Gene Y81G3A.3 (Nematode worm)

Y81G3A.3

Species: Nematode worm
Alias: CE23118, aSWK235, Y81G3A.3
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: II:12.68, WormBase Physical Map location: II: 13084056-13091370

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
Y81G3A.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 509 Kinase domain by global Sugen HMM Fasta, JSON
Y81G3A.3.AA Protein Genbank 1696 None Fasta, JSON

Protein domain

Protein domains of Y81G3A.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD Y81G3A.3.AA RWD 22-138 26 2e-31 111.61 SMART 1-128 (128) Show / Hide 
Range on Protein: 22-138
Range on HMM: 1-128/128
Sequence Identity: 26% (35 aa)

EEKLALDAVYLNQITYIKAHWHVWVPTNCHILLKALDSCFLNG--------DPLGKSKLSVILHVKCSEDYPQRKPAVDLLDPQ-GLSKEDV--QNLLTI
.| .||...| .. . |....| || .||.| ..   ... ..        .   .......||..|.|.||   | ..|..|| .||.|..  | |...
MELEALESIYPDDFECIDEDRHHWV-INCCIQIHIHPHEDEMQITNYDNFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKH

LRQMADTW--EGCVVIAELAHRVREFLTDH
|.......   |...| |....|.|||..|
LQEIWEENWCRGMCMIFEWVQWVQEFLSEH
RWD Y81G3A.3.AA RWD 15-135 21 1.5e-23 88.93 Pfam 1-119 (119) Show / Hide 
Range on Protein: 15-135
Range on HMM: 1-119/119
Sequence Identity: 21% (28 aa)

ENQHLQEEEKLALDAVYLNQI--TYIKAHWHVWVPTNCHILLKALDSCFLNGDPLGKSKLSVILHVKCSEDYP-QRKPAVD-LLDPQGLS---KEDVQNL
..|..||.| .||.. | ...  ......|... |....| .          .   ... ...||..|.|||| .  | .. .   ..|.   ....|.|
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI---------DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQL

LTILRQMADTWE-GCVVIAELAHRVREFL
.. |.......  |.|.| |..  ..|.|
CKKLQEYWEENCHGMVMIFEWIEWLQENL
Kinase Y81G3A.3.AA GCN2 319-343 36 0.001969 7.39 In-house 310-334 (511) Show / Hide 
Range on Protein: 319-343
Range on HMM: 310-334/511
Sequence Identity: 36% (9 aa)

LRLLAAQAICGLRYLHEASMTHKHL
|. ...| ..|| |.|. .| |..|
LWRYFRQILEGLNYIHSQGMIHRDL
Kinase Y81G3A.3.AA PEK 300-344 22 0.024044 3.1 In-house 409-454 (655) Show / Hide 
Range on Protein: 300-344
Range on HMM: 409-454/655
Sequence Identity: 22% (11 aa)

SSEENMQDTY---ELIVQKSNLLRLLAAQAICGLRYLHEASMTHKHLT
.|  ||  ..    .  . ..... ...| ..|| |.|.  | |..|.
WSM-NM-RQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLK
Kinase Y81G3A.3.AA GCN2 491-999 34 1.9e-257 861.54 In-house 1-511 (511) Show / Hide 
Range on Protein: 491-999
Range on HMM: 1-511/511
Sequence Identity: 34% (183 aa)

NVIIRVLGRGGFGDVVL-VRNKMDSTDYAIKRIPLNAKSDKLNRK--IAKEAKFFAKLNHPNMVRYYYAWAEDLIPIVEETSDDDSSLGAVPIPGKEKIG
...|..||.||||.||  |||..|...||||..|.|.|..||..|  |..|.|....|.|...||||.||.|............|...........|...
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

KKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDSSEIDWDAES
..|.....||....|...|..........|.|. ...|..|....||..||..|.|||||.||.| || |......|.|.|.||.|.|||...||||.||
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQ-KR-TFDLTDDHYSYCHSDCEFDDDVFDIDWDIES

EEVEDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTTTTSKSKLAIDVVPVRKPRILCIQMEYCDR
..|.|.||||...|.|.......|...|...       ....|......|||||.|.|...... |..|.....................|.||||||..
NNVRDMESDDNEWEQEQQNNQSFQPKQEDHQ-------NQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEG

ATLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMS---------------SKGKIVGGAAEKSTS
.|||||||.........|.||.|...|.||.|.|...|||||.|| ||||.... |||||||||| ..|.               |...|. ........
KTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQF

IEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSA-GVVLFEMFYRPLPPSMDRVSTLNNLRDDIKIPSDFGAGLAAPMAGL
.... .... ......||.|...||..||.||..      |..|..|.|.||  |...|||.|.|....|.||..|..|| ....|.||... .....  
NQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ------KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDKK-VDNHHKD

ARRTVEKMLQRNPDERPTADDLLNDEDL
........|...|..||.|..||..|.|
QQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase Y81G3A.3.AA PEK 491-999 25 1.1e-197 663.03 In-house 1-655 (655) Show / Hide 
Range on Protein: 491-999
Range on HMM: 1-655/655
Sequence Identity: 25% (167 aa)

NVIIRVLGRGGF-GDVVLVRNKMDSTDYAIKRIPLNAKS---------------DKLNRKIAKEAKFFAKLNHPNMVRYYYAWAEDLIPIVEETSDDDSS
   |..||.||| |.|. |.||.|.. ||||||.||.|.               .|...|. .|.|..|.|||||.|||..|| |. . . ....|....
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

LGAVPIPGKEK-------------------------------IGKKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVK--------------------
|. .......|                               ...||| |. .. .....|.|.   .. .......  .                    
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

----DHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDSSEIDWDAESEEVEDEESDDSDEEDEDDGERLVQLNTETSTG
    ..|.......|..||.......|.|...........   .. |.||.|..|..|||...||......|..|..|.|.|.|.....  |........
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

ADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTTTTSKSKLAIDVVPVRKPRILCIQMEYCDRATLRQYIDENH---------------------
..........|...... .... ......|.| ||.||.......   . ........|.||||||.  |||..||.|.                     
KKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

----------------------CFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNG-----VKIGDFGLATLEAMS------------SK
                      .|.. ...||||...|.||.|.| ..|||||.|| ||||....      |||||||||| ..|.            |.
MNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSY

GKIVGGAAEKSTSIEAMLSPNGVKSKG---------------SDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRV
.|.|.  ...... ... ||.|.....               ...|.|...||.|||.||.. .....|. |. |.|.|| |...|||.|..  ..|.||
WKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERV

STLNNLRD-DIKIPSDFGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDL
 ||..||| .|..|.|| . . ....  ..  . .||...|..||.|...|. | .
KTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase Y81G3A.3.AA S_TKc 491-1001 14 2.9e-45 157.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 491-1001
Range on HMM: 1-231/231
Sequence Identity: 14% (76 aa)

NVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAEDLIPIVEETSDDDSSLGAVPIPGKEKIGKKG
  |.|..|.|.|| | ..|.| .   .|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

KLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSECSSDDEDDDDSSEIDWDAESEEV
                                                                                                    
----------------------------------------------------------------------------------------------------

EDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTTTTSKSKLAIDVVPVRKPRILCIQMEYCDR--A
                                                             . ||.     . .  .    |     |.. |||||    
----------------------------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLG

TLRQYIDENHC------FNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGV
.|..||... .      |.   ...... ...|.|.|.|..  ||||.|| ||.|..   .||.|||||..                             
DLFDYIKKRGRHGLRFPFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------------------

KSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTS-KIDIYSAGVVLFEMFY--RPLPPSMDRVSTLNNLRDDIKIPSDFGAGLAAPMAGLARRTVEKM
         |  .||  |||||..        .|.  |.|..| |..|.||..   | |   .   ......                    |.  ..|.
---------TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------SPEAKDFIRKC

LQRNPDERPTADDLLNDE-----DLPM
||..|..|||| ..|.||     .  .
LQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Y81G3A.3.AA STE 491-932 13 7.2e-36 124.17 In-house 1-261 (359) Show / Hide 
Range on Protein: 491-932
Range on HMM: 1-261/359
Sequence Identity: 13% (70 aa)

NVIIRVLGRGGFGDVVLVRNKMDS-TD--------------YAIKRIPLNAKS---------------DKLNRKIAKEAKFFAKLN--HPNMVRYYYAWA
  .|...|.|.|| |.. .|. .. ..              .|||...|. ..               ..   .| || |.  |.|  ||| |.|| .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EDLIPIVEETSDDDSSLGAVPIPGKEKIGKKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTP
 .  .                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

