Gene MEK1 (Bakers Yeast)

MEK1

Species: Bakers Yeast
Alias: MEK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CAMK
Family: CAMK-Unique

Sequence

Name Sequence Type Origin Length Description Download
MEK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
MEK1.AA Protein Refseq_NP 497 `Disp. for chr. pairing & chr. condensation seen by in situ hybrid. Required for full double strand breaks, normal length synaptonemal complexes, meiotic recomb. & spore viability. mek1 is rescued by spo13 & in early recomb. function; Mek1p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of MEK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA MEK1.AA FHA 47-119 30 4.3e-21 81.18 Pfam 1-73 (73) Show / Hide 
Range on Protein: 47-119
Range on HMM: 1-73/73
Sequence Identity: 30% (24 aa)

VKVGRNDKECQLVLT-NPS-ISSVHCVFWCVFFDEDSIPMFYVKD--CSLNGTYL--NGLLLKRDKTYLLKHCDVIELS
...||. ..| .||  .|| .| .||.. . ..|..    .|..|  || |||..  ||  ....... |.| |.| . 
WTIGRD-PDCDIVLDNDPSFVSRHHCEI-R-RYDNG---RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA MEK1.AA FHA 46-102 33 1.6e-14 55.49 SMART 1-49 (49) Show / Hide 
Range on Protein: 46-102
Range on HMM: 1-49/49
Sequence Identity: 33% (20 aa)

LVKVGRNDKECQLVLTNPSISSVHCVFWCVFFDEDSIPMFYVKDCS---LNGTYLNGLLL
 ...||.   |...|..|||| .||...    |.|     |..|..    ||||.||  .
TWTIGRHS--CDIQLPHPSISRHHCQIR----DGD-----YIIDLGEHSTNGTYVNGRRV
Kinase MEK1.AA CAMK-Unique 162-444 30 7e-155 514.88 In-house 1-363 (363) Show / Hide 
Range on Protein: 162-444
Range on HMM: 1-363/363
Sequence Identity: 30% (112 aa)

EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKP----------------NKFDKEARILLRLDHPNIIKVYHT----FCDRNN------
....||.|.|.||||.............|...........|.|.                .|...|..|....|||||||.|..    ||||..      
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------HLYIFQDLIPGGDLFSYLAKG-----------------DCLTSMSE--TESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEP-----
        ..||......|||||....|.                 .| ...||  .....|....|.|..|.|.||||||||||.||..|....     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------CTRIVLADFGIAKDLNSNKER--MHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKC----DLWSLGVITHIMLTGISPFYGDG
        ...|.|.|||.....|.||..  |.|..|||.|.|||..|..|   ||...|........||..|    |.||||||...||.|..||....
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKN---YQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

SER-------SIIQNAKIGKL-NFKLKQWDI---VSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI
..|       .|......|.. ||. |.|..   .|..||.|||.....|...|...|..|.|.||
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase MEK1.AA CAMK 167-444 23 1.9e-94 304.76 In-house 1-425 (425) Show / Hide 
Range on Protein: 167-444
Range on HMM: 1-425/425
Sequence Identity: 23% (105 aa)

IVGNGTFGHVLITHNSKERDEDVCYHPEN---------------YAVKIIKLK--------------------------------PNKFDKEARILLR--
. | |.|| |             |.| ..               .|.|||. |                                  .. .| .|. .  
TLGRGSFGKVK-----------LCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQ

-----LDHPNIIKVYHTFCDRNN------------------HLYIFQ---DLIPGG----DLFSYLAKGDCL------------TSMSETESLLIVFQIL
     |||||||| |... |...                  |.|..    ....||    |||.|. .  |               ..| |   .. ||.
GIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQIC

QALNYLHDQDIVHRDLKLDNILLCTPEPCT--------------RIVLADFGIAKDLNSNK-----------------------ERMHTVVGTPEYCA-P
.|..|.|...|||||||..||||.. .. .               | ..||| |. .....                       . |.|..|||||.| |
SAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAP

EVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDG------------SERSIIQNAKIGKLNFKLKQ------------WDIV
||  .  ....|  . |   |...|. ||| ||.|||. |||.| .|||||             ... . .. . || .|  ..            || .
EVLNGKGHCNMQ--N-ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDI

SDN--------AKSFVKDLLQTDVVKRLNSKQGLKHIWI
||.        .|.... .||.|  ||.. .| |.| |.
SDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MEK1.AA Pkinase 162-444 30 3.9e-94 323.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 162-444
Range on HMM: 1-293/293
Sequence Identity: 30% (98 aa)

EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDK--------EARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGG----DL
  . |..| |.|| | . |. ....         .||||||.. .| .|        |..|..||.||||.. |..| | ..|.|. ... .||    ||
YHIGRKIGSGSFGCVYKCHHKGTGK--------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDL

FSYLA--KGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLC-TPEPCTRIVLADFGIAKDL-NSNKERMHTVVGTPEYCAPEVGFRANR
|.|.   .. |.. .|| |   .. |||..|.|.|.. |.|||||..|||.  ........ ..|||.|| . . |.. |.|..|||.|.||||      
FDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------

KAYQSFSRAATLE-QRGYDSKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQWDIVS-----------------DNAKSFVK
           .  ...|..|.| ||.|.| ..||.|  ||.|.      ... .|.. . ..| |   .|. .|                 ...|.|.|
-----------IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

DLLQTDVVKRLNSKQGLKHIWI
..|. |  ||.. .| |.| |.
WCLCKDPKKRPTAEQILQHPWF
Kinase MEK1.AA S_TKc 162-444 30 5.5e-84 286.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 162-444
Range on HMM: 1-231/231
Sequence Identity: 30% (91 aa)

EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPG--GDLFSYLAKGDCL
    |..| |.|| |   .. |          . .|.||||   ... .| .|| . .||||.| | .| |  .|||.. ....|  ||||.|. |  . 
YEILRKIGKGAFGKVYKCRHKK--------TGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

TS---MSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAAT
     ..| .   .. ||..||.|.|.. |.||||| .||||..     .| ..|||.|. |       .|..|||.|.||||                 
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------TTFCGTPWYMAPEVL----------------

LEQRGYDS-KCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLK-------HIWI
    ||.  ||| ||.|.|  .||.|  ||.    .  .... .              |. ||.|.. .|| |  ||.   . |.       | |.
----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEK1.AA Ciliate-E2 162-444 26 2.9e-67 229.76 In-house 1-365 (365) Show / Hide 
Range on Protein: 162-444
Range on HMM: 1-365/365
Sequence Identity: 26% (103 aa)

EITNRIVGNGTFG-----HVLITHN---SKERDEDVCYHPE---------NYAVKIIKLKPNKFDKEARILL-----------------RLDHPNIIKVY
 . ... |.|.||      |  . .    |  | .    .           ||.||.| .  .. |    ..                 .|.|||||| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

HTFCD-RNNHLYIFQDLIPGGDLFSYLA-----KGDCLT---SMSETESLLIVFQILQ---------------ALNYLHDQD-IVHRDLKLDNILLCTPE
 .| .  .|..|.  ... |||||.|.      .. ...   ...| | . |  ||||               ||.||| .  |.|||.|..|||.    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

PCTRIVLADFGIAKDLNSN----------K---------------------ERMHTVVGTPEYCAPEVGFRANRKAY--QSFSRAATLEQRGYDSKCDLW
    | ..|||..|... .          |                     .  .|..|||.| |||.    |.| |  |        .| ||| |||.|
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI---LNGKKYDNQ-------QKQKGYDYKCDIW

SLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLK--------------QWDIVSDNAKSFVKD----LLQTDVVKRLN-SKQGLKHIWI
||||| ..||.|  ||         .|. | .|..|  .               |. .|...| . |     .|| |  ||..  .| |.| |.
SLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MEK1.AA RSK 196-444 30 1.2e-64 221.13 In-house 27-278 (278) Show / Hide 
Range on Protein: 196-444
Range on HMM: 27-278/278
Sequence Identity: 30% (84 aa)

YAVKIIKL---KPNKFD-----KEARILLRLD-HPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDI
||.|..|    .... |     .| .||.|   ||.|.. ...| . . .||.  ....||.||  | |  ..  .||.|   .  .|  |. .||.|.|
YAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQT-EGKLYLIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGI

VHRDLKLDNILLCTPEPC-TRIVLADFGIAKD-LNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSRAATLE----QRGYDSKCDLWSLGVITHIMLT
.|||||..|||.   .    .|.| ||| .|   ........| ..| ||.|||.                 |     |.|.|  ||.|||||. . |||
IHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEM-----------------LKRANQQGGHDKACDWWSLGVLMYEMLT

GISPFYG--DGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLN-----SKQGLKHIWI
| .||.|  | .   |... . ||...... |. .|..||.... .|. |  |||.      .. ..| |.
GCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase MEK1.AA RAD53 196-444 28 3.5e-59 174.69 In-house 27-305 (305) Show / Hide 
Range on Protein: 196-444
Range on HMM: 27-305/305
Sequence Identity: 28% (84 aa)

YAVKIIKL------------KPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLA-KGDCLTSMSETESLLIVFQILQALNYLH
.|.|||..            |.  . .|..|| .| ||.||. |  | .    .|.   |. ||.||. ..  . |    .| .. .. .|.. |..|||
VAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNKRCQMGFDEDTCKYYFYQMCDAVKYLH

DQDIVHRDLKLDNILLCTPE-PC--------------TRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGF-------------RANRKAYQSFSRA
|. |.||||| .|||. ... .|                | ..||| .| . .... | |  ||| |.||||                 .          
DNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFV-GEGSFMKTMCGTPQYVAPEVITSKGHNCYHENEERQVQ----------

ATLEQRGYDSKCDLWSLGVITHIMLTGISPFY-GDG---SERSIIQNAKI-GKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI
      || .|.|.||.|.|. |.|.|  ||  ...   ..... .  |  ||..|  ..|| .|..||...| .|. |. ||.. .. | | |.
-----VGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNHPWM
Kinase MEK1.AA RSK 161-444 32 8.7e-54 185.01 In-house 1-271 (271) Show / Hide 
Range on Protein: 161-444
Range on HMM: 1-271/271
Sequence Identity: 32% (98 aa)

WEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFD-----KEARILLRL-DHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLA
 |.   | |.|.|. | . .  . .| .       ||.|||| . ..       .| ||.||  .||.|.| .  | .   ..|.  |.  |||||  | 
YELHECI-GQGSFSKVYVCKKCQHKDTN-----QHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVF-QDEGKVYMIMDFMRGGDLFDRLL

KGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTP-EPCTRIVLADFGIAKDLNSNKERMHTVVGTPEYCAPEVGFRANRKAYQSFSR
|  ..   || |   . . |. |..||| |.||||||| .|||.         | ..||| || | .  .   |  .| .| ||||              
KQKMF---SEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEV--------------

AATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERS--IIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNS-----KQGLKHIWI
   | ..|.|  || ||.||. ..||||  ||..   ..   |||..| |.. .    || .|| ||. .  .|  |  .|| .     .| ..| |.
---LKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase MEK1.AA CAMKL 161-339 27 2.2e-46 145.94 In-house 1-204 (297) Show / Hide 
Range on Protein: 161-339
Range on HMM: 1-204/297
Sequence Identity: 27% (60 aa)

WEITNRIVGNGTFGHVLITHNSKERDEDVCYH----PENYAVKIIK-----LKPNKFDK--------------EARILLRLD---HPNIIKVYHTFCDRN
..|     | |.|| |             . |     | .|.|||.     ..|.. ..              |..|. .|.   |||||| |... ...
YRIGK-TLGKGSFGKVK-----------LATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPE

N-----HLYIFQDLIPGGD--LFSYL-AKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIA---KDL-NSNK
.     ..|..  ...||.  || |. ..|..  .|.| |   .  ||. |.||.|...|||||.|..||||     .  | ..||| .   ..  . . 
HDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPG

ERMHTVVGTPEYCAPEV
. ..|  |.|.|.|||.
QKLKTFCGSPPYMAPEI
Kinase MEK1.AA CAMK1 161-339 31 1e-45 130.81 In-house 1-184 (276) Show / Hide 
Range on Protein: 161-339
Range on HMM: 1-184/276
Sequence Identity: 31% (62 aa)

WEITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK----LKP------NKFDKEARILL---RLDHPNIIKVYHTFCDRNNHLYIFQDLIPGG
 |....| |.|.|. |    . .          ..||.|.|.    .|       .....|  |.    ..||||||| |  . . .||.|. ..|. ||
YEFGKEI-GRGAFSEVYLCTHKETQ----T-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWY-ESDNHFYLVMELVTGG

DLFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIV--LADFGIAKDLNSNKERMHTVVGTPEYCAPEV
.||    . .   . .| .  .|. |||.|..|.|...|||||||  |.|. ....   |.  .||||..| .... . | |..|||.|.||||
ELFDRIVEKG---NYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEV
Kinase MEK1.AA Ciliate-E2a 163-339 31 1.9e-40 116.76 In-house 2-181 (275) Show / Hide 
Range on Protein: 163-339
Range on HMM: 2-181/275
Sequence Identity: 31% (57 aa)

ITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIKLKPNKFDKEARILLRLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSM
 .... |.|.||.| .    .. .. .    .. .  ..| .  .| .|  |. .|||||||| | .. | .|..|.  ... ||.|.... . ..... 
KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYED-ENNYYLVMEYCEGGELYDKIKQCKRFFEE

SETESLLIVFQIL-QALNYLHDQDIVHRDLKLDNILL--CTPE--PCTRIVLADFGIAKDLNSN-KERMHTVVGTPEYCAPEV
 . |   |  |.| |.|.|.| . |.|||||..|||.  | ..  . . |...||| |.. ... |..|.. .||| | ||||
-IQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEV
Kinase MEK1.AA CDPK 162-339 35 3.3e-38 114.92 In-house 1-185 (271) Show / Hide 
Range on Protein: 162-339
Range on HMM: 1-185/271
Sequence Identity: 35% (70 aa)

EITNRIVGNGTFGHV-LITHN---SKERDEDVCYHPENYAVKII---KLKPNK----FDKEARILLRLDHPNIIKVYHTFCDRNNHLYIF--QDLIPGGD
 . ... | |.|| | ...|    . ||           |.|||   ..| ..    | .|  ||  ||||||||.| .. |..|. ||     .  ||.
YKIKKVLGKGHFGQVRKVKHKQKTNQER----------VAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNY-YIVMETEYCTGGE

LFSYLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCT----RIVLADFGIAKDLNSN----KERMHTVVGTPEYCAPEV
|| | .   ..|   |.|. .|. |||.|.|| |.. |||||||  |||... .. .     |.. |.|..|. ..|    .. | . .||| | ||||
LFDYIIEKGHFT---EKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEV
Kinase MEK1.AA CAMK1 357-444 40 2.1e-32 91.48 In-house 185-276 (276) Show / Hide 
Range on Protein: 357-444
Range on HMM: 185-276/276
Sequence Identity: 40% (37 aa)

LEQ---RGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDN-AKSFVKDLLQTDVVKRLNSKQGLKHIWI
||.    .|| .||.|| |||| |.|.| .|||..  .  . .  | ....|  ..|| .||  || |.| .|  |  ||.. .| |.| ||
LECKKDKPYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase MEK1.AA CDPK 357-444 40 5.1e-30 89.44 In-house 186-271 (271) Show / Hide 
Range on Protein: 357-444
Range on HMM: 186-271/271
Sequence Identity: 40% (36 aa)

LEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI
|... |. |||.||.|||  |.| |  ||||. ..  |... | || .|. ..||..||.||  .. .|..|  ||. . | |.| |.
LQKK-YNEKCDIWSCGVILYILLCGYPPFYGK-NDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase MEK1.AA Ciliate-E2a 357-444 38 7.5e-26 73.1 In-house 188-275 (275) Show / Hide 
Range on Protein: 357-444
Range on HMM: 188-275/275
Sequence Identity: 38% (34 aa)

LEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSERSIIQNAKIGKLNFKLKQ-WDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI
|... || |||.||.||| .|.|.| .||.|  ... |.|. |  |..|  .. |  .|...| ..| .|. |  ||.. .| |.| | 
LKHKQYDTKCDMWSCGVIFYILLCGKPPFKGK-TYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase MEK1.AA CAMKL 359-444 29 8.6e-14 40.24 In-house 209-297 (297) Show / Hide 
Range on Protein: 359-444
Range on HMM: 209-297/297
Sequence Identity: 29% (27 aa)

QRGYD-SKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWI
.. ||  | | ||.|||   |..|  || .|     | .       || .. ..   |  ||  .... . .||..  || . .| ..| | 
NKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase MEK1.AA TyrKc 162-442 20 8.7e-14 0.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 162-442
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

EITNRIVGNGTFGHVLITHNSKERDEDVCYHPENYAVKIIK--LKPNKFDKEARILLRL--DHPNIIKVYHTFCDRN------NHLYIFQDLIPGGDLFS
   ... |.| || |   . .           .. ||| .|       | .||||. .|  .||||.. |    .          |.|   . |.||| .
ITLGKKLGEGAFGEVYKGTWK-----------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLAKGDCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSN-----KERMHTV---VGTPE-----YCAPE
|| |       .  . | . .|| .  .|||.. ..||||   |.|.  .    ..  .||| ..|. .       . . ..    |.        .|||
YLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGD-----GSERSIIQNAKIGKLNFKLKQ--WDI----VSDNAKSFVKDLLQT
.                 .  . . .| | || ||    ..|   . | .      | . .|.. | |.   . .     .     .|   .  |.  . 
C-----------------INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHE

DVVKRLNSKQGLKHI
|  .| . ..  . .
DPEDRPTFSEIHECF
Kinase MEK1.AA Pkinase_Tyr 210-327 29 7.5e-12 40.77 Pfam 52-172 (270) Show / Hide 
Range on Protein: 210-327
Range on HMM: 52-172/270
Sequence Identity: 29% (37 aa)

KEARILLRL-DHPNIIKVYHTFCDRNNH--LYIFQDLIPGGDLFSYLAKG-DCLTSMSETESLLIVFQILQALNYLHDQDIVHRDLKLDNILLCTPEPCT
.||.|.  | .||||.. |    |.  .  .||   . |.||| .|| |  .   . .  . | . .|| ....||... ..||||   |.|.    .  
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE--NN-

RIVLADFGIAKDL-NSNKE-RMHT
 .  .||| |.|. |     |...
VVKICDFGLARDIYNDDYYYRKRG