Gene ZC416.4 (Nematode worm)

ZC416.4

Species: Nematode worm
Alias: aSWK196, CE17305, ZC416.4
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:-3.32, WormBase Physical Map location: IV: 3606797-3609148

Classification

Group: CMGC
Family: MAPK
Subfamily: JNK

Sequence

Name Sequence Type Origin Length Description Download
ZC416.4.AA Protein Genbank 375 None Fasta, JSON
ZC416.4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 299 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZC416.4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZC416.4.AA JNK 29-327 57 7.29999999999e-222 743.34 In-house 1-309 (309) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-309/309
Sequence Identity: 57% (177 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQP--FLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHR--
|.||||...||||||.||.|.||.||||||||..|  |  .|...|||||||......|.|||...|.|||...|..||.||.|||.|..||..|||.  
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

LRLDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMRMSDYVGTRYYRAPEVILGLN--YSEKVDIWSVGCILAEM
..||||..|.|.||..|.|||||..|.|||||||||||||..|.||..|||.||.......|..||.||||||||||.|..  |.|.|||||||||.|||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

INHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGAVYVRSL---PQHLARAFNEIVPDSNFLP-ETENPKDHLTLHMARDLLFNMLKINPEERYSV
|.|.|||||||..|||..|...|.|||.||..|..|....||...   |.. ...|.|..||..|.. ....||||||.||||||||.||.|||..|.||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRISV

EDALNHPYT
.|||.|||.
DDALQHPYI
Kinase ZC416.4.AA MAPK 29-327 39 4.7e-156 524.72 In-house 1-328 (328) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-328/328
Sequence Identity: 39% (135 aa)

YVNLKFLNVGAQGIVVMADDLVTTQR------VAIKKMQQPFLLTMSARRAYREFILLTTL-KHPNIIRLLNAFTPD-----TSLSSFQEVYLVMEFMTH
|..||..  ||.|.|..|.|  |.|.      |||||...||  .....|.||| .||  . .|.|||.||. |||.      ||..|...|.|||.| .
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

NLHEVIHRLR-LDHETLSFLVYQSLCA--IKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVD---------------MRMSDYVGTRYYRAP
.|| .|.. . |...  ....|| |..  .|..|  . ||||||||||.||| | ||..||||||    .               | |..|| ||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILG---LNYSEKVDIWSVGCILAEMIN-HTVLFPGKDIRDQWTQISSVLRTPDDHFINQLE-PIGA-VYVRSL---PQHLARAFNEIVPDSNFLPETE
|..|.    .|...||.||||||.|||.. ...||||||  |||..| .|| ||...||.... .  |  |..||   |.. .. . .. |..||     
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-----

NPKDHLTLHMARDLLFNMLKINPEERYSVEDALNHPYT
     .. ..|.|||. || ..|..|..||.||.||| 
-----NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase ZC416.4.AA CMGC 29-327 22 6.9e-113 372.48 In-house 1-513 (513) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-513/513
Sequence Identity: 22% (116 aa)

YVNLKFLNVGAQGIVVMADDLVTTQR--------------VAIKKMQQPFLLTMSAR----------RAYREFILLTTLK-----------------HPN
| ..| .  |. |.|. . |  | |.              |||||. .||  .  |.          ||.||  .|  |.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIRLLNAFTPDTS------------LSSFQEVYLVMEFMTHNLHEVIHRLR----------LDHET------------LSFLV------YQSLCAIK--H
|..|.. |... |            . .|...|||.|.| |.|...|.. .          |..                ...      || |...|  .
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHNLG--FIHRDLKPSNIVVNERCVL--------------------KVLDFGLARRRNVD----------------------MRMSDYVGTRYYRAPEVI
.|  .  .|||||||.|| .|..| |                    |. ||||||  ..                       . ...|| ||.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLN----------YSEKVDIWSVGCILAEMIN--------HTVLFP-----------GKDIRDQWTQISSVLRTP----------------DDHFINQL
||            |....|.||||||.|||..        .  |||           ||.  ||. .|  || ||                .. ..| .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

