Gene SMK1 (Bakers Yeast)

SMK1

Species: Bakers Yeast
Alias: SMK1
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK1

Sequence

Name Sequence Type Origin Length Description Download
SMK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 300 Kinase domain by global Sugen HMM Fasta, JSON
SMK1.AA Protein Refseq_NP 388 involved in sporulation; Smk1p [Saccharomyces cerevisiae] Fasta, JSON

Protein domain

Protein domains of SMK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SMK1.AA ERK 38-337 48 3.2e-201 674.76 In-house 1-307 (307) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-307/307
Sequence Identity: 48% (149 aa)

YEIIQFLGKGAYGTVCSVKFKG---RSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSS-PYDGLYCYQELIDYDLAKVIH
|.||...|.||||.|||...|.   .......|.|||.|.|...|..||..||.|....||||.||..|.|.....|. .|...||..||...||...|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIIN

SSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDI
|...||..|..||.|||||||||||||.||||||||.|||.. |..||||||||||...|.....|...|...|.|||||||||||..||.|.|.|..||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTP-DKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFAS--HEAINLIESLLHWDSTHRLNVEQ
|..|||.||...|||.|.|.|..|||..|....||| ....|.......||.. ||..|||....||.||||.|.  ..||.|.|..|..|...|..||.
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

AISHPFL
...||..
CLEHPYF
Kinase SMK1.AA MAPK 38-337 42 8.70000000001e-161 540.45 In-house 1-328 (328) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-328/328
Sequence Identity: 42% (140 aa)

YEIIQFLGKGAYGTVCSVKFKG----RSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVT-----SS--PYDGLYCYQELIDY
|.|....|.||||.|||.. |     ..   ..|.||||. |..... ||..||.|....|..|.||..|.|    .     .|   .. .|...|| . 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLAKVIHSSVQLSEFHIKYFLYQILCG--LKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQP------HITNYVATRWYRAP
|| ..|.|  .||. ||.||.||||.|  |||||||.||||||||.|||.. |..||||||||||.|.   ...|....|      | | ||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

ELLLS--NQPYSKSVDIWAVGCILAEFYA-RKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFG-TIKAWNLGKNSNN-PVYKKIPWSNIFP----FASHE
|..|.   . |.|.||.|.||||.||..  ||| | |.|...|.. |..|||||... . . .   .|.|. .. .| | |.|.||...||     |...
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AINLIESLLHWDSTHRLNVEQAISHPFL
||.|.| .|..|  .|..||.|..||..
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase SMK1.AA CMGC 38-337 26 3e-120 397.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-513/513
Sequence Identity: 26% (134 aa)

YEIIQFLGKGAYGTVCSVKFKG------------RSPAARIAVKKISNIFNKEILLK----------RAIRELKFMNFFK----------------GHKN
||||. .|.|.||.|.. . |             .    ..|.|||.| | .|.  |          ||.||.|..  ..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVNLIDLEIVTSSP-------------YDGLYCYQELIDYDLAKVIHSSV---------QLSEFH------------IKYFL------YQILCGLK--YI
||.|.|      |              .. ||   |..|.||...|..            ||| |            ||||.      ||||.|||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAD--VIHRDLKPGNILCTLN--------------------GCLKICDFGLARGIHAGFFKCHSTVQP-------------HITNYVATRWYRAPELLL
||..  .||||||| ||| . |                    |.|||||||||| .|    ........             ..|.||.||||||||.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SN---------QPYSKSVDIWAVGCILAEFYAR--------KPVFMGRDS-----------MHQIFEIIKVLGTP----------------DKDILIKFG
.          . |....|.|.||||.|| | .        || | |...            .|.|.|.||||||                ....  . .
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------TIKAWNLGKNSN-NPVYKKIPWSNIFPF-----------------------------------ASHEAINLIESLLHWDS
                    ...|.|  .. |  | ....||.|.||.                                   ....||.|.. .|..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

THRLNVEQAISHPFL
. |. .||| .||..
DKRITAEQALQHPYF
Kinase SMK1.AA p38 38-337 36 3.8e-91 309.12 In-house 1-289 (289) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-289/289
Sequence Identity: 36% (112 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPA-ARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIV---TSSPYDGLYCYQELIDYDLAKVIH
|. .|..|.||||.||..  ....    ..|.||..  | .||  ||. |||.     . | |.. |.|         .     |   .. . || ... 
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMR-HENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMK

SSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDI
.   ||. ||.. .|||| ||||||||..|||||||.||  . .  |.| ||||||                .| ||||||||||| .|.   | . |||
CQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR-----------HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDI

WAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKN--SNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQA
| ||||.||   ... | | | ..|. .|.||.||||. .. |    .|    .|   . | ...   ...|. |.  ||.|.| .|. |.  |. .|.|
WSVGCIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEA----RNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEA

ISHPFL
..||..
MQHPYF
Kinase SMK1.AA S_TKc 38-337 28 1.4e-90 308.15 SMART 1-231 (231) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-231/231
Sequence Identity: 28% (90 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCYQELIDY---DLAKVIHS
|||.. .||||.|.|. .. |.     . |.|.|.         ....||.. .    .|.|||.|.|         | ||   |..|    || ..|..
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKK

SVQ------LSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYS
         ..| |.....|||.|.|.|.||  .||||||| |||..   ..||||||||| .               | .. |.||.|||.|    .|.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL----GYG

K-SVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLN
| ..|.|..||||.|.....| |     |...|..|.                                          |.||...|. .|..| ..|. 
KCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPT

VEQAIS-------HPFL
. .|         ||..
A-EALQDEWDIKCHPWF
Kinase SMK1.AA ERK5 38-337 40 2.1e-87 296.66 In-house 1-295 (295) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-295/295
Sequence Identity: 40% (124 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGL---YCYQELIDYDLAKVIHS
|.||  .| |||| ||| . .      ..|.||| | | .    || .|||| .  |. | ||. . |. .    ||  .   |   .|.. || ..|||
YKIIEKIGNGAYGVVCSARRRKN--GQQVAIKKIPNAFDVVTNAKRTFRELKILRHFR-HDNIIAIRDI-LMPKVPYSEMKDVYVVFDLMESDLHQIIHS

SVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIW
.  ..  ||.||||||| ||||.|||.|||||||| |.|   |  ||| |||.|||.       |   |  .|.||||||||||||..| . | . .|.|
NQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKH---QMFMTEYVATRWYRAPELMFSSHDYTQAIDVW

AVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISH
.||||. |  ||. .| |.  .||.  |..|||.|   ..   .. .  |    .| |  .  .|. ..| |   |..|.  .| ..   |. | .|. |
SVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNY-FQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQH

PFL
|||
PFL
Kinase SMK1.AA ERK7 38-337 38 2.8e-84 286.29 In-house 1-292 (292) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-292/292
Sequence Identity: 38% (116 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQ
|||.. ||||||| |   |   .     .|.|||   |  ..   |  ||  |.  |..| ||. ||.  ..  .    .|   |  . ||  ||     
YEIRKRLGKGAYGIVW--KAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLIN--VIRADNDRDIYLVFEFMETDLHAVIRKGNI

LSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVG
| . | .| .||.|  .||.||..|||||||| |||   .  .|.||||||| |        .  .| .|.||||||||||| ||. . | | || | .|
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEY--DEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIG

CILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPFL
|||.|    ||.| |   |.||  |..... | .  .   |   |||. .. |  . |. . ....| ....||.|.  ||      || .|||..||. 
CILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN--QQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase SMK1.AA ERK1 38-337 43 6.7e-79 268.44 In-house 1-289 (289) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-289/289
Sequence Identity: 43% (132 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLID-LEIVTSSPYDGLYCYQELIDYDLAKVIHSSV
|  .|..|.|||| |||   . .    |.|.||||  |      .| .||.| .. || | ||.|. | .   |      .|  |.|.. || |..  . 
YTNLQYIGEGAYGMVCSAYDTVH--KQRVAIKKIS-PFEHQTYCQRTLREIKILTRFK-HENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLK-TQ

QLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAV
.||  || ||||||| |||||||| |.|||||| |.|      ||||||||||   |   . |      .| |||||||||||..|  . | ||.|||.|
HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--IADPEHDHTGF---LTEYVATRWYRAPEIMLNSKGYTKSIDIWSV

GCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPF
||||||  . .|.| |.  . |.  |. ||| | .| |      || |  .    |  .|.||  .|| |   |. |.. .| .   .|..||.|. ||.
GCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSL--PHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPY

L
|
L
Kinase SMK1.AA CDK 38-337 31 1.5e-77 247.63 In-house 1-284 (284) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-284/284
Sequence Identity: 31% (106 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPA-------ARIAVKKISNIFN-----KEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPYD---------G
||... .| |.||.|    .|.|.           .| |||    .     || .   |||| . .     |.|||.|.|  .....  |          
YEKLEKIGEGTYGVV----YKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHD--VCHTKNMDRNNKDKHENK

LYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGC-----LKICDFGLARGIHA--GFFKCHSTV-QPHITN
||   | .|.||.|...         || ...|.| || |.||  ..|||||| ||| . ||.     ||| ||||||  .         |   .   |.
LYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQ----MS-EPNRTYTH

YVATRWYRAPELLLSNQPYS--KSVDIWAVGCILAEFYA---RKPVFMGRDSMHQIFEIIKVLGTPDKDILIKFGTIKAWNLGKNSNNPVYKKIPWSNIF
 | |.|||||||||  . ||   ..|.|.||||.||..    ||| |.|.   .|.| |....|||. |.   .     .                    
EVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------

PFASHEAINLIESLLHWDSTHRLNVEQAISHPFL
        .|....|  | ..|.. ||| .||..
--------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase SMK1.AA nmo 39-337 39 1.9e-77 237.57 In-house 2-292 (292) Show / Hide 
Range on Protein: 39-337
Range on HMM: 2-292/292
Sequence Identity: 39% (119 aa)

EIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLID-LEIVTSSPYDGLYCYQELIDYDLAKVIHSSVQ
.  . .| ||.| | ||    |.   |.|.||. |.|   .  ||  |||| . ||| | |.. . | |.    . .. .|   ||.  || |.| |  .
QPDRPIGYGAFGVVWSVT-DPRD-GKRVALKKMPNVFQNLVSCKRVFRELKMLCFFK-HDNVLSALDILQPPHKDFFQEIYVVTELMQSDLHKIIVSPQH

LSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAPELLLSNQPYSKSVDIWAVG
||  |.| |||||| ||||.|||...|||.||||.|   |  ||||||||||       |       |.|. | | .|||||.|.  . |.  ||||.||
LSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSK-------HMTQEVVTQYYRAPEILMGARHYTSAVDIWSVG

CILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK-DILIKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLIESLLHWDSTHRLNVEQAISHPF
|| ||   |. .|  .  ..|.  |. .||||   |.       ||  | .   .|  ...        | |||..|.  .||.|   |. ...|. ||.
CIFAELLGRRILFQAQSPIQQLQMITDLLGTPSMEDMKYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPY

L
|
L
Kinase SMK1.AA Pkinase 38-337 28 1.9e-71 248.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-293/293
Sequence Identity: 28% (92 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAAR--IAVKKISNIFNKEILLKRAIR--ELKFMNFFKGHKNIVNLIDLEIVTSSPYDGLYCY--QELIDY-----
|.|.. .|.|..|.|    .|..    .   |||.|.   .|.  .....|  |.. |. . .|.||| |.|          . ..|  .|. .      
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVM

DLAKVIH--SSVQL--SEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCL----KICDFGLARGIHAGFFKCHSTVQPHITNYVATRWYRAP
||. .|.  ..  .  || ..| ..||||.||.|.||  .||||||| |||.  || .    ||||||||. .           ..  | .. |.||.||
DLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------Y-NNS-MTTFCGTPWYMAP

ELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGR----DSMHQIFEIIKVLGTPDKDILIKF---GTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAI
|.....|.|...||.|..||||.|.. ..| | |.    . . |.. | ...|.| .    .     . .  .  . .       .  .   . .| |..
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------F-HWTF-HNWSEECK

