Gene PTK2 (Bakers Yeast)
PTK2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| PTK2.AA | Protein | Refseq_NP | 818 | Putative serine/threonine protein kinase that enhances spermine uptake; Ptk2p [Saccharomyces cerevisiae] | Fasta, JSON |
| PTK2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 305 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of PTK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | PTK2.AA | HAL | 258-562 | 39 | 1.9e-198 | 665.59 | In-house | 4-363 (363) | Show / Hide |
Range on Protein: 258-562 Range on HMM: 4-363/363 Sequence Identity: 39% (143 aa) NKPIGSGGSSEVRKVKSS-------------YRQKDVYALKKLN--MIYHESPEKFYKRCSKEFIIAKHLSHN-----------VHITNTFYLLKVPTTT ||..|.|...||...... ||.|.|.|.|... |.|.|||||..|.|..||.|...|.|. |||.|....|...... NKVLGWGAYGEVKICQRCRNKKDVPPYDTYHYRDKKVFAVKEFRKPMKYNESPEKYCKKCTSEFCIGHTLHHHHFNAKKPPKHVVHIPNICETLDIFYDS YTTRGWGFIMELGVK-DLFQLMERTG-------WKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSP |||..|...||.... |||....|.| |......|..|.|||...|.|..||.|||||||||||......|||||.|||||||.|..|||.... YTTDKWCEVMEYCPYGDLFAMVMRNGGKSRLKGWRKMHYMEICCCFKQLCHGVKYMHDMGIAHRDLKPENCVMTPDGICKLCDFGISDWFHYPPHDWEKN VKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNP----HFRDKGCHKPG |..|.|..||.||..|||||||.||||.||||..|.|...|....||....||....|....|..|..||.|...||.||.|.|. .|..|||..|. VHMCHGIVGSDPYLAPEVMYFDEKKHYDEKFQQEYDPRCVDCWSCGIIYCCMIMKRFPWKIPCKEDDSFRMFCYHYDCFIFHHNVTRTQEFPEKGCYHPF PGSE-----------------YSLARNFKNTDATRIAWRLADPNPATRYTMDDLFNDPFF ...| ....|.|.......|.||..|..||.|.||||.||||.. EEMEPENTPNNVQGKNNVNMGPHHIRHFLPHHCRHIMWRMLDWEPAKRITMDDIFNDPWM |
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| S_TKc | PTK2.AA | S_TKc | 255-562 | 17 | 5.2e-39 | 136.84 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 255-562
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)
DTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVK---DLFQL
. ..||.|. ..|.|.. . ..|.|... .. .| | |. | .| . .. ..||. |||..
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDY
MERTG----WKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAK
... | . | . ....|.......||..|| ||||||||.|... |..|||.. . ..|.| | .|||.
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----
KHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFREFEVSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNP
.|.. . | ...|..|. |. || . .. |. .| . .. . .|
---------GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDP
ATRYTMDDLFN-------DPFF
. |.| .... .|.|
EKRPTA-EALQDEWDIKCHPWF
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| Pkinase | PTK2.AA | Pkinase | 256-482 | 25 | 8.4e-31 | 109.99 | Pfam | 2-212 (293) | Show / Hide |
Range on Protein: 256-482
Range on HMM: 2-212/293
Sequence Identity: 25% (62 aa)
TDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCS-KEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVK-----DLF
. ..||||....|.| . .| ..|.|... ||...| . . | | |.|.| | ... .. | ..||. . |||
HIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIK-KRHEKSWKDQTHRRLSEIQIMKRLNHPN-IVRLYDWFEDKDHIY------MVMEYCEGGLYVMDLF
QLMERTGWKNVPF--NEKYC--LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGIC----KLTDFGISDWYHVIPHDYTSPVKTCQGMIGSPPYTPPEV
.... |.. .| |. | ..|...|...||..|| ||||||||.||...| . |..|||.. . . . ... |.|.| .|||
DYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEV
MYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPF
.| . . | ...|..|. |.. ||
IR-----------GGQYYGPKVDMWSCGCILYEMLCGRPPF
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| Kinase | PTK2.AA | CAMK | 368-562 | 15 | 2e-28 | 88.11 | In-house | 184-425 (425) | Show / Hide |
Range on Protein: 368-562
Range on HMM: 184-425/425
Sequence Identity: 15% (42 aa)
LFKQVAQGIKFCHDNGIAHRDLKPENVLISKE-----------------GICKLTDFGISDWYHVIPHDY--------------TSP--VKTCQGMIGSP
.|.|.......||...|.||||||||.|... . |..||| . . .. |.| . .. . |.|
YFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP
PYTP-PEVMYFDAKKHYPEKFQ-----KPYNPLAMDSYALGIMLITMINNIIPFIDS--------------------CNTDARFR-EFE-----------
.| . ||| .. .. . ||| . . | ..|..| .| || .. . .... . .
EYMAAPEVLNGKGHCNMQ---NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGP
-----VSYDNFINHQNPHFRDKGCHKPGPGSEYSLARNFKN----TDATRIAWRLADPNPATRYTMDDLFNDPFF
.| . | ... .. ..| |.| .. |.|..
EWWDDISDE-----------------------------F-HHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | PTK2.AA | CAMKL | 368-476 | 33 | 1.3e-24 | 75.38 | In-house | 132-230 (297) | Show / Hide |
Range on Protein: 368-476 Range on HMM: 132-230/297 Sequence Identity: 33% (37 aa) LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEG--ICKLTDFGISDWYH-VIPHDYTSPVKTCQGMIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMD .|.|. ....||..||.|||.||||.|... | |..||| | .| .| | ... ||||| .||. .|||. . | YFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCI----FGPGQKLKTFCGSPPYMAPEIFQGN---------NKPYDGPKVD SYALGIMLITMI ..|..| .|. IWSCGVILYAMV |
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| Kinase | PTK2.AA | Ciliate-E2 | 346-562 | 15 | 2.4e-24 | 80.44 | In-house | 119-365 (365) | Show / Hide |
Range on Protein: 346-562 Range on HMM: 119-365/365 Sequence Identity: 15% (47 aa) KDLFQLMERT---------GWKNVPFNEKYCL--FKQVAQ---------------GIKFCHDNG-IAHRDLKPENVLISKEGICKLTDFGISDWYHVIPH .|||.... . .|.|| .. .||..| .....| .. | |||.||||.|. .|..|||.| |. GDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQ DYT-----------SPVKTCQG-------------MIGSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFRE ..| . ....| .|.|.| .||. .. . . | ..||..| |. . || . NRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQ FEVSYD--------------------------NFINH--QNPHFRDKGCHKPGPGSEYSLARNFKNTDATRIAWRLADPNPATRYT-MDDLFNDPFF ..... ..|. . |. . .| |.| .....| |.| CKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK----------------------------------RMLQKDPEKRITGWEQILNHPWF |
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| Kinase | PTK2.AA | Ciliate-E2-Unclassified | 256-482 | 22 | 9.6e-24 | 79.25 | In-house | 2-270 (352) | Show / Hide |
Range on Protein: 256-482
Range on HMM: 2-270/352
Sequence Identity: 22% (64 aa)
TDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLN--MIYH----ESPEKFYKRCSKEFIIAKHLSHNV----------------HITNTFYLLKVPTTTYT
. .| ||.|| ..|.|.. . . .||.| .. .||. .. . .... || . |. .|. .| . || . . |
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY-
TRGWGFIMELGV-KDLFQLME-------------RTGWKNVPFNEKYCL-------FKQVAQGIKFCHDNG-IAHRDLKPENVLISKEG---ICKLTDFG
..||. .||.| .. .. .. | |. .. |.|. ||....| .. | |||.||||.|....| .|..|||
-----IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG
ISDWYHVIPHDYTS--------PVKTCQGMIGSPPYT----PPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPF
|| | . ..|. . . .. ..|.| | .|||. .... .|. . | ..||. | |. . ||
ISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQG--QNYDHSKA------YKCDIWSLGVILYEMLFGYYPF
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| Kinase | PTK2.AA | CMGC | 256-415 | 19 | 6.5e-22 | 67.97 | In-house | 2-256 (513) | Show / Hide |
Range on Protein: 256-415 Range on HMM: 2-256/513 Sequence Identity: 19% (49 aa) TDNKPIGSGGSSEVRKVKS-------------SYRQKDVYALKKLN--MIYHES------PEKFYKRCSKEFIIAKHLS----------------HNVHI . |.||.| ..| | . . . ..|.||. |.| . | .|. | | |||. | .| EIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI TNTFYLLKVPTTTYT-----------TRGWGFIMELGVKDLFQLMERTGW-----KNVPFNEKY--------------CLF------KQVAQGIK--FCH . .. .. . .. . . ...|. .||.|..... ...|..| ... .|. .|.| .|| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH DNG--IAHRDLKPENVLISKEGIC--------------------KLTDFGISDWYHV .. | ||||||||.||.... . |. ||| . |||. SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHP |
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| Kinase | PTK2.AA | CDK | 339-410 | 32 | 9.2e-19 | 56.51 | In-house | 95-160 (284) | Show / Hide |
Range on Protein: 339-410 Range on HMM: 95-160/284 Sequence Identity: 32% (25 aa) FIMELGVKDLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGI-----CKLTDFGIS ...| || ..|. |...| .|. .||.|.| |||||| | ||.. |. |..||| . MVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLA |
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| Kinase | PTK2.AA | Ciliate-E1 | 261-411 | 23 | 1.1e-18 | 57.76 | In-house | 1-157 (202) | Show / Hide |
Range on Protein: 261-411
Range on HMM: 1-157/202
Sequence Identity: 23% (38 aa)
IGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHLSHNVHITNTFYLLKVPTTTYTTRGWGFIMELGVKDLFQLME-------
||.|..| | | |. .. ..|.| |... .. ..|.. ... | | . . | . . .|. .. .|.|. . |.. ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICI----IIFECCCCSLKDYLQNHNRLEY
----RTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISD
.. .. | .| ....| .|. |...| |||.||.|.||...|.....|||||.
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISK
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| Kinase | PTK2.AA | MARK | 368-408 | 44 | 1.9e-18 | 57.04 | In-house | 109-151 (262) | Show / Hide |
Range on Protein: 368-408 Range on HMM: 109-151/262 Sequence Identity: 44% (19 aa) LFKQVAQGIKFCHDNGIAHRDLKPENVLISKEG--ICKLTDFG .|.|. ....||...|.|||.||||.|| ..| |..||| IFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG |
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| Kinase | PTK2.AA | STE11-Unclassified | 370-441 | 33 | 1.8e-16 | 54.92 | In-house | 114-206 (308) | Show / Hide |
Range on Protein: 370-441 Range on HMM: 114-206/308 Sequence Identity: 33% (31 aa) KQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYH------------------VIPHDYTSPVKTCQGMIGSPP---YTPPEV ||. .|... | .|| |||.|..|.|| ..|||||||||.. | . | . |. | |.|. .. ||| KQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPFWMAPEV |
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| TyrKc | PTK2.AA | TyrKc | 255-502 | 17 | 5e-06 | -125.71 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 255-502
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)
DTDNKPIGSGGSSEVRKVKSSYRQKDVYALKKLNMIYHESPEKFYKRCSKEFIIAKHL-SHNVHITNTFYLLKVP-------TTTYTTRGWGFIMELGVK
| .| .|.| ||.| . . .| | |.|. . .| | ..| |. .| . . . . .||. .
ITLGKKLGEGAFGEVYKGTWK---IQV-AVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM------IVMEYMPH
-DLFQLMERTGWKNVPFNEKYCLFKQVAQGIKFCHDNGIAHRDLKPENVLISKEGICKLTDFGISDWYHVI-----PHDYTSP-----VKT---------
|| . ... | .. .. |.|.| . |.... |||| |.|.......| .||| | . .|| .. ||
GDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP
---CQG-------------------MIGSPPY--------TPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTD-ARFR-E
| | .|| .. ||. . . ..... . .| | | . .. . . .| . |
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P--MSF-------VCCPDEMYQIMKQCWHEDPEDRPT
FEVSYDNF
|. .. |
FSEIHECF
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| Kinase | PTK2.AA | CAMKL | 545-562 | 33 | 0.000697 | 8.11 | In-house | 280-297 (297) | Show / Hide |
Range on Protein: 545-562 Range on HMM: 280-297/297 Sequence Identity: 33% (6 aa) PNPATRYTMDDLFNDPFF .|| |.|.... |.|.. VNPEKRPTIHQIMNHPWM |
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| Kinase | PTK2.AA | Ciliate-E2-Unclassified | 546-562 | 41 | 0.001697 | 8.02 | In-house | 336-352 (352) | Show / Hide |
Range on Protein: 546-562 Range on HMM: 336-352/352 Sequence Identity: 41% (7 aa) NPATRYTMDDLFNDPFF || |.|.....| |.| NPNKRITFEQILNHPWF |
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| Kinase | PTK2.AA | CAMK | 260-288 | 12 | 0.0206 | 2.78 | In-house | 1-40 (425) | Show / Hide |
Range on Protein: 260-288 Range on HMM: 1-40/425 Sequence Identity: 12% (5 aa) PIGSGGSSEVRKVKSSYRQK-----------DVYALKKLN .|.|. ..|.... .. .| | .. TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID |
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| Kinase | PTK2.AA | MARK | 545-562 | 27 | 0.022427 | 3.77 | In-house | 245-262 (262) | Show / Hide |
Range on Protein: 545-562 Range on HMM: 245-262/262 Sequence Identity: 27% (5 aa) PNPATRYTMDDLFNDPFF .|| | |.... ..|.. VNPEERPTIEEIMKHPWM |
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| Kinase | PTK2.AA | STE11-Unclassified | 546-562 | 35 | 0.025663 | 4.09 | In-house | 292-308 (308) | Show / Hide |
Range on Protein: 546-562 Range on HMM: 292-308/308 Sequence Identity: 35% (6 aa) NPATRYTMDDLFNDPFF .| |.| . |...|| DPKKRPTANQLLQHPFI |
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| Kinase | PTK2.AA | Pkinase | 544-562 | 26 | 0.030491 | 9.01 | Pfam | 275-293 (293) | Show / Hide |
Range on Protein: 544-562 Range on HMM: 275-293/293 Sequence Identity: 26% (5 aa) DPNPATRYTMDDLFNDPFF ...|. |.| ......|.| CKDPKKRPTAEQILQHPWF |
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| Kinase | PTK2.AA | MARK | 432-494 | 25 | 0.063541 | 2.27 | In-house | 167-218 (262) | Show / Hide |
Range on Protein: 432-494 Range on HMM: 167-218/262 Sequence Identity: 25% (16 aa) GSPPYTPPEVMYFDAKKHYPEKFQKPYNPLAMDSYALGIMLITMINNIIPFIDSCNTDARFRE |.||| .||.. .|||. . | ..||. | .|. || ...... .. GTPPYMAPEIF-----------LKKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYK |
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