Gene RAD53 (Bakers Yeast)
RAD53
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| RAD53.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 269 | Kinase domain by global Sugen HMM | Fasta, JSON |
| RAD53.AA | Protein | Refseq_NP | 821 | `Required for DNA damage-induced checkpoint arest in G1, S/M, and G2/M in mitosis, dispensable for sporulation but required for wild-type spore viability; Mec1p and Tel1p regulate rad53p phosphorylation; Rad53p [Saccharomyces cerevisiae]` | Fasta, JSON |
Protein domains of RAD53.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| FHA | RAD53.AA | FHA | 66-133 | 35 | 1.3e-18 | 72.91 | Pfam | 1-73 (73) | Show / Hide |
Range on Protein: 66-133 Range on HMM: 1-73/73 Sequence Identity: 35% (26 aa) WTFGRNPACDYHLG-NISRLSNKHFQI-LLGEDGNLLLND--ISTNGTWL--NGQKVEKNSNQLLSQGDEITVG ||.||.| ||. | . | | .|..| . .. .... | .|||||.. |||..... |..||.|..| WTIGRDPDCDIVLDNDPSFVSRHHCEIRRYDNG-RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG |
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| FHA | RAD53.AA | FHA | 65-116 | 40 | 1.1e-13 | 52.69 | SMART | 1-49 (49) | Show / Hide |
Range on Protein: 65-116 Range on HMM: 1-49/49 Sequence Identity: 40% (22 aa) VWTFGRNPACDYHLGNISRLSNKHFQILLGEDGNLLLNDIS---TNGTWLNGQKV .||.||.. ||. | . | |..|.|| ||. . | . ||||..||..| TWTIGRHS-CDIQLPHPS-ISRHHCQIR---DGD-YIIDLGEHSTNGTYVNGRRV |
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| Kinase | RAD53.AA | RAD53 | 198-466 | 42 | 1.8e-191 | 576.14 | In-house | 1-305 (305) | Show / Hide |
Range on Protein: 198-466 Range on HMM: 1-305/305 Sequence Identity: 42% (130 aa) SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISK-------RKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDT-ESYYMVMEFVSGGDLMDFVAAHG .......|.|.|.|||.|.|..|....|.|||.| ...|..||.|..|.|.|.|||||.|.|........ ..||||.|...||.|........ YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK A----VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIE-QDDPV---------------LVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRG . ..||.......|...|.||.|..||.||||||.|||.. ||... |.|||||||.|..|.||||||.|||..|||||||.. RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS KDTSVSPDEYEER---NEYSSLVDMWSMGCLVYVILTGHLPFS-GSTQ----DQLYKQIGR-GSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKA |.. ....|.||| ..|.. ||.|||||..|..|.|..||| ..|| .||..||.. |.||.......||||||.|.|...|.|||..|.|...| KGH-NCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA LNHPWI |||||. LNHPWM |
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| Kinase | RAD53.AA | CAMK | 203-466 | 28 | 4.3e-118 | 382.29 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 203-466 Range on HMM: 1-425/425 Sequence Identity: 28% (120 aa) VVGQGAFATVKKAIER-TTGKT-----------FAVKIISKRKVIG---------------------------NMDGVTRELEVLQK-------LNHPRI . |.|.|..||..|.. ||||. .|.|||.|.|. . ... | ||.|...| |.|| | TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VRLKGFYED-----------TES---------YYMVM---EFVSGG----DLMDFVAAH---------------GAVGEDAGREISRQILTAIKYIHSMG ..| .||| | | .|||| |..||| || |.. .| | . |. | . |||. |..|.||.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN ISHRDLKPDNILIEQDDP---------------VLVKITDFGLAKVQGN------------------------GSFMKTFCGTLAYVA-PEVIRGKDTSV | ||||||.|||. .... .||.|||.|.. | |||||||..|.| |||..|| ... IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN SPDE--YEERNEYSSLVDMWSMGCLVYVILTGHLPFSGS-------------TQDQLYKQIGRGSYHEGPLK------------DFRISEE--------A .. .||. |. .||||.|.. |. |.|..|| |. .. .|...| .| |. | . . .||.| . MQ-NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC RDFIDSLLQVDPNNRSTAAKALNHPWI .|.| ..|||||..| |.. .|||||. KDLIRKMLQVDPEKRMTIEQCLNHPWM |
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| Kinase | RAD53.AA | Pkinase | 198-466 | 38 | 8.49999999999e-114 | 389.16 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 198-466 Range on HMM: 1-293/293 Sequence Identity: 38% (120 aa) SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTR---ELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSGG----DLMDFVA--AH | ...|.|.|..|.|.... |||..|||||.||. ..| | |......|||| ||||....|| ..|||||.. || ||.|.. .| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH GAV--GEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVL---VKITDFGLAKV--QGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEE |.. |. . . .||| ...|.||||| ||||||.|||| ..... |||.||||||. |.| |.|||||. |.|||||| . GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR------------G RNEYSSLVDMWSMGCLVYVILTGHLPFSGS------TQDQLYKQIGRGSYHEGPLKDFRIS-----------------EEARDFIDSLLQVDPNNRSTAA ...|.. |||||.||..| |.|..||.|. .|.|....|... .|. .. .|| ||..|||...|..||. | ||. GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE KALNHPWI .|.|||. QILQHPWF |
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| Kinase | RAD53.AA | S_TKc | 198-466 | 35 | 2.6e-104 | 353.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 198-466 Range on HMM: 1-231/231 Sequence Identity: 35% (102 aa) SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYYMVMEFVSG--GDLMDFVAAHGA----- | ...|.|||..|.|.... ||. .|.|||. . . ||...|.| .|| ||.|.....| ...|||||...| |||.|. .| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSS-L | | . .||. |..|.||.|| ||||||.|||. . .||.|||||.. .|||||. |.||||. |. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL------TTFCGTPWYMAPEVL----------------GYGKCK VDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALN-------HPWI .|.|| ||..| |.| ||. ......|.|| |.||.|||. .||.||..| || .||. |||. CDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | RAD53.AA | CAMKL | 197-466 | 33 | 2.1e-91 | 291.97 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 197-466 Range on HMM: 1-297/297 Sequence Identity: 33% (106 aa) FSIIDEVVGQGAFATVKKAIE-RTTGKTFAVKIISKRKVI--GNMDG------------VTRELEVLQKLN---HPRIVRLKGFYEDTES------YYMV . |.. . |.|.|..|| |. ||||. |.||| |.| .|. ..|| . ...|| || |..| .|. | .|.| YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV MEFVSGGD--LMDFVAAHGA----VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGN-----GSFMKTFCGTLAY || .|||. |.|.. .|| |. | . |||. |..|.||.|| |||.||.|||. ... .||.|||.. . . | ..|||||...| MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY VAPEVIRG-KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST--------QDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPN |||.. | .. | ||.||.| . |....|.||| . | . ||..| .| |. | . ...| ..||.| ..|||.|. MAPEIFQGNNKPYDGP-----------KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YY--PPIWYHVS-DCRDLIRKMLQVNPE NRSTAAKALNHPWI | |. .|||| KRPTIHQIMNHPWM |
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| Kinase | RAD53.AA | CAMK1 | 199-425 | 35 | 2.1e-87 | 254.1 | In-house | 2-234 (276) | Show / Hide |
Range on Protein: 199-425 Range on HMM: 2-234/276 Sequence Identity: 35% (86 aa) IIDEVVGQGAFATVKKAIERTT---GKTFAVKIIS-KRKVIG-NM---DGVTRELEVLQK---LNHPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAA ..... | |||..|...... | || .|.|.|. |. . . .| . . .|.|...| ..|| |. .. .||... .|.||| |.||.| | . EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVE HGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVL-VK--ITDFGLAKVQGNGS-FMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERN | |. |.| .||| |..|.||.|| |||||| |.| . |. .| | ||||.| .... .||| |||. ||||||. .| KGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK----------DK EYSSLVDMWSMGCLVYVILTGHLPFSGST-QDQLYKQIGRGSY |. .|||| |. |..|.|. || ... ...|...| ...| PYDKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEY |
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| Kinase | RAD53.AA | RSK | 200-466 | 27 | 1.3e-80 | 274.07 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 200-466 Range on HMM: 1-278/278 Sequence Identity: 27% (80 aa) IDEV--VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGN---MDGVTRELEVLQKLN-HPRIVRLKGFYEDTESYYMVMEFVSGGDLMDFVAAHGA--- . . |.|.. ...| . . ||. .|.|...|.|.. . . .| ..|. . || ||.|. ... . |..||...||.| . .. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDD-PVLVKITDFGLAKV--QGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSS || ... ..| |....|. || ||||||.||| .... . .|.||||..| ... ..|||.|..|.|||... . . .. .. FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLK--------RAN-QQGGHDK LVDMWSMGCLVYVILTGHLPFSG---STQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRST-----AAKALNHPWI .| || |.| | |||..|| | ...... |.|..| . . . .|.||.|.| .|..||..| . |. ..|||. ACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | RAD53.AA | Ciliate-E2 | 198-466 | 24 | 1.2e-77 | 264.25 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 198-466 Range on HMM: 1-365/365 Sequence Identity: 24% (93 aa) SIIDEVVGQGAFATVKKAIERTTG-----------------------KTFAVKIISKR--KVIGNMDGVTRELE----------VLQKLNHPRIVRLKGF .. .. |||.|..|.|. . .. | .|.||..|. . | ... . ||.. .|..|||| |.... . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC YE--DTESYYMVMEFVSGGDLMDFVA------------AHGAVGEDAGREISRQILT---------------AIKYIHSMG-ISHRDLKPDNILIEQDDP .. |....|.|||...||||.|. . . | ..|..||| |..|.|| . | |||.||.|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- VLVKITDFGLAK-----------VQGNGSFMKTF----------------------CGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVY .||.||||.| |... .| . |||. |.|||...||. . .....|. .|.||.|.. | --IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ----QKQKGYDYKCDIWSLGVILY VILTGHLPFSGSTQDQLYKQIGRGSYHEGPL--------------KDFRISEEARDFIDS----LLQVDPNNRST-AAKALNHPWI |.| .|| ..|| . . . . . .|.|. |.| .||.||..| | . ..|||||. EMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | RAD53.AA | CAMK-Unique | 198-466 | 25 | 2.2e-75 | 248.25 | In-house | 1-363 (363) | Show / Hide |
Range on Protein: 198-466
Range on HMM: 1-363/363
Sequence Identity: 25% (91 aa)
SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGV-------------------TRELEVLQKLNHPRIVRLKGF----YEDTE-------
. ...|.|.| |.... |.||| .|.|.. | .. . . .||........||.|..| .. ..| .
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI
--------SYYMVMEFVSGGDLMDFVAA--------------------HGAVGE--DAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQD--D----
.|.|||.. |||| | ... | | . |....| |..| || .| |||||..||.. |
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH
--------PVLVKITDFGLAKVQG-NGSF--MKTFCGTLAYVAPEVIRGKD-TSVSPDEYEERNEYSSLV----DMWSMGCLVYVILTGHLPFSGSTQD-
.|..||||.. | . |.|.|||. |.|||. | . ..|| .. |.. . | ||.| . | |.| .|| ... |
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR
-------QLYKQIGRGSYHEGPLKDFRI----SEEARDFIDSLLQVDPNNRSTAAKALNHPWI
... | | | . . | ... |.|| ||.. ...|||. | .|. .| |.||
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
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| Kinase | RAD53.AA | ULK | 198-466 | 27 | 4.4e-73 | 249.12 | In-house | 1-329 (329) | Show / Hide |
Range on Protein: 198-466
Range on HMM: 1-329/329
Sequence Identity: 27% (92 aa)
SIIDEVVGQGAFATVKKAI-ERTT---GKTFAVKIISKRK-VIGN--------MDGVTRELEVLQKLN--------HPRIVRLKGFYEDTES--YYMVME
..... |.|.|..| |.. ..| .. .|.|.|.| | . | .. ...| ....||. || ||.|. ..|.. . .|..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME
FVSGGDLMDFVAAHGAVGEDA----------GREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP----------VLVKITDFGLAKV-QGN---GS
. ||||... .. .|| ... .||| . |..|...| |||.||.|||| ..| . .||.|||.||. . .
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ
FMKTFC------GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSL-VDMWSMGCLVYVILTGHLPFSGSTQDQLY-----KQIGRGSYHE-----GPLK--
|.|. || | ||... |. |. .|.. .|.||.||. | .|.| ||... ..| | | .. .. ||.
MMMTCVNEKRLCGTPLYMAPQILQGQG---------EQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP
----DFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI
| ||.| .|.| .||.|.. | . .||||.
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
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| Kinase | RAD53.AA | ULK | 198-466 | 26 | 4e-72 | 245.91 | In-house | 1-324 (324) | Show / Hide |
Range on Protein: 198-466
Range on HMM: 1-324/324
Sequence Identity: 26% (89 aa)
SIIDEVVGQGAFA-TVKKAI-ERT--TGKTFAVKIISKRKVIGN---------MDGVTRELEVLQKLN---HPR--IVRLKGFYEDTES--YYMVMEFVS
..... |.|.|. .| |.. ..| ... .|.|.|.| | . . .. .| ....||. || ||.|. ..|.. . .|..||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN
GGDLMDFVAAHGAVGEDA----------GREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDP----------VLVKITDFGLAKV-QGNG---SFMK
|||| .. .. .| ... .||. . |..|...| |||.||.|||| ..| . .||.|||.||. . |. ..
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ
TFC------GTLAYVAPEVIRGKDTSVSPDEYEERNEYSSL-VDMWSMGCLVYVILTGHLPFSGSTQDQLY----KQIGRGSYHE-------GPLKDF--
|.. || | ||... |. |. .|.. .|.||.||. | .|.| ||... ..| | | | | |..
TCVNEKRIKGTPLYMAPQILQGQG---------EQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNG-K-EQQIYIKNQPIQFPKP
----RISEEARDFIDSLLQVDPNNRSTAAKALNHPWI
||.| .|.| .||.|.. | . .||||.
PKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
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| Kinase | RAD53.AA | MARK | 198-371 | 40 | 4.5e-58 | 188.49 | In-house | 1-181 (262) | Show / Hide |
Range on Protein: 198-371 Range on HMM: 1-181/262 Sequence Identity: 40% (74 aa) SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIG--NMDGVTRELEVLQKLNHPRIVRL-KGFYEDTESY--YMVMEFVSGGDLMDFVAAH--GA . . |.|..|.||.|. . ||. .|.||. | | .| | ||.|...||.|| |..| . . .|||. |..|| .|||.|.|.. || | YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD |. | | |||. |..| ||..| |||.||.|||| .. .||.|||.. .|. .|||||..| |||.. .|. LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKP |
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| Kinase | RAD53.AA | MARK | 389-466 | 40 | 4.3e-25 | 79.1 | In-house | 187-262 (262) | Show / Hide |
Range on Protein: 389-466 Range on HMM: 187-262/262 Sequence Identity: 40% (32 aa) VDMWSMGCLVYVILTGHLPFSGST--QDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI ||.||.| . |....|..|| |.| . .|||.| ||.|. | . .| |.|..| .||.|.|. | |. ..|||. VDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD-IPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM |
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| Kinase | RAD53.AA | Pkinase_Tyr | 199-344 | 30 | 3e-22 | 76.0 | Pfam | 2-159 (270) | Show / Hide |
Range on Protein: 199-344 Range on HMM: 2-159/270 Sequence Identity: 30% (49 aa) IIDEVVGQGAFATVKKAIER----TTGKTFAVKIISKRKVIGN---MDGVTRELEVLQKL-NHPRIVRLKGFYE-DTES--YYMVMEFVSGGDLMDFVAA ..... |.||| .|.|.. . |. . |||.. | . .. ||.... .| .|| |||| | . |. .|.|||.. .||| |. . TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK H----GAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAK | ... ....|| . | .|... |||| |.|.. . |||.|||||. HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NN-VVKICDFGLAR |
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| Kinase | RAD53.AA | TyrKc | 198-466 | 23 | 2.7e-18 | 68.03 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 198-466
Range on HMM: 1-280/280
Sequence Identity: 23% (71 aa)
SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKL--NHPRIVRLKGFYEDT-------ESYYMVMEFVSGGDLMDFVAAH
... | ||| .| |.. . . ||| . . . . ||.... || .|| |||| | . | ...|||....||| |. .|
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
GA-VGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNG--------SFMKTF--CGT----LAYVAPEVIRGKDTS
. . . ... || |.||... |||| |.|. . |||.||||.. ... .|. .| . |||.|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------
VSPDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSG-----STQDQLYKQIGRGSYHEGPLKDF-----RISEEARDFIDSLLQVDPNNRSTAAKALN
..... | || | . . |.| | | .| . ....... .| . . | | . ..| . . . . ||..| | .
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--
HPWI
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HECF
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| Kinase | RAD53.AA | CAMK1 | 435-466 | 54 | 1.9e-17 | 47.25 | In-house | 244-276 (276) | Show / Hide |
Range on Protein: 435-466 Range on HMM: 244-276/276 Sequence Identity: 54% (18 aa) ISEE-ARDFIDSLLQVDPNNRSTAAKALNHPWI ||.. | ||| .| |||..| |....|||||| ISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | RAD53.AA | Pkinase_Tyr | 383-423 | 29 | 0.64446 | 3.73 | Pfam | 189-232 (270) | Show / Hide |
Range on Protein: 383-423 Range on HMM: 189-232/270 Sequence Identity: 29% (13 aa) NEYSSLVDMWSMGCLVYVILT-GHLP-FSGSTQDQLYKQI-GRG ..... | || | | . |.| | | . | . ..|..| .| GKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDG |
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| FHA | RAD53.AA | FHA | 601-681 | 24 | 2.4e-09 | 39.37 | Pfam | 1-73 (73) | Show / Hide |
Range on Protein: 601-681 Range on HMM: 1-73/73 Sequence Identity: 24% (21 aa) FFIGRSEDCNCKIE-DNR-LSRVHCFI-FKKRHAVGKSMYESPAQGLDDIWYCHTGTNVSYL--NNNRMIQGTKFLLQDGDEIKII . |||..||. . | . ||.|| | ... . . | . || .. |. |. .|.. |..||.|.. WTIGRDPDCDIVLDNDPSFVSRHHCEIRRYDNG----------RWYIRDLG---CSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG |
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| FHA | RAD53.AA | FHA | 600-664 | 24 | 5e-08 | 33.91 | SMART | 1-49 (49) | Show / Hide |
Range on Protein: 600-664 Range on HMM: 1-49/49 Sequence Identity: 24% (16 aa) PFFIGRSEDCNCKIEDNRLSRVHCFIFKKRHAVGKSMYESPAQGLDDIWYCHTGTNVSYLNNNRM .. |||.. |.. . .. ||.|| |. .. | . | .|| |.|..| TWTIGRHS-CDIQLPHPSISRHHCQIR-------DGD-----YIIDLG-E-H-STNGTYVNGRRV |
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