NLIESLLHWDSTHRLNVEQAISHPFL
 .|...|..| . |.. ||.  ||..
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SMK1.AA MAPK-Unclassified 38-191 36 7e-41 142.14 In-house 1-159 (575) Show / Hide 
Range on Protein: 38-191
Range on HMM: 1-159/575
Sequence Identity: 36% (59 aa)

YEIIQFLGKGAYGTVCSVKFKGRSP-AARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHKNIVNLIDLEIVTSSPY---DGLYCYQELIDY---DLAK
|| .. .| |||| ||  ...  .      | ||.  ||  ... ||. ||.        | ||... |     .      | .|   ..      || .
YEYQKNIGSGAYGQVC--RAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLN-HPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQ

VIHSSV-QLSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGI
.|.|    ... ||.||.|||| ||||.||| .||||||| |.| . .. ..|||||..| |
IIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSI
Kinase SMK1.AA MAPK-Unclassified 205-271 34 8e-27 93.71 In-house 404-501 (575) Show / Hide 
Range on Protein: 205-271
Range on HMM: 404-501/575
Sequence Identity: 34% (34 aa)

HITNYVATRWYRAPELLLSNQPYSKSVDIWAVGCILAEFYAR-----------KPVFMGRD--------------------SMHQIFEIIKVLGTPDK
| | ||.||||||||..||.. |.. ||||..|||.||   .           .| | |.|                    .  ||. |. .||.|..
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPE
Kinase SMK1.AA TyrKc 38-337 20 1.9e-13 -5.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 38-337
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

YEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNFF-KGHKNIVNLIDLEIVTSS-----PYDGLYCYQELIDY-DLAK
 . .. || ||.|.|.  . |        |||.. .       ..  .||.. |  . . |.|||.|.   ..|..       . |.   |. .. || .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYG--VCTQQGRNFMYIEPLMIVMEYMPHGDLKD

VIHSSVQ-LSEFHIKYFLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAG---FFKCHSTVQPH---ITNY-VATRWYRAPELLL
 ....   |.  .  .| .|| ||  |.||  .|||||   |.| . |.. ||.||||.| |. .       ...  .     ... .  ||. ||| . 
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWM-APECI-

SNQPYSKSVDIWAVGCILAEFYARKPVFMGR-----DSMHQIFEIIKVLGTPDKDIL---IKFGTIKAWNLGKNSNNPVYKKIPWSNIFPFASHEAINLI
    ..   |.|. |  . | . .             |  ...| .|  . ...      .                           |. .. |  ...
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------FVCCPDEMYQIM

ESLLHWDSTHRLNVEQAISHPFL
..  | |   | . ..   | ..
KQCWHEDPEDRPTFSEI--HECF
Kinase SMK1.AA MAPK-Unclassified 295-337 15 2.4e-07 22.05 In-house 523-575 (575) Show / Hide 
Range on Protein: 295-337
Range on HMM: 523-575/575
Sequence Identity: 15% (8 aa)

KKIPWSNIFPFASH----------EAINLIESLLHWDSTHRLNVEQAISHPFL
. .... ... .            |.|... ..|  .   | . .|| .||. 
TPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase SMK1.AA Pkinase_Tyr 146-191 52 3e-06 21.9 Pfam 116-161 (270) Show / Hide 
Range on Protein: 146-191
Range on HMM: 116-161/270
Sequence Identity: 52% (24 aa)

FLYQILCGLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGI
. .|| .|. | .|   |||||   |.| | |.. ||||||||| |
MCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI
Kinase SMK1.AA Pkinase_Tyr 38-104 28 0.043646 7.69 Pfam 1-70 (270) Show / Hide 
Range on Protein: 38-104
Range on HMM: 1-70/270
Sequence Identity: 28% (20 aa)

YEIIQFLGKGAYGTVCSVKFK--GRSPAARIAVKKISNIFNKEI-LLKRAIRELKFMNFFKGHKNIVNLI
 .... ||.||.|.|.  . |  . ..    |||.. .   .|  ...  .||.| |  .  |.|||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY