Gene SSN3 (Bakers Yeast)

SSN3

Species: Bakers Yeast
Alias: SSN3
External Links: Saccharomyces Genome Database Link ,
Annotation:

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
SSN3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 314 Kinase domain by global Sugen HMM Fasta, JSON
SSN3.AA Protein Refseq_NP 555 `Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation. Activity of the kinase (SSN3)/cyclin (SSN8) pair required, along with SSN6 & TUP1, for transcriptional repression of a-specific genes; Ssn3p [Saccharomyces cerevisiae]` Fasta, JSON

Protein domain

Protein domains of SSN3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SSN3.AA CDK8 172-463 54 8.8e-234 741.34 In-house 19-329 (329) Show / Hide 
Range on Protein: 172-463
Range on HMM: 19-329/329
Sequence Identity: 54% (170 aa)

IKKPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLER--KCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPR-----MVR
.||.....||.|.|.|||||||||..||||.|||||.|||||||......|...||..  |||.|...||||||..||.||.|....|..|.     ||.
QKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHRHNKAHMKDPTMVPRNMVK

SIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDG------CVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAEL
|||||.|||..|||.|||||||||||||||..||      ||||.|.|.||.|||.|..||..|.||||.|||||||||||||||.|.|.|..|||||||
SIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAEL

IGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITK----FPKYRDNLATWYHSAG--GRDKHALSLLYHLLNYDPIKRI
|...|||...|.|||.|...|....||.||..|.|.|..|.||...|.||.....|    ...|......||....  .||.||..|||..|..||.|||
ITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDSHAYHLLYKMLTMDPTKRI

DAFNALEHKYF
....|.||.||
TCEQAMEHPYF
Kinase SSN3.AA CDK 174-463 33 2.4e-124 399.81 In-house 26-284 (284) Show / Hide 
Range on Protein: 174-463
Range on HMM: 26-284/284
Sequence Identity: 33% (104 aa)

KPLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLER-----------KCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRM
|.   ..|.||...|..| .. . .|....|.|| .| .|| ...  .| ....             . . || ||..||| ....              
KKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD--------------

VRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGC-----VKIGDLGLARKFHNMLQ---TLYTGDKVVVTIWYRAPELLLGARHYT--PAVDLWSVG
....|||||.|..|.|.||..||||||.||... .|.     .||.| ||||.|....|    . | ...||| ||||||||||..||.  ...|.||||
IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVG

CIFAELIG---LQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPI
|||||..     .|.| |.              .|| .| ...|||. ..|| ..|.|.|                             || ..| ||| 
CIFAEMFTDVTRKPLFPGDSE-----------IDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------------DLLNKMLCYDPK

KRIDAFNALEHKYF
||| |  ||.|.||
KRISAEQALQHPYF
Kinase SSN3.AA CMGC 75-463 20 5.5e-109 359.41 In-house 1-513 (513) Show / Hide 
Range on Protein: 75-463
Range on HMM: 1-513/513
Sequence Identity: 20% (122 aa)

YEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKK
||.|..|  ||||.|||.. . . .  .                                                                . |   ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKD----------------------------------------------------------------NGQ-AHHH

PLTVFYAIKKFKTEKDGVEQL---HYTGISQSACREMALCREL-----------------HNKHLTTLVEIFLERK-----------------CVHMVYE
    ..||||.| ...  ...   . .|....|.||  . ..|                 | ... .| .||  ..                 ....| |
ETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFE

YAEHDLLQIIHFHS--HPE---------------------KRMIPPRMVRSIMWQLLDGVS--YLHQNW--VLHRDLKPANIMVTID-------------
| .|||.|.|. ..  ...                     .. ..   .| .|.|.| |.   |.|..|  ..||||||.||... .             
YMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSED

-------GCVKIGDLGLARKFHNMLQT------------------LYTGDKVVVTIWYRAPELLLGARHYT---------PAVDLWSVGCIFAELIG---
       |..||.| ||||..|.                      . .    ||| ||||||.|||..|||         ...| |||||||||..    
WNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQ

-----LQPIFKGEEAKL--DSKKTVPFQVNQLQRILEVLGTPD---------------QKIWPYLEKYPEYDQITK------------------------
     ..|.|.|.  ..  | | .    ..||..| .|||||.               ...||.  |.|.|..  |                        
SLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNR

FPKYR-DNLATWYHSAGG--------------------------------RDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
||...  ..  ..  .                                   |. |. ||  .| ||| ||| |  ||.| ||
FPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SSN3.AA CDK7 199-463 36 2.4e-88 235.32 In-house 44-288 (288) Show / Hide 
Range on Protein: 199-463
Range on HMM: 44-288/288
Sequence Identity: 36% (96 aa)

GISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDG
||  .| ||  . .|..      |. ||  .  . .|... . ||  .|   |        |  . ..| ..| |. |.|.||.||||||| |  . ..|
GINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSI----ILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENG

CVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQK
 .||.| |||| .       ||    |||.|||||||| |||||...||.||||||||||.   |.. |.             . ||.|| . ||||  .
QLKIADFGLARFY-GSPNRIYTHQ--VVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDS-----------DIDQLTRIFQTLGTPTEE

IWPYLEKYPEYDQITKFPKY-RDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
 || . . ..| ....|| | |. |   . .|.. |  .| |.  ..  .|.||. .  .|...||
EWPNMCCMMDYIKFKDFPGYSRTPLRH-IFTAASDD--LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase SSN3.AA CDC2 181-463 36 1.3e-80 247.41 In-house 28-301 (301) Show / Hide 
Range on Protein: 181-463
Range on HMM: 28-301/301
Sequence Identity: 36% (107 aa)

AIKKFKTEKDGVEQLHYTGISQSACREMALCRELH-NKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQ
|.||...| .  .     |. ..| ||  .  ||   . ...| ... . . . || || ..|| .     | | .  .||  |.|.|.|.|.||...||
ALKKIRLEQEDEGD----GVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMD-MSIPKNKHMPPQLVKSYMYQILQGVHFCHQ

NWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAEL---IGLQPIFKGEEAKLDSKK
. ..|||||| || .  .| .||.| |||| |   . |. |. . ||| ||||||.|||...|. .||.||.||||||.   .   |.| |     ||  
RRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTE-HEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHG-----DS--

TVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRD-NLATWYHS-AGGR-----DKHALSLLYHLLNYDPIKRIDAFNALEHKYF
    .  || .| ..||||. ..|| ....|.| .  .||...  .| .   .   ..     |. ...||  .| |||.||| |  ||.|.||
----EIDQLFKIFRILGTPNEQTWPGVTQLPDYKN--TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase SSN3.AA S_TKc 75-463 19 1.2e-74 255.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-463
Range on HMM: 1-231/231
Sequence Identity: 19% (77 aa)

YEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKK
||..  |  |..|||||..                                                                                 
YEILRKIGKGAFGKVYKCRHKK------------------------------------------------------------------------------

PLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEH---DLLQIIHFHSHPEK-RMIPPRMVRSIMWQL
     .|||. |               ....||...... | ... .| ..| . ....|| ||...   ||...|. . .. . . .|. ..|..|.|.
-TGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQI

LDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTP-AVDLWSVGCIFAELIGLQPIFKGEE
.... |.|.....||||||.||...   ..||.| ||||..          . ...| ||.|||.|    .|.. ..| ||.|||..|..  .| |    
CCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP---

AKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALE-------HKY
              |.|......|                                       .. |.... ..|..|| ||. |  ||.       | .
--------------QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase SSN3.AA PITSLRE 232-463 38 1.4e-68 234.15 In-house 78-295 (295) Show / Hide 
Range on Protein: 232-463
Range on HMM: 78-295/295
Sequence Identity: 38% (90 aa)

VHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYR
. || || ||||  ..  ... ...  |.  . . | ||| ||...| ||..||||| .|.  .  |. ||.| ||||..   .   ||  ..||| |||
IYMVMEYVEHDLKSLMENMKRRNQPFKPGE-IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKP-YT--PCVVTLWYR

APELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDN-LATWYHSAG
|||||||.. |...||.|||||||||.| ..|.|.|.             ..|...|   .|||  ||||   . |    .. ||.|  | |     .  
APELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKS-----------EIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAEN

GRDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
     ...||  .| |.| .|| |  || | .|
HISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase SSN3.AA CDK5 199-463 33 3.3e-67 211.23 In-house 40-287 (287) Show / Hide 
Range on Protein: 199-463
Range on HMM: 40-287/287
Sequence Identity: 33% (90 aa)

GISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDG
|.  .| || .| .||  |    |  .    |   .|.|.   ||   .          . .....|.|.||| |... |.. |||||||| | ..   |
GVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG----EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNG

CVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELI-GLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQ
  | .| |||| |    .. |.    ||| |||.|  |.|..||.  .|.||.||||||..  ..| | | . .           .|| || ...|||  
ELKLADFGLARAFGIPVRC-YSHE--VVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVE-----------DQLKRIFKIMGTPCE

KIWPYLEKYPEYD-QITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
  || . | |.|  .....|.| .   .|     . |.. . ||  .| ..| .||.| .||.| ||
DKWPSITKLPDYKPNHQQYPMY-PAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase SSN3.AA Pkinase 75-463 19 1.5e-56 199.01 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-463
Range on HMM: 1-293/293
Sequence Identity: 19% (82 aa)

YEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKK
|.... | .|..|.|||.... ..                                                                            
YHIGRKIGSGSFGCVYKCHHKGTGK---------------------------------------------------------------------------

PLTVFYAIKKFKTEKDGVEQ------LHYTGISQSACREMALCRELHNKHLTTLVEIFLERKCVHMVYEYAEH-----DLLQIIHFHSHPEKRM-IPPRM
     .|.|..| ...  ..      |          .| .. ..|. ..  .| ..| ... ..|| ||.|.     ||  .|.   . ....  ... 
----IVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWE

VRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCV----KIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAEL
....|.|.| |. |.|.....||||||.||..  .| .    ||.| |||..|   .      . ...|.||.|||...|...|.|.|| ||.|||..|.
CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

IGLQPIFKGEEAKLDSKKTVPFQ-------VNQLQRILEVLGTPDQKIWPYL-EKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIK
.                .  ||.       ..|.|.| ...|.|    ||.. ......... . .   . . |  | .   .. ...... .|..|| |
LC---------------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H---F-HWTF-HNW---SEECKDFIKWCLCKDPKK

RIDAFNALEHKYF
|. |  .|.|..|
RPTAEQILQHPWF
Kinase SSN3.AA MAPK 234-463 34 1.6e-54 186.91 In-house 93-328 (328) Show / Hide 
Range on Protein: 234-463
Range on HMM: 93-328/328
Sequence Identity: 34% (88 aa)

MVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDG--VSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHN----------------ML
.| |. |.|| |||.        .     ....|.|.| |  . |.|   |.||||||.|| |. ....||.| ||||....                | 
IVMELMETDLHQIIKSQQ-----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMH

QTLYTGDKVVVTIWYRAPELLLG--ARHYTPAVDLWSVGCIFAELIG-LQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEY-DQ
 | |     |.| ||||||..|.  ..||| ||| |||||||||...  .|.|.|.             ..|...|.||||||..  . ........ . 
MTEY-----VATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKD-----------YIDQWNLIMEVLGTPSEEFIQCICMSEHARNY

ITKF---PKYRD-NLATWYHSAG-GRDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
|  .   |||   .... .  |  . . .|. ||  .|  || |||..  ||.| ||
IQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase SSN3.AA CRK7 204-463 29 4.8e-54 184.69 In-house 48-343 (343) Show / Hide 
Range on Protein: 204-463
Range on HMM: 48-343/343
Sequence Identity: 29% (91 aa)

ACREMALCRELHNKHLTTLVEIFLE---------RK-CVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIM
| ||  . |.|. .   .| || ..          |  . || ||. |||   .  .  .|   . .  ....| |||.|. |.|.. .||||.| .|| 
AIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL---MGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNIL

VTIDGCVKIGDLGLARKFHNML-QTLYTGDKVVVTIWYRAPELLLGARHY--------------------------------------TPAVDLWSVGCI
.   | ||| |.||||...    .  ||    |.| |||.||||||. .|                                      .|..| ||.|||
MNNQGEVKIADFGLARLYNSEEKRRPYTN--RVITLWYRPPELLLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCI

FAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPDQKIWPYLEKYPEYDQITKFPKYRDNLATWYH---SAGGRDKHALSLLYHLLNYDPIKR
..||   .|||.|.               ||  | .. |.|    || . | | .. .    .|.  |         .   .| .| || ..| .|| ||
LGELFTKKPIFQGNN-----------EMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKR

IDAFNALEHKYF
. |  .|.| .|
FTAEECLQHDWF
Kinase SSN3.AA CDK10 199-463 33 2.1e-49 169.91 In-house 40-285 (285) Show / Hide 
Range on Protein: 199-463
Range on HMM: 40-285/285
Sequence Identity: 33% (89 aa)

GISQSACREMALCRELHNKHLTTLVEIFLERK--CVHMVYEYAEHDLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTI
|.  |. ||. |  ... . .  | |.   ..   . .| .| | ||  ..   ..|         |. || |.| |. |||.|...||||| .|...| 
GLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET----QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTD

DGCVKIGDLGLARKFHNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCIFAELIGLQPIFKGEEAKLDSKKTVPFQVNQLQRILEVLGTPD
.||.|. | ||||.. .  . .      .||.||||||||||.|  | |.|.| |||| .||.  .|.. |              . |.. |...||||.
KGCIKVADFGLARMYGVPVKPMTP---KMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPLMPGNS-----------EIHQIDMIIDLLGTPS

QKIWPYLEKYPEYDQITKFPKYRDNLATWYHSAGGRDKHALSLLYHLLNYDPIKRIDAFNALEHKYF
..|||   . |  .. |   .   ||   .|  .   .  . ||  |. |.| ||  | ..|| .||
ENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLS---QSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase SSN3.AA TyrKc 75-416 15 1.4e-10 -51.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-416
Range on HMM: 1-280/280
Sequence Identity: 15% (59 aa)

YEVIGYIAAGTYGKVYKAKRQINSGTNSANGSSLNGTNAKIPQFDSTQPKSSSSMDMQANTNALRRNLLKDEGVTPGRIRTTREDVSPHYNSQKQTLIKK
 . .  .  | .|.|||..                                                                                 
ITLGKKLGEGAFGEVYKGTWK-------------------------------------------------------------------------------

PLTVFYAIKKFKTEKDGVEQLHYTGISQSACREMALCREL--HNKHLTTLVEIFLER-------KCVHMVYEYAEH-DLLQIIHFHSHPEKRMIPPRMVR
   .  |.|. | ..            .  .||. . ..|  |....  |. . ..        . . .| ||..| ||.. .. | .     ....   
---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK----LCMKDLL

SIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLARKFHNM-----LQTLYT-----GDKVVVTIWYRAPELLLGARHYTPAVDLWSVGCI
|..||  .| .|||.. . ||||   |..|. ...|||.| ||.|. ..       .  |.     | | .. |   ||| .   . .|.. | || |  
SFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTTKSDVWSFGVC

---FAELIGLQPI------FKGEE--AKLDSKKTVPFQVN--------QLQRILEVLGTPDQKIWPY-LEKYPEYDQITKFP
      . .  .        . .|  ..... .  |   |          . . ..     .. | .  |. |   .| .. 
MWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIM----KQCWHEDPEDRPTFSEIHECF
Kinase SSN3.AA Pkinase_Tyr 234-309 37 1.7e-09 32.81 Pfam 84-159 (270) Show / Hide 
Range on Protein: 234-309
Range on HMM: 84-159/270
Sequence Identity: 37% (29 aa)

MVYEYAEH-DLLQIIHFHSHPEKRMIPPRMVRSIMWQLLDGVSYLHQNWVLHRDLKPANIMVTIDGCVKIGDLGLAR
.| ||..| |||   . |. ..|. ... .  .. ||  .| .||...   ||||   |..|| ...|||.| ||||
IVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase SSN3.AA CDK8 79-96 66 1.2e-08 22.72 In-house 1-18 (329) Show / Hide 
Range on Protein: 79-96
Range on HMM: 1-18/329
Sequence Identity: 66% (12 aa)

GYIAAGTYGKVYKAKRQI
.||..||||.||||||..
KYIGRGTYGHVYKAKRKK
Kinase SSN3.AA CDK 75-101 41 5.9e-07 18.12 In-house 1-29 (284) Show / Hide 
Range on Protein: 75-101
Range on HMM: 1-29/284
Sequence Identity: 41% (12 aa)

YEVIGYIAAGTYGKVYKAKRQINSG--TN
|| .  |  ||||.||||. ... .  |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTG
Kinase SSN3.AA CRK7 75-93 68 1.6e-05 14.8 In-house 1-19 (343) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/343
Sequence Identity: 68% (13 aa)

YEVIGYIAAGTYGKVYKAK
|| |. |  ||||.|||||
YEMIMQIGEGTYGQVYKAK
Kinase SSN3.AA CDC2 75-93 57 0.000224 8.78 In-house 1-19 (301) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/301
Sequence Identity: 57% (11 aa)

YEVIGYIAAGTYGKVYKAK
|. |  |  ||||.|||.|
YQKIEKIGEGTYGVVYKCK
Kinase SSN3.AA CDK7 75-92 50 0.000985 5.34 In-house 1-18 (288) Show / Hide 
Range on Protein: 75-92
Range on HMM: 1-18/288
Sequence Identity: 50% (9 aa)

YEVIGYIAAGTYGKVYKA
|| |  | .|... ||||
YEKIKHIGEGQFATVYKA
Kinase SSN3.AA CDK5 75-93 57 0.003798 5.25 In-house 1-19 (287) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/287
Sequence Identity: 57% (11 aa)

YEVIGYIAAGTYGKVYKAK
|| .  |  |||| ||||.
YEKMEKIGEGTYGTVYKAR
Kinase SSN3.AA PITSLRE 75-93 47 0.007731 6.42 In-house 1-19 (295) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/295
Sequence Identity: 47% (9 aa)

YEVIGYIAAGTYGKVYKAK
.. .  |. |||| ||.||
FQCLNRIHEGTYGVVYRAK
Kinase SSN3.AA MAPK 75-93 36 0.075876 1.9 In-house 1-19 (328) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/328
Sequence Identity: 36% (7 aa)

YEVIGYIAAGTYGKVYKAK
|. . .|  | || | .|.
YQILKPIGQGAYGVVCSAI
Kinase SSN3.AA CDK10 75-93 42 0.090539 1.63 In-house 1-19 (285) Show / Hide 
Range on Protein: 75-93
Range on HMM: 1-19/285
Sequence Identity: 42% (8 aa)

YEVIGYIAAGTYGKVYKAK
.| .  .  |||| ||.|.
FEKLNRVGEGTYGIVYRAR