E---------------------PIGAVYVRS---LPQHLARAFNEIVPDSNFLPETENPK-----------------------DHLTLHMARDLLFNMLK
.                     . .  |..|   .|..  . .....|..... . . .|                       ...  . |.||| .||.
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

INPEERYSVEDALNHPYT
..|..| ..|.||.||| 
YDPDKRITAEQALQHPYF
Kinase ZC416.4.AA p38 29-327 43 1e-105 357.52 In-house 1-289 (289) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-289/289
Sequence Identity: 43% (134 aa)

YVNLKFLNVGAQGIVVMADDLVTTQR---VAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTP-DTSLSSFQEVYLVMEFMTHNLHEVIHR
|.||...  || | |  | |  | |.   |||||.  ||  .. |.|.|||  || ...| |.| ||. ||| ..|...||.||.|..||   |. ..  
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

LRLDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMRMSDYVGTRYYRAPEVILG-LNYSEKVDIWSVGCILAEMI
 ||  .   ||||| | . |  |  | |||||||||| |||.| |..|||||||    |  | .||.|| |||||..|    | ..|||||||||.||.|
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR--HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

NHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGA-VYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYSVEDAL
   .||||.|  || ..| .|. |||. |.. ..   |  |..|.||.  | | .. .  | .              | |||  ||.. |. | ..|.|.
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQ--------------AIDLLEKMLELDPDKRITAEEAM

NHPYT
 ||| 
QHPYF
Kinase ZC416.4.AA ERK 29-327 36 5e-79 268.85 In-house 1-307 (307) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-307/307
Sequence Identity: 36% (117 aa)

YVNLKFLNVGAQGIVVMADDLV-----TTQRVAIKKMQQPFLLTMSARRAYREFILLTTLK-HPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVI
|  .|..  || |.|. | |       | |.||||| ...|. .  . |..||  ||  .| |.||| |.. . |. .  .. ..|.| |.|.  || .|
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

HRL-RLDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLAR------RRN---VDMRMSDYVGTRYYRAPEVILGLN-YSEKVD
.   .|  .   ...|| ||..|..|  . |||||||||| ||. |.||. ||||||        |   ..  |..|| ||.|||||..| .. |....|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCILAEMINHTVLFPGKDIRDQWTQISSVLRTP-DDHFINQLEPIGAV-YVRSLPQ--HLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNM
|||.|||.|||.. . |||||| ..| ..| ... || ..  ... . ..|  |...||     .. . .| |. |              . | |||  |
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNAN------------CNPQAIDLLEKM

LKINPEERYSVEDALNHPYT
| ..|..|..||..| ||| 
LVFDPDKRITVEECLEHPYF
Kinase ZC416.4.AA S_TKc 29-327 25 6.6e-79 269.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-231/231
Sequence Identity: 25% (81 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTH---NLHEVIHRL
|  |. .  || | |  . .  | ..||||..          ....||  .|   .||||..|. .|         ...|.|||.. .   .|...|.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

R-------LDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMRMSDYVGTRYYRAPEVILGLNYSE-KVDIWSVGC
.       ..  .  |..|| .||....|..|.|||||||.|| ..|  ..|. ||||||.       . ..||..|.||||.    |.  |.|.||.||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

ILAEMINHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGAVYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYS
||.||.    .||      |  ..  ...                                                   . |.|.. ..|. .||.|..
ILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------------------SPEAKDFIRKCLQKDPEKRPT

VEDALN-------HPYT
. .||.       ||. 
A-EALQDEWDIKCHPWF
Kinase ZC416.4.AA Pkinase 29-327 26 2.7e-73 254.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-293/293
Sequence Identity: 26% (86 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYR--EFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTH-----NLHEV
|. .. .  |. | |  . .  | ..||.|..  .       ... |  |  ..  |.||||.||. .|.        ...|.|||.. .      |...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IH---RLRL--DHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVL----KVLDFGLARR--RNVDMRMSDYVGTRYYRAPEVIL-GLNYSEK
|.   . ..  . ... | .|| |......|. |.|||||||.|| .......    |. |||||.      .  |....||..|.|||||. |  |. |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCILAEMINHTVLFPGK----DIRDQWTQISSVLRTPDDHFINQLEPIGAVYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLF
||.||.||||.||..   .|||.    . .||   |  ....| .  . .. .|   ..|  . |                . . .. |..   ..|.. 
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H----------------F-HWTF-HNWSEECKDFIK

NMLKINPEERYSVEDALNHPYT
..|. .|..|.. |..|.||. 
WCLCKDPKKRPTAEQILQHPWF
Kinase ZC416.4.AA ERK5 29-327 35 2.1e-66 226.94 In-house 1-295 (295) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-295/295
Sequence Identity: 35% (109 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHRLR-L
|  .  .  || |.|  |    . |.|||||.   |     |.| .||  .|   .| ||| . .   |   .| ...|| |.. |   || .||    .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

DHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNV------DMRMSDYVGTRYYRAPEVILGL-NYSEKVDIWSVGCILA
  | . . .|| |  .| .|    |||||||||..||| | ||. |||.||           | | .|| ||.|||||... . .|   .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMINHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGAVYVRSLPQH-LARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYSVE
|||    .||||   .|   |  || .|  | |     ..|  |.   |. ..    . .. .   |. .          | |||  ||.  | || .| 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQA---VSADHVYNYFQKNFPN--RQPKDWEKVYPKAD--------RQALDLLARMLRFEPSERITVN

DALNHPYT
 || ||. 
KALQHPFL
Kinase ZC416.4.AA ERK7 29-327 36 6e-65 220.98 In-house 1-292 (292) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-292/292
Sequence Identity: 36% (112 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLK-HPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHRLRL
|  .| |  || |||  | |  | | ||.||.   |     | | .|| ..|  .. |||||||.| .  |  .     .||| |||   || || . ..
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR----DIYLVFEFMETDLHAVIRKGNI

DHET-LSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLAR-----R--RNVDMRMSDYVGTRYYRAPEVILG-LNYSEKVDIWSVGCI
  .    . .|| | |||..|    |||||||||| ..  |..|| ||||||     .   . .  . .|| || |||||. ||  .|   || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

LAEMINHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEP-IGAVYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYS
|.||.    .|||    .|  .|  ..  |    |. ... .... . ...|.  . .....|.              . . | ||| ..|  ||..| .
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQ--------------CCDDAIDLLKRLLVFNPKKRLT

VEDALNHPYT
.|.||.||| 
AEQALQHPYV
Kinase ZC416.4.AA ERK1 29-327 38 3.8e-62 212.78 In-house 1-289 (289) Show / Hide 
Range on Protein: 29-327
Range on HMM: 1-289/289
Sequence Identity: 38% (116 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHRLRLD
|.||...  || |.|. |.| |. |||||||.  ||       |  ||  .||  || ||| . .    || . ....||.| . |   |  ..   .| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKI-SPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADT-IEQMRDVYIVQCLMETDLYKLLKTQHLS

HETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMR----MSDYVGTRYYRAPEVILGLN-YSEKVDIWSVGCILAEMI
 . . . .|| |  .| .|    .||||||||...|  | ||. ||||||    .      . .|| ||.|||||..|    |   .||||||||||||.
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

NHTVLFPGKDIRDQWTQISSVLRTPDDHFINQLEPIGA-VYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLKINPEERYSVEDAL
    .||||   ||   | .||  |  . .| .    |  |..|||     ..... |..                 | |||  ||  ||..|  ||.||
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKAD--------------SKALDLLDKMLTFNPHKRITVEEAL

NHPYT
 ||| 
AHPYL
Kinase ZC416.4.AA nmo 33-248 40 1.3e-55 169.2 In-house 5-223 (292) Show / Hide 
Range on Protein: 33-248
Range on HMM: 5-223/292
Sequence Identity: 40% (89 aa)

KFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVI---HRLRLDH
. .  || |.|    |    .|||.||| . |   .|..| .||  .|   || |.. .|.   |   .. |||.| | | |   || .|     |  ||
RPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQP-PHKDFFQEIYVVTELMQSDLHKIIVSPQHLSSDH

ETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVDMR--MSDYVGTRYYRAPEVILGL-NYSEKVDIWSVGCILAEMINHT
  .   .|| |  .| ||  . .|||.|| |..||  ||||. ||||||  . | .  |   | | ||||||...|   |.. ||||||||| ||..   
--VKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

VLFPGKDIRDQWTQISSVLRTP
.||  .   .|   |  .| ||
ILFQAQSPIQQLQMITDLLGTP
Kinase ZC416.4.AA MAPK-Unclassified 29-178 35 6.3e-36 125.69 In-house 1-157 (575) Show / Hide 
Range on Protein: 29-178
Range on HMM: 1-157/575
Sequence Identity: 35% (56 aa)

YVNLKFLNVGAQGIVVMADDLVT-TQRVAIKKMQQPFLLTMSARRAYREFILLTTLKHPNIIRLLNAFTPDTSLS-SFQEVYLVMEFMTH---NLHEVIH
|   | .  || |.|. | |  .  | |||||    |     ..|. ||  .|  | |||||.. . |...  .   |. .|.||..|     .|| .|.
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

-RL-RLDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLAR
 ..  . |.    . || |  .| ||  . |||||||||. .|. | ... |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase ZC416.4.AA MAPK-Unclassified 186-233 48 6.2e-21 72.05 In-house 405-464 (575) Show / Hide 
Range on Protein: 186-233
Range on HMM: 405-464/575
Sequence Identity: 48% (29 aa)

MSDYVGTRYYRAPEVILGL-NYSEKVDIWSVGCILAEMIN-----------HTVLFPGKD
|. || ||.||||| .| . .|. .|||||.|||.|||..           |  ||||.|
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQD
Kinase ZC416.4.AA TyrKc 29-322 21 1.2e-14 14.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 29-322
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILLTTL--KHPNIIRLLNAFTPDTSLSSF---QEVYLVMEFMTH-NLHEVI
 . .| |  || |.|. .      . ||.|...         .  .||  ... |  .||||.||. . | .     |   . ...|||.| | .|.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

HRLR--LDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRRNVD----MRMSDYV-----GTR-----YYRAPEVILGLNY
.. |  | ...|    .|  |   .||  ..|||||   |. |.|. . |. ||||.|    |     . . |.     |..        |||.|    .
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SEKVDIWSVGCILAEMINHTVLFPGKDIR--DQWTQISSVLRTP--DDHFINQLEPIGAVYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARD
..| |.|| |  . |.       .  .|     ....   ...    .   | . |.                        |         . .  | . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMS-----------------------F--------VCCPDEMYQ-

LLFNMLKINPEER---YSVEDAL
.     . .||.|     . . .
IMKQCWHEDPEDRPTFSEIHECF
Kinase ZC416.4.AA Pkinase_Tyr 75-214 29 1.4e-11 39.83 Pfam 52-199 (270) Show / Hide 
Range on Protein: 75-214
Range on HMM: 52-199/270
Sequence Identity: 29% (46 aa)

REFILLTTL-KHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTH-NLHEVIHRL-----RLDHETLSFLVYQSLCAIKHLHNLGFIHRDLKPSNIVVNERC
||  ....| .||||.||. . |..   .   ..|.|||.| | .|..  ..      .|....|    .|  ..  .|.. ..|||||   |. |.|  
REAKIMKQLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN

VLKVLDFGLARRRNVDMRMSDY--VGT------RYYRAPEVILGLNYSEKVDIWS
| |. ||||||     .  . |  ...      . . |||.|    ...| |.||
VVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWM-APECINYGKFTTKSDVWS
Kinase ZC416.4.AA nmo 298-327 50 8.8e-10 25.62 In-house 263-292 (292) Show / Hide 
Range on Protein: 298-327
Range on HMM: 263-292/292
Sequence Identity: 50% (15 aa)

HMARDLLFNMLKINPEERYSVEDALNHPYT
| | .||  ||  .|. | |..||| ||| 
HEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase ZC416.4.AA MAPK-Unclassified 300-327 39 9.1e-09 27.28 In-house 548-575 (575) Show / Hide 
Range on Protein: 300-327
Range on HMM: 548-575/575
Sequence Identity: 39% (11 aa)

ARDLLFNMLKINPEERYSVEDALNHPYT
..|..  || .||  |.. ..||.||| 
CIDFVQKMLQFNPWKRITADQALEHPYF