Gene TOS3 (Bakers Yeast)

TOS3

Species: Bakers Yeast
Alias: TOS3
External Links: Saccharomyces Genome Database Link
Annotation:

Classification

Group: Other
Family: CAMKK
Subfamily: ELM

Sequence

Name Sequence Type Origin Length Description Download
TOS3.AA Protein Refseq_NP 560 Hypothetical ORF; Tos3p [Saccharomyces cerevisiae] Fasta, JSON
TOS3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 295 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of TOS3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TOS3.AA ELM 50-344 55 1.4e-232 778.99 In-house 1-346 (346) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-346/346
Sequence Identity: 55% (193 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNR---------FEKRSG----YSLQLKV-ENPRVNQEIEVM-------------KRCHHENVVELYEI
.||...||.||.|.||.|||..||.||||||.||         .|||..    ...|.|. ||.|.|||...|             |||||..||.|.|.
YEIIVELGHGQHGYVKKARDITTGQLVAIKIINRKPWNAQQYSHEKRMRQFQTWKKQGKITENMRINQEMRIMNIEKCRWEIFAASKRCHHKHVVQLIEC

LNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQ-----SRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNG-TVKISDFGVAMST-A
|.||.|.|..||||.||||.|||||...|||.|..||||.||.     .||...|.|.||||||.||..||||||||||||.|| |||||||||.|.| .
LDDPFSRKIWLVLEWCSRGEVKWCPDDCMEIDAQWPSILIFQCSVSTFTRKILRDMVKGLEYLHYQGCIHRDIKPSNLLISENGKTVKISDFGVCMFTPQ

TGSTNIQ--SSHEQLLKSRALGTPAFFAPELCSTEKEYS--------------CSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYE
|.|.|.|  .|..|.......|||||||||.|.||.||.              ||..|||||||||.||||||.|||..|...|||..|||.||.||.|.
TNSFNDQNFESCFQRELNKIVGTPAFFAPEMCHTENEYRDYNLTKENLFRFVCCSFMIDIWSLGVTLYCLLFGMLPFFGNNEFELFHKIINDPLKFPIYK

EMLNGATSGIT-MEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFM
||||...|.|| ||||..|||||||||.|||.||.|..|||.||||
EMLNNKVSKITCMEEYEMAKDLLKKLLEKDPQKRMKIQDIKKHPFM
Kinase TOS3.AA CAMKK 50-344 34 1.9e-174 558.54 In-house 1-396 (396) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-396/396
Sequence Identity: 34% (137 aa)

FEILATLGNGQYGKVKLARDLGT-GALVAIKILNR---FEKRSG----YSLQLKV----------ENP----RVNQEIEVMKRCHHENVVELYEILNDPE
.|.. ..|.||.||||||.. .. . ..||||.|.   |.|. .    |. . |.          ...    .| |||..||.|.|.|.| |||...||.
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

STKVYLV-LEYCSRGPVKWCPENKMEIKAVG-----------------PSILTFQQ---------------------SRKVVLDVVSGLEYLH-SQG---
..|.|.| .|||.||...|.|..|.......                 .||...||                      .|...|.. |||||| .|.   
NDKIYMVQMEYCERGQIMWWPYWKQDYQPNWPYQYTELYSNRQYQNKDFSIMSEQQSISEFINQVVKQDQYFIHEDYAWKYFRDCIKGLEYLHNYQKACS

----------------ITHRDIKPSNLLISSNG---TVKISDFGVAMST-ATGSTNIQ-SSHEQLLKSRALGTPAFFAPELCSTEKEYS-----------
                | ||||||.|.||...|   .|||.||||....  . .|... .|..|.....  |||||.||||||.|....           
YIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPELCSKENQKENYNGYKYRFRF

--CSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFD---SIINKPLEFPSYEEMLNGATSGIT-MEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFM
  |. |.|||.||||.||..|||.||..|. ..|..   .|.|.|..||...||||. .| |. .|...|.|||.|..|.|.|.|||....|||||..
IYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNN-VS-IYCPEISEDLKDLIKRMLEKNPTKRITIPQIKVHPWV
Kinase TOS3.AA AGC 50-344 23 1.9e-88 228.08 In-house 1-395 (395) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-395/395
Sequence Identity: 23% (97 aa)

FEILATLGNGQYGKVKLARDL------GTGALVAIKILNRFEKRSGYSLQLK---VENPRVN----------QEIEVMKRCH----------HENVVE-L
||.| ..| | .||| |.|.       .|| . |.|.|.  .    . ...|   ||.  .           .| .....|.          | ..|  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKH----KIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKIL

YEILNDPESTKVYLVLEYCSRGPVK--WCPEN-KMEIKAV---GPSILTFQQSRKVVLD-------VVSGLEYLHS-QGITHRD-IKPSNLLISSNGTVK
.    |.. |..|.|.||..|  |.  .|.    . .      .  ... ...|            .|..|||||| .|| ||| .|| |.|. ..| .|
HYSFQDKDHTYLYFVMEYMPR-YVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIK

ISDFGVAMS--------------------------------TATGSTNIQSSH----------EQLLKSRALG--TPAFFAPELCSTEKEYSCSSAIDIW
..||| .                                  .  . .|.|.            .. . .   |  || . |||         .. | |.|
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNK-CNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL-------YGKACDWW

S--LGVTIYCLLFGKLPFNANSGL----------ELFDSII------NKPLEFPSYEEMLNGATSGITMEEYT--DAKDLLKKLLQKDPDKRIK------
|  ||. .| .|.|. ||....            |.|..|.      |....||..|.        .. ...   .||||.||||.|||.||.       
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP------QFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDF

----LADIKVHPFM
      .|| ||. 
GDKGAEEIKNHPWF
Kinase TOS3.AA S_TKc 50-344 27 3.8e-87 296.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSR--GPVKWCP
.||| ..| | .|||...|. .|| .|||||..                 .. .||...|. ||.|.| ||..  |   ...|.|.|||.   | ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

ENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCST
...   .   .. ..  . |...  ....|||.||.|| |||.||.|.|...  ..||.|||.|                   .   ||| . |||..  
KKRGRHGL--RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCGTPWYMAPEVL--

EKEYSCSS-AIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKV------
    . .  ..|.||.|...| .| |. ||      ..|. |                           .|||...|.|||||.||.   ..        
----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HPFM
 ||..
CHPWF
Kinase TOS3.AA CAMKL 50-344 28 1e-79 254.01 In-house 1-297 (297) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-297/297
Sequence Identity: 28% (93 aa)

FEILATLGNGQYGKVKLARD-LGTGALVAIKILNRFEKR-SGYSLQL------KVENPRVNQEIEVMKRCH---HENVVELYEILNDPES----TKVYLV
..|. ||| | .||||||.. . ||  |||||.... ..   ....       .    |. .||. ||. .   |.|.. |||.. .||     .|.|||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCSRGP---VKWC---PENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNG--TVKISDFGVA-----MSTATGSTNI
.|||| |      .    .. .          ..  . |.    .||...|.||.|| |||||| |.|...||  ..||.||| .     .         
MEYCSGGEMDLFDYIVKHGHRR--------GRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC---------

QSSHEQLLKSRALGTPAFFAPELCST-EKEYSCSSAIDIWSLGVTIYCLLFGKLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYT-DAKD
    .  . .   |.|.. |||...  .|.| .  ..||||.||. | ...|.|||.. .  .      ..   .  .... ..    ..   .  |..|
-IFGPGQKLKTFCGSPPYMAPEIFQGNNKPY-DGPKVDIWSCGVILYAMVCGYLPFDDDTYNK------QGKDNI-YLYWKIMCG-YYPPIWYHVSDCRD

LLKKLLQKDPDKRIKLADIKVHPFM
|..|.||..|.||... .|. ||.|
LIRKMLQVNPEKRPTIHQIMNHPWM
Kinase TOS3.AA CAMK 55-344 21 2.3e-77 248.65 In-house 1-425 (425) Show / Hide 
Range on Protein: 55-344
Range on HMM: 1-425/425
Sequence Identity: 21% (96 aa)

TLGNGQYGKVKLARDLGTG------------ALVAIKILNRF-------------------EKRSGYSLQLKVENPRVNQEIEVMKRCH-------HENV
||| |..|||||...  |.              |||||...                    .....|. .  .   .| .|||.||...       |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VELYEILNDPE-----------------STKVYLVL---EYCSRGPV----------KWCPENKMEIKAVGPSI---------LTFQQSRKVVLDVVSGL
. |||.  ||.                  ...|.|.   |||| |            . |. ...        .         .| .. |...  ..|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF--------DQFDIVERGRFTEREARRYFRQICSAV

EYLHSQGITHRDIKPSNLLISSN-----------------GTVKISDFGVA--MSTATGSTNI--QSSHEQLLKS------------RALGTPAFFA-PE
.|.||..| |||.|| |.|...|                 ...||.||| |  .    .....  . . | . ..               |||.. | ||
HYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPE

LCSTEK-----------EYSCSSAIDIWSLGVTIYCLLFGKLPFNANSG-------------LELFDSIINKPLEFPSYE-------EMLNGATSGITME
. . ..           .  .. ..|.||.||  | .| |..||.. ..              |||  |..   .||...                   .
VLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNY----------GP

EYTD-------------AKDLLKKLLQKDPDKRIKLADIKVHPFM
|. |             .|||..|.||.||.||....... ||.|
EWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TOS3.AA Pkinase 50-344 26 4.6e-72 250.53 Pfam 1-293 (293) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-293/293
Sequence Identity: 26% (87 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYS-----LQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRG---
..|. ..| | .|.|..... ||| .||.||... ...|.       |          .||..|||..|.|.|.||..  |  ....|.|.|||  |   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----------SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYV

-PVK----WCPENKMEIKAVGPSI-LTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTV----KISDFGVA--MSTATGSTNIQSSHEQLL
   .                . .. .. .. ..... ...||||.||.|| |||.||.|.||..||..    ||.|||.|  ..             .  
MDLFDYIST---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-

KSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPFNAN------SGLELFDSIINKPLEFPSYEEMLNGATSGITM--------EEYT
 .   ||| . |||.. . ..|  ....|.||.|...|..|.|..||         . ..... |  .||.|.....  .   . ..         .   
MTTFCGTPWYMAPEVIRGGQYY--GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSE

DAKDLLKKLLQKDPDKRIKLADIKVHPFM
..||..|..|.||| ||.  ..|. ||..
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TOS3.AA Ciliate-E2 50-344 23 7.1e-66 225.11 In-house 1-365 (365) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFE--------KRSGYSLQLKVENPR----VNQEIEVMK----------------RCHHENVVELYE
....  .|.|..|.|.....  .. ..|||| . .         |  .    .|. ...    ..||| .|.                .  | |....||
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

ILNDPESTKVYLVLEYCSRGPVK-WCPENKMEIKAV---GPSILTFQQSRKVVLDVVS---------------GLEYLHSQG-ITHRDIKPSNLLISSNG
   .   ...|||.|||. |  . .. .||   .     .   .| .. ...   ...               .||||||.. | ||||||.|.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

TVKISDFGVAMSTATGSTNIQ-SSHEQLLKSRA----------------------LGTPAFFAPELCSTEKEYS------CSSAIDIWSLGVTIYCLLFG
 .||.||| .    . . |..  .. ....                         .||| . |||  . .|..        . ..|||||||..|..|||
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

KLPFNANSGLELFDSIINKPLEFPSYEEMLNGATSGI------TMEEYTDAKDLLKK----LLQKDPDKRIK-LADIKVHPFM
|.||        .. |......||..|  .. ..  |      . .   ..|||.||    .|||||.|||    .|. ||..
KPPF--------QQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TOS3.AA Ciliate-E2-Unclassified 50-344 22 1.1e-58 201.32 In-house 1-352 (352) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-352/352
Sequence Identity: 22% (87 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKR------------------CHHENVVELYEILNDPESTKV
..|. ..|.|..|||.....  .. . |.|... . ...   ......   .|...|....                  . |...| .... .| .  ..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYK-QKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQ--NI

YLVLEYCSRGPVKWCPENKME--IKAVGP---------SILTFQQSR-----KVVLDVVSGLEYLHSQG-ITHRDIKPSNLLISSNG---TVKISDFGVA
|.|.|||  |  . . ....   .  .|           |.| ||..     .    ...||||||... | ||||||.|.|...||    .||.||| .
YIVMEYCEGGDLWQYIKKRKKQKQ--KGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

M------------STATGSTNIQSSHEQLLKSRALGTPAFF----APELCSTEKEYSCSS-AIDIWSLGVTIYCLLFGKLPFNANSGLE-----------
.                  ...|   .|...... ||| .     |||.   .. .  .. ..||||||| .|..|||..||..|.  .           
KKYQQNNNCDTNQQ-----QKMQIWKQQMMWTFC-GTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----LFDSIINKPLEFPSYEE-------------MLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFM
     |.. |..|...||....             ..|               |||.|.|.|.|.||| . .|. ||..
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase TOS3.AA CAMKK-Unclassified 164-344 28 2e-52 168.95 In-house 178-392 (392) Show / Hide 
Range on Protein: 164-344
Range on HMM: 178-392/392
Sequence Identity: 28% (66 aa)

QQSRKVVLDVVSGLEYLHSQG---------------------ITHRDIKPSNLLISSNGT-----VKISDFGVAMSTATGSTNIQSSHEQL-LKSRALGT
|. .|  ...  || |.| ..                     | |||||| |.||.....     .||.|||.. ..        ....|  ||. | ||
QYLKKYFRQCCKGLQYMHNFNQACSYIIIYINEFDKIDHFQDIIHRDIKPQNILIDHEDNDKGEHFKIADFGISVIM--------EHEQQKKLKNNA-GT

PAFFAPELCSTEKEYSCSSA-------------------------IDIWSLGVTIYCLLFGKLPFNANSGLELFD-SIINKPLEFPS-YEEMLNGATSGI
..| |||..| |.     ..                          ||||||||.||. ...|||....  |||   |..| . ||. |.  ..      
YCFMAPEFWSKENFKYDYNDYSFLPGTFNPLRKTYRIERICFYKKADIWSLGVTFYCMVYHSLPFWHKNLQELFHQMICQKEINFPPQYHPHCS------

TMEEYTDAKDLLKKLLQKDPDKRIKLADIKVHPFM
       .|||..|.. |.|.|||.. .. |||. 
-----HEFKDLIQKMCDKNPKKRITIDQMLVHPWF
Kinase TOS3.AA Meta 50-210 39 4.3e-42 119.32 In-house 1-169 (287) Show / Hide 
Range on Protein: 50-210
Range on HMM: 1-169/287
Sequence Identity: 39% (71 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILN--RFEKRSGYSLQ-------------LKVENP--RVNQEIEVMKRCHHENVVELYEILNDPESTKVY
      .| | ||.||||    .  . |.|||.  .  |  |   .              .  ||  || ||| ..|   | ||| |.|.|.||     |
YRLMEEIGKGSYGVVKLAYNEEDHHHYAMKILSKKKLLKQYGFMRRPPPRGNKPNQGGCIQPRNPLDRVYQEIAILKKLDHPNVVKLVEVLDDPNEDYLY

LVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGV
.| ||  .|||       ||.    |  |  .| ..   |.| |||||| | | ||||||||||... | ||| ||||
MVFEYVEKGPV-------MEVPCDNP--LSEDQAWSYFRDIVCGLEYLHYQKIIHRDIKPSNLLLNDDGHVKIADFGV
Kinase TOS3.AA Meta 235-344 40 9.4e-37 103.63 In-house 187-287 (287) Show / Hide 
Range on Protein: 235-344
Range on HMM: 187-287/287
Sequence Identity: 40% (46 aa)

GTPAFFAPELCSTEKEY-SCSSAIDIWSLGVTIYCLLFGKLPFNA--NSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDK
||||| |||.|| |.    |  | |.|..||| ||..||. || .  |. . |.| | | |..||   |  .            | ||. |..| |.| .
GTPAFMAPEACSEEQNHFYCGRALDVWAMGVTLYCFVFGQCPFIDKTNYIMCLHDKIKNHPVMFPEQPEISE------------DLKDCIKRMLDKNPEH

RIKLADIKVHPFM
|| ...||.||  
RIMIPEIKTHPWV
Kinase TOS3.AA MARK 50-143 34 2.6e-28 89.81 In-house 1-89 (262) Show / Hide 
Range on Protein: 50-143
Range on HMM: 1-89/262
Sequence Identity: 34% (33 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTK-VYLVLEYCSRGPV
...| |.| | |.|||||... ||  |||||...| .    ...       |  |||.||. .|.|...|...   ..... .||..||.|.|..
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKN------VMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGEL
Kinase TOS3.AA MARK 173-298 36 4.9e-26 82.23 In-house 113-230 (262) Show / Hide 
Range on Protein: 173-298
Range on HMM: 113-230/262
Sequence Identity: 36% (47 aa)

VVSGLEYLHSQGITHRDIKPSNLLISSNG--TVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLL
.||...|.||..| |||||| |.|| .||   .||.||| .    .|.          |..   |||.. |||. .  |.| .  ..|||||||  | ..
IVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK---------LNTFC-GTPPYMAPEIFL-KKPY-DGPKVDIWSLGVVLYFMV

FGKLPFNANS--GLELFDSIINKPLEFPSY
 |..|| . .    ||.  | .   ..|..
CGYFPFDGDTQDYKELYKKILRGKYDIPCH
Kinase TOS3.AA CAMKK-Unclassified 50-141 33 1.6e-22 69.9 In-house 1-107 (392) Show / Hide 
Range on Protein: 50-141
Range on HMM: 1-107/392
Sequence Identity: 33% (36 aa)

FEILATLGNGQYGKVKLARDLGT-----GALVAIKILNR--------FEKRSGYSLQLKVENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYL--V
 |.| .|| |..|||||| . .|         |||. ..        . . .. ....| .   | |||..||   |.|.. |||.  ||.  | |.  |
YEFLDKLGRGSFGKVKLATRRYTTDDGVQKQFAIKVFKKQKLKKKKFIYNDNAFTMKMKNRLHLVQQEIAIMKKLWHPNICKLYEVIDDPDNDKIYMGQV

LEYCSRG
.|||..|
MEYCQMG
Kinase TOS3.AA TyrKc 50-344 20 6.2e-14 2.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 50-344
Range on HMM: 1-280/280
Sequence Identity: 20% (66 aa)

FEILATLGNGQYGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVENPRVNQEIEVMKRC--HHENVVELYEILNDP-----ESTKVYLVLEYCSRGP
 . . .||.|..|.| ...       ||.| |.                    .|...|..   ||.|.| || .  ..     ..  ...|.||.. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

VKWC-PENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGST-NIQSSHEQLLK-----SRALG
 |    ... .        |. ..  .  ... .| |||||... |||.   | |...|.||||||||  .| . ..  .   |..   |     .... 
LKDYLRKHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG--LSRDIYDDDQQGESKDYYRKKEHKGGKTML

TPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLL-FGKLPFNA-----NSGLELFDSIINK-PLEFPSY--EEMLNGATSGITMEEYTDAKDLLKKLLQ
     |||     ... .... |.|| ||... .. .|. |         |  |..  . .   .. | .  . |     .  .. .     .. |.  .
PIRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----F-VCCPDEM--YQIMKQCWH

KDPDKRIKLADIKVHPFM
 ||..|   ..|  | ..
EDPEDRPTFSEI--HECF
Kinase TOS3.AA MARK 315-344 30 7.9e-10 28.48 In-house 233-262 (262) Show / Hide 
Range on Protein: 315-344
Range on HMM: 233-262/262
Sequence Identity: 30% (9 aa)

TDAKDLLKKLLQKDPDKRIKLADIKVHPFM
.....|...||. .|..|... .|  ||.|
KECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase TOS3.AA Pkinase_Tyr 50-141 26 3.9e-09 31.55 Pfam 1-92 (270) Show / Hide 
Range on Protein: 50-141
Range on HMM: 1-92/270
Sequence Identity: 26% (26 aa)

FEILATLGNGQYGKVKLARDL----GTGALVAIKILNRFEKRSGYSLQL--KVENPRVNQEIEVMKRC-HHENVVELYEILNDPEST-KVYLVLEYCSRG
 ... .|| |..|.|....      .|.  ||.|.|.      |.. .   . .     .|...||   ||.|.| || .  | .   ..|.|.||.  |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-----GAMHEQNCRED---FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG
Kinase TOS3.AA Pkinase_Tyr 175-211 48 3e-07 25.19 Pfam 122-158 (270) Show / Hide 
Range on Protein: 175-211
Range on HMM: 122-158/270
Sequence Identity: 48% (18 aa)

SGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVA
.|.|||.|... |||.   | |...|..|||.||| |
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA