Gene IRE1 (Bakers Yeast)

IRE1

Species: Bakers Yeast
Alias: IRE1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IRE1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 307 Kinase domain by global Sugen HMM Fasta, JSON
IRE1.AA Protein Refseq_NP 1115 Involved in myo-inositol biosynthesis; implicated as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus; Ire1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of IRE1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ IRE1.AA PQQ 116-147 21 8.5e-07 29.82 SMART 1-33 (33) Show / Hide 
Range on Protein: 116-147
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

ELSLSD-ILIAADVEGGLHAVDRRNGHIIWSIE
   ..| ...... .| |.|.|...|...|...
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 217-248 18 0.006346 16.96 SMART 1-33 (33) Show / Hide 
Range on Protein: 217-248
Range on HMM: 1-33/33
Sequence Identity: 18% (6 aa)

KIVEDE-KVYTGSMRTIMYTINMLNGEIISAFG
 .| .. .||.|..   .|...  .|...  . 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ IRE1.AA PQQ 317-349 21 0.435646 5.13 SMART 1-33 (33) Show / Hide 
Range on Protein: 317-349
Range on HMM: 1-33/33
Sequence Identity: 21% (7 aa)

NTFSKDGMCIAPFRDKSLLASDLDFRIARWVSP
 . ..||. ..  .| .| | | .    .|  .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase IRE1.AA IRE 677-980 43 8.4e-172 577.04 In-house 1-292 (292) Show / Hide 
Range on Protein: 677-980
Range on HMM: 1-292/292
Sequence Identity: 43% (141 aa)

EKILGYGSSGTVVFQGSFQGRP-VAVKRMLIDFCDIALMEIKLLT--ESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVES---------------
..|||.|..||.||.|...||. ||||.|...|.... .||..|.  |||.|||||||||.|..|.|.|.|||||. .|||.||.               
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--KNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN-LNNPSGTSGW
  ||....|...|.......|..|...|..||||..|.||||||.|||.....   ..|..  ||.|..||||||||.|..|..||..| ...|.||.||
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNR---PNQHG--ENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGW

RAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFG-DKYSRESNIIRGIFSLDEMKCLHDRSLIAEAT
..||.|.|                            |...|.|.|.|||||||||||....|.|||| ||..|..||..|...||..|...... |..|.
HPPEMLQE----------------------------FCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWH-IVIAC

DLISQMIDHDPLKRPTAMKVLRHPLF
|||.|||.|||.||||....|.||.|
DLIHQMIHHDPQKRPTIKECLNHPFF
Pkinase IRE1.AA Pkinase 674-980 22 1.8e-56 198.71 Pfam 1-293 (293) Show / Hide 
Range on Protein: 674-980
Range on HMM: 1-293/293
Sequence Identity: 22% (78 aa)

VVSEKILGYGSSGTVVFQGSFQGRP--VAVKRMLIDFCDIAL-------MEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNL-----NLQDLVE--
 . ....| ||.|.| ...  .| .  ||||..  .  .          .||... .  .|||..|.|.. .... .|. .|.|.       | |...  
YHIGRKIGSGSFGCV-YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-SKNV--SDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSG
 ....  |.. .|          ..||..|....|| .||||||||.|||..      |         .. |.||||.|..|       . .. . ||..
RHGCFYFSEWECKF--------YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------CVKICDFGLAKQFD---Y-NNS-MTTFCGTPW

WRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKC---LHDRSLI-
..|||..                               . .  ....|..|.||..|. |. |. || ..   . | .. .. ... ..     |..   
YMAPEVIR------------------------------GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWC

--------------------AEATDLISQMIDHDPLKRPTAMKVLRHPLF
                     |. |.|. ... || |||||. .| || |
SISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc IRE1.AA S_TKc 674-980 23 5.9e-53 183.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 674-980
Range on HMM: 1-231/231
Sequence Identity: 23% (75 aa)

VVSEKILGYGSSGTVVFQGSFQG--RPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNL---NLQDLVESKNVSDENLKL
    ...| |. | .|...   .  | ||.|..     . .. ||..| .  .|||....| .  .  .||. .|.|.    .| |. ....    . ..
YEILRKIGKGAFG-KVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

QKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQ
  |    ....||.......||..||||||||.|||...               .| |.||||...|           .   ||  ..|||.|       
P-E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------HIKICDFGLARQL-----------TTFCGTPWYMAPEVL-------

CQVETEHSSSRHTVVSSDSFYDPFTKRRLTR-SIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLK
                             .. ..|. | ||..|  |. |. ||   . .  ..|.                  || |.|... . || |
---------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEK

RPTAMKVLR-------HPLF
|||| ..|.       || |
RPTA-EALQDEWDIKCHPWF
Kinase IRE1.AA Ciliate-E2 674-980 19 1.9e-39 133.07 In-house 1-365 (365) Show / Hide 
Range on Protein: 674-980
Range on HMM: 1-365/365
Sequence Identity: 19% (82 aa)

VVSEKILGYGSSG-----TVVFQGS-------------------FQGRPVAVKRM-----LIDFCDIALM----------EIKLLTESDDHPNVIRYY-C
    |..| |. |     .|  ..                    ...  .|.|.|      . .  | .|          . | . |...|||.|..| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

SET-TDRFLYIALELCNL-NLQD-LVESKNVSDENLK---LQKEYNPISLLRQIAS---------------GVAHLHSLK-IIHRDLKPQNILVSTSSRF
 .. .|  .|. .|.|.  .|.| . ..|  ......     .|.  . . .||..               .. .||| . |||||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TADQQTGAENLRILISDFGLCKKLDSGQS-----SFRTNLNNPS-----------------------GTSGWRAPELLEESN---NLQCQVETEHSSSRH
            | |.||||.||.|  .      . . .. . .                       || |  ||| |.  .   .              
------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ--------------

TVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKC--LHDRSLIAEAT-------------DLISQ----MI
            .. . . ..||.|.|...|. |. ||.||      . .|. . ..... ..    .  .| . .             |||..    |.
-----------QKQKGYDYKCDIWSLGVILYEMLF-GKPPF------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRML

DHDPLKRPT-AMKVLRHPLF
. || ||.| . ..| || |
QKDPEKRITGWEQILNHPWF
Kinase IRE1.AA CAMK 679-980 19 2.5e-38 120.61 In-house 1-425 (425) Show / Hide 
Range on Protein: 679-980
Range on HMM: 1-425/425
Sequence Identity: 19% (89 aa)

ILGYGSSGTV--VFQGSFQG-----------RPVAVKRML-----------------IDFC--------------DIALMEIKLLTESD------DHPNV
.|| || |.|  ... . .|           . ||.| .                  ||.               .  . ||...          ||||.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRYYC---------------SETT-----DRFLYIAL---ELCNLN------LQDLVESKNVSDEN----LKLQK----EYNPISLLRQIASGVAHLHSL
|. |                . ..     |...|. .   |.|         .. .|| .. . |.    .  ..    |     . |||.|.|...||.
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

KIIHRDLKPQNILVSTSSR----------FTADQQTGAENLRILISDFGLCKKLDSGQSSF-------------------RTNLNNPSGTSGWRA-PELL
.|.|||||| |||......          |        .|  | |.|||. .|.|.|...|                      .. . || .  | ||.|
NIVHRDLKPENILLDDNNDDSDPVEHDEIF-D-----WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL

EESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDK---------------YSRESNIIRGIFS-LDEMKCL-
. .   . |     . .              .|.  ....|. |.|.. |  |. |. || ..               |    .|..| ..  ...    
NGKGHCNMQ---N-A-T------------DEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPI

----------------HDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF
                |   . .|. |||..|   || ||.|.  .|.|| .
SCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IRE1.AA TKL 680-978 17 9.4e-38 131.75 In-house 1-364 (364) Show / Hide 
Range on Protein: 680-978
Range on HMM: 1-364/364
Sequence Identity: 17% (72 aa)

LGYGSSGTVVFQGSFQG----------RPVAVKRMLI---------------------------DFCDIALMEIKLLTESDD--HPNVIRYYCSETTDRF
.| |..| .|..| ..|          ..||||.. .                           . . .   |.. .       |||..... . .  ..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LYIALELC-NLNLQDLVESKNVSDENLKLQKEYNP--ISLLRQIASGVAHLHSLK--------IIHRDLKPQNILVSTSSR------
             |.|  |.| . .| ...                 .  ... ..||.|...||| .        |||||||..||||    .      
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYM

FTADQQTGAENLRILISDFGLCKKLDSGQSSFRT---------------NLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKR
.       ... .. |.||||.. ..  ... .|               ..... || .| |||.|....|... |                .   . ..
Y-----NPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI--------------DE-FCKGF

RLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHD--RSLIA------------EAT-----DLISQMIDHDPLKRPTAMKVLR
  . ..|..|.| |.. ||.  . |. |  ...  . .  | .. |.. ..  | .|             . .     .|. .  |||| |||.. ..| 
EYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK

HP
. 
RL
Kinase IRE1.AA Ciliate-E2-Unclassified 711-980 18 1.3e-37 128.04 In-house 54-352 (352) Show / Hide 
Range on Protein: 711-980
Range on HMM: 54-352/352
Sequence Identity: 18% (65 aa)

IALMEIK---------LLTE---SDDHPNVIRYYCSETTDRFLYIALELC-NLNLQDLVES------------------KNVSDENLKLQKEYNPI---S
......|         .. .   . .||......  ....  .|| .|.| ...|..  ..                  | ..... |       .    
KEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY------KKAKF

LLRQIASGVAHLHSLK-IIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTN------------LNNPSGTSGWR----APE
...|| .|  .||. . |||||.||.|||.. . .          |..| |.|||..||... . .  ||            ..  .|| .      |||
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----------NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE

LLEE-SNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE-----SNIIRG-----IFSLDEMKC-----
.|..  .. .                               ..||.|.|...|..|  |..||.|. . .     ...| .     ..  . ...     
VLQGQNYDHSKA----------------------------YKCDIWSLGVILYEMLF-GYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFP

-LHD----RSLIAEATDLIS----QMIDHDPLKRPTAMKVLRHPLF
          .  || |.|.    .|.. .| ||.|. ..| ||.|
KFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IRE1.AA STE 675-862 22 7.6e-34 116.93 In-house 1-235 (359) Show / Hide 
Range on Protein: 675-862
Range on HMM: 1-235/359
Sequence Identity: 22% (57 aa)

VSE-KILGYGSSGTVVFQ-----------GSF-----QGRPVAVKRMLIDFCD--------------------IALMEIKLLTESDD-HPNVIRYYCSET
    ...| |..|||.             |       .|. .|.|.| .. |.                      |.|||.. .... |||...||... 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TDR-------FLYIALELCN-LNLQDLVESKNVSDENLKLQK-------EYNPISLLRQIASG-VAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAE
 .         |.|..|...   | |....|    ..|....       |   .  .|||  |  ..|||..|||||.||.|||.               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

NLRILISDFGLCKKLDSGQS------------SFRTNLNNPSGTSGWRAPELLE
   . ..|||.|..|..  .            .   . |   ||  | ||| ..
---VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
Kinase IRE1.AA ULK 674-846 26 4.5e-29 98.68 In-house 1-206 (329) Show / Hide 
Range on Protein: 674-846
Range on HMM: 1-206/329
Sequence Identity: 26% (56 aa)

VVSEKILGYGSSGTVVFQGS---FQ---GRPVAVKRMLID-FCDIA-----------LM-EIKLLTESD-------DHPNVIRYYCSETTD--RFLYIAL
 .  ..|| || | .|..|     .   .  ||.| .... .  .            |. |||.. . .        |||....|    |.    .|| .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCNL-NLQDLVESKNVSDENL---KLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAE---NLRILISDFGLCKKLDSG
|.||  .|... . .. . |.    |   |   |. ..||..|  .||. .|||||.||||||..     | | .   .   | .. |.|||..|..|..
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK---KVHPNGVLKIADFGFAKHVDND

---QSSFRTNL
   |  . | .
NMEQQMMMTCV
Kinase IRE1.AA ULK 674-841 27 6.8e-29 99.69 In-house 1-194 (324) Show / Hide 
Range on Protein: 674-841
Range on HMM: 1-194/324
Sequence Identity: 27% (54 aa)

