Gene PTK1 (Bakers Yeast)
PTK1
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| PTK1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 305 | Kinase domain by global Sugen HMM | Fasta, JSON |
| PTK1.AA | Protein | Refseq_NP | 649 | Putative serine/threonine protein kinase that enhances spermine uptake; Ptk2p [Saccharomyces cerevisiae] | Fasta, JSON |
Protein domains of PTK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PTK1.AA | HAL | 197-503 | 40 | 3.9e-199 | 667.83 | In-house | 2-363 (363) | Show / Hide |
Range on Protein: 197-503 Range on HMM: 2-363/363 Sequence Identity: 40% (145 aa) DENKTIGWGGSCEVRKIRSK-------------YRKKDVFALKKLN--MIYNETPEKFYNAAPKEFIIAKQLSHH-----------VHITNTFLLVKVPT . ||..|||...||...... ||.|.|||.|... |.|||.|||.......||.|...|.|| |||.|.. ...... KCNKVLGWGAYGEVKICQRCRNKKDVPPYDTYHYRDKKVFAVKEFRKPMKYNESPEKYCKKCTSEFCIGHTLHHHHFNAKKPPKHVVHIPNICETLDIFY TVYTTRGWGFVMELGLR-DLFAMIQKSG-------WRHVALAEKFCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLS ..|||..|..|||.... |||||....| ||.....|..|.|||...|||..||.|||||||||||....|||.|||.|||||||.|..|||.. DSYTTDKWCEVMEYCPYGDLFAMVMRNGGKSRLKGWRKMHYMEICCCFKQLCHGVKYMHDMGIAHRDLKPENCVMTPDGICKLCDFGISDWFHYPPHDWE SPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPFLESCSFDTGFRDYCDAYENFIRLHDR----AFRNRGNYR ..|..|.|..||.||..||||..|.|||||...||.||||..||...|||.........|....|..|..||..|..|..||..|.. .|...|.|. KNVHMCHGIVGSDPYLAPEVMYFDEKKHYDEKFQQEYDPRCVDCWSCGIIYCCMIMKRFPWKIPCKEDDSFRMFCYHYDCFIFHHNVTRTQEFPEKGCYH PGPGME-----------------YHLARNFKNGHASRVAWRLADPEAATRYTIDDLFEDPWF |...|| .|..|.|...|.....||..|.|.|.|.|.||.|.|||. PFEEMEPENTPNNVQGKNNVNMGPHHIRHFLPHHCRHIMWRMLDWEPAKRITMDDIFNDPWM |
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| S_TKc | PTK1.AA | S_TKc | 196-503 | 19 | 7e-38 | 133.09 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 196-503
Range on HMM: 1-231/231
Sequence Identity: 19% (64 aa)
DDENKTIGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYNAAPKEFIIAKQLSHHVHITNTFLLVKVPTTVYTTRGWGFVMELGLR---DLFAM
. ..|| |. .|.| | | . ..|.|... . . .| | |. || .| . . .|||. ||| .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDY
IQKSGWRH----VALAEKFCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSK
|.| | . . ....|..|....||..|| ||||||||.||. . |..|||.. . ..|.| | .|||.
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----
KHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPFLESCSFDTGFRDYCDAYENFIRLHDRAFRNRGNYRPGPGMEYHLARNFKNGHASRVAW----RLA
.|.... | . .|.|| .. || .. ... |. |. ..
---------GYGKCKCDWWSCGCILYEMLCGYPPFP----------QMQMMFKKIG--------------------------------SPEAKDFIRKCL
DPEAATRYTIDDLFE-------DPWF
. . . |.|. .... .|||
QKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | PTK1.AA | Pkinase | 197-423 | 25 | 2.6e-30 | 108.23 | Pfam | 2-212 (293) | Show / Hide |
Range on Protein: 197-423
Range on HMM: 2-212/293
Sequence Identity: 25% (62 aa)
DENKTIGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYNAAP-KEFIIAKQLSHHVHITNTFLLVKVPTTVYTTRGWGFVMELGLR-----DLF
..|| |.. .|.| . | | ..|.|... .| ..| .... | | | | .| .| .. . .. .| .|||. |||
HIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIK-KRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY------MVMEYCEGGLYVMDLF
AMIQKSGWRHVAL--AEK--FCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVC----KLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEV
..|. ||| .. |. ....|...|...||..|| ||||||||.|.. .|.. |..|||.. . . . . |.|.|..|||
DYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEV
MFYDSKKHYDTELQ-QPYDPRALDCYGLGIILMTLVNNVIPF
.. ..|.... | ...|.|| ... ||
------------IRGGQYYGPKVDMWSCGCILYEMLCGRPPF
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| Kinase | PTK1.AA | CAMK | 309-427 | 23 | 7.3e-30 | 92.83 | In-house | 184-338 (425) | Show / Hide |
Range on Protein: 309-427 Range on HMM: 184-338/425 Sequence Identity: 23% (37 aa) IFKQVACGVKFCHDQGIAHRDLKPENVLLSPD-----------------GVCKLTDFGISDWYHTDPHDL--------------SSP--VKKCAGMIGSP .|.|....|..||...|.||||||||.||. . . |..||| . . . .. ..| .|. . |.| YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP PYAP-PEVMFYDSKKHYDTELQ-----QPYDPRALDCYGLGIILMTLVNNVIPFLESC .|.. ||| . ... . . .||.... |. .|.|| ... || ..| EYMAAPEVLNGKGHCNMQ---NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDC |
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| Kinase | PTK1.AA | CAMKL | 309-417 | 35 | 1.2e-28 | 88.45 | In-house | 132-230 (297) | Show / Hide |
Range on Protein: 309-417 Range on HMM: 132-230/297 Sequence Identity: 35% (40 aa) IFKQVACGVKFCHDQGIAHRDLKPENVLLSPDG--VCKLTDFGISDWYH-TDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQ--QPYDPRA .|.|. ..|..||..||.|||.||||.||. .| . |..||| | .| | .|. |||||..||. . .||| .. YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC----IFGPGQKLKTFCGSPPYMAPEIF-----------QGNNKPYDGPK LDCYGLGIILMTLV |. .|.|| ..| VDIWSCGVILYAMV |
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| Kinase | PTK1.AA | NuaK | 309-423 | 36 | 1.7e-23 | 58.13 | In-house | 104-199 (252) | Show / Hide |
Range on Protein: 309-423 Range on HMM: 104-199/252 Sequence Identity: 36% (42 aa) IFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYG .| |.. | .|| .|.||||| ||.|| .. | ||| | || . | ||| || ||. ||| || FFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQ--------KFLHTFCGSPLYASPEIV-----------NGQPYHGPEVDCWS LGIILMTLVNNVIPF ||..| |.| || LGVLLYTMVYGTMPF |
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| Kinase | PTK1.AA | Ciliate-E2-Unclassified | 309-423 | 27 | 6.1e-22 | 72.91 | In-house | 148-270 (352) | Show / Hide |
Range on Protein: 309-423 Range on HMM: 148-270/352 Sequence Identity: 27% (37 aa) IFKQVACGVKFCHDQG-IAHRDLKPENVLLSPDG---VCKLTDFGISDWYHTDPHDLSS---------PVKKCAGMIGSPPYA----PPEVM---FYDSK .|.|. .| ...| .. | |||.||||.|.. .| .|..||||| | ... . . ... ..|.| | .|||. || . YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHS KHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPF | . |...||.|| .. . || KA-----------YKCDIWSLGVILYEMLFGYYPF |
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| Kinase | PTK1.AA | Ciliate-E2 | 309-423 | 23 | 2.3e-19 | 63.12 | In-house | 150-296 (365) | Show / Hide |
Range on Protein: 309-423
Range on HMM: 150-296/365
Sequence Identity: 23% (37 aa)
IFKQVAC---------------GVKFCHDQG-IAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPH------------DLSSPVKKCAG----------
|.||.. .....| .. | |||.||||.|. .|..|||.| |..| . .. ... |
IMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNM
---MIGSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPF
.|.|.| .||. . | ||.. .| . . | . ||.|| .. . ||
FNTICGTPGYMAPEILNG---KKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF
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| Kinase | PTK1.AA | CMGC | 309-367 | 26 | 3.1e-19 | 58.99 | In-house | 185-267 (513) | Show / Hide |
Range on Protein: 309-367 Range on HMM: 185-267/513 Sequence Identity: 26% (22 aa) IFKQVACGVK--FCHDQG--IAHRDLKPENVLLSPDGVC--------------------KLTDFGISDWYHTDPHDLSSPVKK ...|. .|.| .|| .. | ||||||||.|..... . |. ||| . |||. . . ..... YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQ |
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| Kinase | PTK1.AA | QIK | 309-383 | 38 | 6.7e-19 | 69.12 | In-house | 123-189 (272) | Show / Hide |
Range on Protein: 309-383 Range on HMM: 123-189/272 Sequence Identity: 38% (29 aa) IFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGISDWYHTDPHDLSSPVKKCAGMIGSPPYAPPEVM .|.|.. .|..||...|.||||| ||.|| . |. ||| | |. .. . . |||||| ||.. WFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQG--------QLLMTWCGSPPYAAPEMF |
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| Kinase | PTK1.AA | MARK | 309-349 | 46 | 6.7e-19 | 58.58 | In-house | 109-151 (262) | Show / Hide |
Range on Protein: 309-349 Range on HMM: 109-151/262 Sequence Identity: 46% (20 aa) IFKQVACGVKFCHDQGIAHRDLKPENVLLSPDG--VCKLTDFG ||.|. ..|..||...|.|||.||||.|. .| |..||| IFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG |
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| Kinase | PTK1.AA | PASK | 288-349 | 45 | 7.8e-17 | 48.81 | In-house | 96-155 (260) | Show / Hide |
Range on Protein: 288-349 Range on HMM: 96-155/260 Sequence Identity: 45% (29 aa) DLFAMIQKSGWRHVALAEKFC--IFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFG |||..| || . |. ||.||. .||. |.||| ||| | ||| . .. || ||| DLFDFID----RHPNMDEHLASYIFRQVVAAVKYLHEQGIVHRDIKDENVIIDEHFTIKLIDFG |
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| TyrKc | PTK1.AA | TyrKc | 196-440 | 18 | 2.2e-05 | -135.65 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 196-440 Range on HMM: 1-280/280 Sequence Identity: 18% (57 aa) DDENKTIGWGGSCEVRKIRSKYRKKDVFALKKLNMIYNETPEKFYNAAPKEFIIAKQL-SHHVHITNTFLLVKVP-------TTVYTTRGWGFVMEL-GL .|..| | .||.| . | | |.|. | |. .| | ..| || .| . . . . .. |||. . ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFM----REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM------IVMEYMPH RDLFAMIQKSGWRHVALAEKFCIFKQVACGVKFCHDQGIAHRDLKPENVLLSPDGVCKLTDFGIS-DWYHTDPHDLSSPVKKCAGMIGSPP-----YAPP || ..|.. . . .... . |.||| . |.... |||| |.|.. ....| .||| | |.|. | . |. ... .. |. .| GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP EVMFYDSKKHYDT------------EL----QQPYDP---------RALDCYGLGIILMTLVN-----------NVIPFLESCSFD-----TGFRDYCDA |.. .. . | |. |||| ... . | .. | . ..| |.. .. ECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC Y F |
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| Kinase | PTK1.AA | PASK | 482-503 | 22 | 0.000234 | 9.13 | In-house | 239-260 (260) | Show / Hide |
Range on Protein: 482-503 Range on HMM: 239-260/260 Sequence Identity: 22% (5 aa) RLADPEAATRYTIDDLFEDPWF .. .. | |.... .||| SMLNRCPEKRCTMHQIITDPWL |
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| Kinase | PTK1.AA | MARK | 373-423 | 33 | 0.000535 | 9.15 | In-house | 167-206 (262) | Show / Hide |
Range on Protein: 373-423 Range on HMM: 167-206/262 Sequence Identity: 33% (17 aa) GSPPYAPPEVMFYDSKKHYDTELQQPYDPRALDCYGLGIILMTLVNNVIPF |.|||..||.. |..||| .. | . ||..| ..| || GTPPYMAPEIF-----------LKKPYDGPKVDIWSLGVVLYFMVCGYFPF |
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| Kinase | PTK1.AA | CAMKL | 491-503 | 38 | 0.000596 | 8.33 | In-house | 285-297 (297) | Show / Hide |
Range on Protein: 491-503 Range on HMM: 285-297/297 Sequence Identity: 38% (5 aa) RYTIDDLFEDPWF |.||... ..||. RPTIHQIMNHPWM |
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| Kinase | PTK1.AA | CAMK | 491-503 | 38 | 0.002969 | 5.54 | In-house | 413-425 (425) | Show / Hide |
Range on Protein: 491-503 Range on HMM: 413-425/425 Sequence Identity: 38% (5 aa) RYTIDDLFEDPWF |.||.. ..||. RMTIEQCLNHPWM |
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| Kinase | PTK1.AA | MARK | 491-503 | 38 | 0.004449 | 6.1 | In-house | 250-262 (262) | Show / Hide |
Range on Protein: 491-503 Range on HMM: 250-262/262 Sequence Identity: 38% (5 aa) RYTIDDLFEDPWF | ||... ..||. RPTIEEIMKHPWM |
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| Kinase | PTK1.AA | Ciliate-E2 | 491-503 | 35 | 0.010933 | 5.03 | In-house | 352-365 (365) | Show / Hide |
Range on Protein: 491-503 Range on HMM: 352-365/365 Sequence Identity: 35% (5 aa) RYT-IDDLFEDPWF |.| ...... ||| RITGWEQILNHPWF |
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| Kinase | PTK1.AA | Ciliate-E2-Unclassified | 491-503 | 38 | 0.012744 | 4.94 | In-house | 340-352 (352) | Show / Hide |
Range on Protein: 491-503 Range on HMM: 340-352/352 Sequence Identity: 38% (5 aa) RYTIDDLFEDPWF |.|...... ||| RITFEQILNHPWF |
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| Kinase | PTK1.AA | Pkinase | 489-503 | 33 | 0.391573 | 5.09 | Pfam | 279-293 (293) | Show / Hide |
Range on Protein: 489-503 Range on HMM: 279-293/293 Sequence Identity: 33% (5 aa) ATRYTIDDLFEDPWF . |.|.......||| KKRPTAEQILQHPWF |
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