|||||...| . |.| ..|. | ||||||.||||||...
HCMKCGKN--HK-GHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRD-TMQFKRNTFVGTPYWMAPEVIQC

V----QGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTL--QNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
.    .|||.|.||||||| |||.|.|  ||....||.......  ||.||||.         . . ..|. ..  ||||||.||||||.||| .|.
MEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDD-K----PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Y59A8B.23.AA STE 57-335 33 7.50000000001e-117 394.5 In-house 1-359 (359) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-359/359
Sequence Identity: 33% (121 aa)

YKLDESIGVGATATVFTAYCL------PRNEK---------VAIKCINLEKCQ----------------TSVDELSHEIQAMSQCN--HPNVVSYYTSFI
... | || ||. ||..|..       . .|.         .||| .|||.|.                . .... .||. |..||  |||.| || ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

AQ-------EELWVVMRLLNCGSMLDILKRKVKAIGKEQAQF---GVLDEVSIATVLREVLKG-LEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSG
         .|||..| ... ||  ||.|.| .  .  . ..   ....|  ||...|..||| |.| | .. ||||||..||||     . ..||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

WLASSGGDL----------SRQKVRHTFVGTPCWMAPEVMEQ-----VQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQN-----------
 |..|. ..          ..|. | |||||| ||||||..|     ..|||.|.||||||...||.|||  |.|...||........|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----DPPTLETNAERKDQ----------YKAYGKSFKTLIRDCLQKDPAKRPTASELLK--YSFF
    .||.|... . ...           . . ..||  |. |||||| ||||||.|||   .|.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Y59A8B.23.AA YSK 57-335 43 4.6e-106 320.38 In-house 1-257 (257) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-257/257
Sequence Identity: 43% (122 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQA
..  | || |    |. ..    .. |||| |.||.    .. .  |||  |||  |..  || |.     ||..|  .  ||.|| .|.|         
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKY--------

QFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQ-VQGYDFKADIW
  | .||  ||..|||.||||.| | .  ||||||| |.||  .| . ..||||.| .  .      |. | |||||| ||||||  | | .||||||||
-VGQFDEKYIAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDT------QIKRNTFVGTPYWMAPEVICQEVSYYDFKADIW

SLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
|||| |.|.|.|  || .| ||.|. |   | ||.||         . | |.||  .  || |||..||.|.||||..| 
SLGITAYEMAKGEPPYCDYHPMRVMFLIPKNNPPKLEG--------RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase Y59A8B.23.AA PAKA 57-335 37 1.7e-79 270.44 In-house 1-260 (260) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-260/260
Sequence Identity: 37% (107 aa)

YKLDESIGVGATATVFTAYCLPRNEK--VAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVK-AIGK
||  | || ||. .|..|. .  |..  |||| .|... | . . .  ||  | .|.|.|.| |. |.. ..||||||  .. |.  |...   .  .. 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKN-QPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCN-

EQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSR-QKVRHTFVGTPCWMAPEVMEQVQGYDFKA
      ..||  || |.||.|.|||. | ...||||||  ||||  || . |.||   |  |     |.. |  | | |||| ||||||  . . || | 
------YMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDF---GFCA----QLTQEQQKRNTMVGTPYWMAPEVIRR-KQYDEKV

DIWSLGILAIELATGTAPYHKYPPMKVLMLTLQN-DPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
|||||||.|||.. |  || ..|| . . |  .|  |. ....           ..|.     ||..|. .|..|.|||.. |.
DIWSLGIMAIEMIEGEPPYLNEPPLRAMYLIATNGKPDIKDPD--------KWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase Y59A8B.23.AA S_TKc 57-335 29 7.8e-76 259.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-231/231
Sequence Identity: 29% (84 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNC--GSMLDILKRKVKAIGKE
|.. . || || ..|. ..    ...||||.|.        . .  ||| ... .|||.| .| .|   ..|..|| ...   |...|..|.. .  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

QAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDF-KAD
     ...|  .. ........||| | .| ||||.|  |||| .  .| |.|||..  |             .||.||| .|||||.    ||.. |.|
-----PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GYGKCKCD

IWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLK-------YSFF
.||.|.. .|...|  |..   ..... . .                     ...| .|| ||||||.||||| |.|.         .|
WWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y59A8B.23.AA MST 57-291 39 3.4e-69 219.08 In-house 1-217 (254) Show / Hide 
Range on Protein: 57-291
Range on HMM: 1-217/254
Sequence Identity: 39% (94 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFI--AQEELWVVMRLLNCGSMLDILKRKVKAIGKE
. . | .| |.   |. | ..  .. |||| .. .   .  .|.. ||  |.||. ...| || |..   ....| ||   . || .|| |   .     
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVN---EDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQR-----

QAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADI
     .| |. ||..|. .|.||.| | |  ||||||||||||  .|    ||||||| |        ..  | |..|||.|||||| .. ..|| ||||
-----TLNEQQIACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQL------TDTMAKRNTVIGTPYWMAPEVIQE-IKYDCKADI

WSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTL
||||| |||.| |  ||.   || .. .  |. |||.
WSLGITAIEMAEGMPPYSDIHPMRAMFMIPQKPPPTF
Kinase Y59A8B.23.AA KHS 57-335 37 2.9e-66 221.85 In-house 1-258 (258) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-258/258
Sequence Identity: 37% (106 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQA
| |   .| |    |. |     .| .|.| | .|  .  .  . .||  | .| |||.|.|. |.. .. ||..|     ||. || .           
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKME-PGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYH-----------

QFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEV--MEQVQGYDFKADI
  | | |. || | ||.|.||.|.| .|..|||||  ||||.|.| ...||||||. .. .   ...   |. |.||| ||||||  .|.  ||.   ||
VTGPLSELQIAYVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITAT---IAK---RKSFIGTPYWMAPEVAAVERKGGYNQLCDI

WSLGILAIELATGTAPYHKYPPMKVLMLTLQND--PPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
|..|| |||||    |     ||..|.|  . .  ||.|      ||. | . ..|   .. .| |.| |||||. ||.  |.
WAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL------KDKHK-WSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase Y59A8B.23.AA Pkinase 57-335 26 1.6e-63 222.14 Pfam 1-293 (293) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSH---EIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCG----SMLDILKRKVK
|.. . || |. ..|. ..    ...||.|.|....   ..|.      ||| |  .||||.| .| .|    ....|| ....|    .  |....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

AIGKEQAQFGVL--DEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTI----QIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVME
       . |..  .|  .  .....|.|||| | .| ||||.|  |||. ..|.|     |.|||..  .      . ..   .||.||| .|||||  
------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIR

QVQGYDFKADIWSLGILAIELATGTAPYHKY------PPMKVLMLTLQNDPPTLETNAERKD------------QYKAYGKSFKTLIRDCLQKDPAKRPT
  |.|. |.|.||.|.. .|...|  |.          .|... .... ...  . .  ..               ..  ...| .|..||.|||.||||
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT

ASELLKYSFF
| ..|.  .|
AEQILQHPWF
Kinase Y59A8B.23.AA TAO 57-335 35 2.6e-57 185.65 In-house 1-254 (254) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-254/254
Sequence Identity: 35% (100 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTS--VDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKE
..  . || |.   |. |..   .| |||| ..    |.    ...  |.. . | .|||.. |   .. ..  |.||     ||  |||  . |     
FQDLREIGHGSFGAVYFARDKHTEEVVAIKKMSYSGKQSHEKWQDIIKEVRFLQQVKHPNCIEYKGCYLREHTCWLVMEYC-LGSASDILDVHKKP----

QAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEV---MEQVQGYDFK
      . || || . ...|.||.| |   .||||||||||||...|....||||            |  .   .||||| ||||||   |.  | || |
------MQEVEIAAICHGALQGLRYLHSHKMIHRDIKAGNILLTEHGQVKLADFGSA----------SMVCPANSFVGTPYWMAPEVILAMDEGQ-YDGK

ADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
.|.|||||  ||||    |.     |  |    |||.|||.         . . ..|.  .  |||| |..||.| |.|...| 
VDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQ--------QNEWSDCFHQFVDKCLQKMPQERPSAEECLRHEFV
Kinase Y59A8B.23.AA SLK 57-335 34 3.2e-57 191.53 In-house 1-259 (259) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-259/259
Sequence Identity: 34% (98 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQA
...   .| ||   |  |    ..   | | |....     | .  ||. .|.|.|||.|  | ..  ...||...   . | .  |.    .       
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMV-EIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEH-------

QFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVM----EQVQGYDFKA
   .| |  |. | .... .|.. | |  ||||.||||||.. || ...||||||  . .      .|| | ||.||| ||||||.     . | ||.||
---PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKH-----TMQK-RDTFIGTPYWMAPEVVMCETFKDQPYDYKA

DIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
|||||||  ||.| .  |.|   ||.||.   . .|||||. ..       . |.|| ... ||.||| .|.|...|... ..
DIWSLGITLIEMAQMEPPHHEMNPMRVLLKIQKSEPPTLEQPSH-------WSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase Y59A8B.23.AA PAKL 57-335 34 1.5e-55 190.9 In-house 1-256 (256) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-256/256
Sequence Identity: 34% (98 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQT-SVDELSHEIQAMSQCNHPNVVSYYTSFIAQ-EELWVVMRLLNCGSMLDILKRKVKAIGKE
. ..|  | |.  .|. |     |   ||| | .    .  . ... |||    |. ||.|||. |      ..|. |     ||  |..    . ..| 
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIK--ESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMM----ESCCK-

QAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADI
      |.|  |. .|. .|||| | |  . ||||||| ||||  |. . |||||||  | ..   .. |.     .||| |||||.. . | |. |.||
-----TLNEKQISVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDE---YDGQA--NQMIGTPYWMAPEIINK-QNYNNKCDI

WSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF
||||| |||.| |  |    |||. ..      |||.          | . . |   .  |..||| ||. ...||   | 
WSLGITAIEMADGFPPHYDMPPMRAMYMIPNWPPPTFS-------NPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase Y59A8B.23.AA Pkinase_Tyr 57-211 23 1.4e-18 63.58 Pfam 1-158 (270) Show / Hide 
Range on Protein: 57-211
Range on HMM: 1-158/270
Sequence Identity: 23% (39 aa)

YKLDESIGVGATATVFTAYCL----PRNEKVAIKCINLEKCQTS---VDELSHEIQAMSQC-NHPNVVSYYTSFI-AQEE--LWVVMRLLNCGSMLDILK
 .... .| ||  .|. ...       . .||.|..  |..  .    ... .|.. |.|  .|||.|..|   .  .|   ...|| .  .|..|| |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

RKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVS
..         . . |.   .    ... ||.|| . .. ||||. | |.|....... |.||| .
KHR-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Y59A8B.23.AA TyrKc 57-335 21 2.1e-17 58.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-335
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQC--NHPNVVSYYTSFIAQ-------EELWVVMRLLNCGSMLDILKRK
 .|.. .| ||  .|. .      ..||.|... ..    . .. .|.. |..   .|||.|  |   . |       | |..|| .   |. .| |...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

VKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRH--------TFV-----GTP
 .           |           . .| || | .. ||||. | |.|.....|. |.|||           |||    .        . .     |. 
RPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG-----------LSRDIYDDDQQGESKDYYRKKEHKGGK

--C---WMAPEVMEQVQG-YDFKADIWSLGILAIELATGTAPYHKY-----PPMKVLMLTLQNDPPTLETNAERKDQYKA--------YGKSFKTLIRDC
      |||||..    | . .| |.|| |..  |. |  .. .        . . ..  ..        . .| .| .           .   .....|
TMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--------QGYRMPQPPNDYPMSFVCCPDEMYQIMKQC

LQKDPAKRPTASELLKYSFF
 . ||..||| ||.  ...|
WHEDPEDRPTFSEI--HECF
Kinase Y59A8B.23.AA MST 312-335 45 1.1e-09 26.84 In-house 231-254 (254) Show / Hide 
Range on Protein: 312-335
Range on HMM: 231-254/254
Sequence Identity: 45% (11 aa)

IRDCLQKDPAKRPTASELLKYSFF
.. ||||.| .|.|| .||. .|.
VCKCLQKNPEQRWTAEQLLQHPFI
Kinase Y59A8B.23.AA Pkinase_Tyr 236-280 36 0.000662 13.85 Pfam 180-225 (270) Show / Hide 
Range on Protein: 236-280
Range on HMM: 180-225/270
Sequence Identity: 36% (17 aa)

WMAPEVMEQVQGYDFKADIWSLGILAIELAT-GTAP-YHKYPPMKVL
|||||..     .  | |.|| |.|  |. | |  | |   ..  |.
WMAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVY
Kinase Y59A8B.23.AA Pkinase_Tyr 310-335 34 0.018281 8.97 Pfam 247-270 (270) Show / Hide 
Range on Protein: 310-335
Range on HMM: 247-270/270
Sequence Identity: 34% (9 aa)

TLIRDCLQKDPAKRPTASELLKYSFF
.|...| ..||..||| ||.  ....
DLMKQCWHYDPEDRPTFSEI--HEQL
FRWNK_Fray Y59A8B.23.AA FRWNK_Fray 445-544 59 8.2e-60 204.91 In-house 1-97 (97) Show / Hide 
Range on Protein: 445-544
Range on HMM: 1-97/97
Sequence Identity: 59% (59 aa)

PETLNMVLRVRNQQRELNDIKFDYTKSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERTLTGFAQISLL
....|.|||.|||..|||||.|..|.. ||.||||.|||.|.|.|..|||||||||||||| ....   .|.||.||||...||.|||..| ||||||. 
QPPINLVLRMRNQKKELNDIRFEFTPGKDTAEGIAQELVSAGLVDGRDLVIVAANLQKLIDNPQTM---KSVTFQLNSGCQPNEVPDEKALIGFAQISIH
OSR1_C Y59A8B.23.AA OSR1_C 448-479 28 4.6e-08 32.97 Pfam 1-38 (38) Show / Hide 
Range on Protein: 448-479
Range on HMM: 1-38/38
Sequence Identity: 28% (11 aa)

LNMVLRVRNQQR------ELNDIKFDYTKSADTVEGIA
.|..||.|.. .      |...|.|...   || |..|
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA