Gene CAK1 (Bakers Yeast)
CAK1
Sequence
Protein domains of CAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | CAK1.AA | CDK-Unclassified | 17-275 | 46 | 1.9e-172 | 571.75 | In-house | 1-278 (324) | Show / Hide |
Range on Protein: 17-275 Range on HMM: 1-278/324 Sequence Identity: 46% (130 aa) TRTARIYRSDTYAIKCLALDFDIPPHNAKFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEMNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVA .|....|...|....|.|.||....|.|.......||.|||||||||||.||.||......|.....||...||.|||..||..||||||.|.||...|. YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFYMVM DPPVQKYTNQLDVNRYSLS------FFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMAN-----NSQTSAEPMDSKVTDIS ........|||..|||.|| |..||.||||.||.|||.||||||||||.|||.|||||.|.|.|||......| |.||.|.||....|..| EYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYSTQVS TGIYKAPEVLFGVKCYDGGVDVWSLLIIISQWFQR--------ETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEK |..|.|||.|||.||||.|||.||...|...|||. |...|.|...|......||..|.......|.||.| TRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFK |
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| Kinase | CAK1.AA | CDK | 1-241 | 22 | 5.9e-56 | 177.44 | In-house | 2-222 (284) | Show / Hide |
Range on Protein: 1-241 Range on HMM: 2-222/284 Sequence Identity: 22% (61 aa) MKLDSIDITHCQLVKSTRTARIY---RSDTYAIKCLALDF-------DIPPHNAKFEVSILNKLGNKCKHILPLLESKATDN----------NDLLLLFP ||. | .. | | . . . .|.|.. .. . |. | |.|.| .| ...| |.. |.| | | . |. EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL---HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE FEEMNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSP-KLYIID . .. |...| ....|. .|....|.|.|.|||.|||||...|| ... . .| | | YMDHDLKKYMD-----------------------------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIAD FGISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGVKCYD--GGVDVWSLLIIISQWFQ---RE || . . ...|.| ||. . | | |||.|.| |.|. ..|.||. |.. .|. |. FGLARAFGIPHQMS-EPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRK |
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| Kinase | CAK1.AA | CMGC | 28-230 | 17 | 3.2e-41 | 132.6 | In-house | 41-321 (513) | Show / Hide |
Range on Protein: 28-230
Range on HMM: 41-321/513
Sequence Identity: 17% (52 aa)
YAIKCLALDFDIPPH------------NAKFEVSILNKLG---------------NKCKHILPLLESKATDN----------------NDLLLLFPFEEM
.||| . ..| . . | |..|| .| .. ..|. |... ..| |.| | | . ..
VAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDH
NLYEFMQMHYKRDRRKKNPYYDLLN--------PSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIA--FLHENK--IIHRDIKPQNIMLTNNTST--
.||...... .....|.. . . | . .. . .. . ...|. .|.. ..| .. |||||.||.||....|.
DLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRP----------P-HNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELIT
-------------VSPKLYIIDFGISYDMANNSQT---------------SAEPMDSKVTDISTGIYKAPEVLFGVKCYD---------GGVDVWSL
.. .| |.||| . ..| . .|. ....| |.|||.|.| | |. ..|.||.
RMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSV
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| Kinase | CAK1.AA | CDC2 | 135-230 | 34 | 8.1e-24 | 69.63 | In-house | 107-192 (301) | Show / Hide |
Range on Protein: 135-230 Range on HMM: 107-192/301 Sequence Identity: 34% (33 aa) SFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSA-EPMDSKVTDISTGIYKAPEVLFGVKCYDGGVDVWSL |.. |...|..|.| ..|.|||.||||| . .. . . | |||.. . .. | | .. | | |||.|.| | |. .||.||. SYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-----IKIADFGLARAFGIPIRTYTTE------HEVVTLWYRAPEILLGCKRYSTPVDMWSI |
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| Kinase | CAK1.AA | CAMK | 136-230 | 26 | 1e-22 | 69.41 | In-house | 184-320 (425) | Show / Hide |
Range on Protein: 136-230 Range on HMM: 184-320/425 Sequence Identity: 26% (36 aa) FFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSP------------KLYIIDFGIS--YDMANNSQ--------------TSAEPMDSKVTDISTG .|||........|...|.|||.|| ||.|..| . .| .. ||||| . .| .|. |. .. . | | YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP IYKA-PEVLFG-------------VKCYDGGVDVWSL | | |||| | . |. .|.||. EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSC |
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| Kinase | CAK1.AA | Pkinase | 135-230 | 31 | 1.8e-22 | 80.53 | Pfam | 112-198 (293) | Show / Hide |
Range on Protein: 135-230 Range on HMM: 112-198/293 Sequence Identity: 31% (30 aa) SFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGVKCYDGGVDVWSL ....|...|....|...|||||.||.||.. |. ...... |.|||.. . . . |.. . | | ||||. | . |. ||.||. FYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFC---GTPWYMAPEVIRGGQYYGPKVDMWSC |
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| Kinase | CAK1.AA | Ciliate-E2 | 131-230 | 22 | 2.2e-22 | 73.65 | In-house | 145-282 (365) | Show / Hide |
Range on Protein: 131-230 Range on HMM: 145-282/365 Sequence Identity: 22% (33 aa) RYSLSFFRQMVE---------------GIAFLHENK-IIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISY------------DMANNSQTSAEPMDSKVT . . ...| .. .. .||... ||||||||.||.. . |||||.| .... . .. . KEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPG DIS-------------TGIYKAPEVLFGVKC--------YDGGVDVWSL ... | |.|||.| | | || .|.||| YMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL |
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| Kinase | CAK1.AA | STE | 138-230 | 30 | 1.4e-19 | 65.92 | In-house | 158-254 (359) | Show / Hide |
Range on Protein: 138-230 Range on HMM: 158-254/359 Sequence Identity: 30% (33 aa) RQMVEG-IAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANN--SQTSAE--------PMD-SKVTDISTGIYKAPEVLFG-----VKC || ..| ..||...||||||||.||.| ..|||.. .... .. . . |. |.. | . ||||. . .| RQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKG YDGGVDVWSL || .|.||| YDTKCDIWSL |
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| Kinase | CAK1.AA | Ciliate-E2-Unclassified | 134-230 | 32 | 6e-19 | 62.39 | In-house | 146-256 (352) | Show / Hide |
Range on Protein: 134-230 Range on HMM: 146-256/352 Sequence Identity: 32% (38 aa) LSFFRQMVEGIAFLHENK-IIHRDIKPQNIMLTNNTSTVSPKLY--IIDFGISYDMANNSQTSAEPM--------DSKVTDIS-TGIYK----APEVLFG . .|.| ..|. .||... ||||||||.||...|| . ..| |||||||. .|.. . . . .... | .|. ||||| | KFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG VKCYD---GGVDVWSL . .. .|.||| QNYDHSKAYKCDIWSL |
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| Kinase | CAK1.AA | TKL | 134-229 | 22 | 2.6e-17 | 58.87 | In-house | 135-274 (364) | Show / Hide |
Range on Protein: 134-229 Range on HMM: 135-274/364 Sequence Identity: 22% (32 aa) LSFFRQMVEGIAFLHENK--------IIHRDIKPQNIMLTNNTSTVSPK----------LYIIDFGISYDMANNSQTSAEPMD------------SKVTD ... ... |...|| .. |||||.|..||.. .| .|| . | |||.| .| .... .. .. . | CRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ ISTGIYKAPEVLFGV---------------KCYDGGVDVWS . | . ||||| | . |. .||.| CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYS |
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| Kinase | CAK1.AA | ULK | 134-230 | 31 | 4.5e-17 | 56.23 | In-house | 133-242 (329) | Show / Hide |
Range on Protein: 134-230 Range on HMM: 133-242/329 Sequence Identity: 31% (39 aa) LSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNT----STVSPK------LYIIDFGISYDMANN------SQTSA-EPMDSKVTDIST---G--IYKA ..||.| ..| .||...|||||||||||...|.. |. | | | ||| . . |. .| | . | .| | IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSK---KVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE----------KRLCGTPLYMA PEVLF----GVKCYDGGVDVWSL |..| . . || .|.||| PQILQGQGEQKPYYDYKCDIWSL |
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| Kinase | CAK1.AA | S_TKc | 10-363 | 13 | 2.3e-13 | 19.14 | SMART | 14-220 (231) | Show / Hide |
Range on Protein: 10-363
Range on HMM: 14-220/231
Sequence Identity: 13% (47 aa)
HCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNAKFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEM---NLYEFMQMHYKRDRRKKNPYYD
. ... .. .|||.. ... |..|| | ....| |... . ..| . . . . .|..... . .. .|
KVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK---HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR-------
LLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDIST
. ....|........|...|||||.||.||.|.. . |.|||.. . | . |
-------------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------------TTFCGT
GIYKAPEVLFGVKCYDG-GVDVWSLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKLGIPSIQKWEEVAQHGSVDAFVGMFGADGD
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PWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------------------------------------------
GKYVLDQEKDVQISIVERNMPRLDEIADVKVKQKFINCILGMVSFSPNERWSCQRILQ
. ... | .. . |..|... .||
-------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
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| Kinase | CAK1.AA | CDK-Unclassified | 335-367 | 31 | 2.6e-11 | 33.35 | In-house | 278-324 (324) | Show / Hide |
Range on Protein: 335-367 Range on HMM: 278-324/324 Sequence Identity: 31% (15 aa) KVKQKFIN--------------CILGMVSFSPNERWSCQRILQELEK |.||||.. |...||...|..||.|..|||... KYKQKFHWWNRFPKCKHASENNCEFQMVMYQPYNRWKCMEILQHPWF |
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| Kinase | CAK1.AA | TyrKc | 1-273 | 15 | 0.00011 | -146.87 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 1-273
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)
MKLDSI-------DITHCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNAKF--EVSILNKLGNKCKHILPLLESKATDN-------NDLLLLFPF-EE
.|. . . .... . |.|.| | . | | .|. ||| . ..|. |. .|. |.... . .
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPH
MNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGIS
.| .. . | .. .. ||| | .| ..||....||||. |.....| | ||| |
GDLKDYLRKHRPK-------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLS
YDMANN---SQTSAEPMDSKVTDIST--GIYK--APEVLFGVKC-YDGGVDVWSLLIII--------SQWFQ-----------RETSRMGHVPAMIDD--
| . | . ..| .. . .. |||.. .. . |||| . . . . .| . |. . ..
RDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY
------GSDDM-----------NSDGSDFRLICSIF
.|.| .| |. |...|
PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | CAK1.AA | CDK | 269-363 | 12 | 0.006154 | 5.05 | In-house | 234-280 (284) | Show / Hide |
Range on Protein: 269-363 Range on HMM: 234-280/284 Sequence Identity: 12% (12 aa) ICSIFEKLGIPSIQKWEEVAQHGSVDAFVGMFGADGDGKYVLDQEKDVQISIVERNMPRLDEIADVKVKQKFINCILGMVSFSPNERWSCQRILQ .. ||. .| |. . | .| . ... .| . |. |.|.. || LFKIFRICGTPTEDNWPGVTKLPDY------------------------------------------------DLLNKMLCYDPKKRISAEQALQ |
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| Kinase | CAK1.AA | CMGC | 338-363 | 23 | 0.074887 | 0.82 | In-house | 484-509 (513) | Show / Hide |
Range on Protein: 338-363 Range on HMM: 484-509/513 Sequence Identity: 23% (6 aa) QKFINCILGMVSFSPNERWSCQRILQ ...|. . .| . |..|.... .|| PQAIDLLKKMLQYDPDKRITAEQALQ |
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| Kinase | CAK1.AA | Pkinase | 26-93 | 13 | 3.875037 | 1.57 | Pfam | 25-100 (293) | Show / Hide |
Range on Protein: 26-93 Range on HMM: 25-100/293 Sequence Identity: 13% (11 aa) DTYAIKCLALDFDIP--PHNAKF--EVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEM-----NLYEFMQ--MH ...|.|.. .. . . . .. |..|...| | ...|. |... . .... . ... |. |..... .| KIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N-HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWRH |
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