SGGLKHLSECSSDDEDDDDSSEIDWDAESEEVEDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTT
                                                                                                    
----------------------------------------------------------------------------------------------------

TTSKSKLAIDVVPVRKPRI---LCIQMEYCDRATLRQYIDEN-HCFNAPT----------EVWR--IFSEVLCG-LKYMHDMAMIHRDIKPLNIFLTSQN
                      |.| |||.|  .|.. |...  |..  .          | .   |  ..| | |.| |..  ||||||| ||.|    
----------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----

GVKIGDFGLAT-LEA----------MSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDV------HQTRDIGTQLYMAPELFVDELVH-KAPYTSKIDIY
 ||. |||... |.                                           |       . . ..||. .||||    .  . . .|. | ||.
-VKLCDFGVCGQLTDSMANIQSNNII-------------------------------DCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIW

SAGVVLFEM
| | .. ||
SLGCTIIEM
Kinase Y81G3A.3.AA Pkinase 778-999 21 2.4e-33 118.99 Pfam 75-293 (293) Show / Hide 
Range on Protein: 778-999
Range on HMM: 75-293/293
Sequence Identity: 21% (55 aa)

LCIQMEYCDRA----TLRQYID-ENHCFN--APTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGV----KIGDFGLAT-LEAMSSKGKIVGG
... ||||.       |  ||  ..|.     . |. ... ..|.||.|.|.|  ||||.|| ||.. ... .    ||.|||||  ..           
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------

AAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMD------RVSTLNNLRDDIKIPSD
                     ...  |   ||  |||||.    . .  .|..|.|..|.|..|.||. . .| . .      .   . ... . ....|
-------------------Y-NNS-MTTFCGTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFD

FGAGLAAP---------------MAGLARRTVEKMLQRNPDERPTADDLLNDEDL
.      .               .   ..  ....|...| .||||...|... .
WPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Y81G3A.3.AA Ciliate-E2 778-999 20 3.3e-30 100.86 In-house 109-365 (365) Show / Hide 
Range on Protein: 778-999
Range on HMM: 109-365/365
Sequence Identity: 20% (60 aa)

LCIQMEYCDRATLRQYIDEN--------------HCFNAPTEVWRIFS-----------EVLCGLKYMHDMA-MIHRDIKPLNIFLTSQNGVKIGDFGLA
. . ||||.  .|..|| .|               .. . .  . |..           .....|.|.|     ||||||| ||..     .|| ||||.
IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLS

T---------LEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQ-------TRDIGTQLYMAPELFVDELVH----KAPYTSKIDIYSAGVVLFE
.         .. ..  ...     ..|...  |              |        . .||  ||||| .  .       . .|. |.||.|.||.|.|
KKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD-------------QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MFYRPLPPSMDRVSTLNNLRDDIKIPSD-----------------------------FGAGLAAPMAGLARRTVEKMLQRNPDERPT-ADDLLNDEDL
| .  .|         ...  .|..|.                              ||                .|||..|..|.| ....|| . .
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK---------------RMLQKDPEKRITGWEQILNHPWF
Kinase Y81G3A.3.AA TKL 778-997 19 2.2e-26 92.02 In-house 113-364 (364) Show / Hide 
Range on Protein: 778-997
Range on HMM: 113-364/364
Sequence Identity: 19% (54 aa)

LCIQMEYCDRAT-LRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHD--------MAMIHRDIKPLNIFLTSQNG--------------VKIGDFGLAT-L
||| ||||.. . | ...        .    |.  .. .|. |.|         ...||||.|. ||.. . .               .||.||||.. .
LCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

EAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDE--LVHKA---------PYTSKIDIYSAGVVLFEMFYRPLPPS-M
. .... ..  .  |   |.     .   ..  .. .  . .||  .||||.. ..  . .|.         .|. |.|.|| |.||.|.. | .| . .
SQSGNMNDTMTTMME---SA-----E---HQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

D--------------RVSTLNNLRDDIK-IPSD-FGAGLAAPMAGL---ARRTVEKMLQRNPDERPTADDLLNDE
.               .  ...||  |. |... .      |        ..  ..  . .|..||.....|   
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Y81G3A.3.AA STE-Unique 780-999 28 2.2e-25 86.71 In-house 371-616 (616) Show / Hide 
Range on Protein: 780-999
Range on HMM: 371-616/616
Sequence Identity: 28% (72 aa)

IQMEYCDRATLRQYIDENHC---------FNAPTEVWRIFSEVLCGLKYMHDMA--MIHRDIKPLNIFLTSQN-----GVKIGDFGLATLEAMSSKGK--
|.||||.  ||.| |... |         | . ||| ..  ..| || | |      ||||.|| |||...        |||.|||.||  .  ...|  
IFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPE-TEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDN

-------IVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQLYMAPELFVDELVHKA-----PYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLN-
        .      ||   |   |    .  . .  .. .||  ||.|     | . ..     ||  | ||.| | ..|.|    .|| . | . .  
NSKNSNTWININNNSSTNSTAQQTPMWDLNI-NNYTMKYCCGTPCYMCP-----EVINCRNQINNPYDTKVDIWSLGCMCFHMCCG-CPPWHQRYHMQAY

-NLRDDIKIPSD--FGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDL
  ... |. .    .    .   . . .   || | |||  ||.| .|| .. |
IEMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase Y81G3A.3.AA NEK 778-851 41 7.6e-25 84.69 In-house 81-170 (286) Show / Hide 
Range on Protein: 778-851
Range on HMM: 81-170/286
Sequence Identity: 41% (37 aa)

LCIQMEYCD-RATLRQYIDE-NHC-----FNAPTEVWRIFSEVLCGLKYMHDM-----AMIHRDIKPLNIFLTSQNG----VKIGDFGLA
||| ||||.   .| | | . ...     .    ..|..|   . .||||||.       .|||||| |||||..|     |||||||..
LCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase Y81G3A.3.AA PEK-Unclassified 492-559 36 7.6e-21 69.03 In-house 2-74 (835) Show / Hide 
Range on Protein: 492-559
Range on HMM: 2-74/835
Sequence Identity: 36% (27 aa)

VIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLN---AKSD--KLNRKIAKEAKFFAKLNHPNMVRYYYAWAE
. ....|.|||. |  . .|.| . ||.|.| .|    | |  |   |  .|.   |..|||| .|||  | |
NQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIE
Kinase Y81G3A.3.AA PEK 493-559 38 9.8e-21 64.89 In-house 3-76 (758) Show / Hide 
Range on Protein: 493-559
Range on HMM: 3-76/758
Sequence Identity: 38% (29 aa)

IIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNA--------KSDKLNRKIAKEAKFFAKLNHPNMVRYYYAWAE
 | .||.|||| | .. || |   ||||||..          .. ... |   |..  |.|.|.| |||..|| |
HIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESARE-KVMREVRTLAMLDHHNIVRYFNAWLE
Kinase Y81G3A.3.AA WEE 776-852 28 1.1e-20 66.15 In-house 78-180 (297) Show / Hide 
Range on Protein: 776-852
Range on HMM: 78-180/297
Sequence Identity: 28% (30 aa)

RILCIQMEYCDRA------TLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDM-AMIHRDIKPLNIFLTSQN--------------------GVKIGDF
... ||||||..        . | . .||..  . ..| |. ... ||...|..  |.| |||| |||....                       |||||
DHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEW-MIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDF

GLAT
|..|
GHVT
Kinase Y81G3A.3.AA PEK 780-852 28 2.1e-17 53.51 In-house 416-514 (758) Show / Hide 
Range on Protein: 780-852
Range on HMM: 416-514/758
Sequence Identity: 28% (28 aa)

IQMEYCDRATLRQYIDE--NHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNG------------------------VKIGDFGLAT
|||..|   ||.. .    .   .  ...  .|   . |. | | . ||||| || |||...                           .|||||||.|
IQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT
Kinase Y81G3A.3.AA NEK 491-554 34 2.5e-17 57.89 In-house 1-70 (286) Show / Hide 
Range on Protein: 491-554
Range on HMM: 1-70/286
Sequence Identity: 34% (24 aa)

NVIIRVLGRGGFGDVVLVRNKMDSTD-----YAIKRIPLNAKSDKLNRKIA-KEAKFFAKLNHPNMVRYY
  ||...|.| || | .|| | |.       |..|.| ..  |.|  ..   .|..  ..|.||| |.||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYY
Kinase Y81G3A.3.AA PEK-Unclassified 809-852 43 1.3e-16 53.88 In-house 618-663 (835) Show / Hide 
Range on Protein: 809-852
Range on HMM: 618-663/835
Sequence Identity: 43% (20 aa)

IFSEVLCGLKYMHDMA-MIHRDIKPLNIFLTSQ-NGVKIGDFGLAT
|  ... .|.. |    |.|||||| |||..    ..|||||||..
ITRQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVK
Kinase Y81G3A.3.AA STE-Unique 492-559 34 2.1e-15 50.66 In-house 1-72 (616) Show / Hide 
Range on Protein: 492-559
Range on HMM: 1-72/616
Sequence Identity: 34% (25 aa)

VIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDK----LNRKIAKEAKFFAKLNHPNMVRYYYAWAE
...  .|||.|| |.. .|| |.  .||| |.|. ..|     |  .|..|    ..|.|.| |.|| .| .
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase Y81G3A.3.AA PEK 892-999 29 3.9e-14 42.4 In-house 646-758 (758) Show / Hide 
Range on Protein: 892-999
Range on HMM: 646-758/758
Sequence Identity: 29% (36 aa)

TRDIGTQLYMAPELFVDELVHK---------------APYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLRDDIKIPSDFGAGLAAPMAGLARRTV
|   ||.|||.||     . |.                 |. | |||| | ..||...      |.|. |. .||. . .|..|   .  |    ..  .
TVQVGTHLYMSPE----QCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQ-WPKWFTQKY--P---QEYEFI

EKMLQRNPDERPTADDLLNDEDL
  |.  |||||||||...     
QQMMSMNPDERPTADQISMHDFF
Kinase Y81G3A.3.AA WEE 492-560 31 2.4e-13 41.19 In-house 2-77 (297) Show / Hide 
Range on Protein: 492-560
Range on HMM: 2-77/297
Sequence Identity: 31% (24 aa)

VIIRVLGRGGFGDVVLVRNKMDSTDYAIKRI-PLNAKSDKLNRKIAKEAKFFAKLN-------HPNMVRYYYAWAED
 .. ..|.| ||.|. .|.. |.  ||||..    ...   .|.. .|..  ..|        ||. |||| ||.||
QEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRAL-REVYAHMVLGQIMDCDHHPHIVRYYSAWEED
Kinase Y81G3A.3.AA Pkinase 491-560 27 4.1e-12 43.91 Pfam 1-72 (293) Show / Hide 
Range on Protein: 491-560
Range on HMM: 1-72/293
Sequence Identity: 27% (20 aa)

NVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAK--EAKFFAKLNHPNMVRYYYAWAED
 .|.|..|.|.|| | . ..| ..  .|.|.|..  .... ..  ..  |..  ..||||| ||.|... ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase Y81G3A.3.AA TyrKc 491-999 11 1.7e-10 -52.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 491-999
Range on HMM: 1-280/280
Sequence Identity: 11% (63 aa)

NVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKSDKLNRKIAKEAKFFAKL--NHPNMVRYYYAWAE---------------------DLIPIVEE
 . ...||.| || |.. . |   .. |.| .  .|      . . .||.   ||  .||| || | .  .                     ||     .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

TSDDDSSLGAVPIPGKEKIGKKGKLKTGKSLEDKENKANLGGGDSLMPMNLRGLVKDHSIGVDAKEWSTPFGKPEGPKCASRMRQSKRSTPSGGLKHLSE
. ..                                                                                                
HRPK------------------------------------------------------------------------------------------------

CSSDDEDDDDSSEIDWDAESEEVEDEESDDSDEEDEDDGERLVQLNTETSTGADSVFERSTADEDVVFTAESEDLNAKRRESIELMEINTTTTSKSKLAI
                                                                                                    
----------------------------------------------------------------------------------------------------

DVVPVRKPRILCIQMEYCDRATLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLATLEAMS-SKGKIVGGA
                                   . .   .   . ||  | |..  ||||.   |. ..... |||.||||.       ..|      
---------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG------

AEKSTSIEAMLSPNGVKSKGSDVHQTRDIGTQL----YMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPS-------MDRVSTLNNLRDD--
                 ||   ...... |  .     |||| . .. .    .|.| |..| ||...|.| .  .|        |.    ......   
----------------ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGK----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR

IKIPSD-----FGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDL
 ..| .     |        . . .   ..  ...|..|||  ..   |..
MPQPPNDYPMSF----VCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase Y81G3A.3.AA Ciliate-E2 491-557 19 3.1e-09 27.82 In-house 1-101 (365) Show / Hide 
Range on Protein: 491-557
Range on HMM: 1-101/365
Sequence Identity: 19% (20 aa)

NVIIRVLGRGGFGDVVLVRN-----------------------KMDSTDYAIKRI---PLNAKSDKLN--R-------KIAKEAKFFAKLNHPNMVRYYY
  .|...|.|.||.| ....                       | ..  ||.|..    ..... ...  |       || .| .   .||||| ...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYE

AW
..
CF
Kinase Y81G3A.3.AA TKL 497-554 16 1.8e-07 22.98 In-house 1-91 (364) Show / Hide 
Range on Protein: 497-554
Range on HMM: 1-91/364
Sequence Identity: 16% (15 aa)

LGRGGFGDVVLVRNKMDS--------TDYAIKRIPLNA-------------------------KSDKLNRKIAKEAKFFAKLNHPNMVRYY
.|.|||| |   . .  .        .| |.|... .                          .. ... .. .|..   .|.||| |...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFM
Kinase Y81G3A.3.AA PEK-Unclassified 916-951 38 1.1e-05 14.54 In-house 761-795 (835) Show / Hide 
Range on Protein: 916-951
Range on HMM: 761-795/835
Sequence Identity: 38% (14 aa)

YTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLR
|  . |||| |...|.||  ..  .| || |. |..
YNHRTDIYSVGIIFFQMF-HQMNTTMERVKTIQNCK
Kinase Y81G3A.3.AA STE 976-999 38 1.2e-05 16.05 In-house 334-359 (359) Show / Hide 
Range on Protein: 976-999
Range on HMM: 334-359/359
Sequence Identity: 38% (10 aa)

VEKMLQRNPDERPTADDLLN--DEDL
..| ||..|..||||..||.   . .
INKCLQKDPNKRPTASQLLKSEHPFI
Kinase Y81G3A.3.AA NEK 973-999 25 1.3e-05 16.12 In-house 260-286 (286) Show / Hide 
Range on Protein: 973-999
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

RRTVEKMLQRNPDERPTADDLLNDEDL
.. ...|||..|..||.....|..  .
QNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Y81G3A.3.AA Pkinase_Tyr 815-851 45 0.000149 16.04 Pfam 122-158 (270) Show / Hide 
Range on Protein: 815-851
Range on HMM: 122-158/270
Sequence Identity: 45% (17 aa)

CGLKYMHDMAMIHRDIKPLNIFLTSQNGVKIGDFGLA
.|. | ... .||||.   |. .|..| |||.|||||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Y81G3A.3.AA WEE 979-999 38 0.000185 10.95 In-house 277-297 (297) Show / Hide 
Range on Protein: 979-999
Range on HMM: 277-297/297
Sequence Identity: 38% (8 aa)

MLQRNPDERPTADDLLNDEDL
|....|. |||. .||. . |
MMHPDPEQRPTCQQLLQHPVL
Kinase Y81G3A.3.AA Pkinase_Tyr 492-554 27 0.004598 11.0 Pfam 2-70 (270) Show / Hide 
Range on Protein: 492-554
Range on HMM: 2-70/270
Sequence Identity: 27% (19 aa)

VIIRVLGRGGFGDVVLVRNK----MDSTDYAIKRIPLNAKSDKL--NRKIAKEAKFFAKL-NHPNMVRYY
.....||.| ||.|.. . |     . .. |.| .  .  ...    ..  .|||   .| .||| ||.|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Y81G3A.3.AA NEK 909-932 50 0.013061 5.48 In-house 194-217 (286) Show / Hide 
Range on Protein: 909-932
Range on HMM: 194-217/286
Sequence Identity: 50% (12 aa)

ELVHKAPYTSKIDIYSAGVVLFEM
|...  ||..| || | |.||.||
EVCQNKPYNNKSDIWSLGCVLYEM
Kinase Y81G3A.3.AA Pkinase_Tyr 901-939 33 0.52914 4.02 Pfam 181-214 (270) Show / Hide 
Range on Protein: 901-939
Range on HMM: 181-214/270
Sequence Identity: 33% (13 aa)

MAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPP
|||| . .       .|.| |..| ||...|.| .   |
MAPECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQP