Gene DBF2 (Bakers Yeast)

DBF2

Species: Bakers Yeast
Alias: DBF2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: NDR-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
DBF2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 301 Kinase domain by global Sugen HMM Fasta, JSON
DBF2.AA Protein Refseq_NP 572 kinase required for late nuclear division; Dbf2p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of DBF2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DBF2.AA NDR 177-477 37 1.5e-193 603.04 In-house 1-350 (350) Show / Hide 
Range on Protein: 177-477
Range on HMM: 1-350/350
Sequence Identity: 37% (132 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTR--SEWLVKLLYAFQDLQSLYLAMEFVPGGDFRT---LLINTRC
||.|...|.|..|.|.|.|||||....|.||..|.. .. |...||..||||.....  ..| |||.|.||| |.|||.||..||||..|   ||.....
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

LKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTIS--------------------NERIESMKIRLEKIKDLEFPAFTE
..  .|||||.||.||....| .||.|||.||.|||||..||||||||||. |...                    ...............  .|.....
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCTGGMIRRHWKQNKQKKPMTTYSTFHWTHNSWYYQNMKEHRPQDFMDNWN

KS-----------IEDRR----KMYNQLREKEIN--YANSMVGSPDYMALEVLEGKK-YDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRWKQT
..           ..|..    |..|. ..|...  .|.|.||.||||| ||...|. |..|.|.|||||...| ||||.|| .....||... ..||||
SNPMNQKCKCHTQMKDQMKCNVKVLNNRSWKQNRRCLAYSTVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQT

LRRPRQSDGRAA-FSDRTWDLITRLIA-DPINRLRS----FEHVKRMSYF
...|.......| .|...||||.||.. ||..||.|    ....| ...|
WDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF
Kinase DBF2.AA AGC 177-477 26 1.4e-143 373.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 177-477
Range on HMM: 1-395/395
Sequence Identity: 26% (113 aa)

FEMITQVGQGGYGQVYLARKK------DTKEVCALKILNKKL-LFKLN--ETKHVLTE------------RDILTTTR----------SEWLVK-LLYAF
||... .|.|..|.|||.|||      ||....|.|.|.||    ...  . .|..||            |.||.. .          . ..|| | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDLQS--LYLAMEFVP--------GGDFRTLLINT-R----CLKSGHARFYISE-------MFCAVNALHD-LGYTHRD-LKPENFLIDAKGHIKLTDFG
|| .   ||. ||..|        ||.. ..|..  |    ..   .||||..|       . .|.  ||. .|. ||| ||||| |.|..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAAGTI-----------------SNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKEIN-------------YANSMVG--SPDYMALEVLE
|.   .                 .|... . |.      ...          . .| .|. .... |              .....|  .|.||| |.| 
LCKEGMNDGEKGQQSQSNMKFHWHNKKY-Q-KS------NMD----------T-NK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-

GKKYDFTVDYWS--LGCMLFESLVGYTPFSGSS----------TNETYDNLR------RWKQTLRRPR--QSDGRAAFSDRTWDLITRLIA-DPINRLRS
   |....|.||  |||...| |.||.||.| .           .|.... .       ||... .|.  |....  ||.  .|||..|.  || .|| .
---YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGC

---------FEHVKRMSYF
         .| .|.  .|
GGNDFGDKGAEEIKNHPWF
Kinase DBF2.AA S_TKc 177-477 26 1.4e-86 294.89 SMART 1-231 (231) Show / Hide 
Range on Protein: 177-477
Range on HMM: 1-231/231
Sequence Identity: 26% (85 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPG--GDFRTLLINTRC---
.|.. ..|.|..|.||..|.|.|....|.||..          .|.. |..||   . ...|||...||| ..||. ||...|  || .... . ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKE
   .   |||||. ...||.. .|..|  |||||||| |.|   |||..|||||.                                             
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------------------------

INYANSMVGSPDYMALEVLEGKKYDF-TVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRWKQTLRRPRQSDGRAAFSDRTWDLITRLIA-DPINRLR
    ....|.|.||| |||   .|..  .| ||.||.|.| |.||.||.    ........                  |.  .|.| ..   || .|. 
----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPT

SFEHVK------RMSYF
  |  .       . .|
A-EALQDEWDIKCHPWF
Kinase DBF2.AA MAST 177-426 32 2.9e-77 235.46 In-house 1-281 (337) Show / Hide 
Range on Protein: 177-426
Range on HMM: 1-281/337
Sequence Identity: 32% (90 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQD--LQSLYLAMEFVPGGDFRTLLINTR-CLK
|| |  .. |.||.|||...|.|..  |.|..|.  . . |  ..|  ||.||| .  .. ||. |.||    . |.. ||.. |||. .|| .   |. 
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

SGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISN--ERIESMKIRLE---KIKDLEFPAFTEKSIED------------
   |..|| |   ..  ||  |  ||||||.| |||..||||||||||.   . .   .... ..  .   | .. | .. .... ..            
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGKNHFNEYHIQKNYQQFQQDFGINGNTNKN

---------RRKMYNQLREKEINYANSMVGSPDYMALEVLEGKK-YDFTVDYWSLGCMLFESLVGYTPFSGSSTNE-TYDN
           .  |..|  .|   .. .|.|||.| ||. |.  |  .||.||.| ...| |||..|| |.. .| . .|
QIQQQQEQPQCQQQNEMRPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQN
Kinase DBF2.AA MAST 177-426 31 2.5e-76 245.47 In-house 1-276 (334) Show / Hide 
Range on Protein: 177-426
Range on HMM: 1-276/334
Sequence Identity: 31% (86 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSGH
|| |  .. |.||.|||...|.|..  |.|...|  . . | ...| .||.||. ..... ||. |.||  . |.. ||.. |||. .|| .  ..    
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISN---ERIES--------MKIRLEKIKDLEFPAFT---------------
|..||.|.  ..  ||  |  ||||||.| |||..||||||||||.  .. .    ..|.         ..  .  .. .   |.               
AKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNIFNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQ

EKSIEDRRKMYNQLREKEINYANSMVGSPDYMALEVLEGKK-YDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDN
..  .   .  | .|. .|   .. .|.|||.| ||. |.  .  .||.||.| ...| |||..|| .....|...|
QQQEQPQCQQQN-MRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQN
Kinase DBF2.AA DMPK 177-323 43 9.1e-74 181.34 In-house 1-148 (270) Show / Hide 
Range on Protein: 177-323
Range on HMM: 1-148/270
Sequence Identity: 43% (65 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTR-CLKSG
||... .|.|  |.| . | | |..| | |..||. . |  ||  .  ||||.    |.|...| ||||| . ||. ||. ||||  ||. .    .   
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

HARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAA
 ||||. ||  |....| .|| ||| ||.| |.|  ||||| ||| ..
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCM
Kinase DBF2.AA RSK 180-477 30 1.2e-61 211.16 In-house 1-278 (278) Show / Hide 
Range on Protein: 180-477
Range on HMM: 1-278/278
Sequence Identity: 30% (98 aa)

ITQVGQGGYGQVYLARKK---DTKEVCALKILNKKLLFKLNE-TKHVLTERDILTTTR-SEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRC---
. . |||||| |.| ||.   ||. . | |.|.|. . . .  |.|..|||.|| ... .  .|.| ||||. . ||| ||...||.. | | . ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDA---KGHIKLTDFGLAAG-TIS-NERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLRE
.    |.||..|  .||  ||..|  |||||||| | |     |||||||||..    .. |..  .                                 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT---------------------------------

KEINYANSMVGSPDYMALEVLE---GKK-YDFTVDYWSLGCMLFESLVGYTPFSG---SSTNETYDNLRRWK--QTLRRPRQSDGRAAFSDRTWDLITRL
         ... .||| |.|    ... .|  .|.||||. ..| |.|..|| |   .. .|. .. .. |  .|. ..      .  |.   |||...
--------FCYTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNW------QYLSQEAKDLIRKM

IA-DPINRLRS----FEHVKRMSYF
   || .|| .     | .|. ..|
LHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DBF2.AA Akt 177-322 39 4.8e-56 177.61 In-house 1-148 (264) Show / Hide 
Range on Protein: 177-322
Range on HMM: 1-148/264
Sequence Identity: 39% (59 aa)

FEMITQVGQGGYGQVYLARKKDTKEVC-ALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSG
|...   |.| .|.|.|..||||...  |.|.| |. . . |. .|..||| || ....  .|.| |.||. . ||. |....||.  ..|   |  .  
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

HARFYISEMFCAVNALHDLGYTHRD-LKPENFLIDAKGHIKLTDFGLA
 ||||..|...|  .||  .   || ||||| |.|..|||.||||||.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLC
Kinase DBF2.AA RSK-Unclassified 177-321 41 1.2e-55 173.0 In-house 1-147 (283) Show / Hide 
Range on Protein: 177-321
Range on HMM: 1-147/283
Sequence Identity: 41% (61 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGGDFRTLLI--NTRCLKS
|. .  .|||  |.||| |||||. . |.|.|.|. . . | .| |.||..|. ||     |.| ..||    ||| ||. .||||   |    ..|.  
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

GHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGL
  .|||.||   |   || ..   |||||.| . .  ||..||||.|
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDL
Kinase DBF2.AA SGK 177-322 34 1.2e-53 163.85 In-house 1-172 (283) Show / Hide 
Range on Protein: 177-322
Range on HMM: 1-172/283
Sequence Identity: 34% (59 aa)

FEMITQVGQGGYGQVYLARKKDT------------------KEVCALKILNKKLLF-------KLNETKHVLTER-DILTTTRSEWLVKLLYAFQDLQSL
|. .. .|.|..| ||....||.                  . . |.|.|.|.          | .| ||...|| .||   ..  .|.| ||||  . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLAMEFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLA
|. |..| ||.    |   ....   |||| .|  ||   ||..   .||||||| | |..||..||||||.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLC
Kinase DBF2.AA PKA 177-320 40 1.7e-51 177.37 In-house 1-146 (263) Show / Hide 
Range on Protein: 177-320
Range on HMM: 1-146/263
Sequence Identity: 40% (59 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLV-KLLYAFQDLQSLYLAMEFVPGGDFRTLLINTRCLKSG
|| |. .|.| .| |.|.|.|.... .|.|.|.|    .|. . ||..|. ||. ...  .| |. . ||| . ||. ||.||||.  . | . ... . 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

HARFYIS-EMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFG
||.||.  . ..|   || .   .||||||| ||| .||||.||||
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFG
Kinase DBF2.AA Pkinase 177-323 30 2.7e-43 154.19 Pfam 1-160 (293) Show / Hide 
Range on Protein: 177-323
Range on HMM: 1-160/293
Sequence Identity: 30% (49 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVL-TERDILTTTRSEWLVKLLYAFQDLQSLYLAMEFVPGG----DFRTLLI--NT
.. . ..|.|..|.||....|.| .. |.||..|.   .  .  |.. .|  |.   ...  |.|...|.| ...|. ||...||    |  ...   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RCL--KSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHI----KLTDFGLAA
.|.     ...||. ....... .|. |  ||||||||.||| .|||    |..|||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase DBF2.AA DMPK 376-477 34 8.1e-24 55.01 In-house 162-270 (270) Show / Hide 
Range on Protein: 376-477
Range on HMM: 162-270/270
Sequence Identity: 34% (38 aa)

VGSPDYMALEVL---EGK---KYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRW-KQTLRRPRQSDGRAAFSDRTWDLITRLIADPINRLR--
|| |||.. |||   |.    .|.  .|.||.|  ..| |.| |||.  |. ||| .     |  |  | ..    . | .  ||| .|. |. .||   
VGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEMLYGETPFYADSLVETYGKIMNHCKNHLSFPDDPK--WDVSEEAKDLICQLLCDREERLGRN

SFEHVKRMSYF
..|  |.  .|
GYEDFKCHPFF
Kinase DBF2.AA SGK 377-477 37 5.1e-18 51.79 In-house 187-283 (283) Show / Hide 
Range on Protein: 377-477
Range on HMM: 187-283/283
Sequence Identity: 37% (39 aa)

GSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRRWKQTLRRPRQSDGRAAFSDRTWDLITRLIA-DPINRLRSF---EHVK
|.| |.| ||| .. .| ||| |.||| |.| ..|  ||    ... ||| ..  | |..|.|      .|   ||||. | . || .|| .    . .|
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIIN--QPLQIPPQ------MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIK

RMSYF
.  .|
NHPFF
Kinase DBF2.AA Pkinase 372-477 25 1.4e-15 56.14 Pfam 168-293 (293) Show / Hide 
Range on Protein: 372-477
Range on HMM: 168-293/293
Sequence Identity: 25% (33 aa)

ANSMVGSPDYMALEVLE-GKKYDFTVDYWSLGCMLFESLVGYTPFSGS-STNETYDNLRRWKQTLRRPRQSDGRAAFS-------------------DRT
... .|.|.||| ||.  |..|.  || ||.||.|.| | |..||.|.  . . .| . . ......|  .|     |                   .  
MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

WDLITRLIA-DPINRLRSFEHVKRMSYF
 |.|..... ||  |. ..|...   .|
KDFIKWCLCKDPKKRP-TAEQILQHPWF
Kinase DBF2.AA S_TK_X 478-547 22 5.6e-15 57.01 SMART 1-79 (79) Show / Hide 
Range on Protein: 478-547
Range on HMM: 1-79/79
Sequence Identity: 22% (21 aa)

ADINFSTLRS----MIPPFTPQLD----SETDAGYFD-DFTSEADMAKYADVFKRQDKLTAMVDDSAVSS--------------KLVGFTFRH
..|.. .|..    . |||.|..     |.||...|| .||.|..|              ...||...|.              .  |||...
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--------------LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase DBF2.AA RSK-Unclassified 372-426 36 2.3e-13 37.82 In-house 179-233 (283) Show / Hide 
Range on Protein: 372-426
Range on HMM: 179-233/283
Sequence Identity: 36% (20 aa)

ANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDN
.|| .|. .|.| |.. .      || | || ...| |.| .|. |  .|||. |
TNSFCGTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYN
Kinase DBF2.AA TyrKc 177-474 18 1.8e-11 -37.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 177-474
Range on HMM: 1-280/280
Sequence Identity: 18% (59 aa)

FEMITQVGQGGYGQVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTT--RSEWLVKLLYAFQDL-------QSLYLAMEFVPGGDFRTLLI
 ... . | | .|.||... |   . .| | |..         .  . |  |..    . . .|.|. .  .        . |.. ||..|.|| .  | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NTRC-LKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDFGLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQL--
..|  |.  .   .     |  . ||. .. ||||   | |.......| .||||.              |  . .| .           . ..| .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLS--------------RDIYDDDQQG---------ESKDYYRKKEH

-REKE-INYANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFE--SLVGYTPFSG-----SSTNETYDNLRRWKQTLRRPRQ-----SDGRAAFSDRT
  .|  . .          ||.|..  .|. .  | || | ...|  .. | .| .|      |  | . ....    ...|       .      .|  
KGGKTMLPIR--------WMAPECINYGKFTTKSDVWSFGVCMWEIFTY-GQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSF---VCCPDEM

WDLITRLIAD-PINRLRSFEHVKRM
 .....  .  | .| .  | ....
YQIMKQCWHEDPEDRPTFSEIHECF
Kinase DBF2.AA Akt 372-415 37 2.6e-11 32.32 In-house 159-203 (264) Show / Hide 
Range on Protein: 372-415
Range on HMM: 159-203/264
Sequence Identity: 37% (17 aa)

ANSMVGSPDYMALEVLEGKKYDFTVDYWS-LGCMLFESLVGYTPF
.... |.| |.| |.|.|. .. .|| |. ||| ..| . |  ||
TKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase DBF2.AA Pkinase_C 495-549 25 9.6e-08 30.56 Pfam 1-46 (46) Show / Hide 
Range on Protein: 495-549
Range on HMM: 1-46/46
Sequence Identity: 25% (14 aa)

QLDSETDAGYFD-DFTSEADMAKYADVFKRQDKLTAMVDDSAVSSKLVGFTFRHRN
|. |.||. .|| .||.|..|  .          . .   |.  .  .|||... .
QVKSPTDTSNFDPEFTDEPPMDTP---------PDWR-MSSGDQEPFRGFTYVNPD
Kinase DBF2.AA PKA 379-425 34 5.6e-07 28.2 In-house 162-211 (263) Show / Hide 
Range on Protein: 379-425
Range on HMM: 162-211/263
Sequence Identity: 34% (17 aa)

PDYMALEVLEGK-KYDFTVDYWSLGCMLFESLVGYTPFSGS--STNETYD
|.|.| |.. .|  .   || |.||.  .| |.||.||. .  .....|.
PEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFYDHNRDPMQIYE
Kinase DBF2.AA Pkinase_Tyr 177-266 23 4e-06 21.41 Pfam 1-98 (270) Show / Hide 
Range on Protein: 177-266
Range on HMM: 1-98/270
Sequence Identity: 23% (23 aa)

FEMITQVGQGGYGQVYLARKK----DTKEVCALKILNKKLLFKLNE--TKHVLTERDILTTT-RSEWLVKLLYAFQ-DLQS--LYLAMEFVPGGDFRTLL
 ... . |.| .|.||... |    .||  .| |.| |       .   .  . |  |...  . . .|.|. .   . ..  .|. ||..|.|| .. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL
Kinase DBF2.AA Pkinase_Tyr 291-322 40 1.646821 2.35 Pfam 127-158 (270) Show / Hide 
Range on Protein: 291-322
Range on HMM: 127-158/270
Sequence Identity: 40% (13 aa)

LHDLGYTHRDLKPENFLIDAKGHIKLTDFGLA
|.. .. ||||   | |.. ....| .|||||
LESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase DBF2.AA Pkinase_Tyr 382-429 29 6.32689 0.37 Pfam 181-231 (270) Show / Hide 
Range on Protein: 382-429
Range on HMM: 181-231/270
Sequence Identity: 29% (15 aa)

MALEVLEGKKYDFTVDYWSLGCMLFESLV-GYTP-FSGSSTNETYDNL-RR
||.|..  .|.    | || |  ..| .  | .| . | | .| |. . ..
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED