GCN2

Species: Bakers Yeast
Alias: GCN2
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
GCN2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
GCN2.AA Protein Refseq_NP 1659 Derepression of GCN4 expression; Gcn2p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of GCN2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD GCN2.AA RWD 17-128 31 6.5e-37 129.86 SMART 1-128 (128) Show / Hide
Range on Protein: 17-128
Range on HMM: 1-128/128
Sequence Identity: 31% (40 aa)

NELEAIRSIYMDDFTDLTKRKSSWDKQPQIIFEITLRSVD-----------KEPVESSITLHFAMTPMYPYTAPEIEFKNVQ-NVMDSQL--QMLKSEFK
.||||. |||.|||...  . . |.....| ..|.... .           .|. . .||||| ....||..||.|...|.| ...|.|.  |.|.....
MELEALESIYPDDFECIDEDRHHWVINCCIQIHIHPHEDEMQITNYDNFYEGEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKHLQ

KIHNTS--RGQEIIFEITSFTQEKLDEF
.|...   ||...|||.... ||.|.|.
EIWEENWCRGMCMIFEWVQWVQEFLSEH

RWD GCN2.AA RWD 10-125 28 1.1e-29 109.7 Pfam 1-119 (119) Show / Hide
Range on Protein: 10-125
Range on HMM: 1-119/119
Sequence Identity: 28% (35 aa)

QYYEIQCNELEAIRSIYMDDFTDLTKRKSSWDKQPQIIFEITLRSVDKEPVESSITLHFAMTPMYP-YTAPEIE-FKNVQNVM---DSQLQMLKSEFKKI
 . |.| .||||..|||.|||.| ......|.. .. .|.|.. . . .. . ...||| ... || ...|.|. ... .|.    |.|.| |... ...
MCQEEQEDELEALESIYPDDFED-LRGTICWTEISPWHFTIKI-DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKKLQEY

HNTSR-GQEIIFEITSFTQEKL
 ...  |...|||. .. || |
WEENCHGMVMIFEWIEWLQENL

Kinase GCN2.AA Ciliate-E2 502-527 32 2e-06 18.28 In-house 335-365 (365) Show / Hide
Range on Protein: 502-527
Range on HMM: 335-365/365
Sequence Identity: 32% (10 aa)

DLLSK----MLNNDPKKRLG-TLELLPMKFL
||..|    ||. ||.||..   ..|  ...
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GCN2.AA GCN2 463-527 25 7e-06 16.01 In-house 434-511 (511) Show / Hide
Range on Protein: 463-527
Range on HMM: 434-511/511
Sequence Identity: 25% (20 aa)

DIWQL-GVLFIQIISG-SDIVMN----------FETPQEFLDSTSMDET-LYDLLSKMLNNDPKKRLGTLELLPMKFL
|.. | |..|  .. . ..  |           .| || |      . .  .|.....|| ||.||. . .||  .||
DMYSLGGIIFFEMWYPPFCTQMERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL

Kinase GCN2.AA PEK 500-527 28 1e-05 15.16 In-house 628-655 (655) Show / Hide
Range on Protein: 500-527
Range on HMM: 628-655/655
Sequence Identity: 28% (8 aa)

LYDLLSKMLNNDPKKRLGTLELLPMKFL
..|....||..||..|  . ..|  .|.
QADFIQWMLSHDPQQRPSAQQILQHEFF

Kinase GCN2.AA Pkinase 443-527 15 1.2e-05 20.99 Pfam 175-293 (293) Show / Hide
Range on Protein: 443-527
Range on HMM: 175-293/293
Sequence Identity: 15% (18 aa)

STWIAPELLKFNNAKPQRLTDIWQLGVLFIQIISG-------------SDIVMNFETPQ-----EFLDSTSMD-----------------ETLYDLLSKM
. ..|||......  . .  |.| .|..... ..|             ....| ... .     ..  . |.                  |.. |.....
PWYMAPEVIRGGQYYG-PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LNNDPKKRLGTLELLPMKFL
|. |||||..  ..|  ...
LCKDPKKRPTAEQILQHPWF

Kinase GCN2.AA Ciliate-E2-Unclassified 342-471 19 1.4e-05 15.34 In-house 95-260 (352) Show / Hide
Range on Protein: 342-471
Range on HMM: 95-260/352
Sequence Identity: 19% (32 aa)

KIRLLTEYCNYYPLGDLIQSVGF-----------------VNLATAR-----IWMIRLLEGLEAIHKLG-IVHKCINLETVILVKD--------ADFGST
.| . .|||..  | . |.. ..                 .    |.      ..  .|.||| .|. . |.|  | .| ... ..        .|||. 
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

IPKLVHSTYGYTVL-NMLSRYPNKNGSSVELSPSTWI---APELLKFNNAKPQ--RLTDIWQLGVLF
.     . .  |   . ........ ...  .|.. .   |||.|. .|   .     ||| |||..
KKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL

Kinase GCN2.AA NEK 502-527 38 0.000107 12.92 In-house 261-286 (286) Show / Hide
Range on Protein: 502-527
Range on HMM: 261-286/286
Sequence Identity: 38% (10 aa)

DLLSKMLNNDPKKRLGTLELLPMKFL
.|.|.||. ||..|  . ..| | |.
NLISQMLQKDPEQRPSCNQILEMPFI

Kinase GCN2.AA Ciliate-E2-Unclassified 502-527 38 0.000118 12.09 In-house 327-352 (352) Show / Hide
Range on Protein: 502-527
Range on HMM: 327-352/352
Sequence Identity: 38% (10 aa)

DLLSKMLNNDPKKRLGTLELLPMKFL
|||.|||...|.||..  ..|   ..
DLLQKMLKKNPNKRITFEQILNHPWF

Kinase GCN2.AA Ciliate-E2 342-391 19 0.000935 8.75 In-house 108-184 (365) Show / Hide
Range on Protein: 342-391
Range on HMM: 108-184/365
Sequence Identity: 19% (15 aa)

KIRLLTEYCNYYPLGDLIQSV----GFV-------NLATARIWMIRLLE---------------GLEAIHKLG-IVH
.| | .|||..  | |.|..     ..        ..  ..  |  .|.               .|| .|. . |.|
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH

Kinase GCN2.AA STE-Unique 444-484 20 0.025622 3.36 In-house 513-556 (616) Show / Hide
Range on Protein: 444-484
Range on HMM: 513-556/616
Sequence Identity: 20% (9 aa)

TWIAPELLKFN---NAKPQRLTDIWQLGVLFIQIISGSDIVMNF
....|| .  .   |    .  ||| || ... ...|..  ...
CYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQR

Kinase GCN2.AA Pkinase 345-391 29 0.030491 9.01 Pfam 77-131 (293) Show / Hide
Range on Protein: 345-391
Range on HMM: 77-131/293
Sequence Identity: 29% (16 aa)

LLTEYCNYY----PLGDLIQ--SVGFV--NLATARIWMIRLLEGLEAIHKLGIVH
. .|||.       | |.|.  . | .     ... .|  .|.||| .|. ||.|
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIH

Kinase GCN2.AA STE 502-527 35 0.035357 3.64 In-house 332-359 (359) Show / Hide
Range on Protein: 502-527
Range on HMM: 332-359/359
Sequence Identity: 35% (10 aa)

DLLSKMLNNDPKKRLGTLELLP--MKFL
| ..| |. ||.||  . .||    .|.
DFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GCN2.AA WEE 500-527 32 0.046047 2.8 In-house 270-297 (297) Show / Hide
Range on Protein: 500-527
Range on HMM: 270-297/297
Sequence Identity: 32% (9 aa)

LYDLLSKMLNNDPKKRLGTLELLPMKFL
| .|.  |.. ||..|  . .||    |
LKQLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase GCN2.AA STE 295-391 15 0.228568 0.74 In-house 53-175 (359) Show / Hide
Range on Protein: 295-391
Range on HMM: 53-175/359
Sequence Identity: 15% (20 aa)

NTSNGK------------KEIANLEKELETVLKAK--HDNVNRLFGYTV----ERMGRNNATFVW--KIRLLTEYCNYYPLGDLIQ---SVGF-------
|... .            .|. ...||...  | .  |.|. . .|. .    .          .  .. .  ||...  | |.|.   ..|.       
NNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN--------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQ

----VNLATARIWMIRLLEG-LEAIHKLGIVH
    ..    ..    .|.| |. .|...|.|
HQHRFPESQIAYICRQILKGLLYYLHSHHIIH

Kinase GCN2.AA GCN2 599-981 32 1.9e-162 545.97 In-house 1-511 (511) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-511/511
Sequence Identity: 32% (169 aa)

FEEIAVLGQGAFGQVVK-ARNALDSRYYAIKKIRH--TEEKLST---ILSEVMLLASLNHQYVVRYYAAWLE--------------------EDSMDENV
||||..||.|.|||||| .||..|.|||||||...  ...||..   |..||.||..|.||.|||||.||.|                    ...  . .
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDEPMVTDTNNDDDTNNNYHSDDESEC

FESTDEESDLSESSSD--FEENDLLDQSSIFKNR------TNHDLDNS--------------------------------------------NWDFISGS
|.. .|... ...|.   ..|     ..|.  |       .| ... .                                            .|| | . 
FSGQYEMPKSVNQSEEMCNKEESMEWSMSNERNNSNWHDNGNFFSEWDNPFDQPFGPKCAFRMGQKRTFDLTDDHYSYCHSDCEFDDDVFDIDWD-IESN

GYPDIVFEN--SSRDDENEDL-------------DHDTSSTSSSESQDDTDKESKSIQNVPRRRNFV----KPMTAVKKKSTLFIQMEYCENRTLYDLIH
   |  ...  ......|...             | . . .. ||.|.    ..... .. .  | |    ..   .|.  .|.|||||||..||...|.
NVRDMESDDNEWEQEQQNNQSFQPKQEDHQNQYYDQEDLNNAESEDQNKKKSQQQDKMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYID

SENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKN-------------------------VHRSLDILKLDSQNLPG
........||.||.||||||.|.||||||.|||||||.|||.|...||||||||||.|                         .....| .... |. ..
NHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFS

SSD------NLTSAIGTAMYVATEVLDGTGHYNEKIDMYSL-GIIFFEMIYP-FSTGMERVNILKKLRSVSIEFPPDFD---DNKMKVEKKIIRLLIDHD
..|      ..|...||..|...|..  ..|||.|.||||| |||||||.|| |.|.||||.|||.||  |.|||.|||   ||..| ....|| ...||
QWDQQDEQVHHTGKVGTPFYMCPEQQ--KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR--SCEFPQDFDKKVDNHHKDQQDMIRWCLNHD

PNKRPGARTLLNSGWL
|.||| |..||....|
PQKRPSAQQLLQHEFL

Kinase GCN2.AA PEK 599-981 24 7.79999999999e-148 497.43 In-house 1-655 (655) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-655/655
Sequence Identity: 24% (161 aa)

FEEIAVLGQGAF-GQVVKARNALDSRYYAIKKIRHTEEK-----------------LST-ILSEVMLLASLNHQYVVRYYAAWLE--EDSMDENVFESTD
||||..||.|.| |||.|..|.||..|||||.|..   .                 ... .| ||..||.|||...|||..||.|  |. . ... |...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

EES----------------------------------------------DLSESSSDFEENDLLDQSSIFKNRTNHDLD--------------NSNWDFI
..|                                              . ...|....... ...|.....    | .              ..| .  
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINFGTENENES

SGSGYPDIVFENSSRD-----------------------------------------------------------DENEDLDHDTSSTSS----------
. | . ..|...|| |                                                           ....| .|...  .|          
HISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSH

------SESQDDTDKE--------SKSIQNVPRRRNFVKPMTAVKKKS--------TLFIQMEYCENRTLYDLIHSEN----------------------
      ...||..| .        |.| ..  .  |. .  . .|..         .|.|||||||  || |.|.. .                      
KKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIM

---------------------LNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN-----VKIGDFGLAKN-------------------
                     .....|..||.||||||.| ||||||.|||||||.|||.| . .     |||||||||.|                   
NQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYW

---VHRSLDILKLDSQNLPGSSD---------------------NLTSAIGTAMYVATEVLDGT----GHYNEKIDMYSLGIIFFEMIYPFSTGM-ERVN
   .. ...... ..||.|...|                     ..|...||..|.. |.|.|.    .|||.|.||||||||||||.|||.| | |||.
KYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVK

ILKKLRSVSIEFPPDFD----DNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
.|..||..||.|| ||.    |||.......|.....||| .|| |  .|.....
TLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF

Kinase GCN2.AA S_TKc 599-981 20 5.8e-64 219.72 SMART 1-231 (231) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-231/231
Sequence Identity: 20% (84 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLEEDSMDENVFESTDEESDLSESSSDFEENDLLDQS
.| . ..|.||||.| |.|.  . |..|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRNFVKPMTAVKKKSTLFIQMEYCEN--RTL
                                                      ... .| .  ..  .  | ||   .    . |.. ||||..   .|
------------------------------------------------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL

YDLIHSENLN-----QQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYV
.|.|.. . .         . .....||..|| |.||.||||||||| ||..||  ..||.|||||. .                     |. .||  |.
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYM

ATEVLDGTGHYNE-KIDMYSLGIIFFEMIY---PFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN-------SGW
| |||    .|.  |.|..|.|.|..||..   ||.   .   ..||..               .  | .|| . . ||.|||.|  .|.         |
APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

L
.
F

Kinase GCN2.AA STE 599-981 18 9.1e-59 201.55 In-house 1-359 (359) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-359/359
Sequence Identity: 18% (89 aa)

FEEIAVLGQGAFGQVVKARNAL---------------DSRYYAIKKIRHTE------------------EKLSTILSEVMLLASLN--HQYVVRYYAAWL
.| | ..|.||||.|.||.|                   ...|||.... .                  |..  || |. ..  .|  |...|.|| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EEDSMDENVFESTDEESDLSESSSDFEENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQ
 |.                                                                                                 
KEGHN-----------------------------------------------------------------------------------------------

NVPRRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHS-----ENLNQQR--------DEYWRLFRQILEA-LSYIHSQGIIHRDLKPMNIFIDESRNV
               | ...|.| |||... .| |.|..     ..||..|        ..  .  ||||.. |.|.||..|||||.|| ||..     |
--------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----V

KIGDFGLAKNVHRSLDILKLDSQNLPG-------SSD-NLTSAIGTAMYVATEVLDG-----TGHYNEKIDMYSLGIIFFEMI---YPFST-GMERVNIL
|. |||.....  |.. . . |    .       ... . .. .||  . | ||...      ..|..| |..|||.   ||.   .|...    |.  .
KLCDFGVCGQLTDSMANI-Q-S----NNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFM

KKLRSVSIE----------FPPDFDD-------------------NKMKVEKKIIRLLIDHDPNKRPGARTLLN--SGWL
.   ... .           || . |                   .  .  |  |..  . |||||| |  ||.    ..
IPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI

Kinase GCN2.AA Ciliate-E2 779-981 23 1.5e-46 157.76 In-house 104-365 (365) Show / Hide
Range on Protein: 779-981
Range on HMM: 104-365/365
Sequence Identity: 23% (66 aa)

KKKSTLFIQMEYCENRTLYDLIH--SENLNQQRD--------EYWRLFRQILE---------------ALSYIHSQG-IIHRDLKPMNIFIDESRNVKIG
|....... ||||.  .|.|.|   . . |....        |  ....|||.               || |.||.. |||||.|| ||..     .|| 
KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKII

DFGLAKNVHRSLD---------ILKLDSQNLPGSSDNL---------TSAIGTAMYVATEVLDGTG--------HYNEKIDMYSLGIIFFEMI---YPFS
||||.|... . .         ...  ...  ... ..          . .||..|.| |.| | .        .|..|.|..|||.|..||.   .|| 
DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-

TGMERVNILKKLRSVSIEFPPDF-------------DDNKMKVE-KKIIRL----LIDHDPNKRPG-ARTLLNSGWL
        ...     |.||. .             . .|   | | .|.     ... ||.||.. .  .||  |.
--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GCN2.AA Ciliate-E2-Unclassified 599-981 16 2.9e-45 154.96 In-house 1-352 (352) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-352/352
Sequence Identity: 16% (80 aa)

FEEIAVLGQGAFGQVVKARNALDSRYY-----AIKKIRHTEEKLSTILSEVMLL----ASLNHQYVVRYYAAWLEEDSMDENVFESTDEESDLSESSSDF
.. | ..|||.||.| |...  .  .|     ..|..     .  .   | |.      .... |..|                                
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQR-K------------------------------

EENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRNF---------------VKP
                                                                                .                || 
--------------------------------------------------------------------------------YNKIMQQILLNHPHPFIVKM

MTAVKKKSTLFIQMEYCENRTLYDLIHS------------ENLNQQR---DEYWR------LFRQILEALSYIHSQG-IIHRDLKPMNIFIDESR---NV
. . ..| ...| |||||. .| . | .            .|..|..   ..  .      .|.|||..|.|.|... |||||.|| ||..|..    ..
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYI

KIGDFGLAKNVHRSLDILKLDSQNLPGS---------SDNLTSAIGTAMYV----ATEVLDGTGHYN---EKIDMYSLGIIFFEMI---YPFS--TGME-
|| |||..|        .. ....  ..         ...... .|| .|     | |||.| ....   .|.|..|||.|..||.   |||.  .  . 
KIIDFGISK-------KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQH

------------RVNILKKLRSVSIEFPP--------DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
            | .....     |.||.        . ...     ..... ... .||||...  .||  |.
QQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GCN2.AA Pkinase 781-981 28 8.6e-44 155.93 Pfam 72-293 (293) Show / Hide
Range on Protein: 781-981
Range on HMM: 72-293/293
Sequence Identity: 28% (69 aa)

KSTLFIQMEYCENR----TLYDLIH-SENLNQ--QRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNV----KIGDFGLAKNVHRSLDILKL
|. . . |||||.      |.|.|. ... .   . .|  . ..|||..| |.||.||||||||| ||.||.  ..    ||.|||||| .         
KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------

DSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGM----ERVNILKKLRSVSI---EFPPDFDDNKM--------
       ..  .|.  ||  |.| ||. |  .|  |.||.|.|.|..||.    ||. |     . .. ..... .     .|. . .....        
-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------KVEKKIIRLLIDHDPNKRPGARTLLNSGWL
         .  |..|. ... ||.|||.|. .|.. |.
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GCN2.AA STE-Unique 779-981 24 5.3e-42 145.86 In-house 364-616 (616) Show / Hide
Range on Protein: 779-981
Range on HMM: 364-616/616
Sequence Identity: 24% (63 aa)

KKKSTLFIQMEYCENRTLYDLIHSENLN--------QQRDEYWRLFRQILEALSYIHSQG--IIHRDLKPMNIFIDESR-----NVKIGDFGLAKNVHRS
| . .. |.|||||. || ..| .             . .|  .. .||||.| |.|||.  |||||||| |||.. .      .|||.|||.|.     
KEQNWVWIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPD

-----LDILKLDSQNLPGSS-------------------DNLTSAIGTAMYVATEVLDGT----GHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILK--
     .    . . .    .                    .... .||  | . ||. .      .|. | |..|||...|.|.  . . ..| ...   
HFEKDNNSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYI

KLRSVSIEFPP-----DFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
 ..  .   ||     .  .   .    .|..... .|..|| |  || ..||
EMCIHIHCQPPQCPIENIPPKCQPEQQQFIEKCLERNPHHRPSAHQLLHHFWL

Kinase GCN2.AA HRI 814-981 36 1.2e-35 123.06 In-house 437-613 (613) Show / Hide
Range on Protein: 814-981
Range on HMM: 437-613/613
Sequence Identity: 36% (68 aa)

RLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN----VKIGDFGLAKNVHRSLDILKLD--------------SQNLPGSSDNLTSAIGTAMYVATEV
..| ||.| . |||  .|.|||.|| |||  .  .    |||||||||       |||.                .   |  .   || .|| .| . | 
KIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACE-----DILQEPKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQ

LDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
|||.  |  | ||||.|.| ||.  || | ||| ..|  .|   |   |.    .  |  | | .|      .|| |  || |   
LDGS-QYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTGQI---PESLRKRCPVQAKYIQHLTRRNASQRPSAIQLLQSELF

Kinase GCN2.AA NEK 779-858 37 1.1e-27 94.75 In-house 76-171 (286) Show / Hide
Range on Protein: 779-858
Range on HMM: 76-171/286
Sequence Identity: 37% (37 aa)

KKKSTLFIQMEYCE-NRTLYDLIHSENLNQQR--------DEYWRLFRQILEALSYIHSQ-----GIIHRDLKPMNIFIDESRN----VKIGDFGLAK
.....|.| ||||| . .||..| |  ...|.        .. |. | |.. || |.|..      |.|||.||.|||.. ..|    |||||||..|
EQNNCLCIVMEYCEGGGDLYQKIKS--IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISK

Kinase GCN2.AA WEE 781-918 26 4.3e-26 84.58 In-house 77-229 (297) Show / Hide
Range on Protein: 781-918
Range on HMM: 77-229/297
Sequence Identity: 26% (45 aa)

KSTLFIQMEYCEN--RTLYDLI-HSENLNQ--QRDEYWRLFRQILEALSYIHSQ-GIIHRDLKPMNIFIDESR--------------------NVKIGDF
.....||||||..    |...| ...| |.  . .. | ....|...|..|||. |..| |.|| |||| .                      . |||||
DDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDF

GLAKNVHRSLDILKLDSQNLPGSSDNLTSA-IGTAMYVATEVLDG--TGHYNEKIDMYSLGIIFFEM
|.....                 . | ...  | . | | |.| |  .  .. | | .|||| ..|.
GHVTDMNS--------------NNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL

Kinase GCN2.AA PEK 724-858 25 3.2e-25 80.18 In-house 334-514 (758) Show / Hide
Range on Protein: 724-858
Range on HMM: 334-514/758
Sequence Identity: 25% (48 aa)

DIVFENSSRDDENEDLDHDTSSTSSSESQDDTD-------KESKSIQNVP---------------RRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIH
.|.|| || .|       ...|| . ..|.  .       ..|||  ..                .  | .  |     . ...|||..|.  || |.. 
SIIFEDSSCEDNKP--KEYSMSTKQHQQQQCQNQQTNQKCSSSKSCMENNWLLTSHHNNNNNNNNNNNNKNWKMHPTGNCIYMYIQMQLCRKETLKDWMR

S--ENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRN--------------------------VKIGDFGLAK
      .  . .   .| ||.|.. |||| |.||||||| |||   |.                           .|||||||..
NRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFF--SMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLVT

Kinase GCN2.AA PEK 877-981 30 3.8e-25 79.91 In-house 641-758 (758) Show / Hide
Range on Protein: 877-981
Range on HMM: 641-758/758
Sequence Identity: 30% (37 aa)

SSDNLTSAIGTAMYVATEVLDGT---------------GHYNEKIDMYSLGIIFFEMIYP-FSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRL
|. . |   ||  | . | . ..               ..||.| | ||||.||||.|.| ||| |||. ....||  .  .|..|.. |   | . | .
SCHRHTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR--NGQWPKWFTQ-KYPQEYEFIQQ

LIDHDPNKRPGARTLLNSGWL
.....|  || |  .. .   
MMSMNPDERPTADQISMHDFF

Kinase GCN2.AA WEE 599-668 37 1.8e-24 79.03 In-house 1-80 (297) Show / Hide
Range on Protein: 599-668
Range on HMM: 1-80/297
Sequence Identity: 37% (30 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS---TILSEVMLLASLN-------HQYVVRYYAAWLEEDSM
|.|. ..|.| ||.|.|.|...|.. |||||...   ..|    .| ||  ...|        | ..|||| || | |.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHM

Kinase GCN2.AA PEK 599-685 25 8e-22 68.59 In-house 1-132 (758) Show / Hide
Range on Protein: 599-685
Range on HMM: 1-132/758
Sequence Identity: 25% (34 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTE--------EKLST--ILSEVMLLASLNHQYVVRYYAAWLEED----------------------
||.| .||.| || | .| | .|  .||||.|.            ...    . ||  ||.|.|   |||. ||||..                      
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWLETPELLPPNNKMRSTSFSTVNGKQI

-------SMDENVFES------TDEESDLSES
         ..  |.        ||.... |.
DSNNDNDIYNNHFFFDGNWGQDEDEDEYENED

Kinase GCN2.AA STE-Unique 600-667 32 6.2e-21 70.66 In-house 1-77 (616) Show / Hide
Range on Protein: 600-667
Range on HMM: 1-77/616
Sequence Identity: 32% (25 aa)

EEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK-------LSTILSEVMLLASLNHQYVVRYYAAWLEE--DS
...  .|.|.|| |....|  |....|||.|.    |        . |.||......|.||..|.|| .||..  ||
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLWGGCDS

Kinase GCN2.AA HRI 599-665 40 2.6e-20 67.74 In-house 1-70 (613) Show / Hide
Range on Protein: 599-665
Range on HMM: 1-70/613
Sequence Identity: 40% (28 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEK---LSTILSEVMLLASLNHQYVVRYYAAWLEE
||. ...|.| .|.| | |. ||  .||||||. .. .   .  .. ||  || |.|  .|||  ||.|.
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEH

Kinase GCN2.AA NEK 599-667 33 8.9e-19 63.08 In-house 1-78 (286) Show / Hide
Range on Protein: 599-667
Range on HMM: 1-78/286
Sequence Identity: 33% (26 aa)

FEEIAVLGQGAFGQVVKARNALDSRY-----YAIKKIRHT---EEKLSTIL-SEVMLLASLNHQYVVRYYAAWLEEDS
.|.| ..|||.||.| |.|   |..      |..|||  .   |..    . .|| .|..|.|...|.|| ...||..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQN

Kinase GCN2.AA Pkinase 599-668 26 7.2e-16 57.19 Pfam 1-75 (293) Show / Hide
Range on Protein: 599-668
Range on HMM: 1-75/293
Sequence Identity: 26% (20 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLST----IL-SEVMLLASLNHQYVVRYYAAWLEEDSM
.. . ..|.|.||.| |...  ... .|.|.|.  .|| .     .. ||. ....||| ..||.| .. ..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHI

Kinase GCN2.AA TyrKc 599-981 12 9.3e-12 -32.6 SMART 1-280 (280) Show / Hide
Range on Protein: 599-981
Range on HMM: 1-280/280
Sequence Identity: 12% (55 aa)

FEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASL--NHQYVVRYYAAWLEE--------------------------DSMDE
 . . .|| ||||.|.|..     .  |.|....    .  ...|  .. .|  .|. .|| |.. ...                           .  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

NVFESTDEESDLSESSSDFEENDLLDQSSIFKNRTNHDLDNSNWDFISGSGYPDIVFENSSRDDENEDLDHDTSSTSSSESQDDTDKESKSIQNVPRRRN
.                                                                                                   
K---------------------------------------------------------------------------------------------------

FVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRS-LDILKL
                                     . ..      || .  .|.||...|||||   |. ..| . |||.||||.....         
------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---

DSQNLPGSSDNLT-----SAI--GTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI---YPFSTG-----MERVNILKKLRSV-SIEFPPD--------
       |.|  .     ..         | |..  .| ...| | .| |.  .|.     .   |     |.   .......    . ||.        
------ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVC

FDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL
  |   .. . |..   ..||..||  ...     .
CPD---EMYQ-IMKQCWHEDPEDRPTFSEI--HECF

Kinase GCN2.AA Ciliate-E2 599-666 18 2.1e-10 31.89 In-house 1-105 (365) Show / Hide
Range on Protein: 599-666
Range on HMM: 1-105/365
Sequence Identity: 18% (19 aa)

FEEIAVLGQGAFGQVVKARNALDSR-----------------------YYAIKKIRHTEEKLSTILSEVM--------------LLASLNHQYVVRYYAA
.. | ..|||.||.| |... .. .                       .||.| ... . .       .|              .| .||| .....| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WLEED
. |.|
FQEKD

Kinase GCN2.AA Pkinase_Tyr 788-860 31 2e-08 29.13 Pfam 86-161 (270) Show / Hide
Range on Protein: 788-860
Range on HMM: 86-161/270
Sequence Identity: 31% (24 aa)

MEYCENRTLYDLIHSE---NLNQQRDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNV
|||...  |.|  ..    . .    .     .|| ....| .|...|||||   |. ..|.. |||.|||||. .
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI

Kinase GCN2.AA Pkinase_Tyr 599-661 23 8.9e-07 23.58 Pfam 1-72 (270) Show / Hide
Range on Protein: 599-661
Range on HMM: 1-72/270
Sequence Identity: 23% (17 aa)

FEEIAVLGQGAFGQVVKARNA----LDSRYYAIKKI--RHTEEK--LSTILSEVMLLASL-NHQYVVRYYAA
 . . .||.||||.|.|..       .    |.|..   ...|   .   ..|. .. .| .|. .||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGV

Kinase GCN2.AA WEE 955-981 33 0.003922 6.44 In-house 271-297 (297) Show / Hide
Range on Protein: 955-981
Range on HMM: 271-297/297
Sequence Identity: 33% (9 aa)

KKIIRLLIDHDPNKRPGARTLLNSGWL
| .|.. .. || .|| .. ||..  |
KQLIKWMMHPDPEQRPTCQQLLQHPVL

Kinase GCN2.AA NEK 955-981 22 0.004554 7.11 In-house 260-286 (286) Show / Hide
Range on Protein: 955-981
Range on HMM: 260-286/286
Sequence Identity: 22% (6 aa)

KKIIRLLIDHDPNKRPGARTLLNSGWL
...|....  || .|| .. .|.   .
QNLISQMLQKDPEQRPSCNQILEMPFI