Gene SSK22 (Bakers Yeast)

SSK22

Species: Bakers Yeast
Alias: SSK22
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
SSK22.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
SSK22.AA Protein Refseq_NP 1331 `functionally redundant with, and homologous to, SSK2; Ssk22p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of SSK22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SSK22.AA STE11-Unclassified 1034-1310 45 1.8e-179 602.51 In-house 1-308 (308) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-308/308
Sequence Identity: 45% (140 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTT----TMKKI-FPLIKEEMTVLEMLNHPNIVQYYGVE--VHRDKVNIFMEYCEGGSLASLLDH
|||..|||.|.|||||...|...||..|||.|.|||..    .|.|. ...|..||.||..|||.|||||||.|  .|.|..||||||..|||..|.|..
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

GRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFG--VETKSL-------NEMMGTPM---
....||||...||...||||||||..|..|||||..|||.||.||.|..|||.|......||||||....|.|.   .....       ..|.|||.   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

YMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDN---EWAIMYHVAAGRIPQLPNRDE---------MTAAGRAFLERCLVQDPTMRATAV
.||||.|..|. .|.....|.|.|||.|.|||||..||||..|   .||||..|....|||.|....         .......||..|. .|| .|.|| 
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

ELLIDPWM
.|| .|. 
QLLQHPFI
Kinase SSK22.AA STE11 1034-1310 42 3e-154 518.74 In-house 1-303 (303) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-303/303
Sequence Identity: 42% (128 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTM----------KKIFPLIKEEMTVLEMLNHPNIVQYYGVEVH---RDKVNIFMEYCEGGSL
|||. .|| |.||.||...|. .||..|||.|.|.....|          .|....|.||. ....|||.|||.|||...|   .|.||||||||.||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

ASLLDHGR---IEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGI-IKYVDFGTARTVVGSRTRTVRNAAVQDFG--VETKSLN-EMMGTP
.|.|.|..   . ||||...||  .||||.|||. |..|||||..|||||..|. .|..|||.|. .... |.|  . ..|. .  . |.... .|||||
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQN-HCKSMTGTPYNSMMGTP

MYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDN-EWAIMYHVAAGRIPQLPNRDEMT------AAGRAFLERCLVQDPTMRATAVELLI
|.||||.|...  .|.  ..|.|.|||.|.|||||..||.|.|. ..|.|.....|. |. | ...|.      ...|.|| .|...|| .|.|| .|| 
MWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQ

DPWM
.|. 
HPFI
Kinase SSK22.AA STE 1034-1310 26 2.6e-94 319.65 In-house 1-359 (359) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-359/359
Sequence Identity: 26% (100 aa)

WQKRSFIGGGTFGQVYSAINLE---------------NGEILAVKEIKIHDTTTM-------------KKIFPLIKEEMTVLEMLN--HPNIVQYYGVEV
|.. ..|| |.||.|| |.| .               .||| |.|.... . ...             ....  |..|. ..  .|  |||||.||| ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

H-------RDKVNIFMEYCEGGSLASLLDH--GRIED------------EMVTQVYTFELLEG-LAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTAR
.       .|...|.|||..|||| ....|  |. ..            | .  ......|.| |.|||. ...|||||| ||||     .| .|||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

TVVGSRTRTVRNAAVQDFGV-----ETK-SLNEMMGTPMYMAPETISG--SA-VKGKLGADDVWALGCVVLEMATGRRPW---SNLDNEWAIM--YHVAA
 .. | ..  . .   .         ..   | . ||| .|||| |..  .. .||     |.| |||...|||||. ||   ... . ..|.  ||...
QLTDSMANI-Q-S---NN-IIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQ

---------GRIPQLPNR-----------------DEMTAAGRAFLERCLVQDPTMRATAVELLI--DPWM
         | .|.||..                 ....   . |...||. ||  |.|| .||    |. 
QFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase SSK22.AA S_TKc 1034-1310 29 1.9e-87 297.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-231/231
Sequence Identity: 29% (85 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEG--GSLASLLDHGRI--
...   || |.||.|| ... . |.| |.|.||             |. |. .|.. .|||||..|.| .. |.. ..||||.|  |.| ..... .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----EDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSA
     .| ... |. .....|.|.|. |..|||.||||||||    ||  ||| || .                       . . ||| ||||| .    
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL----

VKGKLG-ADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLI-------DPWM
  |  . . |.|..||.. ||..|. |..    . . |...              .  .. |...||. ||. | || |.|        .||.
--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase SSK22.AA Pkinase 1034-1310 29 8.7e-67 232.99 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-293/293
Sequence Identity: 29% (93 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKK-----IFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGG----SLASLL
... . || |.||.|| ...  .|.| |||.|| ...   |.     .      |  .. .|||||||..|..   .|.. . |||||||    .|....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

D---HGRI-EDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGII----KYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYM
    ||..  .| . . |  ..|.||.|.|. |..|||.||||||.| || |    |  ||| |. .                      ..   ||| ||
STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------------Y-NNS-MTTFCGTPWYM

APETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNL------DNEWAIMYHVAAGRIPQLPNRDEMT-----------------AAGRAFLERCLVQ
||| |     ..   . |.|..||.. ||..|| |...       |  . |     .    . |. ...                   ... |...|| .
APEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPTMRATAVELLIDPWM
||. | || ..| .||.
DPKKRPTAEQILQHPWF
Kinase SSK22.AA MEKK15 1034-1310 36 1.7e-61 210.59 In-house 1-264 (264) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-264/264
Sequence Identity: 36% (103 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIH--DTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIED
|.|   .| | .| ||  .  . | ..||| ...   |    |. .  ..||. .|  | | ||| | || ..   |||||..  |||..|..      |
WKKGNILGKGAYGTVYCGL-TNTGQLIAVKQVELDEIDKEKAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPLD

EMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLG
|||   ||  .|.| .|||.  |||||||  |..|   |||| .||| |.          | .     . ..  |  | ||| .|||| |  .    |  
EMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAK----------RLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRK--

ADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAA-GRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM
  |.|..|| | ||||.. || ..|   |. |  |  . .|||| .       | | . ||  |   |.||..||  |..
-SDIWSIGCTVFEMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVK--FSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase SSK22.AA ASK 1040-1310 36 4.7e-57 188.23 In-house 2-254 (254) Show / Hide 
Range on Protein: 1040-1310
Range on HMM: 2-254/254
Sequence Identity: 36% (100 aa)

IGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDH--GRIE-DEMVTQ
.| ||.| || . ....   .|.|||. .|     .  ||  ||. . . | | ||||| |   . . . ||||   ||||..||    | .. .|   .
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR---YVQPLH-EEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMN

VYTFELLEGLAYLHQSGVVHRDIKPENILLD-FNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDV
 ||  .|||| |||.  .|||||| .|.|.  . |..|  ||||.. . |       | . . |           ||  ||||| |    ..|   . |.
FYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAG------INPCTETF----------TGTLQYMAPEVID-QGQRGYGKPADI

WALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRI-PQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM
|..|| ..|||||. |.  |..  | |..|   .. |..|  .|..|. ..|. ||   ||. ||.| .|| ||..
WSFGCTMVEMATGKPPFHELGEPQAAMFKVGMYKKHPEIP--EELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase SSK22.AA CAMK 1039-1310 18 3.3e-52 166.15 In-house 1-425 (425) Show / Hide 
Range on Protein: 1039-1310
Range on HMM: 1-425/425
Sequence Identity: 18% (78 aa)

FIGGGTFGQVYSAINLENG------------EILAVKEIKIHDTTT------------------------MKKIFPLIKEEMTVLEM-------LNHPNI
 .| |.||.|. .|. ...            .  |.| |.    .                           |    .. |. .. .       |.||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYYGVEVH-------------------RDKVNIFM---EYCEGG----SLASLLDHG---------------RIEDEMVTQVYTFELLEGLAYLHQSGV
.. | |                      .... ..|   |||.||     | . .                  .  .|  .. |   ......|.|. ..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPENILLDFN-----------------GIIKYVDFGTARTVVGSRTRT----VRNAAVQ----DFGVETKSLNEMMGTPMYMA-PETISGSA---
||||.|||||||| |                 . || .||| |. . ..   .    . ..  .    . . |.. .... ||| ||| || ..|.    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-MHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------VKGKLGADDVWALGCVVLEMATGRRPWS---------------NLDNEW-AIMYHVAAGRIPQLPN---------RDEMTAA--------GR
         ..   . |.|..|..   | .|. |.                |. . .  ||        |....          |. .           .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

AFLERCLVQDPTMRATAVELLIDPWM
 .. ..|. ||. |.|. . | .|||
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase SSK22.AA Ciliate-E2 1040-1310 21 4.7e-49 166.51 In-house 7-365 (365) Show / Hide 
Range on Protein: 1040-1310
Range on HMM: 7-365/365
Sequence Identity: 21% (80 aa)

IGGGTFGQVYSAINLENGE-----------------------ILAVKEI-KIHDTTTMKKIFPL---------IKEEMTVLEMLNHPNIVQYYGVEV--H
|| |.||.|| . . ....                       | |.| . |     ....|  .         | .|. .|| ||||||...| .     
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQLNHPNIIKMYECFQEKD

RDKVNIFMEYCEGGSLASLLDHGRIE-----------DEMVTQVYTFELLE---------------GLAYLHQSG-VVHRDIKPENILLDFNGIIKYVDF
.... . ||||.||.| ... . ..            .|   . .. ..|.               .| |||. . ..||||||||||.     || .||
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDF

GTARTVVGSRTRTV----RNAAVQDFGVETKSLNEM------------MGTPMYMAPETISGSA------VKGKLGADDVWALGCVVLEMATGRRPWSNL
|... .  .. ..     ..   . .. ....   |             |||.||||| ..|         ||   . |.|.||..  || .|..|.   
GLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---

DNEWAIMYHVAAGRIPQLP----------------NRDEMTAAGRAFLER----CLVQDPTMRAT-AVELLIDPWM
       .        ..|                . .. .  .  .. .    .|. ||  | | . ..|  ||.
-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase SSK22.AA MEKK2 1034-1310 35 8.8e-48 165.06 In-house 1-262 (262) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-262/262
Sequence Identity: 35% (99 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIH-DTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRD--KVNIFMEYCEGGSLASLLDHGRIE
|..   .| | ||.||     . |  |||| ...  | .  .|    .. |. .|  | |. ||||||    .    . |||||  |||.   |      
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

DEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKL
 | ||  ||  .|||..|||.  .||||||  ||| |  | .|  ||| ..     |  |.        |. .     . ||| .|.|| |.|     | 
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASK-----RLQTICMHIT---GMKS-----VTGTPYWMSPEVINGEGYGRKA

GADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM
   |||..|| | || | . || . .   ||         ||||.  ..   .| ||.|| |.    |  | |||   ..
---DVWSIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQ--HVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase SSK22.AA ULK 1034-1310 23 4.6e-47 162.67 In-house 1-324 (324) Show / Hide 
Range on Protein: 1034-1310
Range on HMM: 1-324/324
Sequence Identity: 23% (79 aa)

WQKRSFIGGGTFG-QVYSAINLEN---GEILAVKEIK---IHDTTTM---KKIFPLIKEEMTVLEMLN---HPN--IVQYYGVEVHR--DKVNIFMEYCE
....  .| |.|| .|| ..| ..   ... |.| |    . .   .   . .  |.| |  .. .|.   |||  ||..| .      . . |.||||.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGSLASLLD---------HGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFN------------GIIKYVDFGTARTV-VGSRTRTVRNA
|| | ...           ...  |. .. .   ...|. .||. ...||||||.|||.  .            |..|  ||| |..|  ..   ...  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

AV-QDFGVETKSLNEMM---GTPMYMAPETISGSAVKGKLG-A-DDVWALGCVVLEMATGRRP---WSNLD-NEWAIMYHVAAG---------RIPQLP-
.| .                |||.||||. ..|   . . . .  |.| |||.  || .|. |   | . | ... |. ..  |         .  | | 
CVNE------------KRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPK

--NRDEMTAAGRAFLERCLVQDPTMRATAVELLIDPWM
  . .      . .. |.|. |.. | .  |..  ||.
PPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase SSK22.AA MEKK4 1034-1180 43 3.5e-43 145.98 In-house 1-145 (271) Show / Hide 
Range on Protein: 1034-1180
Range on HMM: 1-145/271
Sequence Identity: 43% (65 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKI--HDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIED
||    || | || ||...|   .|..|.||. .   |. ..| |     .|.  .| . ||| | |||||||| .. ||||||  | | ..   |   .
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIA----DEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGNMQ

EMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTA
| ..  ||  || .  |||| |.||||||| || ||  ...|  ||| .
EHMIRQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCS
Kinase SSK22.AA MEKK4 1210-1310 41 1.7e-29 98.36 In-house 163-271 (271) Show / Hide 
Range on Protein: 1210-1310
Range on HMM: 163-271/271
Sequence Identity: 41% (46 aa)

MGTPMYMAPETISGSAVK-------GKLGADDVWALGCVVLEMATGRRPWS---NLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRA
|||. ||||| ..            |   | |.|.||||| ||.|| |||      | . .||| |  |  |. |  | |   |..|.  ||  ||..| 
MGTAAYMAPEVYTYTEKDETTGSYSGHGRAADIWSLGCVVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIP--DKMSPEGKDFFDHCLEHDPKDRW

TAVELLIDPWM
||.|||  .  
TANELLDHTFC
Kinase SSK22.AA TyrKc 1034-1308 23 2.7e-16 40.74 SMART 1-280 (280) Show / Hide 
Range on Protein: 1034-1308
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEML--NHPNIVQYYGVEVHR-------DKVNIFMEYCEGGSLASLL
 ..   .| | ||.|| ..     .  ||| .| .           . .|. .. .|  .|||||. ||| ..        . . | |||...|.| . |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-DHGRIEDEMVTQV-YTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGS-RTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETI
 .|..    | . . . .   .| .|||. ...|||.   |.|.. |...|  ||| .| .    ..     .. .   . ...   .|     ||||.|
RKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAPECI

SGSAVKGKLG----ADDVWALGCVVLEMAT-GRRPWSN-----LDNEWAIMYHVAAGRIPQLPNRDE------MTAAGRAFLERCLVQDPTMRATAVELL
       . |    . |||. | .  |. | |  |...     ..|.  .. .| .|. .  |  |.      ....     ..|   || .| |  |. 
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

IDP
 . 
ECF
Kinase SSK22.AA Pkinase_Tyr 1040-1159 25 4.1e-11 38.25 Pfam 7-137 (270) Show / Hide 
Range on Protein: 1040-1159
Range on HMM: 7-137/270
Sequence Identity: 25% (34 aa)

IGGGTFGQVYSAINL----ENGEILAVKEIKIHDTTTMKKI--FPLIKEEMTVLEML-NHPNIVQYYGVEV-HRDK--VNIFMEYCEGGSLASLLDH---
.| | ||.|| ..      ...   ||| .|    ..|..        .|. ..  | .|||||..||| . ...   . | |||...|.| . |     
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHRE

-GRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDI
 ..  .      . ..  .|..||.. . .|||.
DKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase SSK22.AA Pkinase_Tyr 1234-1258 37 0.158838 5.79 Pfam 196-222 (270) Show / Hide 
Range on Protein: 1234-1258
Range on HMM: 196-222/270
Sequence Identity: 37% (10 aa)

DVWALGCVVLEMAT-GRRP-WSNLDNE
|||. | .  |. | |. | . ...||
DVWSFGVLMWEIFTYGEQPTYPGMSNE