Gene ALK2 (Human)

ALK2

Species: Human
Alias: ACVR1, ACTRI, ACVRLK2, ALK2, FOP, SKR1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP , GeneCards
Annotation: Consensus chromosomal location: 2q24.1,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
ALK2.NA RNA Sugen Kinome 2881 None Fasta, JSON
ALK2.AA Protein Sugen Kinome 509 None Fasta, JSON
ALK2.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON

Protein domain

Protein domains of ALK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ALK2.AA Activin_recp 33-107 24 1.9e-26 89.42 Pfam 1-121 (121) Show / Hide 
Range on Protein: 33-107
Range on HMM: 1-121/121
Sequence Identity: 24% (30 aa)

YMCV-CEGLS------CG-NE-------DHCE-----------GQQCFSSLSINDG---FHVYQK----GCFQVYEQGK----MTCKT----PPSP---G
..|. |.| .      |. ||       ..||           ..||. |...||.    ...|.    ||....|...    ..||.    ...|   |
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

QAVEC-CQ-GDWCNRNITAQL
. .|| |. .|.||||.| ..
HNHECWCCETDYCNRNLTPPP
Kinase ALK2.AA Type1 208-495 74 1.1e-278 764.87 In-house 1-290 (290) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-290/290
Sequence Identity: 74% (217 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLR
|...||.|||||||||||.|.|||||||||.||||.|||||||.|.|||.||||||||||.||....|.|||||||.|||.|||||||. .|||| ..||
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

IVLSIASGLAHLHIEIFGTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIW
...|.|.||||||.||||||  |||||||||.|||||.||||||||||||||||.|.|.|.|.|.|.||||||||||||||||||....||.|||..||.
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTL
.||||.||.|||....||||||..|.||.||||||||||||||||...|||||||| |.|.....||||||||||||.||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ALK2.AA STKR 208-495 59 4.8e-221 720.75 In-house 1-312 (312) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-312/312
Sequence Identity: 59% (186 aa)

ITLLECVGKGRYGEVWRGSWQG----ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSR-HSSTQLWLITHYHEMGSLYDYLQLTTLDT
|.|.||.|||||||||.|.|.|    |.||||||.||||.|||||||.|.|.|.||||||.|||.||... .| ||.||||.|||.|||.|||. .|.|.
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

VSCLRIVLSIASGLAHLHIEIF--GTQ--GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVG-------NNPRVGTKRYMAPEVLDETI
 ...|. .|.|.|||||| ||.  |||  .||||||||.||||||||..|.|||||.|||..|...|||.|..       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

QVDCFDS-YKRVDIWAFGLVLWEVARRMVSNG------IVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWF-SDPTLTSLAKLMKECWYQNPS
...||.| .||.|..|.|||.||.|||. ..|      ||..|..||||.|||.||||||.||||...|||||||||  ..| ..|..|.|.|||...|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase ALK2.AA Type2 208-495 40 1.2e-112 373.33 In-house 1-315 (315) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-315/315
Sequence Identity: 40% (126 aa)

ITLLECVGKGRYGEVWRGSWQGE-----NVAVKIFSSRDEKSWFRETELYNT-VMLRHENILGFIASDM---TSRHSSTQLWLITHYHEMGSLYDYLQLT
|.|.| .||||.|.||...|...      ||||||. .|  ||  | ..| . ....||||| ||...           ..||.| .|. |||.|||   
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TLDTVSCLRIVLSIASGLAHLHIEIF-GTQ---GKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQ--------LDVGNNPRVGTKRYMAPEV
|.| ..|.|. .|.| |||||| ||  ..|    ||.|||||.||||.||| .. |||||.|||.  . ....         |  |   |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDETIQVD-CFDSYKRVDIWAFGLVLWEVARRMVSNG---IVEDYKPPFYDVVPND-PSFEDMRKVVCVDQQRPNIPNRWFSDPTLT-SLAKLMKECWYQ
|. ...   | |. |..|. |.||||||.. |    .    | .|..||   | .  ||||||. .|  . .||..|. |   |... .|  .. .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPSARLTALRIKKTL
 . |||||. ..  .
DAEARLTAQCVQERM
Kinase ALK2.AA TKL 214-495 29 1.2e-112 380.49 In-house 1-364 (364) Show / Hide 
Range on Protein: 214-495
Range on HMM: 1-364/364
Sequence Identity: 29% (111 aa)

VGKGRYGEVWRGSWQG----------ENVAVKIFSSRD-------------------------EKSWFRETELYNTVM---LRHENILGFIASDMTSRH-
.|.|..|||..| |.|          . ||||.|.|..                         | ||||..| . ..|   |||.||. |..... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIF--GTQGKPAIAHRDLKSKNILVKKNGQ--------------C
        ...||.... |.. |||..||.         .|..|.||.|...|| ...  .|  ||.|.|||||||||||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVMHSQSTNQLDVG---------------NNPRVGTKRYMAPEVLDETIQVDC----------FDSYKRVDIWAFGLVLWEVARRMVSNGIVE
.|.|.||. ..|||.|. | .               .....||.|.||||||..... ..          |.  ...|...||.||||.. | .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFS-------DPTLTSLAKLMKECWYQNPSARLTALRIKKTL
 |..|.......|| ||.| ..||....|| ||..| .       .....|..|||..|| ..|..|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ALK2.AA Pkinase 208-495 22 4e-77 267.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-293/293
Sequence Identity: 22% (75 aa)

ITLLECVGKGRYGEVWRGSWQGEN--VAVKIFSSRDEKSWFRET-----ELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMG----SLYDYLQ
.......|.| .|.|... ..|..  |||||.. |.||||...|     |..   .|.|.||. .. . ..    .. ..... |.|.|    .|.||..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---LTTL--DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQC----CIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVL
    ...  .   | .... |..||...| .         | |||||. |||...||..    .|.| |||  ..   .  .. .. ..|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL-----------------TSL
      .. .  ..||.|..|..|.|.. .           |||.. . ....  |.....| . ..|.  ... ...                    ..
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AKLMKECWYQNPSARLTALRIKKT--L
 ...| |. ..|. |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ALK2.AA TKL-Unique 210-495 27 1.5e-37 130.03 In-house 1-290 (290) Show / Hide 
Range on Protein: 210-495
Range on HMM: 1-290/290
Sequence Identity: 27% (86 aa)

LLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETE-LYNTV----MLR-HENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQ-------
 .. .| | ||.| .| | |. ||.|.|.   |.| ..... ..| |    .|. |.||. ...  |    .  .. ... | ..|||||.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----LTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKN-----GQCCIADLGLAVMHSQSTNQLDVGNN-----PRVGTKRYM
     ..|.    ..... ||.|. .||     . ..| |.||||||.|.||  |      .  |.| ||.   |....    ...      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLH-----HCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV--DQQRPNIPNRWFSDPTLTSLAKLMKECWYQ
|||||        ..  . .|...|| ||||    .... |   || |. ..     ..|  ...| .  . .|| |||..       .. .|...|| .
APEVLRMNF----CQYSEKSDVYSFGIVLWE----IATRKITKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHC-----PKEYRDLIQQCWHH

NPSARLTALRIKKTL
.|| | .   | . |
DPSQRPSFDEIIHRL
Kinase ALK2.AA MLK 208-414 26 2.6e-37 127.03 In-house 1-229 (291) Show / Hide 
Range on Protein: 208-414
Range on HMM: 1-229/291
Sequence Identity: 26% (66 aa)

ITLLECVGKGRYGEVWRGSWQGEN-----VAVKIFS-------SRDEKSWFRETELYNTVMLRHEN----ILGFIASDMTSRHSSTQ-LWLITHYHEMGS
|...| .|.| .|.||.| |....     ||||..        . .. .|  |.| .   .|.|.|    |  | .      ..... . ....| | ||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV----CLQPPCHFCIVMEYCEGGS

LYDYLQLTT---------------LDTVSCLRIVLSIASGLAHLHIEIFGTQGKP-AIAHRDLKSKNILVK------KNGQCCIADLGLAVMHSQS-TNQ
||..|   .                |  . ... | .|.|.. || .      .| .| ||||||.|||.       ..|.. |.| |.. . .|. || 
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM

LDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV
 .     . || ..|||||.   .. . ..  . .|.| .|.||||.
MS-----NAGTYAWMAPEVIQQ-FRCEKYS--EKCDVWSWGVVLWEM
Kinase ALK2.AA S_TKc 208-502 20 3.5e-31 110.85 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-502
Range on HMM: 1-231/231
Sequence Identity: 20% (64 aa)

ITLLECVGKGRYGEVWRGSWQG--ENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEM--GSLYDYLQLTT----
 ..|. .||| .|.|... . .  . ||.|| .    ..  || ..      .|.||  .. .  .     . |.... | .   |.|.||..       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCF
   ..   . ...  |...|...|        .  | |||||  |||. .  .  |.| |||              .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

DSYK--RVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKK-
 .|   ..|.|..| .|.| . .          .|||.         . | |...                   ..  ... |.  .|. |.||  . . 
-GYGKCKCDWWSCGCILYEMLCG----------YPPFP-------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

-TLTKIDNSL
  . |..  .
EWDIKCHPWF
Kinase ALK2.AA TK 208-414 16 2.7e-25 81.1 In-house 1-387 (486) Show / Hide 
Range on Protein: 208-414
Range on HMM: 1-387/486
Sequence Identity: 16% (65 aa)

ITLLECVGKGRYG---EVWRGSWQGEN---------------------------VAVKIFS---SRDEKSWFR-----------------ETELYNTVML
|||..  |.| .|   ||..| |.|.|                           ||||.     . ...  |                  | .. .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIA----SDMTSRHS----STQLWLITHYHEMGS----LYDYLQ-------------------------------------------------
.|.||. ...    ..  .. .    .  ..... | . |.    | |||.                                                 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LTTLDTVSCLR----------------IVLSIASGLAHLHIEIF-GTQGKPAI---AHRDLKSKNILVKKNGQ-----------CCIAD
           ||| | ... .                . . ||.|...||   . .      |    ||||   |.|| .|..           | |||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIAD

LGLAV-------MHSQSTNQLDVGNNPRVGT-----------------------KRYMAPEVLDETIQVDC---FDSYKRVDIWAFGLVLWEV
 ||.           .|     . .....|.                        |.||||.|.. .   .          |.|.|| ..||.
FGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI
Kinase ALK2.AA STE 208-488 18 5.3e-20 67.41 In-house 1-348 (359) Show / Hide 
Range on Protein: 208-488
Range on HMM: 1-348/359
Sequence Identity: 18% (70 aa)

ITLLECVGKGRYGEVWRGSWQ--------GEN---------VAVKIFSSRDEKS---------------WFRE---TELYNTVMLR--HENILGFIASDM
 ...|..||| .|.| ..           ||.         .|.|. . .....                 ..    |.     ..  |.||  .. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TSR--HSS-TQLWLITHYHEMGSLYDYLQL--TTLDT-------------VSCLRIVLSIASG-LAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
     |.. ..||..  | . ||| | ..    ....                 .|. .|  | |..||           | |||.|. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVMHSQSTN------------QLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPND
..| |..   ..|                .  .|  |||  .|||||..   |    . |  ..||| .|....| |          . |||. |  |  
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA----------TGKPPWHDMHPMR

PSFEDMRKVVCVD---------QQRPNIPN------------------RWFSDPTLTSLAKLMKECWYQNPSARLTA
  |. ... ....         .. | .|.                  . .|..    .   .. |   .|. | ||
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE----FKDFINKCLQKDPNKRPTA
GS ALK2.AA GS 178-208 70 1e-18 69.46 SMART 1-31 (31) Show / Hide 
Range on Protein: 178-208
Range on HMM: 1-31/31
Sequence Identity: 70% (22 aa)

STLADLLDHSCTSGSGSGLPFLVQRTVARQI
.|..|.....||||||||||.||||||||||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS ALK2.AA TGF_beta_GS 178-206 65 3.9e-18 62.67 Pfam 1-29 (29) Show / Hide 
Range on Protein: 178-206
Range on HMM: 1-29/29
Sequence Identity: 65% (19 aa)

STLADLLDHSCTSGSGSGLPFLVQRTVAR
.|..|.....||||||||||.|||||.||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase ALK2.AA TyrKc 208-495 23 1.1e-16 47.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-495
Range on HMM: 1-280/280
Sequence Identity: 23% (74 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVML--RHENILGFIASDMTSR---HSSTQLWLITHYHEMGSLYDYLQLTT--L
|||..  | | .|||..| |  ..||||   .  ..   || ..    .|  .|.||. ...  ...     .. .|.... | . |.| |||. .   |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQS------TNQLDVGN--NPR-VGTKRYMAPEVLDETI
 .   | . . ||.| ..||           . ||||   |.||..|... |.| ||.  .         .   ..    . . .   | ||||..    
CMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

QVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDP-----TLTSLAKLMKECWYQNPSARL
.  .| .    |.|.|| ..||    . ..|     ..| .... .. | ..... |     .|  ||     |       . . ..||.||  .|. | 
NYGKFTTK--SDVWSFGVCMWE----IFTYG-----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPEDRP

TALRIKKTL
|   |.. .
TFSEIHECF
Kinase ALK2.AA UTK 208-358 21 6.8e-15 47.38 In-house 1-175 (296) Show / Hide 
Range on Protein: 208-358
Range on HMM: 1-175/296
Sequence Identity: 21% (41 aa)

ITLLECVGKGRYGEVWRGSWQ------GE-NVAVKIFSSRDEKSWFRE---TELYNTV------MLR-HENILGFIASDMTSRHSSTQLWLITHYHEMGS
. |... |.|..||| .....      .|  ||||  .... .  ..|   . .. .       ... |.|.|....  . .      ....| | | |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP----WMIVTEYMENGD

LYDYLQLTTL---------DTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNG-------QCCIADLG---LA
| .||.  .          .  . |  .. ||.|...||   |         ||||  .|.|| ...       .| |||.|   ..
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF--------VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMS
Kinase ALK2.AA Pkinase_Tyr 208-320 25 3.4e-11 38.54 Pfam 1-128 (270) Show / Hide 
Range on Protein: 208-320
Range on HMM: 1-128/270
Sequence Identity: 25% (33 aa)

ITLLECVGKGRYGEVWRGSWQ------GENVAVKIF--SSRDE---KSWFRETELYNTVML-RHENILGFIASDM-TSRHSSTQLWLITHYHEMGSLYDY
||...  |.| .|||..| |       .  ||||.   .. .|   .  | . |.     | .|.||. ...  .  ....  |..... | . |.|.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDY

LQLT-----TLDTVSCLRIVLSIASGLAHLH
|.        |..   | . . ||.|...|.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase ALK2.AA Dicty4 306-387 33 2e-10 31.14 In-house 112-189 (277) Show / Hide 
Range on Protein: 306-387
Range on HMM: 112-189/277
Sequence Identity: 33% (30 aa)

LR---IVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAV----MHSQSTNQLDVGNNPRVGTKRYMAPEVL
.|   . ...| |...||  .      | | |||||| |.|| || .  ..|.||.       ....||  .     .||  .|||||.
KRAMRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA-----CGTPCWMAPEVM
Kinase ALK2.AA Dicty4 208-244 37 1.2e-09 28.57 In-house 1-37 (277) Show / Hide 
Range on Protein: 208-244
Range on HMM: 1-37/277
Sequence Identity: 37% (14 aa)

ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKS
|.  .  ||| .||| .|.| |  ||||.. .. ...
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNF
Kinase ALK2.AA Pkinase_Tyr 334-414 29 2.7e-08 28.72 Pfam 134-207 (270) Show / Hide 
Range on Protein: 334-414
Range on HMM: 134-207/270
Sequence Identity: 29% (24 aa)

HRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQL-DVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEV
||||  .|.||..|... |.| |||  . ... .   .. . .    . ||||.. . .    | .    |.|.|| ..||.
HRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGK-LPIKWMAPECINYGK----FTTK--SDVWSFGVLMWEI
Kinase ALK2.AA UTK 469-495 22 5e-05 13.15 In-house 270-296 (296) Show / Hide 
Range on Protein: 469-495
Range on HMM: 270-296/296
Sequence Identity: 22% (6 aa)

SLAKLMKECWYQNPSARLTALRIKKTL
.. .||..||...|. | .. .. ...
PVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase ALK2.AA TK 473-495 34 0.000106 10.84 In-house 464-486 (486) Show / Hide 
Range on Protein: 473-495
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

LMKECWYQNPSARLTALRIKKTL
||..||  .|. | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase ALK2.AA Dicty4 448-485 34 0.000161 11.18 In-house 231-263 (277) Show / Hide 
Range on Protein: 448-485
Range on HMM: 231-263/277
Sequence Identity: 34% (13 aa)

VCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSAR
||  . || ||     | ...|...|...||  .|. |
VCNKKLRPPIP-----DWCPPSWKHLIQWCWDHDPQHR
Kinase ALK2.AA Pkinase_Tyr 470-495 38 0.004567 11.01 Pfam 245-270 (270) Show / Hide 
Range on Protein: 470-495
Range on HMM: 245-270/270
Sequence Identity: 38% (10 aa)

LAKLMKECWYQNPSARLTALRIKKTL
. .|||.|| ..|. | |   |   |
IYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ALK2.AA MLK 469-485 52 0.00745 5.89 In-house 265-281 (291) Show / Hide 
Range on Protein: 469-485
Range on HMM: 265-281/291
Sequence Identity: 52% (9 aa)

SLAKLMKECWYQNPSAR
...||||.|| |.|. |
HWKKLMKQCWNQDPHKR
Kinase ALK2.AA UTK 403-414 58 0.05143 2.69 In-house 222-233 (296) Show / Hide 
Range on Protein: 403-414
Range on HMM: 222-233/296
Sequence Identity: 58% (7 aa)

DIWAFGLVLWEV
|.|.|| |.||.
DVWSFGVVCWEI