Gene HOG1 (Bakers Yeast)

HOG1

Species: Bakers Yeast
Alias: HOG1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
HOG1.AA Protein Refseq_NP 435 osmoregulation; Hog1p [Saccharomyces cerevisiae] Fasta, JSON
HOG1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 280 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of HOG1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HOG1.AA ERK 23-302 53 1.5e-202 679.23 In-house 1-307 (307) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-307/307
Sequence Identity: 53% (164 aa)

YNDLNPVGMGAFGLVCSATDTL-----TSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLR-HENLICLQDIFLS----PLEDIYFVTELQGTDLHRLLQ
|......|.||.|.||||.|..     |.|.||||||...|......|||.||.|||.|.. |||.|||.||...    ...|||.|.||. ||||.  .
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

TR-PLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDP-----------QMTGYVSTRYYRAPEIMLTWQKYDVEVDI
.. .|.....|||.||||.||||.|||.||||||||||||.|.|||||||||||||..|.           .||.||.||.||||||||.||||. ..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSP-PKDVINTICSENTLKFVTSLPH--RDPIPFSERFKT--VEPDAVDLLEKMLVFDPKKRITAAD
||.|||||||...||||||||.|||...|....|.| ... ...|||||..|....||.  |.|.|....|..  ..|.|.|||||||||||.||||...
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHPYS
.|.||| 
CLEHPYF
Kinase HOG1.AA MAPK 23-302 50 1.5e-185 622.67 In-house 1-328 (328) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-328/328
Sequence Identity: 50% (167 aa)

YNDLNPVGMGAFGLVCSATDTLTSQP------VAIKKIMKPFSTAVLAKRTYRELKLLKHL-RHENLICLQDIFLS----------PLEDIYFVTELQGT
|..| |.| ||.|.||||.|..|.|       ||||||..||......||||||.|||.|. .||| |.|.|||             ..|||.|.|| .|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHRLLQTRP-LEKQFVQYFLYQILRG--LKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ-----------------MTGYVSTRYYRAP
|||....... |. . .|||.||||||  ||| |||.||||||||||||.|||||||||||||||. ||.                 ||.||.||.||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLT--WQKYDVEVDIWSAGCIFAEMIE-GKPLFPGKDHVHQFSIITDLLGSPPKDVINTIC-SENTLKFVTSL---PHRDPIPFSERFKT----VEPD
||||   |..|.  ||.||.|||||||.  .||||||||...|.  |...||.|....|. || ||.  ... ||   |.....|... |.     . |.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLLEKMLVFDPKKRITAADALAHPYS
|.|||||||||||.||||...||.||| 
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase HOG1.AA p38 23-302 53 8.20000000001e-150 503.99 In-house 1-289 (289) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-289/289
Sequence Identity: 53% (154 aa)

YNDLNPVGMGAFGLVCSATDTLTSQP---VAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSP-------LEDIYFVTELQGTDLHRLLQ
|..| ||| ||.| ||.| |. |.|    |||||.|.|| ... ||||||||.||||.|||| ||| |.|  |       ..|.|.||.. |.||.... 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVF-TPPAHSMNDFQDVYMVTHFMGADLNNIMK

TRPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIE
.  |  . .|. .|||||||||.||||.|||||||||| .||.|.|.| |||||| .|  ||||| || |||||||| | .|.  ||||| ||| ||.| 
CQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELIT

GKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYS
|..||||.||..|   |. ..|.|.. ... | ||.   .. |.| .    |.. |.  .| |.|||||||. || |||||..|..||| 
GRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase HOG1.AA CMGC 23-302 28 1.8e-136 451.41 In-house 1-513 (513) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-513/513
Sequence Identity: 28% (146 aa)

YNDLNPVGMGAFGLVCSATDTLTSQP--------------VAIKKIMKPFSTAVLAK----------RTYRELKLLKHLR-----------------HEN
|  ....| |..| |....|..| |.              ||||||..||     ||          |..||.|.||||.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LICLQDIFLSP----------------LEDIYFVTELQGTDLHRLLQT----------RPLEKQF------------VQYFL------YQILRGLK--YV
...|.||| ..                ....|.|.|. ..||.....           .||.               ..||.      ||||||||  | 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VIHRDLKPSNILINENCDL--------------------KICDFGLARIQDPQ------------------------MTGYVSTRYYRAPEIML
||..  .|||||||.|||||.||.|                    |||||||||. .|                         .| ||.||.||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

TW---------QKYDVEVDIWSAGCIFAEMIEG--------KPLFP-----------GKDHVHQFSIITDLLGSP----------------PKDVINTIC
 |         ..|. ..|.||.|||||||. |        |||||           ||.|..|   | ..||.|                ... .| |.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SENTLKFVTS---LPHRDPIPFS------------------------ERFKT-----------VEPDAVDLLEKMLVFDP
                    ||   ... |   .| . |.|..                        |.||.             |.|.|||.|||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

KKRITAADALAHPYS
.|||||..||.||| 
DKRITAEQALQHPYF
Kinase HOG1.AA ERK1 23-302 51 6.4e-116 391.42 In-house 1-289 (289) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-289/289
Sequence Identity: 51% (150 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSP----LEDIYFVTELQGTDLHRLLQTRPLEK
| .|. .| ||.|.|||| ||.. | ||||||  ||      .|| ||.|.|.  .|||.| .|||  ..    . |.| | .|  ||| .||.| .|  
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLKTQHLSN

QFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ------MTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIE
  . ||||||||||||.||| |.||||||||.|.|  ||||||||||||| ||.      .| || ||.||||||||  . |   .|||| ||| |||. 
DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS

GKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYS
 .|.||||  . |   |  .|||| .| .| |  |    .. ||||.  .|. . |   .. |.|||.||| | |.||||  .|||||| 
NRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase HOG1.AA ERK5 23-302 45 6.9e-112 378.01 In-house 1-295 (295) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-295/295
Sequence Identity: 45% (133 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIF-----LSPLEDIYFVTELQGTDLHRLLQ-TRPL
|. .  .| ||.| ||||   .. | ||||||   |     ||||.||||.|.| ||.|.| ..||      .| . |.| | .|   ||| ..    |.
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

EKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDP--------QMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFA
    . ||||||||||||.||| ||||||||||.|.||||.||| |||.||             || || ||.|||||.|.  . |   .|.|| |||| 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTS-LPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYS
|||  . .||||  .|| ..| . || ||  .| .. ..    .. . .| | | .... .   .. |.||| .||.|.| .|||.. || ||. 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase HOG1.AA JNK 23-302 41 3.4e-104 352.44 In-house 1-309 (309) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-309/309
Sequence Identity: 41% (129 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKP--FSTAVLAKRTYRELKLLKHLRHENLICLQDIF-----LSPLEDIYFVTELQGTDLHRLLQT--
|  | ..| || |.||.| |..| |.|||||.|.|  |     .|| |||....|.. |.| | .  .|     |. ..|.| | |.    |. . .   
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

RPLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ--MTGYVSTRYYRAPEIMLTWQ-KYDVEVDIWSAGCIFAEM
  |  . . |..||...| |. ||.|.||||||||||..|. |.|||||||.|| .||.  || || ||||||||. .     |   ||||| |||.|||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

IEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSL---PHRDPIPFSERF--------KTVEPD-------AVDLLEKMLVFDPKKRIT
| .. |||||||  |.  | ..|| | .  ..    .    .| ..   |   |..|.|.|         . ||.       | ||| .||| .| .|| 
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRIS

AADALAHPYS
  ||| ||| 
VDDALQHPYI
Kinase HOG1.AA nmo 24-302 45 2.3e-101 312.54 In-house 2-292 (292) Show / Hide 
Range on Protein: 24-302
Range on HMM: 2-292/292
Sequence Identity: 45% (132 aa)

NDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLE----DIYFVTELQGTDLHRLLQT-RPLEK
.   |.| ||||.| | ||    . ||.||. . |   | .|| .||||.|   .|.| . . ||  .|      .|| ||||   |||...    .|  
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQHLSS

QFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ----MTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGK
  |. |||||||||||.|||...|||.|| |.|.| || ||||||||||.....    ||  | | |||||||..  ..|   ||||| ||||||... .
DHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGRR

PLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPD-----AVDLLEKMLVFDPKKRITAADALAHPYS
 ||  .  ..|  .|||||| |  . . . | |     .   ||. |  ..  ..   ||     ||.|| .||.||| ||| . ||||||| 
ILFQAQSPIQQLQMITDLLGTPSMEDMKYAC-EGAKAHMLRMPHKPPC-LQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase HOG1.AA S_TKc 23-302 31 8.2e-99 335.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-231/231
Sequence Identity: 31% (93 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGT---DLHRLLQTRP----
|  |...| |||| |. .... | . ||||.|          ....||...||. .|.|.. | |.| .  ...|.|.|. ..   ||..... |.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDV-EVDIWSAGCIFAEMI
   .    .....|||...|.| || |.|||||||.|||..|   .|||||||||.     | .. |..|.|||..    .|.  ..|.|| |||..||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

EGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALA-------HPYS
 |.|.||      |   . ...|                                      |.| |...|.|..||.||.|| .||.       ||. 
CGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HOG1.AA ERK7 23-302 41 5.4e-96 325.23 In-house 1-292 (292) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-292/292
Sequence Identity: 41% (121 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLR-HENLICLQDIFLSPLE-DIYFVTELQGTDLHRLLQ-TRPLEKQ
|. .  .| ||.|.|  |.|  | | ||.|||   |  .. | ||.||  .|. .. |.|.| | ...    . ||| | |   ||||   .  . |.  
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDI

FVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR----IQ-----DPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEM
 .|| .||.|| .||.||. ||||||||||||.. .| .|.|||||||    ..     .| .| || || ||||||.|  ..|   || || ||| .||
HKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEM

IEGKPLFPGKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYS
. |||.|||   ..|   | .... | .  |. | |.   . . ..... . .... ..   .||.||| ..||| ||||.|| .||.||| 
LRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase HOG1.AA Pkinase 23-302 32 2.6e-86 297.84 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-302
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYR--ELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGT-----DLHRLLQ---
|  . ..| |.|| |. ...  |.. ||.|.| |.       ..  |  |....|.|.|.| . | |.| .   .||.|.|. .      ||.....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR

TRPL--EKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDL----KICDFGLA----RIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWS
 ...  . . .. ..|||||||.| || |.|||||||.||||..|...    ||||||||       .. ||... |..|.|||. .. |.|. .||.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCIFAEMIEGKPLFPGK----DHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALA
.|||..||. |.|.|||.    . . |  .|   .| |..  . . ||. . . ..  . .  . .... . ..... |.....| .|||||.||...| 
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPYS
||. 
HPWF
Kinase HOG1.AA MAPK-Unclassified 23-172 46 2e-69 236.95 In-house 1-163 (575) Show / Hide 
Range on Protein: 23-172
Range on HMM: 1-163/575
Sequence Identity: 46% (75 aa)

YNDLNPVGMGAFGLVCSATDTLT-SQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFL--SPLE----DIYFVTELQGT---DLHRLLQ
|     .| ||.| || |.|. .  |.|||||. . | . ...||. ||. .| .| |.|.| .||||   ...     ||| |...  |   ||| ...
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

TRP--LEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR-IQDPQ
 .   .. | .|||.||||||||| |||..|||||||||.|||..| ..|||||..| | | |
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDNQ
Kinase HOG1.AA MAPK-Unclassified 173-302 38 1.3e-53 184.48 In-house 405-575 (575) Show / Hide 
Range on Protein: 173-302
Range on HMM: 405-575/575
Sequence Identity: 38% (65 aa)

MTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEG-----------KPLFPGKD--------------------HVHQFSIITDLLGSPPKDVI
||.||.||.||||||||  . ||  |||||.|||||||.             .|||||.|                    |. |   | | ||.||. ..
MTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEEDC

NTICSENTLKFVTSLPHRDPIPFS-ERFKTVE---------PDAVDLLEKMLVFDPKKRITAADALAHPYS
| | . .. |.. |.    |..|.   | ..          ... |.. |||.|.|.||||| .|| ||| 
NFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase HOG1.AA TyrKc 23-300 22 6.3e-15 18.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-300
Range on HMM: 1-280/280
Sequence Identity: 22% (72 aa)

YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHL--RHENLICLQDIFLSPL------EDIYFVTEL-QGTDLHRLLQT
   .   | |||| |. .| .   ..||.|.. .        .  .||......|  .|.|...|  . ...       | .. |.|.  . ||.  |. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RP--LEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ-MTGYVSTRYYR----------------APEIMLTWQKY
.   |  .   .| .|| .|  | || ..|||||   |.|..||   ||.||||.|  .   ..| .|. |||                ||| .    |.
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF

DVEVDIWSAGCIFAEMIE-GKPLFPG-------KDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFD
  . |.|| |    |.   |..  ||        ..|...    . .  || |    .                       | .  ..  .. ..   .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS----------------------FVCCPDEMYQIMKQCWHED

PKKRITAADALAHP
|..| | ..     
PEDRPTFSEIHECF
Kinase HOG1.AA Pkinase_Tyr 30-167 35 1.9e-13 46.16 Pfam 8-159 (270) Show / Hide 
Range on Protein: 30-167
Range on HMM: 8-159/270
Sequence Identity: 35% (54 aa)

GMGAFGLVCSATDT----LTSQPVAIKKIMKPFSTAVL--AKRTYRELKLLKHL-RHENLICLQDIFLSPLED--IYFVTEL-QGTDLHRLLQTR-----
| |||| |. .| .     | .|||.|.. |. ..      .   ||.|..|.| .|.|...|  . ..  |   || |.|. .. ||.  |...     
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ

PLEKQFVQYFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLAR
||  .    . .|| .|. | .| . |||||   |.|..||   |||||||||
PLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR