Gene Y69F12A.1 (Nematode worm)

Y69F12A.1

Species: Nematode worm
Alias: Y69F12A_449.c, CE24572, Y69F12A.1, aSWK128
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: III:-0.7, WormBase Physical Map location: III: 7452406-7453978

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
Y69F12A.1.AA Protein Genbank 382 None Fasta, JSON
Y69F12A.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 308 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Y69F12A.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Y69F12A.1.AA Worm6 70-337 47 8.4e-159 533.86 In-house 1-279 (279) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-279/279
Sequence Identity: 47% (132 aa)

YELTSELGQGSFGAVFGVTRKSDKR--HFAMKCES--VNMKRAILPHEAGVLLALNHLKSPHFLEMVDHGIVNNR-FLFVVLKLVGMNLWDMRAHLPDKK
...| ..|.|.||||. |..||||.  .||||||.   ||||  |..|. ||.|..| |..||....|.| |.|| |...|..|||.||||.|...||.|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

YTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGR---EEDDTYHTVFLLDFGLCR--KIAMKGKDLRTPR-KECAFRGTTRYAALAAHDNKEQSR
....|.|.||.|.|....|||..||.|||.||.||.|||   .||. .||...||||.||  |   ||..||||| ..|.||||.|||.||.|...||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDIESWWYMIAEMIVFDIPWKQFRGTDRDNVRGMKWRLRADETYFKFLFRKCCYEQMSAILLYLDQLSYSSIPDYDFV
|||.|||.||..||||...||......|.........| | ........|..|..|....|. |.||.|| . |||.|.
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase Y69F12A.1.AA CK1 70-337 25 3.4e-105 355.77 In-house 1-339 (339) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-339/339
Sequence Identity: 25% (86 aa)

YELTSELGQGSFG-AVFGV-----TRKSDK-----RHFAMKCESV-NMKR-AILPHEAGVLLALNHLK--------SPHFLE----------MVDHGIVN
....  .|.|.|| ... |     ......      ..|||.|.. .|..   | .|. ....|...|        ..||..          ...|| ..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NRFLFVVLKLVGMNLWDMRA--HLPDKKYTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREE-----------DDTYHTVFLLDFGLCR-KIA
... ..|. |.|.||.| |.   ....| ...|.|.||.|.| .|...|. ||.|||||| ||..||.|           ......|...|||..| | .
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

MKGKDL------------RTPRK---ECAFRG-TTRYAALAAHDNKEQSRKDDIESWWYMIAEMIVFD--IPWKQFRG-----TDRDNVRGMKWRLRADE
.|...             |.||.    . ||| |.||. ...|..|||.|.||..||.||..|...     ||.  .      ...  ..  .   . ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK

TYFKFLFRKCCYE------QMSAILLYLDQLSYSSIPDYDFV
 ...|. ..|...      ..  |. |...|.|...|||...
MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase Y69F12A.1.AA TTBKL 70-341 33 5.5e-78 262.87 In-house 1-288 (288) Show / Hide 
Range on Protein: 70-341
Range on HMM: 1-288/288
Sequence Identity: 33% (98 aa)

YELTSELGQGSFGAVFGVTRKSD-KRHFAMKCESVNMK--RAILPHEAGVLLALNHLKSPHFLEMVDHGIVNNRFLFVVLKLVGMNLWDMRAHLPDKK-Y
.. . ..|.| ||.|. |  ..| | ..||| |.  .    ...  |. ||..|.  .||||..... |  . .. |.|. |.|.|| | |. .| ||  
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGK-RKDYNFMVMTLCGPNLQDLRKMMPNKKRF

TLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREED--DTYHTVFLLDFGLCRKIAMKGKDL-----------RTPRK---ECAFRGTTRYAALA
. .|..||. |.|..|...|..||.|||.|| |...| ...  .. ..|.|.|||..|..|.| ...           |.||.    . |||||||. ..
SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN

AHDNKEQSRKDDIESWWYMIAEMIVFDIPWKQFRGTDRDNVRGMKWRLRADETYFKFLFR-KCCYEQMSAILLYLDQLSYSSIPDYDFVYHHL
.|| |||.|.||. || |||.|. .   ||.  . .|....  || .   ||. || ..| . |  ..  .  .| .|.| . |||. .|...
MHDRKEQGRHDDLWSWMYMIIELHCG-LPWT--NMEDKMEIEHMK-KNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase Y69F12A.1.AA TTBK 70-337 34 1.6e-53 184.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 70-337
Range on HMM: 1-257/257
Sequence Identity: 34% (92 aa)

YELTSELGQGSFGAVFGVTRKSDK-RHFAMKCESVNMKRAILPHEAGVLLALNHLKSPHFLEMVDHGIVNNRFLFVVLKLVGMNLWDMRAHLPDKKYTLT
   .   |.| || ..  .    .  . |.| ||.. .. .|  |  ||  |   .  |    .  |  |..| ..|..| | || |.| . |. ...| 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCD--HVCRFIGCGR-NDKFNYMVMQLQGKNLADLRRKQPRGCFSLS

TTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMKGKDLRTPRKECAFRGTTRYAALAAHDNKEQSRKDDIESWWYM
||||.  | | ...  | |||||||||| |||.||    |.  ...||||| |.      . |.||.   |||| |||.  || |.|  |.||  |  ||
TTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNP-STCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYM

IAEMIVFDIPWKQFRGTDRDNVRGMKWRLRADETYFKFLFRKCCYEQMSAILLYLDQLSYSSIPDYDFV
  | ..   ||   .  |.| |  ||      | |   .  | | ....  .  .  | |   ||| ..
LVEFVQGQLPWRKIK--DKDQVGEMK------EKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase Y69F12A.1.AA Dual 70-269 30 1.2e-37 124.05 In-house 1-213 (282) Show / Hide 
Range on Protein: 70-269
Range on HMM: 1-213/282
Sequence Identity: 30% (65 aa)

YELTSELGQGSFGAVFGVTRKSD----KRHFAMKCESVNMKRAILPHEAGVLLALNHLK---------SPHFLEMVDHG-IVNNRFLFVVLKLVGMNLWD
      || | |. |  | | |     . ....| || . ... |     . .                 .| |.|| | ..  .  ..|  ..|  | .
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

MRAHLPDKKYTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAM-KGKDLRTPRKECAFRGTTRYAALAAHDNK
 |     .  .  .   .| |.|  ..||| .|.|||.||| ||..| ..| |  ||...||.. ||    . |  ||.||   . |. |||  |    |
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDET--TVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQK

EQSRKDDIESWWYMI
.| ||||.|.| ||.
DQGRKDDLECWIYMV
Kinase Y69F12A.1.AA CK1-Unique 70-269 23 2e-36 123.8 In-house 1-220 (337) Show / Hide 
Range on Protein: 70-269
Range on HMM: 1-220/337
Sequence Identity: 23% (53 aa)

YELTSELGQGSFGAVFGVTRKSDK------RHFAMKCESVNMKRA--ILPHEAGVLLALNHLK-----SPHFLEMVDHGIVNNRFLFVVLKLVGMNLWDM
.  . ..| |..| |  |    .         ..|| | . |..   .|  |  |..... .      . ||.|  | . .     . |. ..| ..   
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFH-QHRDWWWIVMTMHGPSMEEC

RAHLPDKKYTLT------TTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRK--IAMKGKDLRTPRKECAFRGTTRYAAL
.  .   ..||       . .. ..|.| ...  | .||.||..|| |.  .       |. . ||.| ||.  .  .   .| ||.   |||. .|.  
CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC

AAHDNKEQSRKDDIESWWYMI
. |  .|..|.|| ||| ||.
SCHQCREHGRRDDMESWFYML
Kinase Y69F12A.1.AA CK1-A 70-280 31 1.1e-25 87.6 In-house 1-206 (261) Show / Hide 
Range on Protein: 70-280
Range on HMM: 1-206/261
Sequence Identity: 31% (66 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPHEAGVLLALNHLKSPHFLEMVDHGIVNNRFLFVVLKLVGMNLWDMRAHLPDKKYTLTT
| |  ..| |||| ..      .    |.| || . .   |  || |   |.  . . . .|  .|   . .  .|. |.|  | |.   . ....|. |
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGCEKD-YNVMVMDLLGPSLEDL-FNFCKRRFTMKT

TLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMKGKDLRTP-RKECAFRGTTRYAALAAHDNKEQSRKDDIESWWYM
 | .|.| .. .  .|  .|.|||||| || .|   .     .||.|||| .|   .      | |..    || |||.. ||   ||||.||.||  |.
VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI--GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYV

IAEMIVFDIPWK
.       .||.
MMYFNRGKLPWQ
Kinase Y69F12A.1.AA CK1-D 70-280 29 4.5e-20 67.38 In-house 1-206 (261) Show / Hide 
Range on Protein: 70-280
Range on HMM: 1-206/261
Sequence Identity: 29% (62 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPHEAGVLLALN-HLKSPHFLEMVDHGIVNNRFLFVVLKLVGMNLWDMRAHLPDKKYTLT
| .   .| |||| ..  |  .     |.| |..  |   |  |. .   ..  .  |.   .   |  |     .|. |.|  | |.  .  ..|. | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYN----VMVMDLLGPSLEDLFNYC-HRKFSLK

TTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMKGKDLRTP-RKECAFRGTTRYAALAAHDNKEQSRKDDIESWWY
| | .|.| .. .  .|   |.|||||| || .|       ..|...|||| ..          | | .    || |||..  |   ||||.||.||  |
TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGK--RGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGY

MIAEMIVFDIPWK
..       .||.
VLMYFNRGSLPWQ
Kinase Y69F12A.1.AA CK1-Unclassified 163-219 43 4.4e-16 43.97 In-house 99-154 (244) Show / Hide 
Range on Protein: 163-219
Range on HMM: 99-154/244
Sequence Identity: 43% (25 aa)

KKYTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIG-REEDDTYHTVFLLDFGL
.| .| |.| ||.| .  .  ||. .|.|||||| || .| ..    .|.|.. ||||
RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGK--NHHQVYIIDFGL
Kinase Y69F12A.1.AA CK1 162-219 43 4.3e-15 48.57 In-house 99-155 (271) Show / Hide 
Range on Protein: 162-219
Range on HMM: 99-155/271
Sequence Identity: 43% (25 aa)

DKKYTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGL
..| .| |.| ||.| .  .  .|  .|.|||||| || .||      |.|.. ||||
NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGL
Kinase Y69F12A.1.AA Pkinase 70-247 20 2.3e-14 51.86 Pfam 1-179 (293) Show / Hide 
Range on Protein: 70-247
Range on HMM: 1-179/293
Sequence Identity: 20% (40 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPH------EAGVLLALNHLKSPHFLEMVDHGIVNNRFLFVVLKLVGMN--LWDMRAHLP
|.. . .|.|||| |.  ..|.. . .|.|. ..  ..   .       |. ... ||   .|. ... |     .. . .|. ....   . |  ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

---DKKY--TLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMKGKDLRTPRKECAFRGTTRYAA
   ....  .  .  ... |.| ||  .|. |..|||.|| |. |  .....  .| . ||||....      .   .    | || .|.|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase Y69F12A.1.AA S_TKc 70-327 16 5.8e-14 27.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 70-327
Range on HMM: 1-231/231
Sequence Identity: 16% (46 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPHEAGVLLALNHLKSPHFLEMVDHGIVNNRFLFVVLKLVGM---NLWDMRAHLPDKK--
||.  ..|.|.|| |. .. |...|..|.|. .       .  |  .|      . |.   . |.      .|..|. ...    .| |.  . . ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--YTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMKGKDLRTPRKECAFRGTTRYAALAAHDNKEQSRKDDI
  ..  .. ... |.. .|  .|. |..|||.|| |  . .       .. . ||||.|..               | ||  | |           . . 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-------GYGK

-ESWWY----MIAEMIVFDIPWKQFRGTDRDNVRGMKWRLRADETYFKFLFRKCCYEQM---SAILLYL-------DQLS
 .. |.    ...||..   |.         ..  |  ... ..    |. . ....     .|  .         ..  
CKCDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y69F12A.1.AA CK1-Unclassified 70-125 28 5.1e-11 28.78 In-house 1-56 (244) Show / Hide 
Range on Protein: 70-125
Range on HMM: 1-56/244
Sequence Identity: 28% (16 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPHEAGVLLALNHLKS
|...  .|||||| .. .. . .....|.| |. | |   |. || .. .|.. ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHN
Kinase Y69F12A.1.AA CK1-Unclassified 241-264 62 3.2e-09 23.39 In-house 178-201 (244) Show / Hide 
Range on Protein: 241-264
Range on HMM: 178-201/244
Sequence Identity: 62% (15 aa)

GTTRYAALAAHDNKEQSRKDDIES
||.||| . ||  .||||.|| ||
GTARYASINAHLGIEQSRRDDLES
Kinase Y69F12A.1.AA CK1 70-122 26 3e-08 24.69 In-house 1-55 (271) Show / Hide 
Range on Protein: 70-122
Range on HMM: 1-55/271
Sequence Identity: 26% (15 aa)

YELTSELGQGSFGAVFGVTRKSDKRHF---AMKCESVNMKRAILPHEAGVLLALNH
|...  .|||||| .. ...  .....   |.| |. . |   |. || ..  |..
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQG
Kinase Y69F12A.1.AA CK1 241-264 58 2.2e-07 21.71 In-house 178-201 (271) Show / Hide 
Range on Protein: 241-264
Range on HMM: 178-201/271
Sequence Identity: 58% (14 aa)

GTTRYAALAAHDNKEQSRKDDIES
||.||| . .|  .||||.|| ||
GTARYASINTHLGIEQSRRDDMES
Kinase Y69F12A.1.AA TyrKc 70-323 16 2.3e-05 -135.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 70-323
Range on HMM: 1-280/280
Sequence Identity: 16% (53 aa)

YELTSELGQGSFGAVFGVTRKSDKRHFAMKCESVNMKRAILPHEAGVLLAL--NHLKSPHFLEMVDHGIVNN--------RFLFVVLKLVGMNLWDMRAH
 .|  .|| | || |.  | |   .  | |.   .  |. . .|| ..  |  .|   |. . ..  |..            |..|. .  | . | . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHH---PNIVRLY--GVCTQQGRNFMYIEPLMIVMEY--MPHGDLKDY

LPDKK--YTLTTTLRIAEQTLAGLRDLHRVGFLHRDIKPPNFAIGREEDDTYHTVFLLDFGLCRKIAMK------GKDLRT----PRK----------EC
| ...   .. . | .. |  .| . ||. .. |||.   |  .|..      ||   ||||.|.|  .      ..  |.     .|          ||
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

AFRGTTRYA--------------ALAAHDNKE---QSRKDDIESWWYMIAEMIVFDIPWK----QFRGTDRDNVRGMKWRLRADETYFKFLFRKCCYE--
 . |.   .               . .    .   |  . . .     . .    ..|       |               .. .  .. . ..|. |  
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMSF--------------VCCPDEMYQ-IMKQCWHEDP

----QMSAILLYL
     .|.|  ..
EDRPTFSEIHECF
Kinase Y69F12A.1.AA Dual 319-341 34 0.006373 5.51 In-house 260-282 (282) Show / Hide 
Range on Protein: 319-341
Range on HMM: 260-282/282
Sequence Identity: 34% (8 aa)

ILLYLDQLSYSSIPDYDFVYHHL
.. | . ..|.| ||||     |
LVSYVNGYQYDSTPDYDYFRNCL