Gene MPS1 (Bakers Yeast)

MPS1

Species: Bakers Yeast
Alias: MPS1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: Other
Family: TTK

Sequence

Name Sequence Type Origin Length Description Download
MPS1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 277 Kinase domain by global Sugen HMM Fasta, JSON
MPS1.AA Protein Refseq_NP 764 Required for spindle pole body duplication and a mitotic checkpoint function.; Mps1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of MPS1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MPS1.AA TTK 440-716 40 1.9e-210 702.97 In-house 1-344 (344) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-344/344
Sequence Identity: 40% (141 aa)

YEKIELLGRGGSSRVYKVKGS-GNRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQK-RVIQLLDYEMG--DGLLYLIMECGDHDLSQILNQRSG-MP
|..|...|.||||.|..|... ....||||.|..|..|...|.|...|||.|.||..|| ..|||.||||.  ....|..|||||.||...|..... |.
YSIIKQIGCGGSSKVFQVLSEDSKKIYALKYVCLDFADPQTIQGYMNEIEMLNKLQQQKDCIIQLYDYEMTMEEQYIYMVMECGDCDLNKWLQKYKTPMN

LDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANAVPE-HTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHE--------
|...|...|...||.|..|.|..|||||||||||||.|.|.||.||||||||... .|.||..|.||||.|||.|||...|.|.......|.        
LNPWFMWCYWQQMLQCVHVIHQHGIVHSDLKPANFVMVQGMLKLIDFGIANAIQNDDTTNIVKESQIGTFNYMSPEAIQDMSYGNENMCMHHKKPRLKIN

------------------GNK----------------------------------WKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQN-RLLAIMNPDVK
                  ..|                                  ||....||.||||||.|.|||||.|....|.|. ...||.||..|
CKSDVWSLGCILYSMVYGRTKFQHIVHRLLKMQAICNPDHFIDFQPIENELLLDVWKISCKSDVWSCGCILYYMIYGKTPFQHIQNQYSKMHAICNPHHK

IPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFL
|.||||....|||.|..|..||.||||||.|||.....|...|.
IEFPEHPPYYEKINKMLIHVMKCCLYRNPKKRWSIPELLNHPFH
Kinase MPS1.AA S_TKc 440-716 25 1e-75 258.77 SMART 1-231 (231) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-231/231
Sequence Identity: 25% (75 aa)

YEKIELLGRGGSSRVYKVKGSG-NRVYALKRVSFDAFDDSSIDGFKGEIELLEKLKDQKRVIQLLDYEMGDGLLYLIMECGDH---DLSQILNQRSG---
||.....|.|. ..|||..  . .|..|.|...         . .. ||..|.|  . . ...|.|.    . ||..||. |.   || ... .| .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

-MPLDFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKV
  |..   .|||...... ..  |. ||.| ||||.|  | .  .||.|||.|  .          |..|||.||||| |                  . 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL---------TTFCGTPWYMAPEVL------------------GY

GR-PSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLS-------STFL
|. ..|.||||||.| |..|.||.     ..... ..                  ...|..... || ..|.||.|. ..|          ..
GKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MPS1.AA Pkinase 440-716 24 1.6e-53 188.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

YEKIELLGRGGSSRVYKVKGSGNRV-YALKRVSFDAFDDSSIDGFKG--EIELLEKLKDQKRVIQLLDYEMGDGLLYLIMECGDH-----DLSQILNQRS
|.... .|.|....||| .  |..  .|.|... .  ...         ||... .| . . ...|.|. . .. .|..||. ..     ||. ..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GMPL--DFNFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLV-KGIL----KIIDFGIANAVPEHTVNIYRETQIGTPNYMAPEALVAMNYTQNSENQH
. ..  . . ..|| ...|  ..  |. ||.| ||||.|. .. .| .    ||.|||.|  .  .  |    |  |||.||||| .             
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR------------

EGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSF------QGQNRLLAIMNPDVKIPFPEHTS--------------NNEKIPKSAIELMKACLYRNPDKR
     . |...||||||||.|.|. |.||. .         . ..  || |... ..|.  |              .  ..........| || ..| ||
--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKR

WTVDKVLSSTFL
.| . .| . ..
PTAEQILQHPWF
Kinase MPS1.AA AGC 440-716 19 1.1e-45 114.89 In-house 1-395 (395) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-395/395
Sequence Identity: 19% (81 aa)

YEKIELLGRGGSSRVYKVKG-------SGNRVYALKRVSFDA--------FDDSSIDG--------FKGEIELLEKLKD---------QKRVIQ-LLDYE
.| . ..|.|. ..|| |.        . ...||.| .. .           .  .          .. | . |||..             ... |    
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

MGDGL--LYLIME-----------CGDHDLSQILNQR-SGMPLDFNFVRFYTKE-------MLLCIKVVHD-AGIVHSD-LKPANFVLVK-GILKIIDFG
  .    ||..||           .|. .| ..|  |     .| . .|||. |       ..|..   |.  ||.| | ||| | .| . | .|. |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

IANAVPEHTVN------------------------------------------------IYRETQIG--TPNYMAPEALVAMNYTQNSENQHEGNKWKVG
 .  ..    .                                                    |  |  ||.||||| |                    |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------------------YG

RPSDMWS--CGCIIYQMIYGKPPYGSFQGQ----------NRLLAIM------NPDVKIPFPE--HTSNNEKIPKSAIELMKACLYRNPDKRWT------
.. | ||   ||..|.|..|.||. . . |               ||      | .||.||||  ..  .... . |  |.| .| ..|.|| .      
KACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDF

----VDKVLSSTFL
    .. . .  . 
GDKGAEEIKNHPWF
Kinase MPS1.AA Ciliate-E2 440-716 18 2.7e-44 149.97 In-house 1-365 (365) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-365/365
Sequence Identity: 18% (73 aa)

YEKIELLGRGGSSRVYKV--KGSGNRV-----------------YALKRVSFDAFDDSSIDGFKGEIELLEKLK---------------DQKRVIQLLDY
|..|...|.|. . |||.  .  ....                 .. | .    .  . |  .| || .. ...               . . .|.. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

EM--GDGLLYLIME-CGDHDLSQILNQRSGM---------PLDFNFVRFYTKEMLL---------------CIKVVHDAG-IVHSDLKPANFVLVKGILK
     |  .||.|| |   || .......           ... . .....|. |                ...  |  . |.| |.|| | ..    .|
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IK

IIDFGIA----------------NAVPEHTVNIYRETQ--------------IGTPNYMAPEALVAMNYTQNSENQHEGNKWK-VGRPSDMWSCGCIIYQ
|||||..                .  ..  ....| .               .|||.||||| |   .|. .       .| |  .  .|.||.|.|.|.
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-------QKQKGYDYKCDIWSLGVILYE

MIYGKPPYGSFQGQNRLLAIMNPDVKIPFPEHTSN----------NEKIPKSAIELMKA----CLYRNPDKRWT-VDKVLSSTFL
|..||||.        .  |.. ....|.|| ...          ..|...... |.|     .| ..|.|| |  ...|   ..
MLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase MPS1.AA CMGC 440-652 20 1.7e-40 130.21 In-house 1-341 (513) Show / Hide 
Range on Protein: 440-652
Range on HMM: 1-341/513
Sequence Identity: 20% (71 aa)

YEKIELLGRGGSSRVYKVKG---------------SGNRVYALKRVS-FDAFDDSSI-----DGFK----GEIELLEKLK----------------DQKR
||.|. .|.|  . ||| .                 .|...|.|...    ...        |||.     ||..|..|.                . . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIQLLDYEMGDG-----------------LLYLIMECGDHDLSQILNQRS-------GMPLDFNF------------VRFYT------KEMLLCIK--VV
...|.|. . ..                  |||..|. |||| |.. . .       .|||.               .....      . .| ..|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HDAG--IVHSDLKPANFVLVK---------------------GILKIIDFGIANAVPEHTVNIY-------------------RETQIGTPNYMAPEALV
| ..  |.| ||||.|  . .                     |.|||.||| | .. .|  ..                      ... |  | ||| |.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

-AMNYTQNSENQHEGNKWKV-----GRPSDMWSCGCIIYQMIYG--------KP
 . .||..                 . | ||||.|||.. |. |        ||
GWKHYTNH-----------NYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKP
Kinase MPS1.AA STE 440-716 19 4.2e-40 139.3 In-house 1-359 (359) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-359/359
Sequence Identity: 19% (74 aa)

YEKIELLGRGGSSRVYKV----KG---SGNRV---------YALKRVSFDAFD---------------DSSIDGFKGEIELLEKLKD-QKRVIQLLDYEM
.|.|| .|.|..  |||     ..   . ..|         .| |.....  .               .. .. .. ||... |...  . ... .....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GDG-------LLYLIMECGDH-DLSQILNQ--RSGMPLD----------FNFVRFYTKEMLLC-IKVVHDAGIVHSDLKPANFVLVKGILKIIDFGIANA
 .|        |...||  |   |..|...    |.||.           . ....... |    .  |. .|.| |.||||  |     |..|||..  
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----VKLCDFGVCGQ

VPEH--------------TVNIYRETQIGTPNYMAPEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLLAIMNP---
. ..              |    | | .||| .|||| .  .. . .        . . .. .|.|| || |  |. ||||.  ..    ...|..    
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R--------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHM

-----------DVKIPFPEHTSNN-------------EKIPKSAIELMKACLYRNPDKRWTVDKVLS--STFL
           .   |.|.|.|.|             .|  .. .. .. || ..|.||.|... |.    |.
QQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MPS1.AA CAMK 445-716 18 1.8e-39 124.38 In-house 1-425 (425) Show / Hide 
Range on Protein: 445-716
Range on HMM: 1-425/425
Sequence Identity: 18% (79 aa)

LLGRGGSSRVYKVKGS-GN------------RVYALKRVSFDAFD--------------------------DSSIDGFKGEIELLEKLK------DQKRV
 ||||. . |....    .            . .| | .. .  .                          ... . .. |||.. ||.      | . .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLLD-YE------------MGDG-------LLYLIM---ECGDHD------LSQILNQRSG------------MPLDFNFVRFYTKEMLLCIKVVHDAG
|.|.. ||              .         .|..|   |  .        .. |  ....              ..   .|.| . ..  ..  |. .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHSDLKPANFVLVK------------------GILKIIDFGIANAVPEHTVNI---------------------YRETQIGTPNYMA-PEALVA-----
||| |||| |  |..                  . .|||||| || ...   |                        .|. ||| ||| || |       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

MNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRLL-------------AIMNPDVKIPFPE--HTS---------------NNE
|   . .     ..|  .|...||||||.| | |  |.||. .  ... .               ||. .   | |.  ..|                . 
MQ--N-A-T--DEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-

KIPKSAIELMKACLYRNPDKRWTVDKVLSSTFL
.. .... | . .| ..|.||.|.. .|.  ..
FVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase MPS1.AA Ciliate-E2-Unclassified 440-716 19 3.8e-38 129.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 440-716
Range on HMM: 1-352/352
Sequence Identity: 19% (71 aa)

YEKIELLGRGGSSRVYKV--KGSGNRVYALKRVS-FDAFDDSSIDGFKGEIELLEKLKDQKR----------------------VIQLLDYEMGDGLLYL
|..|. .|.|| . |||.  |  .  .||.|  . .  ... .|   . || . .|   .|                       .. .....  .  .|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

IMECGDH-DLSQILNQRSG---------------MPLDFNFVR-----FYTKEMLLCIKVVHDAG-IVHSDLKPANFVLVKG----ILKIIDFGIAN---
.||  .. ||.|....|..                 .. . ..     ||... |....  |  . |.| |.|| | .. ..     .|||||||.    
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

AVPEHTVN-----------IYRETQIGTPNYM----APEALVAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQN---------
  .. . .               |..||||||    ||| |   || . .              .|.||.|.|.|.|..|..|... .            
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-----------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI

---RLLAIMNPDVKIPFPEHTSNN----EKIPKSAIELMK----ACLYRNPDKRWTVDKVLSSTFL
   . . . .   . ..    ...     .....|... .     .|  ||.|| | ...|   ..
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase MPS1.AA TKL 555-714 17 2.4e-23 80.93 In-house 149-364 (364) Show / Hide 
Range on Protein: 555-714
Range on HMM: 149-364/364
Sequence Identity: 17% (39 aa)

HDAG--------IVHSDLKPANFVLVKGI---------------LKIIDFGIANAVPEHTVNIY-----------------RETQIGTPNYMAPEALVAM
|  .        |.| |||..|  . .                 .|| |||..  . ... .                   . ||.|||..||||.|  .
HSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQ

NYTQNSE--NQHEGNKWKVGRPSDMWSCGCIIYQMIYGKPPYGSFQGQNRL---------LAIMNPDVKIPFPEHTSN------NEKIPKSAIELMKACL
.....     . . ....    .|..| | ... .. ...||  .    ..           . .   . | |.. .|      .. .|.| ..||. | 
MNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCW

YRNPDKRWTVDKVLSST
  .|.|| . ...|.  
DHDPEKRPSFQEILKRL
Kinase MPS1.AA ULK 440-611 25 2.1e-21 71.57 In-house 1-223 (329) Show / Hide 
Range on Protein: 440-611
Range on HMM: 1-223/329
Sequence Identity: 25% (57 aa)

YEKIELLGRGGSSRVYKV--KGSG---NRVYALKRVSFDAFDDSS--------IDGFKGEIELLEKLKDQ---KR----VIQLLDYEMGDGL--LYLIME
|.... || |   .|||   | ..   | ..| | .. . .. ..        .. .| ||... |||..   |     ...|.|. . .    .|.|||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

CGDH-DLSQILNQRSGMPLDF--------NFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKG--------------ILKIIDFGIANAVPEHTVNI
  .. ||.|..... ..|.|         . .. . |  |   |  |. .|.| |.||.| .|..               .||| ||| |  | . ....
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQN-ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQ

Y-RETQI------GTPNYMAPEAL
    |.       ||| ||||. |
QMMMTCVNEKRLCGTPLYMAPQIL
Kinase MPS1.AA ULK 440-611 24 9.4e-21 70.41 In-house 1-219 (324) Show / Hide 
Range on Protein: 440-611
Range on HMM: 1-219/324
Sequence Identity: 24% (54 aa)

YEKIELLGRGGSS-RVYKV--KGSG--NRVYALKRVSFDAFDDSSID--------GFKGEIELLEKLK--DQKR--VIQLLDYEMGDGL--LYLIMECGD
|.... || |     |||   | ..  | ..| | .. . . ... .         .| ||... |||    .   ...|.|. . .    .|.|||  .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

H-DLSQILNQRSGMPLDF--------NFVRFYTKEMLLCIKVVHDAGIVHSDLKPANFVLVKG--------------ILKIIDFGIANAVPEHTVN-IYR
. ||.|..... . |.          . .. . |  .   |  |. .|.| |.||.|  |..               .||| ||| |  | . . .   .
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQN-ILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMC

ETQI------GTPNYMAPEAL
 |.       ||| ||||. |
QTCVNEKRIKGTPLYMAPQIL
Kinase MPS1.AA ULK 635-716 26 2.5e-15 50.88 In-house 233-324 (324) Show / Hide 
Range on Protein: 635-716
Range on HMM: 233-324/324
Sequence Identity: 26% (25 aa)

SDMWSCGCIIYQMIYGKPPYGS-FQGQN----RLL------AIMNPDVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFL
.|.|| |||.|.|.|||.|. | |. |.    .|.       |.  . .|.||    .. || .  ..| . .| .....| . . ...  ..
CDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPP-KDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase MPS1.AA ULK 635-716 25 5.9e-14 45.18 In-house 237-329 (329) Show / Hide 
Range on Protein: 635-716
Range on HMM: 237-329/329
Sequence Identity: 25% (24 aa)

SDMWSCGCIIYQMIYGKPPYGS-FQGQN-----RLLAIMNP------DVKIPFPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFL
.|.|| |||.|.|.|||||. . |. |.     .|. . .|      . .. ||    |. .| .  ..| . .| .....| . . ...  ..
CDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDG-NDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase MPS1.AA TyrKc 440-715 19 2.4e-08 -87.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 440-715
Range on HMM: 1-280/280
Sequence Identity: 19% (61 aa)

YEKIELLGRGGSSRVYKVKGSGNRVYALKRVSFDAFDDSSIDGFKGEIELLEKL-KDQKRVIQLLDYEMGD-------GLLYLIMECGDH-DLSQILNQR
 .... ||.|   .||| . .  .  | | .  ||     .  |  |.... || .. . ...|. . . .       . |...||  .| || . |  .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

SGMPLDFNFVRFYTKEMLLCIKVV-------HDAGIVHSDLKPANFVLVKG-ILKIIDFGIANAVPEH-TV----NIYRETQ-IGTP-----NYMAPEAL
 .         . .|..|     .       |. ...| ||   |  . .. . || ||| . .. .. .       || ..  |.        ||||..
RPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

VAMNYTQNSENQHEGNKWKVGRPSDMWSCGCIIYQMI-YGKPPYGS----FQGQNRLLAIMNPDVKIPFPEHTSNNEKI-----PKSAIELMKACLYRNP
    .|                 || || |  .. .  ||..||      .    ....        | |..    . .     |.   ..|| |  ..|
NYGKFTTK---------------SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSFVCCPDEMYQIMKQCWHEDP

DKRWTVDKVLSSTF
..| |   .  . |
EDRPTFSEI-HECF
Kinase MPS1.AA CMGC 675-716 30 6.2e-07 17.84 In-house 473-513 (513) Show / Hide 
Range on Protein: 675-716
Range on HMM: 473-513/513
Sequence Identity: 30% (13 aa)

FPEHTSNNEKIPKSAIELMKACLYRNPDKRWTVDKVLSSTFL
| .|   ...... ||.|.| .|  .||||.|..  |.  ..
F-NHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase MPS1.AA TKL 446-517 16 0.0012 9.02 In-house 1-118 (364) Show / Hide 
Range on Protein: 446-517
Range on HMM: 1-118/364
Sequence Identity: 16% (19 aa)

LGRGGSSRVYKVKGSG---------NRVYALKRVSFDA-----------------------FDDSSIDGFKGEIELLEKLK-DQKRVIQLLDYEMGDGL-
.|.||.. ||| |  |         ... | |. . .                         ...|   |. | |.. ... .   ..|.. | .  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LYLIME
            |...||
CVCMHPVGPWGQLCIVME