VVSEKILGYGSSGTVVFQG----SF-QGRPVAVKRMLID-FCDIALM------------EIKLLTESD--DHPN--VIRYY-CSETTD-RFLYIALELCN
 .  ..|| || | .|..|    .  |.  ||.| . .. . .. ..            ||... . .   |||  ....| ..||..  ..|| .|.||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

L-NLQDLVESKNVSDENL---KLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAE---NLRILISDFGLCKKLDSGQSS
  .|... . .. . |     |   |   |. ..||..|  .||. .|||||.||||||..     | | .   .   | .. |.|||..|..|... .
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSK---KVHPNGVLKIADFGFAKHVDNNNME
Kinase IRE1.AA CMGC 674-921 17 7.7e-29 91.15 In-house 1-343 (513) Show / Hide 
Range on Protein: 674-921
Range on HMM: 1-343/513
Sequence Identity: 17% (65 aa)

VVSEKILGYGSSGTVVFQGSF----------------QGRPVAVKRMLIDFCD---------------IALMEIKLLTES----------------DDHP
    | .| |. | ||...                   .. ||.|..  .| .               .|| |||.| .                 ..|.
YEIIKKIGEGTYG-VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHN

NVIRYYCSETTDR-----------------FLYIALELCNLNLQDLVESKN--VSD-ENLKLQKEY-----------NPISLL------RQIASGVA--H
|... | . ...                   ||.  |..  .| .. ....    .  ...|               |  ...      .||  |..  .
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

LHSLK--IIHRDLKPQNILVST---------------SSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR----------------TNLNNPSGTSG
.|| .  ||||||||.|||..                ...        ..| |. | ||||...... .. .                 .  . .   . 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC--------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTR

W-RAPELLEES------NNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSK-------GKHPF
| ||||.|  .      |                            ..  | .||. | ||.|. .. .       ||  |
WYRAPEILLGWKHYTNHN---------------------------YSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLF
Kinase IRE1.AA PEK 741-848 18 7.2e-16 51.04 In-house 358-517 (655) Show / Hide 
Range on Protein: 741-848
Range on HMM: 358-517/655
Sequence Identity: 18% (31 aa)

LYIALELCN-LNLQDLVESKNVSDE---------------------------------------NLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKP
|||  |.|.  .| |. .. . . .                                       |.. . .    ...|||..|....||  .|||||||
LYIQMEYCEKKTLRDWIDNNG-C-PVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKP

QNILVSTSSR--FTADQQTGAENLRILISDFGLCKK----------------------LDSGQSSFRTNLNN
.||... ...  .          . . | ||||...                      ..... . .|| .|
SNIFLDCDGQHHQ----------MQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQN
Kinase IRE1.AA TyrKc 674-979 20 1.1e-10 -49.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 674-979
Range on HMM: 1-280/280
Sequence Identity: 20% (68 aa)

VVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALM-EIKLLTES-DDHPNVIRYYCSETTD-------RFLYIALELCNL-NLQDLVESKNVSD
.. .|.|| |  | .|..|    ..|||| .  |    ..| |......   .|||..| |   |..         |.| .|.. . .|.|   ..    
ITLGKKLGEGAFG-EVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

ENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSG-QSSFRTNLNNPSGTSGWR------
 . .|      .|   |||.| ..||| ..|||||   |.||.                .. ||||||....... |.  ..    .....| .      
CMKDL------LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

--APELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGD-----KYSRESNIIRGIFSLDEMKCLHD---
  ||| .                        .. . . .        |..| | . . |.. |. |  .     .  .|  .|. . . . |.. ..   
WMAPECI-----------------------NYGKFTTKS--------DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE--VIEYVKQGYRMPQPPNDYP

----RSLIAEATDLISQMIDHDPLKRPTAMKVLRHPL
    .   .  . ...|  ..|| .||| .. ... .
MSFVCCPDEMYQ-IMKQCWHEDPEDRPT-FSEIHECF
Kinase IRE1.AA PEK 952-980 41 5.8e-10 30.1 In-house 627-655 (655) Show / Hide 
Range on Protein: 952-980
Range on HMM: 627-655/655
Sequence Identity: 41% (12 aa)

EATDLISQMIDHDPLKRPTAMKVLRHPLF
.. |.|..|..||| .||.|.  | |..|
KQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase IRE1.AA Pkinase_Tyr 674-835 25 8.3e-10 33.83 Pfam 1-161 (270) Show / Hide 
Range on Protein: 674-835
Range on HMM: 1-161/270
Sequence Identity: 25% (46 aa)

VVSEKILGYGSSGTVVFQGSFQ------GRPVAVKRMLIDFCDIA------LMEIKLLTESDDHPNVIRYY--CSETTDR-FLYIALELCNL-NLQDLVE
..  | || |. | .|..|         . ||||| .  .  . .      . |.|....  .|||..|.|  |..  .   .|| .|.. . .| |   
ITFGKKLGEGAFG-EVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKL
..    |. .  .    ..  .|||.| ..|.| ..|||||   |.||.              |. . |.||||.. .
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------------NNVVKICDFGLARDI
Kinase IRE1.AA CMGC 952-980 48 8.5e-08 20.72 In-house 485-513 (513) Show / Hide 
Range on Protein: 952-980
Range on HMM: 485-513/513
Sequence Identity: 48% (14 aa)

EATDLISQMIDHDPLKRPTAMKVLRHPLF
.| ||...|   || ||.||   |.|| |
QAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase IRE1.AA STE 952-980 41 4.5e-05 14.01 In-house 329-359 (359) Show / Hide 
Range on Protein: 952-980
Range on HMM: 329-359/359
Sequence Identity: 41% (13 aa)

EATDLISQMIDHDPLKRPTAMKVLR--HPLF
|  | |..  . || ||||| . |.  || .
EFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IRE1.AA ULK 902-980 25 0.001596 8.44 In-house 234-324 (324) Show / Hide 
Range on Protein: 902-980
Range on HMM: 234-324/324
Sequence Identity: 25% (24 aa)

DIFSMGCVFYYILSKGKHPFGDKYSRESN--IIRGIFS------LDEMKCLHDR------SLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF
||.|.||.||..|  || ||     .. .  |.. |        . . . .  .       .  |  |||..|.  |. .| .   .. ||.|
DIWSLGCIFYEMLY-GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase IRE1.AA ULK 902-914 61 0.055625 2.81 In-house 238-250 (329) Show / Hide 
Range on Protein: 902-914
Range on HMM: 238-250/329
Sequence Identity: 61% (8 aa)

DIFSMGCVFYYIL
||.|.||.||..|
DIWSLGCIFYEML
Kinase IRE1.AA PEK 724-734 45 0.088116 1.1 In-house 72-82 (655) Show / Hide 
Range on Protein: 724-734
Range on HMM: 72-82/655
Sequence Identity: 45% (5 aa)

DHPNVIRYYCS
.|||..||...
NHPNIVRYHNA
Ribonuc_2-5A IRE1.AA Ribonuc_2-5A 985-1115 43 8.8e-69 239.62 Pfam 1-137 (137) Show / Hide 
Range on Protein: 985-1115
Range on HMM: 1-137/137
Sequence Identity: 43% (60 aa)

KKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERY-RK---YHSSKLMDLLRALRNKYHHFMDL-PEDIAELMGPVPDG
|.|.|| .||||.|||.||||| .|. ....|  |. .|||. |.||.|||.. .| ||   |......|||||.|||.||.... ||.. |..|..|||
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FYDYFTKRFPNLLIGVYMIVKE-NLSDDQILREFLYS
|. |||.|||.||...|....| .... ...... ..
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG IRE1.AA PUG 1046-1100 37 4.8e-24 87.12 SMART 1-66 (66) Show / Hide 
Range on Protein: 1046-1100
Range on HMM: 1-66/66
Sequence Identity: 37% (25 aa)

SKLMDLLRALRNKYHHFMDL--------PEDIAELMGPVPDGFYDYFTKRFPNLLI---GVYMIVK
....||||..||.|||....        .... |.||.||.||. |||..||.|.|    .|...|
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK