Gene ZC581.1 (Nematode worm)

ZC581.1

Species: Nematode worm
Alias: aSWK229, ZC581.1, CE15235
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: I:1.22, WormBase Physical Map location: I: 6671269-6673150,

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
ZC581.1.AA Protein Genbank 357 None Fasta, JSON
ZC581.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of ZC581.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ZC581.1.AA NEK8 4-267 51 3.4e-231 667.51 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-278/278
Sequence Identity: 51% (142 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDS
||..|||||||||.|||.|.|.|.||..||.|.||.|.|.|||....|.|...|...|||.||.|.|.|..||.|.|.|.||.||||...|..|......
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

NMR----------EYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTKSAAST---VIGTPNYLSPEICESRPYN
..|          .||.|...|.||.|...|..||||.||.|||||.|||.|.|...|.|..||||||...||....|   |.|||.|.|||.||..|||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

QKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRS-KQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV
||||||.|||||||...|.|||...||||.|.||... ...|..||.||...|||.|.|......||..||....||.
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase ZC581.1.AA NEK 4-267 38 2.3e-137 462.63 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-286/286
Sequence Identity: 38% (112 aa)

YEKVRVVGRGAFGVCWLCRGKNDASH---QKVIIKLINTHGMTEKEENSIQ-SEVNLLKKVQHPLIIGYIDSFIMDN--QLGIVMQYAE-GGTLERLIND
||.....|.|.||.....| |.| .|   .....| ||. .|.|||    | .||..||. .|| |..|.|||| ..  .| ||| |.| ||.|...|..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

QRAIKDSN-MREYFPEKTVLDYFTQILIALNHMHQK-----NIVHRDLKPQNILMNRRKT---VLKLSDFGISKELGTK-SAAST-VIGTPNYLSPEICE
   ||     ..||.|....|.|.|...||..||..     .|.|||.||||| .... .   ..|. ||||||.|... ..|.| ..||| |.|||.|.
---IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQ

SRPYNQKSDMWSLGCVLYELLQL--ERAFDGE--NLPAIVMKITRS-KQNPLGDH--VSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV
..|||.|||.|||||||||.  |  ...|...  |.|. .|||..  . .|. .|   |.| ..|....|.   ..||...|.|..|..
NKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase ZC581.1.AA NEK1 4-267 38 6.2e-93 315.06 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-276/276
Sequence Identity: 38% (111 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQ--LGIVMQYAEGGTLERLINDQ--RA
|.. ...| |.||  || . |  .. |   || ||   | |||      ||..|.|  || |..| .||.   .  | ||| |..|| | . || |  . 
YHYIKQIGEGSFGKAWLVKHK--EDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKG

IKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMN--RRKT--------------VLKLSDFGISKEL-GTKSAASTVIGTPNYLSPE
         |.| . ...|.|| .||||.| ..| |||.|.|||     .                 ..|| ||||.. |  | . |.|.|||| |||||
-------KLFSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

ICESRPYNQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV
||. .|||.|||.||||||||||. | ..|.. |... |.||...   |.  | |.... ||  ..|     || | |.|. | .
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase ZC581.1.AA S_TKc 4-267 31 7.3e-89 302.44 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-231/231
Sequence Identity: 31% (87 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEG--GTLERLINDQRAIK
||..|..|.||||....|| |.  ....| || |.         ..|..|...||| .|| |. ..|.|   . | .|| |..|  |.| ..| ...  .
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

DSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTKSAASTVIGTPNYLSPEICESRPYNQ-KSDMWSLGC
    | .||| ..  |. ||. ||...|...|.||||||.|||...   ..|..|||....|      .|..|||.|..||..   .|.  |.|.||.||
---LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLS-------DPLV
.|||.|  .  |.  .. ..  ||            | ..| .....|.   .||| . ..|        .| .
ILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ZC581.1.AA Pkinase 4-267 26 1.2e-70 245.77 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-293/293
Sequence Identity: 26% (82 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQS--EVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGG----TLERLINDQ
|...|..|.|.||....|. |..    .| .| |. ..  .... .     |. ..|...|| |. ..|.|  .. . .|| |.|||     | ..|   
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

RAIKDSNMREYF--PEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTV---LKLSDFGISKE--LGTKSAASTVIGTPNYLSPEICE-SRPY
       ..  |  .|... .|..||| .|...|...|.||||||.|||.... ..   .|..|||..|   .  .| ..|. |||.|..||..  ...|
------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYY

NQKSDMWSLGCVLYELLQLERAFDGE------NLPAIVMKITR---SKQNPLGDHVS-----------------NDVKMLVENLLKTHTDKRPDVSQLLS
 .|.||||.||.|||.|  .  |.|.      .  ... .| .   . . |  . .|                  . | .....|.    |||   |.| 
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

DPLV
.| .
HPWF
Kinase ZC581.1.AA NEK4 4-267 35 2.3e-70 240.06 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-257/257
Sequence Identity: 35% (96 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQ--LGIVMQYAEGGTLERLINDQRAIK
|. ..|||.| .|  || | . |    . ..| ..      .|      |..|| . .|| |. | .|.  .|   | ||| . ||| | |    |.   
YCHMKVVGKGSYGEVWLVRHRRD--KKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKN--

DSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELG-TKSAASTVIGTPNYLSPEICESRPYNQKSDMWSLGC
     .  .|. |.. | || .||  ||.|.|.||||| ||| .  .| ..|. |||||. |      |.|.|||| |.|||.  .|||. |||.|||||
-----QFLEEYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLT-KKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGC

VLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV
 .||.  |  |||  ... .. .|   .  |.    | | . ||  .|.   .||| . ...  | .
CVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase ZC581.1.AA CAMK 9-267 21 2.6e-70 225.56 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-267
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

VVGRGAFGVCWLCRGKNDAS----------HQKVIIKLINTHGMT--------------------------EKEENSIQSEVNLLKKVQ-------HPLI
. |||.||.  ||. ||.            .||| || |..  ..                          .| . ....|....||.|       || |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGYIDSFIM-------------------DNQLGIVM---QYAEGGTL-ERLINDQRAIKD----------SNMREYFPEKTVLDYFTQILIALNHMHQKN
|  .. .                     |... .||    |..|| | ..| .  .. ..            .| .|.|. .  || ||. |....|..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IVHRDLKPQNILMNRRK----------------TVLKLSDFGISKELGT------------------------KSAASTVIGTPNYLS-PEICES-----
|||||||| |||.. ..                  .|..||| ....                              .|. ||| | . ||. ..     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RPYNQKSDMWSLGCVLYELLQLERAFDGE-------------NLPAIVMKITRSK-QNPL--------------GDHVSND--------VK
         ..|..|.||||.|..|| .|  .  |.|.             |.. .  ||.. | . |                |..|..        .|
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

MLVENLLKTHTDKRPDVSQLLSDPLV
 |. ..|..  .||. ..| |..| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ZC581.1.AA Ciliate-E2 4-267 22 4.7e-67 229.09 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-365/365
Sequence Identity: 22% (85 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQ----------------KVIIKLINTHGMTEKEENSIQSEVNLLKKVQ----------------HPLIIGYIDS
|..... |.|.||. ..|. ...   .                || ||...   | ... ..| .| .......                || || ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FI--MDNQLGIVMQYAEGGTLERLINDQRAIKDSN---MREYFPEKTVLDYFTQIL---------------IALNHMHQKN-IVHRDLKPQNILMNRRKT
|.   || . .|| |..||.|. .|....  ....     .|| || ......|||                ||...|.|| |.|||.||.|||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VLKLSDFGISKELGTK--------------------------------SAASTVIGTPNYLSPEICESRP---------YNQKSDMWSLGCVLYELLQLE
 .|..|||.||.. ..                                  . |..|||.|..||| .. .         |. |.|.||||..|||.|  .
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

RAFDGENLPAIVMKITRSKQNPLG--------------------DHVSNDVKMLVEN----LLKTHTDKRPD-VSQLLSDPLV
. |           .   ||...                     ...|...| |  .    .|.   .||..  .|.|  |  
PPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ZC581.1.AA STE 4-267 23 3e-65 223.08 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-359/359
Sequence Identity: 23% (85 aa)

YEKVRVVGRGAFG-VCWLCRGKND---ASHQK---------VIIKLINTHGMT---------------EKEENSIQSEVNLLKKVQ--HPLIIGYIDSFI
.|.....|.|||| |.  .. ||.    . ..         . || .|    .               ..|...|. |....|| .  || |. |.....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-------MDNQLGIVMQYAEGGTLERLIND--QRAIKDSNMR---EYFPEKTVLDYFTQILIA-LNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGIS
        |..| |.| | .||.|. .|.    .   ... |    .|||. .  .  ||| . |.. |...|.|||.||.|||.       ||.|||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KELGTKSA-----------------ASTVIGTPNYLSPEICES------RPYNQKSDMWSLGCVLYELLQLERAF-DGENLPAIVMKITRS---------
. |  ..|                   |..||| . .||. .        .|. |.|.|||||.. |..  .  . |. .. |. |... .         
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----KQNP--LGD------------------HVSNDVKMLVENLLKTHTDKRPDVSQLLS--DPLV
    .. |    .                  ..| . |  ... |.   .|||..||||.   | .
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ZC581.1.AA ULK 4-267 25 1.7e-63 217.3 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-329/329
Sequence Identity: 25% (85 aa)

YEKVRVVGRGAFGVCWLCRGKNDASH----QKVIIKLINTHGMTEKEEN--------SIQSEVNLLKKV--------QHPLIIGYIDSFIMD--NQLGIV
|.. .. | |.||    ..|.|  ..    .||..| |    | .|. .        ....|. ..||         .|| |. ..| |  .  | . |.
YCLNHCLGKGSFG--KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII

MQYAEGGTLERLINDQRAIKDSNMRE----YFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKT-----------VLKLSDFGISKELGT-
| | .||.|| .|. ..    ... .    ...|. .. .| ||| .. ..|..||.|||.||||||..  ..           |||..||| .| .   
MEYCNGGDLEQYIKKNKK---LPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDND

---KSAASTVI------GTPNYLSPEICESR----PYN-QKSDMWSLGCVLYELLQLERAFDGENLPAIV-MKITRSKQN-----------PLG------
   .  . |        ||| | .|.| ...    ||.  |.|.|||||..||.|  .  | .      . ..|.. ..|           ||       
NMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGN

-DHVSNDVKMLVENLLKTHTDKRPDVSQLLSDPLV
 ...|...| |   .|.   ..| .  .|.. |..
DPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase ZC581.1.AA ULK 4-267 23 3.1e-62 213.05 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-324/324
Sequence Identity: 23% (79 aa)

YEKVRVVGRGAFGVCWLCRGKNDASH---QKVIIKLINTHGMTEKEEN--------SIQSEVNLLKKVQ---HPL--IIGYIDSFIMD--NQLGIVMQYA
|.. .. | |.||    ..|.|  ..   |.| .| |.  .| .|. .        ....|....||     ||   |. ..| |  .  | . |.| | 
YCLNHCLGKGSFG-VKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

EGGTLERLINDQRAIKDSNMRE----YFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKT-----------VLKLSDFGISKELGTKSAAS
.||.|| .|. ..    ... .    ...|. .. .| ||. .. ..|..||.|||.||||||..  ..           |||..||| .| .   . . 
NGGDLEQYIKKNKK---LPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

TVI----------GTPNYLSPEICESR----PYN-QKSDMWSLGCVLYELLQLERAFDGENLPAIV----------------MKITRSKQNP--LGDHVS
...          ||| | .|.| ...    ||.  |.|.|||||..||.|  .  | .      .                .| .  . ..   ....|
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

NDVKMLVENLLKTHTDKRPDVSQLLSDPLV
...| |   .|.   ..| .  .... |..
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase ZC581.1.AA Ciliate-E2-Unclassified 4-267 24 6.4e-59 202.05 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-267
Range on HMM: 1-352/352
Sequence Identity: 24% (88 aa)

YEKVRVVGRGAFGVCWLCRGKND--------ASHQKVII-KLINT--------HGMTEKEENSIQS----EVN-LLKKVQHPLIIGYIDSFIMDNQLGIV
|..... |.|.||. ..|. |..        .. ....  |.|..        . | .|.. ..|.    . . .|.  .||.|. ... |  .. . ||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MQYAEGGTLERLINDQRA--------IKDSNMREYFPEKTVL-----DYFTQILIALNHMHQKN-IVHRDLKPQNILMNRRKT--VLKLSDFGISKELGT
|.|.|||.|.  |...           .. . |. |.|. ..     .|| ||| .|...|.|| |.|||.||.|||..  .    .|..||||||....
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

----------------KSAASTVIGTPNYL----SPEICESRPYN----QKSDMWSLGCVLYELLQLERAFDGEN-------------------LPAIVM
                .  ..|..|||||.    .||. ..  |.     |.|.||||..|||.|  .. |...|                   |  . .
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

--KITRSKQNP--LGDHVSNDVKMLVE----NLLKTHTDKRPDVSQLLSDPLV
  .|  .|...    .|.|. .| ...     .||   .||.. .|.|  |. 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ZC581.1.AA Pkinase_Tyr 4-206 22 9.7e-17 57.32 Pfam 1-208 (270) Show / Hide 
Range on Protein: 4-206
Range on HMM: 1-208/270
Sequence Identity: 22% (48 aa)

YEKVRVVGRGAFGVCWLCRGK--NDASHQKVIIKLINTHGMTEKE--ENSIQSEVNLLKKV-QHPLIIGYIDSFI-MDNQ--LGIVMQYAEGGTLERLIN
 .. .. |.||||. .... |   |  ...| .| .  .| ....    .  .|....|.  .|| |. ..   .  . .  . ||| |...| |     
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTKSAAST-VIGT-----PNYLSPEICESRPY
..|     . .. .. |. |.. .||  .... ..||..||||   |.| .. . | | .||| .. .   .     . ..        ..||    . .
KHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKF

NQKSDMWSLGCVLYELL
. ||| || | ...|..
TTKSDVWSFGVLMWEIF
Kinase ZC581.1.AA TyrKc 4-265 18 1.2e-16 46.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

YEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKV--QHPLIIGYIDSFIMD-------NQLGIVMQYAEGGTLERLI
 .. .. |.||||. .... |     ..| .| .. .      .  . .| ....|.  .|| |.  .   . .        .| ||| |...| |   .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

NDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDFGISKELGTK-----SAASTVI----GTP-----NYLS
 . |          .. |. |.. .||    .. |.||..||||   |.| .... . | |||| |.... .     |    .     |.        ..
RKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEICESRPYNQKSDMWSLGCVLYELLQLERAFDGE-----NLPAIVMKITRSK-QNPLGDH--------VSNDVKMLVENLLKTHTDKRPDVSQLLSDP
||    . .. ||| || | ...|.. .      .       .. |..  ..    |  ..         . .. .. .   .   ..||  |.. .. 
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF