Gene FUS3 (Bakers Yeast)

FUS3

Species: Bakers Yeast
Alias: FUS3
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
FUS3.AA Protein Refseq_NP 353 Required for the arrest of cells in G(sub)1 in response to pheromone and cell fusion during conjugation; Fus3p [Saccharomyces cerevisiae] Fasta, JSON
FUS3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of FUS3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase FUS3.AA ERK 13-309 59 3.7e-218 731.03 In-house 1-307 (307) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-307/307
Sequence Identity: 59% (183 aa)

FQLKSLLGEGAYGVVCSATHKP-----TGEIVAIKKI-EPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS
.|. ...|.|||||||||..|.     ||..|||||| ..||.|... |||||||.|.||| |||||..|.|..|.|.|..|..|...|||.||||..| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TQ-MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAM
.| .|||||.|||.||.|...| .| .|||||||||||.|.|||||||.|||||||..|.|...|.|  ..|. ||||||||||||||.||.  ||..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHE--CNQNFMTEYVATRWYRAPEIMLSWQKYTKAM

DVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPM--YPAAPLEKMFPR--VNPKGIDLLQRMLVFDPAKRITA
|.||||||.||.. |.|.|||.||.||. .|| |||||||..||..|.|..|..|||.||.  .|. |.|..||.  .||..||||..|||||| ||||.
DIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITV

KEALEHPYL
.|.|||||.
EECLEHPYF
Kinase FUS3.AA MAPK 13-309 53 3.2e-190 638.22 In-house 1-328 (328) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-328/328
Sequence Identity: 53% (175 aa)

FQLKSLLGEGAYGVVCSATHKP------TGEIVAIKKIE-PFDKPLFALRTLREIKILKHF-KHENIITIFNIQRP------DSFENFNEVYIIQELMQT
.|. . .|.|||||||||..|.      .|..||||||. ||..|... ||.||||.|.|| .||||| ...| .|      .| |.||..||..|||.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRVISTQ-MLSDDHIQYFIYQTLRA--VKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE-SAADNSEPTGQQS----GMTEYVATRWYRA
|||..| .| .|||||||||.|| ||.  .| .|  |||||||||||.|.|.|||||.|||||||.||  .  ....... ..     ||||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDP-HCFQKMHMTEYVATRWYRA

PEVMLT--SAKYSRAMDVWSCGCILAELFL-RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIE-SPRAREYIKSL---PMYPAAPLEKMFPR----VN
||.||   . .|. |.|.||.|||.||.   |.|.|||.|| .|. ||. ..||| |. ...||. |..||.||.||   |.||. |.|||||     .|
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTP-SEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNAN

PKGIDLLQRMLVFDPAKRITAKEALEHPYL
|. ||||..|||||| ||||..|||.|||.
PQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase FUS3.AA CMGC 13-309 26 1e-142 472.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-513/513
Sequence Identity: 26% (139 aa)

FQLKSLLGEGAYGVVCSATH--------------KPTGEIVAIKKIE-PFDKPLFAL----------RTLREIKILKHFK-----------------HEN
..  . .|||.||||.....              . |.||||||||  || ..  |.          |.|||||||||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IITIFNIQRPDS-------------FENFNEVYIIQELMQTDLHRVIST----------QMLSDDH------------IQYFI------YQTLRAVK--V
|.....| ...              . .||..|.. |.|..||...|            . ||. |            |.||.      || ||..|   
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHGSN--VIHRDLKPSNLLINSNCDL--------------------KVCDFGLARIIDESAADNSEPTGQQSG------------MTEYVATRWYRAPEV
.|  .  .|||||||.|.|||.||.|                    |.|||||||....   .. ....|. .            .|.||.||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQS-FKNVNKDDKPNRPYTHYVVTRWYRAPEI

MLTS---------AKYSRAMDVWSCGCILAELFLR--------RPIFP-----------GRDYRHQLLLIFGIIGTPH---------------SDNDLRC
.| .          .|. ..|.||.|||.||....        .|.||           |... .|| .|| ..|||                ....  .
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNM

IE--------------------SPRAREYIKS---LPMYPAAPLEKMFPR-----------------------------------VNPKGIDLLQRMLVF
|.                    |. || ||.|   .|..|  |....||.                                    .|..||||..||..
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQY

DPAKRITAKEALEHPYL
||.|||||..||.|||.
DPDKRITAEQALQHPYF
Kinase FUS3.AA ERK1 13-309 55 5.8e-135 454.67 In-house 1-289 (289) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-289/289
Sequence Identity: 55% (164 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDD
.   . .||||||.||||  . ... |||||| ||.   .  |||||||||. ||||||| | .| | |. |.. .|||.|.|| ||| ... || || |
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKISPFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSND

HIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCI
|| ||.|| || .| .|  ||.||||||||||.|  ||||.|||||||| |     . . ||    .|||||||||||||.|| |  | ...|.|| |||
HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADP----EHDHTGF---LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI

LAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL
|||.   ||||||. |  || .| |..| | | .||.||   .||.|..|||. |  |....||.  .| .|||..|| | | ||||  ||| ||||
LAEMLSNRPIFPGKHYLDQLNHILGVLGSP-SQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase FUS3.AA p38 13-309 44 3.1e-131 442.27 In-house 1-289 (289) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-289/289
Sequence Identity: 44% (136 aa)

FQLKSLLGEGAYGVVCSATHKPTGEI---VAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRP--DSFENFNEVYIIQELMQTDLHRVIST
.|  . .|.|||| ||.|  . ||.    |||||. .|| ....| || ||.. ||| .|||.| . ..  |  .| ..|..||.. ..|..||.... .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDV
| |||||||. .|| ||. |  |  ..|||||||||. .| .|.|.. ||||||              . . ||.|||||||||||.||   .|  . |.
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-------------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDI

WSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEH
|| |||.|||  .|. ||| |. .||  |  ..|||     .  |.| .|| ||.|.| .|   ....|.. ||. |||| .||. || |||||.||..|
WSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEF-WQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQH

PYL
||.
PYF
Kinase FUS3.AA ERK5 13-309 46 4.1e-118 398.71 In-house 1-295 (295) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-295/295
Sequence Identity: 46% (140 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDS-FENFNEVYIIQELMQTDLHRVI-STQML
..    .|.||||||||| .. .|. ||||||   ||.   | ||.||.|||.||.|.||| | .| .|   .  . .||.. .||  ||| .| | | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDE-SAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWS
. .|| ||.|| || .| .|  .||||||||||||.| ||.||. |||.|| .   |...      .|  ||||||||||||||.|. |  |  |.||||
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDK------HQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWS

CGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKS-LPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHP
 |||. |.  || .|||. | ||| ||  ..|.| .   .. . . . . |... .|     ..||..|.  ....||| |||.|.|..|||. .|| ||
VGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMP-PPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHP

YL
.|
FL
Kinase FUS3.AA ERK7 13-309 44 7.29999999999e-115 387.9 In-house 1-292 (292) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-292/292
Sequence Identity: 44% (134 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFK-HENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVIS-TQML
..... || ||||.|  |. | |...||.|||   |  .  | || ||| .|. |. |.||| . |. |    .|   .|.. | | |||| ||   ..|
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR---ADNDRDIYLVFEFMETDLHAVIRKGNIL

SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSC
 | | || .|| |||.| .|  |||||||||||.|..|.| .||||||||| | .  .       |.  .|||||||||||||..| | .| .. | || 
KDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY----DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL
||||.|.   .|.|||    .|. .|  .|. | .  |.  |.|  |   .....  .  .|..|.|   . .||||.|.||| | ||.||..||.||| 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKP-TQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase FUS3.AA S_TKc 13-309 28 3.5e-102 346.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT---DLHRVISTQM-
...  ..|.||.|.|. ..|| ||.|||||.|          ...|||.|||. .|.||.... . .       ...|.. |.. .   ||...|  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSR
      ..  |.....||...|.. .|  ..|||||||.|.|...   .|.|||||||..                 | .. |.||.||||.    .|..
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL----GYGK

-AMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAK
 . |.|||||||.|.. ..| ||      |. ..| .||                                       | ..|.....|..||.||.|| 
CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-

EALE-------HPYL
|||.       ||..
EALQDEWDIKCHPWF
Kinase FUS3.AA Pkinase 13-309 30 2.4e-98 337.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-293/293
Sequence Identity: 30% (97 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLR---EIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQT-----DLHRVI
..... .|.|..|.|. ..|| ||.|||.|.|.  ..    ..|.|   ||.|.|...|.||.... . .       ...|...|...      ||...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYI

S---TQML--SDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDL----KVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVML
|      .  |..... ..||.||... .|  ..|||||||.|.||..|...    |.||||||. .|         .  .| || .. |.||.|||| .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------Y-NNS-MTTFCGTPWYMAPEVIR

TSAKYSRAMDVWSCGCILAELFLRRPIFPGR----DYRHQLLLIFGIIG-TPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRML
.. .|... |.|||||||.|....||.|||.    . . |. .|. | |  .|.| .  | .|..   ..   .      ...  ..... ..|.. ..|
GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWSEECKDFIKWCL

VFDPAKRITAKEALEHPYL
 .||.||.||...|.||..
CKDPKKRPTAEQILQHPWF
Kinase FUS3.AA nmo 13-309 40 9.5e-97 298.05 In-house 1-292 (292) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-292/292
Sequence Identity: 40% (123 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI-EPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVI-STQMLS
 |    .| ||.||| | |    |  ||.||. . |   . . |  ||.|.|  |||.|..   .| .|   . |.|.|.. |||| |||..| | | ||
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCG
 ||.. |.|| || .| ||  |..|||.|| |||.|||| ||.|||||||. ..  . .         ||. | | .|||||... . .|. |.|.|| |
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKH---------MTQEVVTQYYRAPEILMGARHYTSAVDIWSVG

CILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFP--RVNPKGIDLLQRMLVFDPAKRITAKEALEHPY
|| |||  || .|  .   .|| .|  ..|||  ..     |  .|    ...       | ..      .   ..||.|||.||| ||| .|.||.|||
CIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPY

L
|
L
Kinase FUS3.AA CDK 13-309 34 4.5e-96 307.88 In-house 1-284 (284) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-284/284
Sequence Identity: 34% (111 aa)

FQLKSLLGEGAYGVVCSATHKPTG-----EIVAIKKIE-PF-----DKPLFALRTLREIKILKHFKHENIITIFNIQRPD-------SFENF-NEVYIIQ
..    .|||.||||  | .| ||     .|||.|||         .|  |   ..|||..||.  |.||.... .   .       ..  . | .|.. 
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDK--HENKLYMVF

ELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCD-----LKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWY
| | .||  ...        |. ...| ||..  .|  ...||||||.|.|||.|       ||. ||||||.         .. . .  .|  | |.||
EYMDHDLKKYMD--------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ---MS-EPNRTYTHEVVTLWY

RAPEVMLTSAKYS--RAMDVWSCGCILAELFL---RRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGI
||||. | | .||   . |.||.|||.||.|.   |.|.|||.   .|| .|| |.|||  ||   . . |                             
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------

DLLQRMLVFDPAKRITAKEALEHPYL
|||..||..||.|||.|..||.|||.
DLLNKMLCYDPKKRISAEQALQHPYF
Kinase FUS3.AA MAPK-Unclassified 13-164 45 2.1e-61 210.34 In-house 1-162 (575) Show / Hide 
Range on Protein: 13-164
Range on HMM: 1-162/575
Sequence Identity: 45% (74 aa)

FQLKSLLGEGAYGVVCSATHKPT-GEIVAIKKIE-PFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFEN--FNEVYIIQELMQT---DLHRVI-
  .. ..| ||||.|| |. | . .  |||||.   |  .  . |.|||| || .  |.||| | .| .... .|  |  .||  ..|||   ||| .| 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

STQ-MLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLAR-IIDE
| |  ... |||||.|| ||  | ||  ..||||||||||||| .| ...||||..| | |.
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDN
Kinase FUS3.AA MAPK-Unclassified 179-309 35 2.9e-49 169.96 In-house 405-575 (575) Show / Hide 
Range on Protein: 179-309
Range on HMM: 405-575/575
Sequence Identity: 35% (61 aa)

MTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-----------RPIFPGRD--------------------YRHQLLLIFGIIGTPHSDND
||.||.|||||||| || .  |. . | || |||.||. ..           ||.|||.|                    .  |. .||   |.|    |
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPP-EED

LRCIESPRAREYIKSLPMYPAAPLE-KMFPRVN---------PKGIDLLQRMLVFDPAKRITAKEALEHPYL
.. |....||.||.|.   . ..    ||. .          .  ||..| ||.|.| ||||| .|||||| 
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase FUS3.AA TyrKc 13-309 22 1.5e-14 12.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-309
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

FQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHF--KHENIITIFNIQRPDSFENF---NEVYIIQELMQT-DLHRVI-S
 .|.  |||||.|.|. .| |   . ||.|.. .          .||..|....  .|.||. .. . . ..   |     ..|. |.|   ||.  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRK

TQM-LSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDES-AADNSEPTGQQSG--MTEY-VATRWYRAPEVMLTSAKY
..  |. ..  .| .|  .    ||  |.|||||   | |...|   |..||||.| |..  ..  |. .  ...   . . .  ||. |||..    |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYGKF

SRAMDVWSCGCILAELFLRRPIFPGRDYRH---QLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR
. . |||| |  . |.|     . .  |     | .  . .|    . . ... ...   . .              |..  ..  .. ..   .||..|
TTKSDVWSFGVCMWEIF----TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-------------FVCCPDEMYQIMKQCWHEDPEDR

ITAKEALEHPYL
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PTFSEI--HECF
Kinase FUS3.AA Pkinase_Tyr 13-72 32 1.3e-10 36.59 Pfam 1-67 (270) Show / Hide 
Range on Protein: 13-72
Range on HMM: 1-67/270
Sequence Identity: 32% (22 aa)

FQLKSLLGEGAYGVVCSATHK----PTGEIVAIKKI-EPFDKPL-FALRTLREIKILKHF-KHENII
 ..   |||||.|.|. .| |     |.  ||.|.. |  ...  .    .||.||.|.. .|.||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV
Kinase FUS3.AA Pkinase_Tyr 128-217 34 3.2e-05 18.32 Pfam 127-208 (270) Show / Hide 
Range on Protein: 128-217
Range on HMM: 127-208/270
Sequence Identity: 34% (31 aa)

LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTG-QQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELF
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LESKNCIHRDLAARNCLVTENNVVKICDFGLARDI------YNDDYYYRKRGGGK-LPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIF